The US health care system transition to the ICD-10-CM will occur in October 2015. The logistical and financial impact of the transition for billing codes frequently used by pediatricians has not been studied.

The findings of this study evaluate the government-provided mappings from ICD-9-CM to ICD-10-CM for accuracy and provide the diagnostic codes used by pediatricians, which may be adversely affected by the transition to ICD-10-CM. (Read the full article)

Neurocognitive deficits, academic delays, and behavioral and emotional problems are well documented in school-age children in relation to socioeconomic disadvantage and residential instability. Despite adversity, early intervention can facilitate healthy cognitive, emotional, and social development.

Homeless youth demonstrated elevated rates of untreated psychiatric disorders, low academic achievement, and impaired neurocognition. Mental health and neurocognitive symptoms were associated with vocational outcome. Intervention beyond employment services alone is needed to improve functioning. (Read the full article)

More children with special health care needs are surviving to adulthood and entering the adult health care system. Effective transition of care can promote continuity of developmental and age-appropriate care for these individuals.

Existing studies provide modest transition care support. Methods for providing transition care warrant attention, and future research needs are wide ranging. Consistent and accepted measures of transition success are critical to establishing an adequate body of literature to affect practice. (Read the full article)

The built environment may affect weight status by presenting opportunities or barriers for exercise and nutritious eating. Although there is substantial cross-sectional evidence linking neighborhood factors and childhood obesity, causal uncertainty remains, owing to conceptual and methodological challenges.

This prospective study examined neighborhood influences on obesity during the transition to adolescence, a sensitive period for excess weight gain. Girls living in neighborhoods characterized by physical disorder or increased access to food and service retailers exhibited higher obesity risk. (Read the full article)

Phototherapy decreases bilirubin concentration in skin more rapidly than in blood. During and after phototherapy, transcutaneous bilirubin measurements are considered unreliable and therefore discouraged.

Transcutaneous bilirubin underestimates total serum bilirubin by 2.4 mg/dL (SD, 2.1 mg/dL) during the first 8 hours after phototherapy. This gives a safety margin of ~7 mg/dL below the treatment threshold to omit confirmatory blood sampling. (Read the full article)

In most previous studies, transcutaneous bilirubin measurement has been found to provide an accurate estimate of total serum bilirubin levels. However, most of these studies were conducted in settings that optimized accuracy.

This study provides a "real-world" assessment of the accuracy of transcutaneous bilirubin measurements in multiple clinical settings and identification of sources of discrepancy between transcutaneous and total serum bilirubin measurements. (Read the full article)

Low case volume has traditionally been associated with poor outcomes in complex surgical procedures, including pediatric liver transplantation.

This retrospective analysis supports the association between low case volume and poorer outcomes in pediatric liver transplantation, and, in addition, shows that candidates listed in low-volume centers have severely limited access to transplantation. (Read the full article)

High bilirubin levels are associated with sensorineural hearing loss. Exchange transfusions are recommended when bilirubin levels reach certain thresholds. However, the relative and excess risks of hearing loss in infants with bilirubin levels at/above exchange transfusion thresholds are unknown.

In this Northern California population of term and late preterm infants, elevated bilirubin levels were not associated with an increased risk of sensorineural hearing loss unless the levels were at least 10 mg/dL above exchange transfusion thresholds. (Read the full article)

Over one hundred languages should help make a few conversations easier to get through, but that's still well short of the hundreds of languages Gboard typing supports.

The Trump administration's move to narrowly define gender according to sex assigned at birth could impact transgender students and schools' policies with respect to their rights.

The Education Department's office for civil rights will investigate whether a Georgia elementary school's policy for transgender students contributed to the alleged assault of a girl.

Equipping teachers to help transgender students feel safe and included requires special training, advocates say.

Participate in a chat about how multimedia tools are transforming teaching and learning in core academic subjects.

Two things are true as I sort through my reflections on transformative learning experiences: We need intensive, immersive opportunities for learning (such as a trip to Kenya) and we also need to build in mini-opportunities for transformative learning every day.

The collapse of the state and the disappearance of security forces from a large part of the territory may turn the Central African Republic (CAR) into a source of instability in the heart of Africa.
Please note the full report is only available in French.

