Dr. Alexander von Paleske ----- 13.9.2024 - Annalena Baerbock wird wohl als die bisher reisefreudigste Aussenministerin in die Geschichte eingehen, wobei die zurückgelegten Kilometer allerdings im umgekehrt proportionalen Verhältnis zu ihren aussenpolitischen Erfolgen stehen, hingegen propartional zu den Flurschäden, die sie anrichtete. Nicht nur kaum messbare Erfolge, sondern sie hat es geschafft, ihren Ruf und damit den Deutschlands gegenüber Staaten wie China, der Türkei, aber auch...

The bean-to-bar chocolate brand from Udaipur focuses on using indigenous Indian fruits and berries

"The holy Martyrs Manuel, Sabel, and Ishmael, Persians by race and brethren according to the flesh, were sent by the Persian King as ambassadors to Julian the Apostate to negotiate a peace treaty. While with him at a place near Chalcedon, they refused to join him in offering sacrifice to his idols. Scorning the immunity universally accorded ambassadors, he had them slain in the year 362. This was a cause of the war with Persia in which Julian perished miserably the following year." (Great Horologion)

"The holy Martyrs Manuel, Sabel, and Ishmael, Persians by race and brethren according to the flesh, were sent by the Persian King as ambassadors to Julian the Apostate to negotiate a peace treaty. While with him at a place near Chalcedon, they refused to join him in offering sacrifice to his idols. Scorning the immunity universally accorded ambassadors, he had them slain in the year 362. This was a cause of the war with Persia in which Julian perished miserably the following year." (Great Horologion)

"The holy Martyrs Manuel, Sabel, and Ishmael, Persians by race and brethren according to the flesh, were sent by the Persian King as ambassadors to Julian the Apostate to negotiate a peace treaty. While with him at a place near Chalcedon, they refused to join him in offering sacrifice to his idols. Scorning the immunity universally accorded ambassadors, he had them slain in the year 362. This was a cause of the war with Persia in which Julian perished miserably the following year." (Great Horologion)

"The holy Martyrs Manuel, Sabel, and Ishmael, Persians by race and brethren according to the flesh, were sent by the Persian King as ambassadors to Julian the Apostate to negotiate a peace treaty. While with him at a place near Chalcedon, they refused to join him in offering sacrifice to his idols. Scorning the immunity universally accorded ambassadors, he had them slain in the year 362. This was a cause of the war with Persia in which Julian perished miserably the following year." (Great Horologion)

Baeumler and M-D PRO, which is based in Mississauga, Ontario, Canada, will engage with contractors and installers through a series of educational initiatives on social media. The collaboration aims to educate pros on using installer-friendly solutions that increase efficiency, reduce costs, and maintain quality. 

Auer Hall, Simon Music Center
Thursday, November 14, 2024, 5 – 6:30pm

Ik-Hwan Bae was professor of music in violin and chamber music at the IU Jacobs School of Music from 1999 until his passing in 2014. He was born in Seoul, Korea, and made his professional debut with the Seoul Philharmonic at age 12. He studied with Ivan Galamian at The Juilliard School and was busily engaged in concertizing and teaching throughout his career.

More info: events.iu.edu…

[Inter-Korea] :
The South Korean military has dismissed North Korea’s claims that a drone invaded its airspace earlier this month after taking off from the South’s Baengnyeong Island near the western de facto maritime border. At a press briefing Monday, spokesperson Lee Sung-joon from Seoul’s Joint Chiefs of ...

[more...]

Advances in physics have been significantly driven by state-of-the-art technology, and in photonics and X-ray science this calls for the ability to manipulate the characteristics of optical beams. Orbital angular momentum (OAM) beams hold substantial promise in various domains such as ultra-high-capacity optical communication, rotating body detection, optical tweezers, laser processing, super-resolution imaging etc. Hence, the advancement of OAM beam-generation technology and the enhancement of its technical proficiency and characterization capabilities are of paramount importance. These endeavours will not only facilitate the use of OAM beams in the aforementioned sectors but also extend the scope of applications in diverse fields related to OAM beams. At the FERMI Free-Electron Laser (Trieste, Italy), OAM beams are generated either by tailoring the emission process on the undulator side or, in most cases, by coupling a spiral zone plate (SZP) in tandem with the refocusing Kirkpatrick–Baez active optic system (KAOS). To provide a robust and reproducible workflow to users, a Hartmann wavefront sensor (WFS) is used for both optics tuning and beam characterization. KAOS is capable of delivering both tightly focused and broad spots, with independent control over vertical and horizontal magnification. This study explores a novel non-conventional `near collimation' operational mode aimed at generating beams with OAM that employs the use of a lithographically manufactured SZP to achieve this goal. The article evaluates the mirror's performance through Hartmann wavefront sensing, offers a discussion of data analysis methodologies, and provides a quantitative analysis of these results with ptychographic reconstructions.

