pacs PacSun - Free Shipping on All Women's Swim. By www.allonlinecoupons.com Published On :: Free Shipping on All Women's Swim. # Expiration: 2-8-2026 Full Article
pacs PacSun elevates shopping experience with Manhattan Active Point of Sale By www.retailtechnologyreview.com Published On :: Manhattan Associates Inc has announced that PacSun, the specialty retailer of emerging youth brands and trending fashion, has selected Manhattan Active Point of Sale to enhance its omnichannel sales strategy and deliver a seamless, unified customer shopping experience. Full Article EPoS Systems
pacs PODCAST | Fresh-Lock’s Award-Winning Flexible Packaging for Laundry Detergent Pacs By www.packagingstrategies.com Published On :: Mon, 20 May 2024 00:00:00 -0400 Packaging Strategies recently sat down with Natalie Kaczorowski and Todd Meussling of Fresh-Lock® to discuss the company’s development of the award-winning Costco Kirkland Signature® Ultra Clean Premium Laundry Detergent Pacs. Full Article
pacs Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer [Cell Biology] By www.jbc.org Published On :: 2020-12-11T00:06:20-08:00 We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical tumors. Absence of exonic mutations and overexpression at the RNA level suggested a transcriptional and/or posttranscriptional regulation. University of California Santa Cruz genome browser analysis of PACS-1 micro RNAs (miR), revealed two 8-base target sequences at the 3' terminus for hsa-miR-34a and hsa-miR-449a. Quantitative RT-PCR and Northern blotting studies showed reduced or loss of expression of the two microRNAs in cervical cancer cell lines and primary tumors, indicating dysregulation of these two microRNAs in cervical cancer. Loss of PACS-1 with siRNA or exogenous expression of hsa-miR-34a or hsa-miR-449a in HeLa and SiHa cervical cancer cell lines resulted in DNA damage response, S-phase cell cycle arrest, and reduction in cell growth. Furthermore, the siRNA studies showed that loss of PACS-1 expression was accompanied by increased nuclear γH2AX expression, Lys382-p53 acetylation, and genomic instability. PACS-1 re-expression through LNA-hsa-anti-miR-34a or -449a or through PACS-1 cDNA transfection led to the reversal of DNA damage response and restoration of cell growth. Release of cells post 24-h serum starvation showed PACS-1 nuclear localization at G1-S phase of the cell cycle. Our results therefore indicate that the loss of hsa-miR-34a and hsa-miR-449a expression in cervical cancer leads to overexpression of PACS-1 and suppression of DNA damage response, resulting in the development of chemo-resistant tumors. Full Article
pacs Post-Adoption Central Support (PACS) By www.iriss.org.uk Published On :: Tue, 26 Apr 2016 15:17:27 +0000 Full Article Webwatch adoption adoption agencies attachment foster care foster carers foster children Institute for Research and Innovation in Social Services (IRISS) post adoption services
pacs Will environmentalists embrace super PACs? By www.mnn.com Published On :: Fri, 31 Jul 2015 14:11:58 +0000 Many green activists have railed against money in politics. But in order to win, they may need to play the game. Full Article Politics
pacs PACs and billionaires continue to fund Colorado’s U.S. Senate candidates By www.denverpost.com Published On :: Fri, 17 Apr 2020 22:52:35 +0000 Powered in part by billionaire investors, business titans and a few famous musicians, John Hickenlooper dominated the U.S. Senate race’s fundraising battle in the first three months of 2020. Full Article Colorado News Colorado Politics Election Latest News News Politics Andrew Romanoff campaign finance Cory Gardner Election 2020 John Hickenlooper U.S. Senate 2020
pacs U.S. IPO Weekly Recap: ORIC Pops 61% And SPACs Make A Comeback By seekingalpha.com Published On :: Sat, 25 Apr 2020 14:51:56 -0400 Full Article ORIC PCPL.U IPOC.U ADCT EBON NGJY GOED Renaissance Capital IPO Research
pacs U.S. IPO Weekly Recap: Biotech Hot Streak Continues Amid Another Wave Of SPACs By seekingalpha.com Published On :: Sun, 03 May 2020 16:26:17 -0400 Full Article LYRA VNT PCOR IPOB.U FVAC.U IPOC.U CGROU Renaissance Capital IPO Research
pacs Super PACs: The Nominating Committees of the Future By webfeeds.brookings.edu Published On :: Wed, 23 Jul 2014 10:30:00 -0400 Editor's Note: This blog post is part of The Primaries Project series, where veteran political journalists Jill Lawrence and Walter Shapiro, along with scholars in Governance Studies, examine the congressional primaries and ask what they reveal about the future of each political party and the future of American politics. Even though they have come to dominate political campaigns, Super PACs and their shadowy counterparts are barely old enough to qualify for pre-kindergarten. Since these big-bucks independent groups have only been legal since 2010, we are still groping to understand the long-term role that Super PACs are apt to play in congressional politics—especially primaries. With the demonization of the Koch Brothers by the Democrats