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The Hinge of Moral History

Were the new Gentile converts obliged to observe all the mandates of the Torah? As the Apostle Paul contemplated this, he came to the understanding that history not only matures, but had a pivotal point. Fr. Pat preaches from Galatians 3:23-4:5.




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Obesity Drug's Promise Now Hinges On Insurance Coverage

Yuki Noguchi | NPR

When a promising new drug to treat obesity was approved by the Food and Drug Administration for sale in the U.S. last month, it was the first such treatment to gain approval since 2014.

In clinical trials, weekly injections of semaglutide — or Wegovy, as it's been branded -- helped people drop an average of 15% of their body weight. That's an average of about 34 pounds over 16 months, before their weight plateaued, a far greater weight loss, obesity specialists say, than achieved with other drugs on the market. At least as important, Wegovy raised none of the alarm bells with the FDA or obesity doctors that it might trigger serious side effects of the sort experienced by some people taking fen-phen or some previous medical treatments for obesity.

But with a price tag for Wegovy of $1,000 to $1,500 a month, a very big question remains: Will insurers cover its significant cost for the many millions of people like Marleen Greenleaf, who might benefit?

Greenleaf grew up on the island of Trinidad, where her entire family paid little heed to what they ate and paid a high medical price, she says: "My husband has diabetes, my sister has diabetes, my brother has diabetes."

Since then, she's tried — and failed — at numerous diets, says Greenleaf, now 58 and an administrator at a charter school in Washington, D.C. Then, in 2018, she signed up for the clinical trial of a new drug — a once-weekly shot that changes the way her brain signals hunger.

A drug that finally stops her cravings

She noticed the change soon after her first injection of Wegovy: "For me, there was something that triggered in my brain to tell me that I was not hungry," she says. No more fierce cravings for the chocolate chip cookies she adores. Without the cravings she was able to slow down and reconsider the foods she'd been reaching for.

"I also wanted to eat healthier," she says. "I was looking at options, reading labels, looking at the calories — not just the calories, but also the sugar."

Over the 68-week research trial, Greenleaf dropped 40 pounds. Her blood pressure fell, which meant she qualified to donate her kidney to her husband, who was on dialysis.

"It was one of the best gifts of life that I could have ever given," she says.

But after that study ended, Greenleaf regained some of the weight. Wegovy is considered a long-term, possibly lifelong medication to treat chronic obesity. In the pre-marketing clinical studies, weight loss topped out at a total average weight loss of 15-18%, even as people continued to take the drug. And, as was the case with Greenleaf, once they stopped getting the weekly injections some of that weight came back.

Now, Greenleaf wants to resume the Wegovy shots.

"My only challenge actually is getting the insurance company to approve it," she says.

Reimbursement for obesity drugs' cost is patchy

Insurance coverage, it turns out, is a giant question — not just with Wegovy, but with obesity drugs in general. Some private insurers do include some prescription obesity drugs in the list of medicines they'll cover; it's too early to tell whether Wegovy will make those lists. Many doctors and patients are optimistic, because it is a higher dose of an existing diabetes medication called Ozempic, which is often covered by insurers.

A few select state Medicaid programs will cover medications that treat obesity, in some circumstances. But, significantly, Medicare does not cover obesity drugs — and many private insurers typically follow Medicare's lead.

Yet the demand for a good treatment is there, says Dr. Fatima Cody Stanford, a leading obesity researcher at Harvard. She was not involved in conducting the Wegovy clinical trial, but closely followed it. "I'm excited about it," she says, because of the dramatic weight loss.

The drug acts on the brain so people eat less and store less of what they eat. That helps address the excess weight as well as helping with numerous related diseases of the liver or heart, for example.

Why the FDA has been slow to approve obesity treatments

There is a long history of drugs that have looked like promising treatments for obesity, then failed. Decades ago, amphetamines, were prescribed, until their addictive properties became apparent. In the 1990s, the combination of fenfluramine and phentermine — administered as the diet drug fen-phen — was heavily marketed, only to later be pulled from the market for causing heart valve problems.

Those experiences and others have made physicians skeptical.

"In obesity medicine field, we've learned to be cautiously optimistic each time we have a new medication that looks promising," says Dr. Ihuoma Eneli, director of the Center for Healthy Weight and Nutrition at Nationwide Children's Hospital in Columbus, Ohio, who was not involved in the study of Wegovy.