BD Kim unveils 12.5-meter artwork at Baekdu Mountain, inviting Elon Musk to lead a new art era

BAE Systems on Friday said it signed a contract with the Netherlands to provide eight new Bofors 40 Mk4 40mm naval guns for the Royal Netherlands and Belgian Navies. The […]

U4SSC - Verification Report - Baerum, Norway

U4SSC - City Snapshot - Baerum, Norway

Bae Systems The Combination Of British Aerospace Bae And Marconi Electronic Systems Mes Specializes In The Design Development Re... David Armitstead, Head Of Procurement As And Fc, Preston, England, United Kingdom

Meanwhile, Byron locals are not happy with the docusoap as they reportedly paddle out into the ocean to protest the show in addition to launching a petition against the new project.

Look back at celebrity couples who have walked the BET Awards red carpet, including Will and Jada Pinkett Smith, Alicia Keys and Swizz Beatz, Dwyane Wade and Gabrielle Union, and more.

#BlackLoveGoals

Mary Jane Goes OFF on the new girl.

We used virus-mediated anterograde and retrograde tracing, optogenetic modulation, immunostaining, in situ hybridization, and patch-clamp recordings in acute brain slices to study the release mechanism and μ-opioid modulation of the dual glutamatergic/GABAergic inputs from the ventral tegmental area and supramammillary nucleus to the granule cells of the dorsal hippocampus of male and female mice. In keeping with previous reports showing that the two transmitters are released by separate active zones within the same terminals, we found that the short-term plasticity and pharmacological modulation of the glutamatergic and GABAergic currents are indistinguishable. We further found that glutamate and GABA release at these synapses are both virtually completely mediated by N- and P/Q-type calcium channels. We then investigated μ-opioid modulation of these synapses and found that activation of μ-opioid receptors (MORs) strongly inhibits the glutamate and GABA release, mostly through inhibition of presynaptic N-type channels. However, the modulation by MORs of these dual synapses is complex, as it likely includes also a disinhibition due to downmodulation of local GABAergic interneurons which make direct axo-axonic contacts with the dual glutamatergic/GABAergic terminals. We discuss how this opioid modulation may enhance LTP at the perforant path inputs, potentially contributing to reinforce memories of drug-associated contexts.

GABAergic inhibitory interneurons comprise many subtypes that differ in their molecular, anatomical, and functional properties. In mouse visual cortex, they also differ in their modulation with an animal’s behavioral state, and this state modulation can be predicted from the first principal component (PC) of the gene expression matrix. Here, we ask whether this link between transcriptome and state-dependent processing generalizes across species. To this end, we analysed seven single-cell and single-nucleus RNA sequencing datasets from mouse, human, songbird, and turtle forebrains. Despite homology at the level of cell types, we found clear differences between transcriptomic PCs, with greater dissimilarities between evolutionarily distant species. These dissimilarities arise from two factors: divergence in gene expression within homologous cell types and divergence in cell-type abundance. We also compare the expression of cholinergic receptors, which are thought to causally link transcriptome and state modulation. Several cholinergic receptors predictive of state modulation in mouse interneurons are differentially expressed between species. Circuit modelling and mathematical analyses suggest conditions under which these expression differences could translate into functional differences.

Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory brainstem of neonatal mice of both sexes is significantly attenuated by ZD7288, a blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (I_h), or by genetic deletion of HCN1. GABAergic inhibitory interneurons predominantly express HCN1, on which BIL selectively acts to increase their intrinsic excitability and mortality by enhancing HCN1 activity and Ca²⁺-dependent membrane targeting. Chronic BIL elevation in neonatal mice in vivo increases the fraction of spontaneously active interneurons and their firing frequency, I_h, and death, compromising audition at the young adult stage in HCN1^+/+, but not in HCN1^–/– genotype. We conclude that HB preferentially targets HCN1 to injure inhibitory interneurons, fueling a feedforward loop in which lessening inhibition cascades hyperexcitability, Ca²⁺ overload, neuronal death, and auditory impairments. These findings rationalize HCN1 as a potential target for managing HB encephalopathy.

