Spain unites in solidarity with massive aid effort after devastating floods

A pivotal study has uncovered a genetic defense mechanism in lily plants against Botrytis cinerea, the fungus behind gray mold disease. Central to this defense is LlHSFA4, a transcription factor that, when activated, initiates a robust response against the pathogen. This discovery could transform strategies for protecting horticultural crops from severe fungal infections.

Australian authors devastated after losing thousands to Shawline Publishing, now in liquidation  ABC News

OM Philippines hosts micro-business workshops that offer a future with hope.

జూనియర్ ఎన్టీఆర్, జాన్వీ కపూర్ జంటగా నటించిన మూవీ దేవర. యువసుధ ఆర్ట్స్, ఎన్టీఆర్ ఆర్ట్స్ బ్యానర్‌లపై మిక్కిలినేని సుధాకర్, నందమూరి కళ్యాణ్‌రామ్‌లు ఈ సినిమాను సంయుక్తంగా తెరకెక్కించగా కొరటాల శివ దర్శకత్వం వహించారు. ఇటీవలే థియేటర్‌లో బిజినెస్ క్లోజ్ చేసిన దేవర రీసెంట్‌గా ఓటీటీలలోకి అడుగుపెట్టాడు. స్క్రీన్‌పై సంచలనం సృష్టించిన ఎన్టీఆర్ ఇక్కడ ఎలాంటి రికార్డులు

The list of short english words written in Devanagari.

egrep -x '.{1,2}' eng_words.txt

ऑनऑफऑलटीटूडेडॉदफीलॉसन

The owners of a coffee shop in Stockton say they have seen footfall drop significantly.

This article examines the conditions under which organizations publicly respond to unfavorable consumer evaluations that challenge their market identity. Because organizations' market identities are certified by expert evaluations, consumers' devaluations that challenge these expert evaluations represent an identity threat. However, organizations do not always react to consumers' devaluations because of the risks associated to public responses. Hence, we first predict that organizations are more likely to respond to severe devaluations than to weaker ones; second, we propose that organizations, when faced with severe devaluations, are more likely to craft responses that justify their actions and behaviors. We further contend that, for any market identity under consideration, an organization's reputation amplifies these relationships. Analyses of a dataset of London hoteliers' responses to online reviews posted on TripAdvisor during the period 2002-2012 lend substantial support to our hypotheses.

Patrick Doherty volunteered for a new medical intervention of gene-editor infusions for the treatment of genetically-based diseases.; Credit: /Patrick Doherty

Patrick Doherty had always been very active. He trekked the Himalayas and hiked trails in Spain.

But about a year and a half ago, he noticed pins and needles in his fingers and toes. His feet got cold. And then he started getting out of breath any time he walked his dog up the hills of County Donegal in Ireland where he lives.

"I noticed on some of the larger hill climbs I was getting a bit breathless," says Doherty, 65. "So I realized something was wrong."

Doherty found out he had a rare, but devastating inherited disease — known as transthyretin amyloidosis — that had killed his father. A misshapen protein was building up in his body, destroying important tissues, such as nerves in his hands and feet and his heart.

Doherty had watched others get crippled and die difficult deaths from amyloidosis.

"It's terrible prognosis," Doherty says. "This is a condition that deteriorates very rapidly. It's just dreadful."

So Doherty was thrilled when he found out that doctors were testing a new way to try to treat amyloidosis. The approach used a revolutionary gene-editing technique called CRISPR, which allows scientists to make very precise changes in DNA.

"I thought: Fantastic. I jumped at the opportunity," Doherty says.

On Saturday, researchers reported the first data indicating that the experimental treatment worked, causing levels of the destructive protein to plummet in Doherty's body and the bodies of five other patients treated with the approach.

"I feel fantastic," Doherty says. "It's just phenomenal."