and the attacks on liberal givers like Tom Steyer from the right, it is easy to assume that Super PAC donors are ideologues. Scorched-earth contests like the Mississippi Republican Senate primary further fuel this impression. Thad Cochran versus Chris McDaniel could be viewed as a proxy war between the GOP establishment (personified by Karl Rove's Super PAC American Crossroads) and the Tea Party (working through groups like Club for Growth Action). But there is another very important, but far less publicized, role that Super PACs are playing in this year's congressional primaries. And when the internecine warfare in the Republican Party dies down, this type of Super PAC involvement in party primaries may become the norm. Two recent GOP House primaries in winnable districts in New York illustrate this alternative model. In both cases, Super PACs took on the role—once left to the political parties—of vetting the candidates. Super PAC donors and their campaign consultants made their own decisions about who is electable and who has the right political pedigree. And in these New York primary contests without any clear ideological markers, heavy spending by Super PACs made all the difference. Twenty-nine-year-old Elise Stefanik was a major beneficiary of Super PAC spending in her primary in New York's rural 21st District that runs from the Saratoga racetrack to the Canadian border. Stefanik has never run for public office before, but she boasts all of the right credentials to appeal to Washington Republican politicos. Even though she calls herself a "small businesswoman" in her TV ads, Stefanik served on the White House domestic policy staff under George W. Bush and was in charge of 2012 debate preparation for Paul Ryan. Small wonder that American Crossroads and Karl Rove invested heavily in Stefanik's primary race, spending $772,000 in attack ads excoriating her GOP rival, Matt Doheny. This was, by the way, the only House primary in the nation in which American Crossroads has made a significant investment to distinguish between Republicans. And the Super PAC's involvement was certainly not motivated by ideology. As the Watertown Daily Times put it on the eve of the Stefanik-Doheny primary, "It's difficult to point to a single issue on which a big divide exists between the two." Yes, Doheny—a largely self-funding investment banker who had lost two prior races for the House—was a flawed Republican candidate. And Stefanik was the embodiment of the kind of message discipline beloved by campaign consultants. But it is hard to believe that electability alone prompted attack ads with tag lines like: "Matt Doheny—it would be a big mistake to send him to Congress." American Crossroads, which spent more than either the Stefanik or Doheny campaigns, prevailed in the June 24th primary. Stefanik romped home with 61 percent of the primary vote. The same pattern emerged in the Republican primary in New York's 1st District on the tip of Long Island. The major player this time was the US Jobs Council, which is heavily funded by hedge-fund mogul Robert Mercer, whose home is in the district. As Mother Jones reported in an article by Molly Redden, Mercer's Ahab-like obsession has been defeating Democratic incumbent Tim Bishop ever since the congressman voted for the Dodd-Frank financial reform legislation. Both candidates in the Republican primary to oppose Bishop had their weaknesses in appealing to a conservative electorate. State Senator Lee Zeldin carried the burden of votes in Albany that could be interpreted as raising taxes. George Demos, a former SEC lawyer, was heavily supported by his wife's in-laws who, in normal times, are liberal California Democrats. In truth, there were scant philosophical differences between the two conservative Republicans. Newsday columnist Lane Filler wrote, "Both oppose abortion, think taxes are too high, support gun rights, hate Common Core, favor a strong national defense, are against 'amnesty' for immigrants here illegally...I have not turned up any meaningful difference between them on policy." But that didn't prevent the US Jobs Council from spending more than $200,000 on attack ads that portrayed Demos, who had been endorsed by Rudy Giuliani and George Pataki, as a creature of "Nancy Pelosi's people." A typical ad charged that Demos "is trying to use the Pelosi cash machine to buy a seat in Congress." Even though Demos donated $2 million to his own campaign, it was not enough to hold off the onslaught of Super PAC attacks. In the end, Zeldin defeated Demos in the primary by a 62-to-38 percent margin. Politico reporter Ken Vogel in his praiseworthy new book, Big Money, likens Super PAC donors to meddlesome "sports junkies who plunk down hundreds of millions of dollars to buy a professional team." Often the motivation of these mega-givers is the arrogant belief that because they are rich, they know more about politics than the pros. With it comes the certainty that they can pick winners and losers in primaries just like they do with stocks on Wall Street. And that is why the heavy Super PAC influence in these two little-covered New York House primaries may represent the wave of the future in party politics. Authors Walter Shapiro Image Source: © Carlos Barria / Reuters Full Article