Part of the visual album of Joan Baez' "Whistle Down the Wind," this cover of Joe Henry's "Civil War" was directed by New York University's Deborah Willis

Taylor Swift and Beyoncé have achieved a degree of power in the music industry that singer/songwriters of earlier eras like Joan Baez—as the folk icon tells us—never even contemplated. Six decades ago, Baez was part of a folk revival that regarded music not merely as entertainment but as a vessel for political engagement and social change. In the documentary Joan Baez: I Am a Noise, the now-83-year-old musician and activist reflects on her career and legacy. Smithsonian senior editor Jennie Rothenberg Gritz interviewed Baez about the film and about the shifting intersection of art and activism. We present excerpts from that conversation in this episode. Then, veteran music critic Evelyn McDonnell discusses how the political dimensions of pop music have changed since Baez’s era, and what it means that many fans now look Beyoncé and Taylor Swift not just for great music, but for comment on the state of the world. Clips from Joan Baez: I Am a Noise in this episode are used with permission from Magnolia Pictures & Mead Street Films. Learn more about that film here (https://www.magpictures.com/joanbaez/) . Evelyn McDonnell’s latest book is The World According to Joan Didion (https://www.harpercollins.com/products/the-world-according-to-joan-didion-evelyn-mcdonnell?variant=41001679487010) . You can learn more about Evelyn and her work at her site, Populism (https://populismblog.wordpress.com/about-2/) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Rye Dorsey, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music.

Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli—a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling the production of plasticity-related proteins in the brain. The mechanistic target of rapamycin complex 1 (mTORC1) controls mRNA translation, mainly through phosphorylation of the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks). mTORC1 signaling decreases throughout brain development, starting from the early postnatal period. Here, we discovered that in mice, the age-dependent decrease in mTORC1 signaling occurs selectively in excitatory but not inhibitory neurons. Using a gene conditional knockout (cKO) strategy, we demonstrate that either up- or downregulating the mTORC1-4E-BP2 axis in GAD65 inhibitory interneurons, but not excitatory neurons, results in long-term object recognition and object location memory deficits. Our data indicate that the mTORC1 pathway in inhibitory but not excitatory neurons plays a key role in memory formation.

Rakul gets goofy.... Rashmika is hawt... Pooja goes retro...

Call Me Bae: Unpretentious, easy-peasy entertainment that distracts from the ugliness of real life, vouches Mayur Sanap.

Call Me Bae is a spirited new addition in guilty pleasures for the fashion-loving, rom-com starved soul, applauds Sukanya Verma.

Aubrey Plaza was glimpsed stepping out for some fresh air and a dog walk in Los Angeles this Saturday. The 35-year-old took the precaution of wearing a face mask as she led her two pooches.

The post Community ecologist Sunshine Van Bael explains her work in Panama with leafcutting ants appeared first on Smithsonian Insider.

(United States Fourth Circuit) - Affirming the district court's grant of a declaratory judgment to the plaintiff that it hadn't breached any contractual agreement with Korea, but refusing a permanent injunction barring Korea from suing them in Korean courts in a contract suit between a US defense contractor and Korea in a complex set of exchanges involved in upgrading the country's fighter planes.

#BlackLoveGoals

Annalena Baerbock und Robert Habeck warnen vor einem gesellschaftlichen Rückschritt infolge der Coronakrise. Was würden sie tun, wenn sie an der Macht wären?

In cyanobacteria, metabolic pathways that use the nitrogen-rich amino acid arginine play a pivotal role in nitrogen storage and mobilization. The N-terminal domains of two recently identified bacterial enzymes: ArgZ from Synechocystis and AgrE from Anabaena, have been found to contain an arginine dihydrolase. This enzyme provides catabolic activity that converts arginine to ornithine, resulting in concomitant release of CO2 and ammonia. In Synechocystis, the ArgZ-mediated ornithine–ammonia cycle plays a central role in nitrogen storage and remobilization. The C-terminal domain of AgrE contains an ornithine cyclodeaminase responsible for the formation of proline from ornithine and ammonia production, indicating that AgrE is a bifunctional enzyme catalyzing two sequential reactions in arginine catabolism. Here, the crystal structures of AgrE in three different ligation states revealed that it has a tetrameric conformation, possesses a binding site for the arginine dihydrolase substrate l-arginine and product l-ornithine, and contains a binding site for the coenzyme NAD(H) required for ornithine cyclodeaminase activity. Structure–function analyses indicated that the structure and catalytic mechanism of arginine dihydrolase in AgrE are highly homologous with those of a known bacterial arginine hydrolase. We found that in addition to other active-site residues, Asn-71 is essential for AgrE's dihydrolase activity. Further analysis suggested the presence of a passage for substrate channeling between the two distinct AgrE active sites, which are situated ∼45 Å apart. These results provide structural and functional insights into the bifunctional arginine dihydrolase–ornithine cyclodeaminase enzyme AgrE required for arginine catabolism in Anabaena.