The advance is being hailed not just for amyloidosis patients but also as a proof-of-concept that CRISPR could be used to treat many other, much more common diseases. It's a new way of using the innovative technology.

"This is a major milestone for patients," says Jennifer Doudna of the University of California, Berkeley, who shared a Nobel Prize for her work helping develop CRISPR.

"While these are early data, they show us that we can overcome one of the biggest challenges with applying CRISPR clinically so far, which is being able to deliver it systemically and get it to the right place," Doudna says.

CRISPR has already been shown to help patients suffering from the devastating blood disorders sickle cell disease and beta thalassemia. And doctors are trying to use it to treat cancer and to restore vision to people blinded by a rare genetic disorder.

But those experiments involve taking cells out of the body, editing them in the lab, and infusing them back in or injecting CRISPR directly into cells that need fixing.

The study Doherty volunteered for is the first in which doctors are simply infusing the gene-editor directly into patients and letting it find its own way to the right gene in the right cells. In this case, it's cells in the liver making the destructive protein.

"This is the first example in which CRISPR-Cas9 is injected directly into the bloodstream — in other words systemic administration — where we use it as a way to reach a tissue that's far away from the site of injection and very specifically use it to edit disease-causing genes," says John Leonard, the CEO of Intellia Therapeutics, which is sponsoring the study.

Doctors infused billions of microscopic structures known as nanoparticles carrying genetic instructions for the CRISPR gene-editor into four patients in London and two in New Zealand. The nanoparticles were absorbed by their livers, where they unleashed armies of CRISPR gene-editors. The CRISPR editor honed in on the target gene in the liver and sliced it, disabling production of the destructive protein.

Within weeks, the levels of protein causing the disease plummeted. Researchers reported at the Peripheral Nerve Society Annual Meeting and in a paper published in The New England Journal of Medicine.

"It really is exciting," says Dr. Julian Gillmore, who is leading the study at the University College London, Royal Free Hospital.

"This has the potential to completely revolutionize the outcome for these patients who have lived with this disease in their family for many generations. It's decimated some families that I've been looking after. So this is amazing," Gillmore says.

The patients will have to be followed longer, and more patients will have to be treated, to make sure the treatment's safe, and determine how much it's helping, Gillmore stresses. But the approach could help those struck by amyloidosis that isn't inherited, which is a far more common version of the disease, he says.

Moreover, the promising results potentially open the door for using the same approach to treatment of many other, more common diseases for which taking cells out of the body or directly injecting CRISPR isn't realistic, including heart disease, muscular dystrophy and brain diseases such as Alzheimer's.

"This is really opening a new era as we think about gene-editing where we can begin to think about accessing all kinds of different tissue in the body via systemic administration," Leonard says.

Other scientists who are not involved in the research agree.

"This is a wonderful day for the future of gene-editing as a medicine,"
agree Fyodor Urnov, a professor of genetics at the University of California, Berkeley. "We as a species are watching this remarkable new show called: our gene-edited future."

Doherty says he started feeling better within weeks of the treatment and has continued to improve in the weeks since then.

"I definitely feel better," he told NPR. "I'm speaking to you from upstairs in our house. I climbed stairs to get up here. I would have been feeling breathless. I'm thrilled."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Fast Guard Service looks toward assistance customers in the aftermath of multiple tornados plaguing the Midwest.

By Jessica Corbett Common Dreams “We face a stark choice [between] radical, disruptive changes to our physical world or radical, disruptive changes to our political and economic systems to avoid those outcomes.” As people across the globe mobilize to demand … Continue reading →

Juste avant l’averse, le paysage est plongé dans une lumière douce et diffuse. Un champ de canola, vibrant de vie, s’étend à perte de vue, contrastant avec le ciel menaçant chargé de nuages sombres. Au centre de cette mer florale, une maison bleue se dresse fièrement, entourée de bâtiments et de structures rustiques, évoquant une...