So far, Eneli does not see any obvious concerns with the class of drugs that includes Wegovy, and calls the results so far "very promising." Wegovy is similar to another drug made by Novo Nordisk — Saxenda — which has been on the market since 2014, and which Eneli occasionally prescribes to her pediatric patients who are struggling with obesity.

In clinical research studies, the primary side effects reported after taking Wegovy affected the digestive system: nausea, diarrhea, vomiting, constipation, abdominal pain or intestinal infections.

Eneli says such side effects and their frequency are milder than the problems that have arisen in the past. That good safety profile may mean the drug is "less likely to come up with unanticipated risks," she says.

But, the new drug will be of little use, she and other doctors who treat obesity say, if it's not also affordable for patients.

"Before I even bring up that drug with my patients, I'm looking to see which insurance they are having on the left side of my screen — because that will determine whether I bring it up," Stanford, the Harvard physician, says. "If it's out of reach, like I said, I won't bring it up."

Stanford says her patients on existing obesity medications do extraordinary things to keep their coverage so they can afford to stay on the drugs.

"Several nurses here at the hospital that are my patients stayed working — they were supposed to retire — so they could stay on their injectable medication," Stanford says,"because that's how beneficial it was to them."

Why some are willing to pay out of pocket

Some people, like David Scheesley, 42, says he would consider paying for Wegovy, even if he had to pay the full sticker price. The Hanford, Calif., correctional officer has tried since 2019 to lose weight on various diets — low-fat, all-meat, all-vegetable — without success. His weight has led to other health concerns — with his blood fats and his heart — which makes Scheesley think of his 5-year-old son.

"I want to see him for a lot of years; I don't want to have a stroke," he says. "I don't want to have diabetes. I want to be there for him. So, for me personally, that [monetary cost] is not astronomical, if it can give me some more time."

Novo Nordisk, the company that makes Wegovy, is in talks with insurers, and acknowledges that ensuring health insurance coverage of its drug is critical. The challenge, says Douglas Langa, executive vice president of Novo Nordisk North America, is getting doctors, patients, and politicians to recognize obesity as a disease — and that therefore insurance should cover the cost of medicine to treat it.

"There's a medical component to [obesity] that needs to be recognized; this is a disease state like we should be treating any other disease state," Langa says. He says about 40% of private insurers cover Saxenda, the similar weight-loss medication the company makes.

Langa tells insurance companies this, making the case for why prescriptions for Wegovy should be covered. His company is also heavily lobbying Congress to pass legislation to allow Medicare to cover obesity medications. It makes sense from a financial perspective, he argues, because obesity is the root disease underlying so many other diseases.

"We do believe insurers understand that [untreated obesity] is a gateway into 60 other health conditions," Langa says. The need is hard to ignore, he adds. More than 100 million people in the U.S. alone struggle with obesity.

Copyright 2021 NPR. To see more, visit https://www.npr.org.

This content is from Southern California Public Radio. View the original story at SCPR.org.




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How do you assess risks? It hinges on leadership & culture

Not many people walk around throughout their day with a risk assessment in hand. We should, however, always have an informal risk assessment tool in our mind that allows us to perform at least a cursory assessment until we can dig deeper or in a more formal way.




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The Silent Guardians: Why Your Data Center's Safety Hinges on Security Guards

The Crucial Role of Security Guards in Data Centers




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Why the Future of Packaging Hinges on Inclusivity

While a stubborn clamshell container or vacuum-sealed jar lid might serve as a minor inconvenience to some, it can be a major struggle for others. 




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Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights

The following article, Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights, was first published on Conservative Firing Line.

(Natural News) Liberals have been working hard to portray Trump as a misogynist, and it worked on a lot of women – with some of them buying into the false narrative that he will work against women so wholeheartedly that they are now having very public meltdowns over his victory. Revolver put together some of the …

Continue reading Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights ...




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The Success of Social-Emotional Learning Hinges on Teachers

Too often, teachers are asked to use SEL practices without enough training and ongoing support, tanking the effectiveness.




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UN Reports Ending AIDS by 2030 Hinges on Policy Decisions This Year

A new report by UNAIDS warns that the global commitment to ending medlinkAIDS/medlink as a medlinkpublic health/medlink threat by 2030 hangs in the balance.




