It is time. We need a new Regism and cannot go to the pub to think of one. Can you help?

It is no secret that we like to use the odd bit of shorthand at The Register when biting the hand that feeds IT. Now we need a fresh one for Microsoft.…

Things will change forever, nods ex-Facebooker Alex Stamos

Video conferencing software biz Zoom has bought Keybase in a surprise move just weeks after hiring Facebook's one-time CSO.…

Virus knocks hackers online: Show will try going virtual amid pandemic

Annual Las Vegas hacker gathering DEF CON has officially called off its physical conference for this year due to the coronavirus pandemic.…

Opposition spokesman on tourism, Dr Wykeham McNeill, is calling for an investigation into allegations that some employers of tourism workers have not been turning over income tax deductions to government.  The situation has resulted in...

Hi everyone, Maybe we aren’t *completely* dead. Stay tuned.

Компания Xiaomi осенью прошлого года выпустила смартфон Mi Note 10, но обновление Android 10 добралось до аппарата только сейчас.

Аналитики из Canalys опубликовали рейтинг 10 самых продаваемых смартфонов на глобальном рынке в первом квартале 2020 года.

At Let Grow, a wise mom named Kate Sundquist admits that while her kids were already good at playing, they certainly weren’t good at filling hours and hours of free time, playing by themselves. (Read the piece here.) So she her and boys created a schedule. “While these routines might seem restrictive or even the […]

These “cards” are really an excuse for kids to interview their moms and shower them with the ultimate gifts: attention to mom’s quirky uniqueness, gratitude, and offers of help! Here you go — click here! (Mother’s Day is SUNDAY!)

A man walks in a bar with his pet monkey. He sits down and orders a drink, meanwhile the monkey is running around all over the place and jumps up on a pool table. He grabs the 8 ball, shoves it into his mouth and swallows it hole. “Holy crap!” says the bartender, completely livid. […]

The post The Not So Stupid Monkey appeared first on Funny & Jokes.

Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. Here, we studied the molecular, cellular, and clinical impact of ARID1A aberrations on cancer immunity. We demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to IFN-responsive genes, impaired IFN gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies and in murine cancer models. Impaired IFN signaling was associated with poor immunotherapy response. Mechanistically, ARID1A interacted with EZH2 via its carboxyl terminal and antagonized EZH2-mediated IFN responsiveness. Thus, the interaction between ARID1A and EZH2 defines cancer IFN responsiveness and immune evasion. Our work indicates that cancer epigenetic driver mutations can shape cancer immune phenotype and immunotherapy.

An in-depth understanding of immune escape mechanisms in cancer is likely to lead to innovative advances in immunotherapeutic strategies. However, much remains unknown regarding these mechanisms and how they impact immunotherapy resistance. Using several preclinical tumor models as well as clinical specimens, we identified a mechanism whereby CD8+ T cell activation in response to programmed cell death 1 (PD-1) blockade induced a programmed death ligand 1/NOD-, LRR-, and pyrin domain–containing protein 3 (PD-L1/NLRP3) inflammasome signaling cascade that ultimately led to the recruitment of granulocytic myeloid-derived suppressor cells (PMN-MDSCs) into tumor tissues, thereby dampening the resulting antitumor immune response. The genetic and pharmacologic inhibition of NLRP3 suppressed PMN-MDSC tumor infiltration and significantly augmented the efficacy of anti–PD-1 antibody immunotherapy. This pathway therefore represents a tumor-intrinsic mechanism of adaptive resistance to anti–PD-1 checkpoint inhibitor immunotherapy and is a promising target for future translational research.

Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat.

Woot is ending the week with a refurbished sale on the 15-inch MacBook Pro, available in multiple storage sizes and colors. The sale starts with the 256GB SSD model (16GB RAM, Intel Core i7) for $1,579.99.

Note: MacRumors is an affiliate partner with Woot. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.

For more storage, the 512GB SSD model (16GB RAM, Intel Core i9) is on sale for $1,849.99. Woot's refurbished sales are offering more than $800 in savings when compared to the original prices of these notebooks, which began at $2,399.00 when they launched in May 2019.

Similar to previous Woot sales, each MacBook Pro comes with a One Year Limited Woot Warranty. Each device has been refurbished and is ensured to be in full working condition. When shipped, they are packaged in a generic white box.

You can find even more discounts on new MacBooks by visiting our Best Deals guide for MacBook Pro and MacBook Air. In this guide we track the steepest discounts for the newest MacBook models every week, so be sure to bookmark it and check back often if you're shopping for a new Apple notebook.