Satellite images show devastation in Sudan 1 year since conflict began (ABC News)

"Satellite imagery shows the reduction in green vegetation cover, the increased aridity points to the neglect or destruction of previously irrigated fields” Oliver Kirui told ABC News.

The post Satellite images show devastation in Sudan 1 year since conflict began (ABC News) appeared first on IFPRI.

The Australian musician talks about the motivation and meaning behind Wild God, a new album with his band The Bad Seeds.

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We talk with John deVadoss about the philosophies underlying the development of .NET and Azure software. We discuss the "Fiefdoms and Emissaries" concept of building loosely coupled systems, talk about strengths and drawbacks and how to build services...

The devastating 17 July 2023 debris flow at Quetame in Colombia, which killed at least 14 people including three children.

A devastating microburst hit West Phoenix last Wednesday evening with 77 mph winds, causing a warehouse roof collapse that trapped and killed a 22-year-old worker; it took rescuers three days to locate the body using K-9s, drones, and heavy equipment. 

Hay categorías regionales en las que un tercio de los equipos han perdido todo bajo las aguas. Leer

Milei anticipó que si la baja se sostiene, modificará la devaluación mensual del dos por ciento que sufre el peso para reducirla a un uno por ciento. Leer

En una breve comparecencia, el secretario primero de la Mesa del Congreso agradece "al sistema público de salud que la cuidó y le prolongó la vida de la mejor manera posible durante nueve meses" Leer

[This Day] On the back of galloping inflation, regulating expenses, and devaluation of the local currency, a total of 23 leading companies on the Nigeria Exchange Limited (NGX), reported a whooping N5.1 trillion operating expenses in the half year (H1) ended June 2024.

Defense Secretary Lloyd Austin says passage of a six-month temporary spending bill would have widespread and devastating effects on the department and the military. He wrote in a letter Sunday to key members of Congress that passing a continuing resolution that caps spending at 2024 levels, rather than taking action on the proposed 2025 budget will hurt thousands of defense programs, and damage military recruiting just as it is beginning to recover after the COVID-19 pandemic. Republican House Speaker Mike Johnson has teed up a vote this week on a bill that would keep the federal government funded for six more months.

The post Pentagon chief says a six-month temporary budget bill will have devastating effects on the military first appeared on Federal News Network.

The scene is all too familiar now. The long and tortured Stanley Cup playoff history of the Capitals means little to the current generation of players. None of them were born or raised here, after all.

Updated at 8:44 a.m. ET From airlines to paper mills, the job news is grim, and there are growing signs it won't be getting better anytime soon. On Thursday, the Labor Department reported nearly 2.4 million new applications for state and federal unemployment benefits last week. And United Airlines is warning that it may have to furlough as many as 36,000 employees this fall. Demand for air travel has collapsed as a result of the coronavirus pandemic. The president of the flight attendants union called the warning a "gut punch" but also "the most honest assessment we've seen on the state of the industry — and our entire economy." Union President Sara Nelson tweeted that demand for air travel had recovered a small fraction of its pre-pandemic levels this summer and "even those minimal gains evaporated over the last week due to surging COVID-19 cases across the country." Jobs in other industries are facing similar threats as the coronavirus tightens its stubborn grip on the country. Derse

Glenn Fleishman returns to the show to talk about Elon Musk’s impending acquisition of Twitter, Apple’s credibility problem when arguing against being required to allow sideloading on iOS, and Glenn’s new (and much-needed) book, “Take Control of Untangling Connections”.

En este episodio, La Luciérnaga se enciende para hablar de la tutela que busca reversar la suspensión del alcalde de Medellin, Daniel Quintero. Además, se pausa la compra de Twitter por parte del empresario Elon Musk. También, el peso Colombiano cae a preocupantes niveles.La Luciérnaga un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

a 1% change in several swing states...

Melodic, blackened death metal perfection.

Raheem DeVaughn's got it going on!

