Lipid rafts are organized plasma membrane microdomains, which provide a distinct level of regulation of cellular metabolism and response to extracellular stimuli, affecting a diverse range of physiologic and pathologic processes. This Thematic Review Series focuses on Biology of Lipid Rafts rather than on their composition or structure. The aim is to provide an overview of ideas on how lipid rafts are involved in regulation of different pathways and how they interact with other layers of metabolic regulation. Articles in the series will review the involvement of lipid rafts in regulation of hematopoiesis, production of extracellular vesicles, host interaction with infection, and the development and progression of cancer, neuroinflammation, and neurodegeneration, as well as the current outlook on therapeutic targeting of lipid rafts.

1 May 2007 , Number 8

Corruption and Misuse of Public Office,
Colin Nicholls Qc, Tim Daniel, Martin Polaine and John Hatchard, Oxford University Press.

Mathematical Reviews will be at the JMM in Denver, January 13-18, 2020. The Joint Mathematical Meetings is the largest gathering of mathematicians in the world.  There are lots of great activities:  invited lectures, special sessions, editorial meetings, exhibits, and the chance to … Continue reading →

All organizations need simple and effective employee reviews with 360 degree options. Teamphoria completely replaces paper and spreadsheet based employee reviews Template and Software.

One of the hurdles that anyone who submits research or analysis to The BMJ has to deal with is peer review. The problems of the process, and some of the potential solutions, was a big part of the Peer Review Congress which took place last week. In this interview, Sophie Cook, The BMJ's UK research editor, talks to Lisa Bero, who’s a professor...

U.K. Prospective Diabetes Study Group
Nov 1, 1995; 44:1249-1258
Perspectives in Diabetes

Posttreatment high-grade gliomas are usually monitored with contrast-enhanced MRI, but its diagnostic accuracy is limited as it cannot adequately distinguish between true tumor progression and treatment-related changes. According to recent Response Assessment in Neuro-Oncology recommendations, PET overcomes this limitation. However, it is currently unknown which tracer yields the best results. Therefore, a systematic review and metaanalysis were performed to compare the diagnostic accuracy of the different PET tracers in differentiating tumor progression from treatment-related changes in high-grade glioma patients. Methods: PubMed, Web of Science, and Embase were searched systematically. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Metaanalysis was performed using a bivariate random-effects model when at least 5 studies were included. Results: The systematic review included 39 studies (11 tracers). ¹⁸F-FDG (12 studies, 171 lesions) showed a pooled sensitivity and specificity of 84% (95% confidence interval, 72%–92%) and 84% (95% confidence interval, 69%–93%), respectively. O-(2-¹⁸F-fluoroethyl)-l-tyrosine (¹⁸F-FET) (7 studies, 172 lesions) demonstrated a sensitivity of 90% (95% confidence interval, 81%–95%) and specificity of 85% (95% confidence interval, 71%–93%). For S-¹¹C-methyl)-l-methionine (¹¹C-MET) (8 studies, 151 lesions), sensitivity was 93% (95% confidence interval, 80%–98%) and specificity was 82% (95% confidence interval, 68%–91%). The numbers of included studies for the other tracers were too low to combine, but sensitivity and specificity ranged between 93%–100% and 0%–100%, respectively, for ¹⁸F-FLT; 85%–100% and 72%–100%, respectively, for 3,4-dihydroxy-6-¹⁸F-fluoro-l-phenylalanine (¹⁸F-FDOPA); and 100% and 70%–88%, respectively, for ¹¹C-choline. Conclusion: ¹⁸F-FET and ¹¹C-MET, both amino-acid tracers, showed a comparably higher sensitivity than ¹⁸F-FDG in the differentiation between tumor progression and treatment-related changes in high-grade glioma patients. The evidence for other tracers is limited; thus, ¹⁸F-FET and ¹¹C-MET are preferred when available. Our results support the incorporation of amino-acid PET tracers for the treatment evaluation of high-grade gliomas.

On the campaign trail, Donald Trump made immigration the centerpiece of his campaign, offering a more detailed policy agenda than on any other issue. In the year since the election that propelled the Republican into the White House, how has the Trump administration’s record matched up with the rhetoric? This policy brief examines the executive orders and other changes to existing policy and practice made during 2017.