If you were to Google the definition of a comedian you would see it defined by Dictionary.com as an entertainer whose act is designed to make an audience laugh. Likewise the New York Times has a comedy critic, Jason Zinoman, who defines comedy in a moment of reflecting on his own career of analyzing them.

This often dictates the form of my column, since while the goal of comedy is to make you laugh, what’s fascinating about the art form — especially these days, when it’s so fragmented and aesthetically diverse — is that there are many ways artists accomplish that goal.

However, if you were to ask one furry who considers himself one, 2 Gryphon, you’d find an entirely different etymology of the word, and what the job of a comic is.

It's the JOB of the comic to bring forth uncomfortable things and question them in a way that makes people think about them.Since that has become "wrong", expect that the Western world will not be laughing as much. https://t.co/EIExUX5W2h— 2, The Ranting Gryphon (@2_gryphon) June 9, 2019

It is this quote that we are going to be over-analysing today. I have broken this down into three main points as to why this definition of the job of a comedian is not only a fundamental misunderstanding of the role, but also a resignation of the foundational principles of comedy.

read more

Linda McMahon is running for the US Senate in Connecticut. For twenty (20) years, she ran World Wrestling Entertainment (WWE) with her husband, Vince McMahon. A few years ago, a documentary film examined the WWE's celebration of violence against women. Her campaign doesn't want Connecticut voters to see that film. Watch these excerpts from the film to see why. Continue reading →

After being elected in 2008 on "hope and change", "change you can believe in", and "change the way Washington works", President Obama now says that he cannot change Washington from the inside? Then why should we re-elect him in 2012? Continue reading →

Barack Obama promised to change the way things work in Washington, and after four years, nothing has changed: Corporate money controls President Obama and Congress. We need real change: vote for Rocky Anderson. Continue reading →

Have you ever noticed that the Internal Revenue Service's regulations often are illogical? Does anyone at the IRS think through its regulations? Continue reading →

Are you a taxpreparer who is unsatisfied with the quality of Intuit's ProSeries tax software program? I am not a happy user of ProSeries tax software. Choose your tax software carefully. I will be searching for an alternative tax software vendor for the year 2014. Continue reading →

Bernie Sanders offers a real deal to the middle class and not the raw deal of Hillary Clinton Continue reading →

Senator Bernie Sanders does not think that Hillary Clinton can stand up and fight for the middle class. Continue reading →

Bernie Sanders does not have to win the Iowa primary; however, if the gets 35%, 40%, or 45% of the vote, that would set him up nicely for the New Hampshire primary, next door to his state of Vermont. Continue reading →

Sen. Bernie Sanders (I-Vt.) warns not to underestimate him in the 2016 Democratic race for the White House. Sanders, who is formally launching his campaign Tuesday, said he has a strong message. Continue reading →

Jimmy Dore says that voting your conscience means voting for Jill Stein if you are a progressive. Continue reading →

Bernie Sanders' voting record is not progressive. It has been reported on Facebook that Bernie has voted 98% of the time in agreement with Senate Democrats and 93% of the time in agreement with Hillary Clinton. And here is Bernie Sanders' illustrious "progressive" voting record...LOL. Show this to all his crazed cult followers who claim he is a progressive and has done so much for us...LOL. Continue reading →

Гитарист SLIPKNOT Jim Root в недавнем интервью рассказал о том, что использует время на карантине для сбора идей для возможного сольного альбома:

«Теперь, когда мы переживаем эту безумную пандемию, я пытаюсь заставить себя писать.

Многие люди спрашивали меня о создании сольного проекта, и сейчас, думаю, у меня появилось дополнительное время, которое я могу ему посвятить. Я уже некоторое время сочиняю материал, который, возможно, не впишется в привычное творчество SLIPKNOT. Но в настоящее время я испытываю что-то вроде творческого кризиса.

Мне бы хотелось запустить соло-проект, потому что я хочу заниматься делом. У меня нет семьи, я никогда не был женат. И мне известно, что Corey (фронтмен SLIPKNOT) упоминал о желании сделать сольный проект вне STONE SOUR. И если бы я не писал для SLIPKNOT, я бы не знал, куда девать своё время.

Мне легко сочинять аранжировки и идеи для SLIPKNOT — они для меня естественны, просто потому, что я провёл очень много времени с (покойным басистом SLIPKNOT) Paul'ом Grey'ем. Когда пишешь столь много, сколько я написал для последних двух альбомов, особо задумываться не приходится. Но для сольного проекта я собираюсь думать до тех пор, пока с ума не сойду, поэтому, быть может, этот материал вообще никогда не выйдет.