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Unhinged man shouts he has HIV, then punches, spits at train operator in Brooklyn

The C train reached its last stop just after 9 a.m. Saturday at the Euclid Ave. station in East New York when the man insisted he needed five more minutes before he could leave the car.




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Unhinged man shouts he has HIV, then punches, spits at train operator in Brooklyn

The C train reached its last stop just after 9 a.m. Saturday at the Euclid Ave. station in East New York when the man insisted he needed five more minutes before he could leave the car.




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What the D in OECD stands for, by Barbara Ischinger, Director for Education and Skills

Did you know that the Organisation for Economic Co-operation and Development helped to lay the groundwork for the United Nations’ Millennium Development Goals? Even though Development is part of our name, there are many people who don’t realise just how much of our resources are devoted to developing economies and not only to the development of the OECD’s 34 member countries.




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OECD Education Today… and tomorrow (Barbara Ischinger, Director for Education and Skills)

When we think of innovation in education these days, we immediately think of technology: getting more computers into more classrooms, offering online courses to students in higher education. - See more at: http://oecdeducationtoday.blogspot.fr/2012/12/oecd-education-today-and-tomorrow.html#sthash.dv2MKgEf.dpuf




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Education for policymakers - Barbara Ischinger, Director, OECD Directorate for Education and Skills

Education is one OECD department that has embraced the information revolution.




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Video: Barbara Ischinger on tackling the global talent gap

Dr Barbara Ischinger, Director of Education and Skills, OECD, France - Better Skills, Better Lives (Tackling the global talent gap - Global Skills Exchange, Leipzig Germany, 6th July 2013)




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Africa: making growth more inclusive hinges on unlocking potential of local economies, says the African Economic Outlook 2015

With Africa’s population set to double by 2050, modernising local economies will be vital to make the continent more competitive and to increase people’s living standards, according to the African Economic Outlook 2015, released at the African Development Bank Group’s 50th Annual Meetings.




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Africa: Economic transformation hinges on unlocking potential of cities, says the African Economic Outlook 2016

How Africa urbanises will be critical to the continent’s future growth and development, says the African Economic Outlook 2016 released today at the African Development Bank Group’s 51st Annual Meetings.




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Hinged reusable endocavity needle guide

A reusable needle guide suitable for an ultrasonic probe to be use for an endocavity examination of a patient is disclosed. The needle guide basically comprises at least a first and second guide members and a mounting (e.g., clamp) assembly. The clamp assembly serves to releasably mount the needle guide on the probe. The first guide member has a first passageway-forming surface. The second guide member has a second passageway-forming surface. The guide members are connected together to enable them to be pivoted from a closed orientation to an open orientation and vice versa. The first and second passageway-forming surfaces form an elongated passageway to guide a needle therethrough when in the closed orientation. The first and second passageway-forming surfaces are disposed at an angle to each other when they are in the open orientation, whereupon the first and second passageway-forming surfaces can be readily cleaned.




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Seal arrangement and hinge of a chain with the seal arrangement

A sealing arrangement used to create a seal between a first part of a chain and a second part of the chain, wherein the second part can at least be pivoted in relation to the first part, includes a sealing ring with an annular sealing lip for sealing a lubricant area between parts which can be pivoted towards each other, and an elastic ring which is adapted to be fixed to one of the parts and which is adapted to exert pressure in the sealing ring. In addition, a supporting ring is arranged between the sealing ring and the elastic ring.




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Hinge used for the treatment of anterior and posterior cruciate ligament injury and method for using the same

A device and method for using the device arranged to maintain anatomical alignment between a joint by creating a dynamic load around the joint to restore and maintain the anatomical alignment. The orthotic device uses a hinge to create a directed force on a tibia by maintaining misalignment of an instant center of rotation (ICoR) of the hinge at a position relative to an anatomical knee joint.




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Adjustable hinge

An adjustable hinge having a first support arm, a second support arm, and a deformable insert that is between the first support arm and the second support arm.




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Computer hinge with hollow and partially annular clutch

A hinge assembly having a hollow and partially annular clutch is arranged to pivotally couple a portable computer base portion to a portable computer lid portion. The hinge assembly includes at least an elongated, hollow and partially open cylindrical portion that includes a partially annular outer region and a central bore region, the central bore region suitably arranged to provide support for electrical conductors between the base and lid portions. The hinge assembly also includes a plurality of fastening components that couple the hollow clutch to the base portion and the lid portion of the portable computer, with at least one of the fastening regions being integrally formed with the hollow and partially open cylindrical portion such that space, size and part count are minimized.