pacs Want to reduce the influence of super PACs? Strengthen state parties By webfeeds.brookings.edu Published On :: Thu, 24 Mar 2016 10:30:00 -0400 Super PACs and other lightly regulated political organizations are dumping hundreds of millions of dollars into American elections. What should be done about it? Unlike many candidates for federal or state office, so-called independent expenditure groups face no restrictions on how much individuals and groups can give to them. And thanks to several federal court decisions, including Citizens United v. Federal Election Commission, independent groups can spend unlimited amounts to influence elections. The public understandably worries about the political clout of wealthy groups—especially since donors often can hide their identities. Reformers have proposed various remedies: disclosure rules, the appointment of a liberal Supreme Court justice to reverse Citizens United, even a constitutional amendment to overturn that decision. Those long-shot strategies, however, are unlikely to create the kind of small-donor democracy that many reformers seek. Money, like water, will inevitably flow into the political system. Laws can’t do much to reduce the amount of money in politics; what they can change is where the money goes. An easier path to improving politics In our new Brookings paper, The State of State Parties, we suggest an easier path to improving politics—one that is right under our nose. Strengthening state political parties can help offset the clout of super PACs. Our study, based on a survey of 56 state-party organizations plus detailed interviews with 15 of their leaders, points to the distinctive and constructive role that state parties play in American politics. In an era when politics seems to be spinning out of control, party organizations are among the few actors that seek to integrate and balance interests—for instance, by recruiting candidates with broad appeal, by playing honest broker among contending partisan factions, and by building coherent strategies among campaigns up and down the ticket. Party organizations also generate a lot of grassroots activity to mobilize volunteers and voters. How regulations on parties increase super PAC spending State parties are among the most heavily regulated entities in American politics, a situation that diminishes their influence relative to non-party groups. For instance, the vast majority of state parties face restrictions on the source and size of donations, and some contribution limits are unrealistically low. In Massachusetts, no donor can give more than annual aggregate of $5,000 to all local and state parties. That’s a paltry sum in statewide elections that can easily cost $55 million, including $20 million in independent expenditures. Super PACs and other groups naturally fill the vacuum because they do not have to contend with limits on raising and spending money. Often, outside groups effectively drown out the parties. In our survey, only half the parties said they advertise on TV and radio sometimes or often, usually because they lack the resources to do more. The figure below shows that parties’ independent spending is miniscule compared to the growing expenditures of non-party groups over the past five election cycles. In the 2014 election cycle, the parties accounted for just six percent of total independent spending in the states for which we had good data. An especially significant finding is that restraints on political parties seem to amplify the activities and influence of outside groups. As illustrated in the table below, 65 percent of respondents in states with contribution limits to parties said that independent groups sponsor more than half or almost all political ads, compared to only 23 percent in states without contribution limits. In other words, independent spending is significantly lower when parties are not limited. These differences translate into electoral clout. In states with contribution limits, 65 percent of respondents said independent spending is often a key factor in gubernatorial elections, while fewer than half said the same in states with no limits. Correlation does not prove causality, but our findings provide strong circumstantial evidence that when you restrict the parties, you get more independent expenditures by non-party groups. It’s not hard to strengthen state parties We recommend changes to strengthen state parties and restore them to a place of prominence in campaigns. First, state governments should raise or eliminate contribution limits so the parties can acquire sufficient resources to compete with outside actors. This would allow state parties to serve as clearinghouses for campaign money, which would bring more “dark money” toward accountability and