The Attorney-General and Minister of Legal Affairs Kathy Lynn Simmons has issued a public notification that convicted sex offender Devaun Cox is set to be released, with the 38-year-old due to be released on April 27th. Photo provided by the Government The full Public Notice follow below [PDF here]: Related Stories Govt Advisory: Sex Offender […]

The Ministry of Legal Affairs and the Ministry of National Security addressed public concerns over sex offender Devaun Cox, noting that he was recently remanded in custody. A Government spokesperson said, “The Ministry of Legal Affairs and Ministry of National Security remain committed to addressing the concerns raised by residents regarding the recent release of repeat sex […]

In the wake of the devastation rendered by Hurricane Helene, Carolina Furfare released a newsletter on October 1 stating the cancellation of the event that was to occur this weekend, and indicating that the hotels and facilities were needed in order to assist with rescue and sheltering efforts after the Hurricane hit the mountainous region.

This weather event hit the top ten most fatal and costly hurricanes in the United States even before full recovery efforts could be finalized. People who pre-registered have been given the option to roll over to next year, or to Bewhiskered 2025; due to the cancellation being so close to event day they cannot guarantee refunds for now.

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HONG KONG/WASHINGTON -- China has vowed to strengthen security after a hit-and-run attack in the southern city of Zhuhai killed 35 people, shocking the nation and highlighting what some experts see as an alarming pattern. On Tuesday evening, authorities revealed the scope of the devastation left…

In this emergency episode of the Arsenal Women Arsecast, Tim and Jamie run the rule over the resignation of Jonas Eidevall as the Head Coach of Arsenal Women. Tim talks a little bit about how Arseblog News became aware of and were able to (just about) break the story on Tuesday morning. Then Tim and Jamie analyse where things went wrong, how the situation took a serious turn in the last week, why it didn't quite click the way the club and Jonas wanted it to and looked ahead to how Arsenal might succession plan for his departure. Tim and Jamie then each share one high point from Eidevall's reign.

Get extra bonus content and help support Arseblog by becoming an Arseblog Member on Patreon: https://www.patreon.com/arseblog

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Satellite images and on-the-ground photos show the scale of destruction caused by the floods.

A surprising brain defect could hold the key to schizophrenia’s toughest symptoms.

A businessman, Patrick served two terms as governor of Massachusetts and has credited education with his own dramatic rise to success.

On September 2, 1935, Florida was hit by the most intense hurricane ever recorded—a category 5. Despite early warnings by the weather authorities, a calamitous loss of life shocked the nation

The photographer talks about what he aims for in his shots of industrial scars on the American landscape. Read more at http://www.smithsonianmag.com/science-nature/Devastation-From-Above.html.

More than 14 months after flooding caused by heavy rainfall forced the Ottawa Birth and Wellness Centre to shut down its birthing unit, it's once again welcoming expecting families.

Zimbabwe sought to assure citizens that its gold-backed currency would not suffer another steep devaluation and steps were being taken to assure its defence.

OM Chile responds quickly to help local churches provide relief after a forest fire in Valparaíso kills 15 people and destroys 3,000 homes in April.

A man recently took to Reddit, seeking help identifying an unknown Devanagari text he found at a flea market in Germany.

The couple, together for nine years, had announced the wedding date in January and were eagerly looking forward to their long-awaited special day.

The ongoing, escalating violence in Lebanon forces millions of Lebanese civilians to face daily bombardment, repeated orders of evacuation, routine destruction of critical infrastructure, and limited access to basic services. With the death toll and rates of displacement on the rise, humanitarian organizations fear that the upcoming winter season is expected to exacerbate these harsh […]

Scientists warn of vastly higher impacts on billions of people’s livelihood and cost to the global economy by the accelerating losses in the world’s snow and ice regions, aka the cryosphere. Over 50 leading cryosphere scientists released an annual report on the status of the world’s ice stores on Tuesday (November 12) at the UN […]