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Portable electronic device with hinge structure

portable electronic device includes a host module, a display module and a hinge structure. The hinge structure is pivotally connected to the host module and the display module. The hinge structure includes a support frame, a rotating component and two pivotal components. An end of the rotating component is installed inside the support frame and another end of the rotating component is installed inside the display module, so that the display module is capable of rotating in a first rotating direction relative to the support frame. The two pivotal components are disposed at opposite sides of the support frame and separated from the rotating component. An end of each pivotal component is installed inside the support frame and another end of each pivotal component is installed inside the host module, so that the display module is capable of rotating in a second rotating direction relative to the host module.




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Agricultural implements with float-restricted hinged wings

A towable soil pulverizer having a center section and foldable wings mounted by hinges on opposite sides of the center section to fold upwardly or downwardly about substantially longitudinal hinge axes. Each hinge has a spaced ball joint and guide roller in roller slot. A wing float axis for each wing extends substantially perpendicular to the longitudinal hinge axis in a transverse direction, each wing also being pivotal about the float axis. The hinge design with the float axis prevents weight transfer between the center section and wing sections when the pulverizer operates over uneven soil, providing uniform soil conditioning over the width of the pulverizer. The center section rollers are positioned ahead of, behind, or co-linear with the wing rollers. Lockout kits are provided for mounting in the roller guide slots for restricting motion.




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Counterbalance mechanism for bottom-hinged aircraft fuselage doors

A counterbalance mechanism for counterbalancing weight of a bottom-hinged door (such as a clamshell-type airstair door of an aircraft) includes an operator handle, a hoist rod pivotally connected at one end to the operator handle and at an opposite end thereof to the door near a bottom region thereof. A force accumulator assembly is provided which includes a force biasing member which accumulates and dissipates a bias force when opening and closing the door, respectively, to provide mechanical counterbalance to the weight of the door. A bellcrank assembly operatively connects the operator handle to the force accumulator. In such a manner, weight counterbalancing of the door is achieved.




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Fixing element for locking a hinged hand crank on the input shaft of a support winch for a semi-trailer

The invention relates to a fixing element for locking a hinged hand crank on the input shaft of a support winch for semi-trailers, wherein the hand crank is fastened to the input shaft in an articulated manner and can pivot between at least one folded-in rest position and at least one folded-out usage position. According to the invention, said fixing element has a fastening section for fastening to the hand crank and a spring bar connected to the fastening section on which at least one locking section is formed, wherein the locking section reaches over the end face of the input shaft in a form-fitting manner in a folded-out usage position of the hand crank and is simultaneously pulled against said end face of the input shaft.




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Hinged arm safety mechanism for foam dart launcher

A dart launcher comprises a housing, a safety arm, and a trigger. The housing includes a launching section configured to receive a dart having a minimum threshold length. The safety arm is movably attached to the housing and extends at least partially across the launching section. The safety arm is positioned so that the dart having the minimum threshold length engages at least a portion of the safety arm upon insertion into the launching section. The trigger is movable with respect to the housing and is operable to cause the dart having the minimum threshold length to launch from the launching section.




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Hinge Mechanism

A hinge mechanism rotatably joins a post and a hinge in a manner that allows for rapid assembly and disassembly. A first stop, second stop, and third stop are used to create a gravity-assisted rotation system for the hinge mechanism, with the hinge rotating between a horizontal locked position, raised unlocked position, and rotated collapsed position. A pin is placed through corresponding pin receptacles of the post and the hinge in order to secure the two together. The pin is locked within the post by a locking member, which secures the pin in a manner that facilitates easy pin insertion and removal. The hinge mechanism can be integrated into a variety of apparatuses, such as a table with rotating top; the top can be rotated to the collapsed configuration in order to serve as a seat back or left in the locked configuration to be used as a table top.




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Hinged rail for barrier operators

A movable barrier system wherein the trolley system comprises at least two guiding rail portions. At least one of the guiding rail portions is supported by a support member secured to the headroom area of the building support structure. The trolley traverses the at least two guiding rail portions by a hinged coupling device.