In cyanobacteria, metabolic pathways that use the nitrogen-rich amino acid arginine play a pivotal role in nitrogen storage and mobilization. The N-terminal domains of two recently identified bacterial enzymes: ArgZ from Synechocystis and AgrE from Anabaena, have been found to contain an arginine dihydrolase. This enzyme provides catabolic activity that converts arginine to ornithine, resulting in concomitant release of CO2 and ammonia. In Synechocystis, the ArgZ-mediated ornithine–ammonia cycle plays a central role in nitrogen storage and remobilization. The C-terminal domain of AgrE contains an ornithine cyclodeaminase responsible for the formation of proline from ornithine and ammonia production, indicating that AgrE is a bifunctional enzyme catalyzing two sequential reactions in arginine catabolism. Here, the crystal structures of AgrE in three different ligation states revealed that it has a tetrameric conformation, possesses a binding site for the arginine dihydrolase substrate l-arginine and product l-ornithine, and contains a binding site for the coenzyme NAD(H) required for ornithine cyclodeaminase activity. Structure–function analyses indicated that the structure and catalytic mechanism of arginine dihydrolase in AgrE are highly homologous with those of a known bacterial arginine hydrolase. We found that in addition to other active-site residues, Asn-71 is essential for AgrE's dihydrolase activity. Further analysis suggested the presence of a passage for substrate channeling between the two distinct AgrE active sites, which are situated ∼45 Å apart. These results provide structural and functional insights into the bifunctional arginine dihydrolase–ornithine cyclodeaminase enzyme AgrE required for arginine catabolism in Anabaena.

In cyanobacteria, metabolic pathways that use the nitrogen-rich amino acid arginine play a pivotal role in nitrogen storage and mobilization. The N-terminal domains of two recently identified bacterial enzymes: ArgZ from Synechocystis and AgrE from Anabaena, have been found to contain an arginine dihydrolase. This enzyme provides catabolic activity that converts arginine to ornithine, resulting in concomitant release of CO2 and ammonia. In Synechocystis, the ArgZ-mediated ornithine–ammonia cycle plays a central role in nitrogen storage and remobilization. The C-terminal domain of AgrE contains an ornithine cyclodeaminase responsible for the formation of proline from ornithine and ammonia production, indicating that AgrE is a bifunctional enzyme catalyzing two sequential reactions in arginine catabolism. Here, the crystal structures of AgrE in three different ligation states revealed that it has a tetrameric conformation, possesses a binding site for the arginine dihydrolase substrate l-arginine and product l-ornithine, and contains a binding site for the coenzyme NAD(H) required for ornithine cyclodeaminase activity. Structure–function analyses indicated that the structure and catalytic mechanism of arginine dihydrolase in AgrE are highly homologous with those of a known bacterial arginine hydrolase. We found that in addition to other active-site residues, Asn-71 is essential for AgrE's dihydrolase activity. Further analysis suggested the presence of a passage for substrate channeling between the two distinct AgrE active sites, which are situated ∼45 Å apart. These results provide structural and functional insights into the bifunctional arginine dihydrolase–ornithine cyclodeaminase enzyme AgrE required for arginine catabolism in Anabaena.

Twenty-seven years after signing Barry Bonds to a then-record free-agent contract, the Giants are in the market for yet another superstar outfielder. San Francisco's interest in Bryce Harper remained a prominent topic of conversation during Saturday's FanFest at Oracle Park, with CEO Larry Baer weighing in on the potential franchise-altering benefits of landing a marquee player.

Berlin : A. Hirschwald, 1864.

Jessica A. Gorski
Aug 1, 2002; 22:6309-6314
BRIEF COMMUNICATION

The coronavirus pandemic has put on hold contract-extension talks between All-Star shortstop Javier Baez and the Chicago Cubs.

Police in Georgia say former NBA player Shannon Brown faces an aggravated assault charge in suburban Atlanta after he was accused of firing a rifle at two people who were looking at homes for sale.