Это один из тех случаев, когда ты задаёшься вопросом вроде: "И в каком направлении я иду? Я вообще думал о направлении?" Позволю ли я вещам просто случиться естественным образом? Буду ли использовать те наработки, которые создавались для SLIPKNOT, но к которым SLIPKNOT вовсе не стремятся и считают их не очень-то подходящими для группы? Не то чтобы существовали правила насчёт того, что можно считать SLIPKNOT’овским, а что нет. Хорошая песня есть хорошая песня, кому бы она ни предназначалась.

Разумеется, SLIPKNOT — это мой приоритет навсегда. Я буду фокусироваться на группе, как только смогу, пока команда жизнеспособна, пока все мы пожелаем продолжать совместную работу.

Что я сделаю в рамках сольного проекта? В каком направлении двинусь? Думаю, это естественным образом вытекает из всех аранжировок, которые я сделал для последних двух записей SLIPKNOT. Не знаю, нужен ли мне другой механизм творческого самовыражения. Но я намерен постараться — поставить цель и посмотреть, смогу ли я её достигнуть. Времени у нас теперь предостаточно». #Slipknot #Metal #_Metal #AlternativeMetal #Alternative_Metal #NuMetal #Nu_Metal

IBM announced today a new experimental laboratory for nanotechnology research in Brazil. The NanoLab is part of a $4M investment within the recently upgraded IBM Research-Brazil lab in Rio de Janeiro and will focus on projects related to research in Oil & Gas, Agriculture and Health across Latin America.

The Weather Company, an IBM Business, and PRISA Noticias, one of the world’s leading Spanish-language media groups and owner of EL PAÍS newspaper, announced today a collaboration to combine the most accurate forecasts with one of the Spanish-speaking world’s largest media groups. The Weather Company will provide in-depth weather data and forecasts, as well as tailored content across PRISA properties. In turn, PRISA Noticias will provide locally relevant articles, photos and video content within the Spanish versions of The Weather Channel app and website (weather.com). The collaboration will also enable local marketers to access advanced data-driven advertising solutions from IBM Watson Advertising (formerly The Weather Company’s ad sales business) across both companies’ properties.

Earlier this week I predicted the demise of conventional IT caused by the wide adoption of SD-WAN and SASE, accelerated by the emergency demands of everyone working from home. Now that Congress has passed a $2.2 trillion COVID-19 bail-out, let’s throw-in the implications of that legislation to see what effect it is all likely to have on what used to be IT. The short version is to expect an even bigger bloodbath as IT employees at all levels are let go forever. Please understand that some version of this bloodbath was going to happen anyway. What matters right now is how we respond to it. While my previous column was generally about turning lower-level IT nerds into Uber drivers, this one goes a little further […]






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IBM today announced that Joanne Wright, Vice President Supply Chain has been selected to speak at the upcoming Supply Chain Summit Conference, which takes place in Chicago on June 14-16.

Discovering buried treasure is every fourth-grader's dream afternoon.

- The majority of Australians are stressed by their daily commute affecting health, lifestyles and Australia’s productivity - Accurate and timely information on road conditions key to reducing stress for Australians - National study highlights Australian commuter habits and frustrations

予約受付中 発売後はAmazonで購入が難しくなることが多いです… 宝塚おとめ2020年度版 宝塚ムック 発売日： 2020/4/24 【OG】早花まこ さんnoteに退団後初投稿♪ 　note｜早花まこ 　https://note.com/maco_sahana 　note｜早花まこ｜宝塚を卒業しました...

IBM (NYSE: IBM) today announced the Australian results of the 2012 Smarter Consumer Study – the largest study of its kind – which looks at the purchasing trends, habits and expectations of more than 28,000 consumers globally, including more than 1800 from Australia. Over the last three years, the study has tracked the annual evolution of the ‘empowered consumer’.

At the most recent MSRI board of trustees meeting on Mar 7 (conducted online, naturally), Nicolas Jewell (a Professor of Biostatistics and Statistics at Berkeley, also affiliated with the Berkeley School of Public Health and the London School of Health and Tropical Disease), gave a presentation on the current coronavirus epidemic entitled “2019-2020 Novel Coronavirus […]

This set of notes focuses on the restriction problem in Fourier analysis. Introduced by Elias Stein in the 1970s, the restriction problem is a key model problem for understanding more general oscillatory integral operators, and which has turned out to be connected to many questions in geometric measure theory, harmonic analysis, combinatorics, number theory, and […]

The square root cancellation heuristic, briefly mentioned in the preceding set of notes, predicts that if a collection of complex numbers have phases that are sufficiently “independent” of each other, then similarly, if are a collection of functions in a Lebesgue space that oscillate “independently” of each other, then we expect We have already seen […]

In contrast to previous notes, in this set of notes we shall focus exclusively on Fourier analysis in the one-dimensional setting for simplicity of notation, although all of the results here have natural extensions to higher dimensions. Depending on the physical context, one can view the physical domain as representing either space or time; we […]

1) Because the quarantine is less hard on me than it is on others, I sometimes forget to give myself a break for the ways in which it is hard. Privilege doesn't mean nothing ever hurts. I'm gonna try to be kinder to myself about all this.