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Pinch-relief hinged assemblies and children's products including pinch-relief hinged assemblies

Hinged assemblies, and children's products including at least one hinged assembly, include a base member and a hinged member operatively and pivotally coupled to the base member to define a hinge. The hinge is configured to release if an obstruction is positioned between the hinged member and the base member while the hinged member is being closed and if a closing torque is greater than or equal to a release torque. The hinge also may be configured to not release when an opening torque is applied when the hinged member is in its open position even when the opening torque is greater than the release torque.




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Hinge mechanism for a vehicle hood

A hinge including a first hinge half rotatably connected to a second hinge half is described. A support mechanism selectively supports the first hinge half at one or more rotated positions relative to the second hinge half. The support mechanism includes a support which is selectively biased toward a support position in which the support is capable of supporting the first hinge half at a rotated position relative to the second hinge half. The support can further be selectively biased into a disengaged position in which the support is not capable of supporting the first hinge half relative to the second hinge half. With the support in a disengaged position, the first hinge half is freely pivotable relative to the second hinge half. An automatic reset mechanism may be utilized in connection with the hinge to reposition the support from the disengaged position to the support position as the hinge approaches a predefined position.




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Trigger hinge

A trigger hinge used in a mobile flip-up electronic device is disclosed to include a female shaft, a male shaft set mounted in the female shaft, and a trigger device mounted at the male shaft set. When the user opens or closes the mobile flip-up electronic device to rotate the male shaft set relative to the female shaft, a pushing and moving piece of the trigger device is moved forward or backward to switching on/off switch, and thereby booting up or shutting down the mobile flip-up electronic device. Thus, the invention enhances the application and convenience of use of mobile flip-up electronic devices.




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Hinge structure

A hinge structure includes a first shaft, a second shaft, a pivot base and a position-limiting mechanism. The first and second shafts are pivoted on the pivot base. The position-limiting mechanism includes a first position-limiting portion, a second position-limiting portion and a position-limiting component. The first position-limiting portion is fixed to the first shaft. The second position-limiting portion is fixed to the second shaft. The position-limiting component is slidably disposed on the pivot base and has first and second ends opposite to each other. When the position-limiting component moves to a first position, the first end and the first position-limiting portion interfere with each other to stop the first shaft and the pivot base from rotating relatively. When the position-limiting component moves to a second position, the second end and the second position-limiting portion interfere with each other to stop the second shaft and the pivot base from rotating relatively.




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Gear cam mounting device in dual-hinge device for a portable terminal

A gear cam mounting device in a dual-hinge device for a portable terminal is provided, in which first and second hinge shafts provide first and second parallel hinge axes, respectively, first and second gear cams are fixed around the first and second hinge shafts, in engagement with each other, and first and second locking units penetrate respectively through the first and second gear cams in a direction that is perpendicular to the first and second hinge axes, for locking the first and second gear cams to surround the first and second hinge shafts.




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Hinge in composite material and process for its manufacture

Disclosed is a hinge having a rigid portion integral with a flexible portion suitable to be bent with respect to the rigid portion, wherein the rigid portion has a substrate in a rigid composite material and the flexible portion has a first flexible sheet, wherein a first portion of the first flexible sheet is joined at least partially to the substrate by means of at least one first layer of resin for composite materials, wherein the flexible portion also has a second flexible sheet joined at least partially by means of at least one second layer of resin for composite materials both to the first portion of the first flexible sheet and to at least one second portion of the first flexible sheet which is not joined to the substrate.




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Vertical adjustable hinge

A vertically adjustable hinge includes a first leaf rotatably connected to a leaf assembly. The leaf assembly defines an opening with at least a first inclined surface and includes a block received in the opening. The block defines a threaded hole and at least a second inclined surface abutting the first inclined surface. A leaf assembly housing receives the leaf assembly and the block. The leaf assembly housing defines screw holes for receiving a screw that passes through the threaded hole. A rotation of a screw in the threaded hole causes a horizontal translation of the block, which in turn causes a vertical translation of the leaf assembly.




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Hinge for transport cases, trunks, suitcases and the like

A hinge for transport cases, trunks, suitcases and the like, comprising two elements which are mutually articulated about a common axis and are both able to rotate with respect to the common axis. Each element is delimited by two parallel walls and has a total width that is equal to the width of the channel delimited between the stiffening ribs of the transport case, suitcase or trunk on which it will be installed. Each element is associable with the stiffening ribs of the respective transport case, once it is inserted between the ribs, without requiring any mechanical machining of the surfaces of the case.