Joseph Tran
Oct 1, 2012; 30:173-178
Practical Pointers

Warren Clayton
Mar 1, 2009; 27:52-58
Features

Richard R Rubin
Nov 1, 1992; 15:1640-1657
Behavioral Diabetes Series

Alison J. Dunkley
Apr 1, 2014; 37:922-933
Current Concepts of Type 2 Diabetes Prevention

David M. Nathan
Jan 1, 2014; 37:9-16
DCCT/EDIC 30th Anniversary Summary Findings

Jennifer M. Yamamoto
Jul 1, 2018; 41:1346-1361
Reconsidering Pregnancy With Diabetes

David M. Nathan
Jan 1, 2014; 37:9-16
DCCT/EDIC 30th Anniversary Summary Findings

Alan J. Garber
May 1, 2011; 34:S279-S284
Diabetes Treatments

The 2021 Code on Dental Procedures and Nomenclature — better known as the CDT Code — could include changes or additions to codes regarding oral/oropharyngeal cancer, caries management by risk assessment, laboratory surface scanning for diagnostic purposes, and counseling for the control and prevention of adverse oral, behavioral, and systemic health effects associated with high-risk substance use.

The ADA Standards Committee on Dental Informatics has approved the technical report for circulation and comment.

The American Dental Association is seeking qualified individuals to join a canvass committee to consider approval of the 2020 revision of the Systemized Nomenclature of Dentistry.

The Centers for Medicare and Medicaid Services has set a deadline of May 15 for covered recipients to review and dispute Open Payments data for program year 2019.

MPI experts participate in a video chat shortly after the Migration Policy Institute released an analysis comparing the major provisions of the Senate bill to those of the individual House bills considered to date in House committees. 

You could be forgiven for thinking the television images in the experiment were from 2006. They were really from 1982: Israeli forces were clashing with Arab militants in Lebanon. The world was watching, charges were flying, and the air was thick with grievance, hurt and outrage.

Is Pluto a planet? The world's astronomers met in Prague last week to vote on this question, and in a sort of cosmic game of "Survivor," they voted Pluto off the solar system.

President Bush said last week that his thinking on the U.S. situation in Iraq was informed by an analogy: the October 2000 bombing of the USS Cole in Yemen. The lack of a sufficient American response to that and other al-Qaeda attacks, Bush said, led to the Sept. 11, 2001, attacks.

In the interest of promoting democracy, Pakistan's president, Gen. Pervez Musharraf, recently announced that he had to lock up most of his country's democracy activists. And because he wanted the Pakistani Supreme Court to independently rule on whether he could continue as president, Musharraf also...

Michele Heisler
Oct 1, 2008; 26:161-165
Practical Pointers

Jennifer M. Perkins
Apr 1, 2007; 25:57-62
Feature Articles

AHP readers will be interested in a review article now available online from History of the Human Sciences “Within a single lifetime: Recent writings on autism.” Written by Gregory Hollin the piece reviews five recent books on autism.

The decision comes after a state investigation of one Tulsa school found that the individualized education programs for students there frequently used generic educational goals.

Schools must make the critical decision whether to reinforce the learning that students have already done this year or introduce new content.

The Chan Zuckerberg Initiative, states like Vermont and Rhode Island, and companies such as AltSchool all generated headlines about personalized learning in 2017.

Implementing the Basin Plan requires the Murray Darling Basin Authority to evaluate the economic, social and environmental outcomes directly attributable to the Basin Plan. This report draws together all the data and modelling used to separate the Basin Plan effects (both positive and negative) from all the other drivers of change at the community scale in the southern Basin. This work built upon the analysis undertaken by the MDBA to support the Northern Basin Review. The community-level analysis adopted by the MDBA complements the industry and broad Basin-scale summary of social and economic conditions presented in the 2017 Basin Plan Evaluation report. A strong reliance is placed on the community outcomes as this represents the finer scale relationships between the types of irrigated production and local businesses, and between the towns and the surrounding farming communities. Further work is required to align these community-level outcomes with the observed regional, industry and Basin scale changes.