2) I'm now getting two weekly farm boxes. I'm not sorry at all.

3) We've killed off 18.5% of our consumer debt since January. We rock.

4) ( Plant diary for May 7 with a pic )

Corporations Will Not Save Us: The Sham of Corporate Social Responsibility

Last August, the Business Roundtable – an association of CEOs of America’s biggest corporations – announced with great fanfare a “fundamental commitment to all of our stakeholders” and not just their shareholders. 

They said “investing in employees, delivering value to customers, and supporting outside communities“ is now at the forefront of their business goals — not maximizing profits.

Baloney. Corporate social responsibility is a sham.

One Business Roundtable director is Mary Barra, CEO of General Motors. Just weeks after making the Roundtable commitment, and despite GM’s hefty profits and large tax breaks, Barra rejected workers’ demands that GM raise their wages and stop outsourcing their jobs. Earlier in the year GM shut its giant assembly plant in Lordstown, Ohio.

Nearly 50,000 GM workers then staged the longest auto strike in 50 years. They won a few wage gains but didn’t save any jobs. Barra was paid $22 million last year. How’s that for corporate social responsibility?

Another prominent CEO who made the phony Business Roundtable commitment was AT&T’s Randall Stephenson, who promised to use the billions in savings from the Trump tax cut to invest in the company’s broadband network and create at least 7,000 new jobs. 

Instead, even before the coronavirus pandemic, AT&T cut more than 23,000 jobs and demanded that employees train lower-wage foreign workers to replace them.

Let’s not forget Jeff Bezos, CEO of Amazon and its Whole Foods subsidiary. Just weeks after Bezos made the Business Roundtable commitment, Whole Foods announced it would be cutting medical benefits for its entire part-time workforce.

The annual saving to Amazon from this cost-cutting move is roughly what Bezos – whose net worth is $117 billion – makes in a few hours. Bezos’ wealth grows so quickly, this number has gone up since you started watching this video.

GE’s CEO Larry Culp is also a member of the Business Roundtable. Two months after he made the commitment to all his stakeholders, General Electric froze the pensions of 20,000 workers in order to cut costs. So much for investing in employees.  

Dennis Muilenburg, the former CEO of Boeing, also committed to the phony Business Roundtable pledge. Shortly after making the commitment to “deliver value to customers,” Muilenburg was fired for failing to act to address the safety problems that caused the 737 Max crashes that killed 346 people.  After the crashes, he didn’t issue a meaningful apology or even express remorse to the victims’ families and downplayed the severity of the fallout to investors, regulators, airlines, and the public. He was rewarded with a $62 million farewell gift from Boeing on his way out.

Oh, and the chairman of the Business Roundtable is Jamie Dimon, CEO of Wall Street’s largest bank, JPMorgan Chase. Dimon lobbied Congress personally and intensively for the biggest corporate tax cut in history, and got the Business Roundtable to join him. JPMorgan raked in $3.7 billion from the tax cut. Dimon alone made $31 million in 2018.

That tax cut increased the federal debt by almost $2 trillion. This was before Congress spent almost $3 trillion fighting the pandemic – and delivering a hefty portion as bailouts to the biggest corporations, many of whom signed the Business Roundtable pledge. 

As usual, almost nothing has trickled down to America’s working class and poor. 

The truth is, American corporations are sacrificing workers and communities as never before in order to further boost runaway profits and unprecedented CEO pay. And not even a tragic pandemic is changing that. 

Americans know this. A record 76 percent of U.S. adults believe major corporations have too much power. 

The only way to make corporations socially responsible is through laws requiring them to be – for example, giving workers a bigger voice in corporate decision making, requiring that corporations pay severance to communities they abandon, raising corporate taxes, busting up monopolies, and preventing dangerous products (including faulty airplanes) from ever reaching the light of day.  

If the CEOs of the Business Roundtable and other corporations were truly socially responsible, they’d support such laws, not make phony promises they clearly have no intention of keeping. Don’t hold your breath.  

The only way to get such laws enacted is by reducing corporate power and getting big money out of our politics.

The first step is to see corporate social responsibility for the sham it is. The next step is to emerge from this pandemic and economic crisis more resolved than ever to rein in corporate power, and make the economy work for all.