transparency. Second, parties should be allowed full freedom to coordinate their activities with their candidates and allied groups. This would make them more valuable to candidates and would allow the parties to perform their irreplaceable role of supporting candidates across the party ticket. We also suggest giving parties favorable tax treatment so that donors are more likely to give to parties than candidate-sponsored super PACs or interest groups. We also recommend other regulatory changes that would encourage parties to do more grassroots work with voters. Loosening the constraints on state parties would not stop the flow of money into politics (nothing can do that), but would channel more of the money to accountable actors. That’s why we think of this solution as building canals, not dams. And the incremental steps we propose require no sea-changes in public opinion or heroic legislation. In fact, they command support in both parties’ establishments, making them a good starting point for reform. That’s why we conclude that strengthening state parties is a realistic path toward a better balanced, more effective, and more accountable political system. Authors Raymond J. La RajaJonathan Rauch Image Source: © Mike Blake / Reuters Full Article
pacs Campaign Finance in the 2012 Elections: The Rise of Super PACs By webfeeds.brookings.edu Published On :: Thu, 01 Mar 2012 09:30:00 -0500 Event Information March 1, 20129:30 AM - 11:00 AM ESTSaul/Zilkha RoomsThe Brookings Institution1775 Massachusetts Avenue, NWWashington, DC 20036 From “American Crossroads” to “Americans for a Better Tomorrow, Tomorrow,” so-called "super PACs" have emerged as the dominant new force in campaign finance. Created in the aftermath of two landmark court decisions and regulatory action and inaction by the Federal Election Commission (FEC), these independent spending-only political action committees are collecting unlimited contributions from individuals, corporations and unions to advocate for or against political candidates. The legal requirements they face—disclosure of donors and non-coordination with the candidates and campaigns they are supporting—have proven embarrassingly porous. Increasingly, super PACs are being formed to boost a single candidate and are often organized and funded by that candidate’s close friends, relatives and former staff members. Their presence is most visible in presidential elections but they are quickly moving to Senate and House elections. On March 1, on the heels of the FEC’s February filing deadline, the Governance Studies program at Brookings hosted a discussion exploring the role of super PACs in the broader campaign finance landscape this election season. Anthony Corrado, professor of government at Colby College and a leading authority on campaign finance, and Trevor Potter, nonresident senior fellow at the Brookings Institution, a former chairman of the FEC and lawyer to Comedy Central’s Stephen Colbert, presented. After the panel discussion, the speakers took audience questions. Participants joined the discussion on Twitter by using the hashtag #BISuperPAC. Video Full Video: The Rise of Super PACsWhy Corporations Spend on ElectionsGOP Likely to Benefit Most from Super PACs Audio Campaign Finance in the 2012 Elections: The Rise of Super PACs Transcript Uncorrected Transcript (.pdf) Event Materials 20120301_super_pacs Full Article
pacs @Brookings Podcast: The Influence of Super PACs on the 2012 Elections By webfeeds.brookings.edu Published On :: Fri, 09 Mar 2012 16:20:00 -0500 Super PACs have already spent tens of millions of dollars in the race for the GOP presidential nomination, with more to come. Expert Anthony Corrado says that the unlimited spending by the PACs, made possible by two Supreme Court decisions, is giving wealthy individuals unprecedented influence in the 2012 elections. previous play pause next mute unmute @Brookings Podcast: The Influence of Super PACs on the 2012 Elections 07:13 Download (Help) Get Code Brookings Right-click (ctl+click for Mac) on 'Download' and select 'save link as..' Get Code Copy and paste the embed code above to your website or blog. Video The Influence of Super PACs on the 2012 Elections Audio @Brookings Podcast: The Influence of Super PACs on the 2012 Elections Image Source: © Jessica Rinaldi / Reuters Full Article
pacs WIRED Live - A Super PAC to End All Super PACs By www.wired.com Published On :: Wed, 10 Sep 2014 10:30:00 +0000 Harvard Law professor Lawrence Lessig calls for a mayday on democracy and explains how he plans to do so with an innovative Kickstarter campaign. Full Article
pacs 2019 International Symposium on Intelligent Signal Processing and Communication Systems (ISPACS) [electronic journal]. By encore.st-andrews.ac.uk Published On :: IEEE / Institute of Electrical and Electronics Engineers Incorporated Full Article
pacs UP Govt confirms selection of 49,568 constables of police & PACs By indianexpress.com Published On :: Tue, 03 Mar 2020 00:05:43 +0000 Full Article Cities Lucknow