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HANDEL, G.F.: Messiah (1742 version) (Mields, Schachtner, Kristjánsson, Berndt, Gaechinger Cantorey, Rademann) (ACC-30499)




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Trump and Biden’s bitter election race hinges on new crisis

When Americans were yesterday learning of the country’s worst employment numbers since the Great Depression, the reaction of their president was a window into how he is setting up to fight the general election.




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Stay and Play at Home with Popular Past Google Doodles: Fischinger (2017)

Date: April 29, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating Oskar Fischinger!
 

 



Help stop the spread of COVID-19 by following these steps.  
 



Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

 

 

 

Location: Global

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It’s time to stop whingeing and get behind the Government, says LEO McKINSTRY



AS THEY grapple with the gargantuan challenge of the coronavirus pandemic, ministers are under continual fire for their handling of the crisis. According to a brigade of armchair critics and political axe-grinders, the Government has failed on every front, from the inadequate supply of medical equipment to the dismal lack of preparedness.




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The Success of Social-Emotional Learning Hinges on Teachers

Too often, teachers are asked to use SEL practices without enough training and ongoing support, tanking the effectiveness.




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Drake: Dark Lane Demo Tapes review – rap’s whingeing king hits a dead end

OVO
There are flashes of skill and rawness in this odds-and-ends mixtape but it feels like a clumsy lunge at commercial success

In a world where the boundary between mixtapes and albums is becoming ever more blurred, the title of Drake’s latest album highlights its interstitial nature. That said, it’s still slightly misleading. There are tracks here that sound like demos – the mopey James Blake-isms of Chicago Freestyle are audibly unpolished – but for the most part, it ’s a way of collecting up leftovers and leaks, spare tracks he apparently has lying around the studio.

Those inclined to view Drake’s career with a cool eye might be surprised he has any spare tracks lying around the studio, given the state of his last album. Listening to Scorpion, 25 songs long, required a certain degree of mental stamina: you needed to steel yourself against the panicky sensation that you might die of old age before it ended. But it wasn’t the sheer quantity that was the problem so much as the quality of what was there. Scorpion had its moments but was so hopelessly uneven that it was easy to buy into the theory that its length was not due to its author’s teeming multiplicity of fantastic ideas, but an attempt to game the streaming services: more songs means more streams, more streams means a higher chart placing.

Continue reading...




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Premier League 'Project Restart' hinges on crunch talks with players this week

Premier League clubs and their squads will hold crunch meetings this week, with players holding the key to the top-flight's plans for a return to action next month.




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Success from the UN climate summit will hinge on new ways to build national action

Next week’s U.N. Climate Action Summit in New York, and the roughly yearlong process it will kick off, presents the world with a challenge. On the one hand, the science of climate change is clear and it points to a need for a substantially enhanced global response—and quickly. Over the next year, as part of…

       




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Market's comeback hinges on the economy reopening without major setbacks

The old saw, 'sell in May and go away' might not apply this year if the U.S. economy reopens smoothly.




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Africa: making growth more inclusive hinges on unlocking potential of local economies, says the African Economic Outlook 2015

With Africa’s population set to double by 2050, modernising local economies will be vital to make the continent more competitive and to increase people’s living standards, according to the African Economic Outlook 2015, released at the African Development Bank Group’s 50th Annual Meetings.




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Africa: making growth more inclusive hinges on unlocking potential of local economies, says the African Economic Outlook 2015

With Africa’s population set to double by 2050, modernising local economies will be vital to make the continent more competitive and to increase people’s living standards, according to the African Economic Outlook 2015, released at the African Development Bank Group’s 50th Annual Meetings.




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'Spoilt brat' fitness coach who whinged about luxury hotel quarantine in Perth hits back at critics

Jess Pinili, 26, has been holed up a room at in Perth's five star Duxton Hotel since returning from Bali on Sunday, where she'll remain for another 10 days.




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Jeb Bush calls Donald Trump 'unhinged' and 'dishonest' in new video 

Jeb Bush has his own countdown to contribute to conclude the year. The Bush campaign put out a new video blasting the 'chaos candidate' Donald Trump, pointing out his more clueless moments.




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[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00095