Malaria parasites invade and replicate within red blood cells (RBCs), extensively modifying their structure and gaining access to the extracellular environment by placing the plasmodial surface anion channel (PSAC) into the RBC membrane. Expression of members of the cytoadherence linked antigen gene 3 (clag3) family is required for PSAC activity, a process that is regulated epigenetically. PSAC is a well-established route of uptake for large, hydrophilic antimalarial compounds and parasites can acquire resistance by silencing clag3 gene expression, thereby reducing drug uptake. We found that exposure to sub-IC50 concentrations of the histone methyltransferase inhibitor chaetocin caused substantial changes in both clag3 gene expression and RBC permeability, reversing acquired resistance to the antimalarial compound blasticidin S that is transported through PSAC. Chaetocin treatment also altered progression of parasites through their replicative cycle, presumably by changing their ability to modify chromatin appropriately to enable DNA replication. These results indicate that targeting histone modifiers could represent a novel tool for reversing epigenetically acquired drug resistance in P. falciparum.

OptrA is an ATP-binding cassette (ABC)-F protein that confers resistance to oxazolidinones and phenicols, and can be either plasmid or chromosomally encoded. We isolated 13 Enterococcus faecalis strains possessing linezolid MIC ≥ 4 mg/L from nursery pigs in swine herds located across Brazil. Genome sequence comparison showed that these strains possess optrA in different genetic contexts occurring in 5 different E. faecalis sequence type backgrounds. The optrA gene invariably occurred in association with an araC regulator and a gene encoding a hypothetical protein. In some contexts, this genetic island was able to excise and form a covalently closed circle within the cell which appeared to occur in high abundance, and to be transmissible by co-resident plasmids.

BACKGROUND AND OBJECTIVES:

Annual incidence of venous thromboembolism (VTE) including postoperative VTE in hospitalized children is rising significantly. A growing body of evidence supports the role of red blood cells (RBCs) in pathologic thrombosis. In this study, we examined the association of perioperative RBC transfusion with postoperative VTE in pediatric patients.

BACKGROUND AND OBJECTIVES:

Rates of sexually transmitted infections (STIs) have increased over the decade. Guidelines recommend HIV testing with incident STIs. Prevalence and factors associated with HIV testing in acute STIs are unknown in adolescents. Our objective was to determine the prevalence of completed HIV testing among adolescents with incident STIs and identify patient and health care factors associated with HIV testing.

BACKGROUND:

In the United States, transgender youth are at especially high risk for HIV infection. Literature regarding HIV prevention strategies for this vulnerable, often-hidden population is scant. Before effective, population-based HIV prevention strategies may be adequately developed, it is necessary to first enhance the contextual understanding of transgender youth HIV risk and experiences with HIV preventive services.

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

Prospective transfer students can explore the Lehigh Valley Campus virtually during the Transfer Thursday events

Russell B. Toomey
Oct 1, 2018; 142:e20174218-e20174218
ARTICLES

Kristina R. Olson
Mar 1, 2016; 137:e20153223-e20153223
ARTICLES

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

Google Translate is not the only app that can help you converse with someone speaking a different language. Here's how to translate real-time conversations with the Google Assistant.

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

A Penn State Abington faculty member is teaching students enrolled to integrate the content into their daily lives to help them manage the impact of the coronavirus.

Within days of the University's shift to remote learning, faculty, instructors and teaching assistants in the Department of Geography moved 35 resident instruction courses into remote delivery mode to teach 1,947 students.

Penn State Schuylkill biology student Eric Thompson will graduate with honors on May 9. After surviving pediatric cancer in his early teens, Thompson has transformed a tragic situation into a passion to help people. This fall, he will embark on a new academic journey at Thomas Jefferson University’s Sidney Kimmel Medical College, where he will commit himself to earning his M.D. and delivering medical expertise to underserved communities.

In 2019 alone, Corner LaunchBox had 10 accelerator program graduates, supported five new startups anchored in Pennsylvania, and helped create 20 new jobs. More than 900 individuals utilized the facility for a variety of free and low-cost activities, including the 10-week Corner Opportunity accelerator program, an Idea TestLab, small business and entrepreneurship workshops, free legal clinics, weekly information sessions, and networking events.

Penn State faculty are going beyond using traditional video in their courses by incorporating virtual-reality immersive experiences. They are discovering how those experiences help enhance active learning and focus students' attention on critical lessons in their courses.

Combining a transparent LCD panel, driver-facing camera, and AI facial detection system, the Virtual Visor blocks the sun's glare, not your view of the road.

A Holyrood committee has called on the Scottish Government to include a “sunset clause” in legislation that will enable the Common Agricultural Policy (CAP) to continue to operate during a post-Brexit transition period

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

A group of 12 came to France through the Transform conference, to partner with a church and establish connections in the local refugee camp.

Transform mission conference one year, outreach team in France the following year, the sisters from Mexico are eager to share the love of Christ, realising the audience was different from what they expected.

A partnership works to create and implement a district-wide NGSS-aligned science curriculum and instructional model.

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

Two young Bangladeshi women experienced great joy and release from the OM tailoring courses, bringing dignity, honour and financial gain to their communities and families.

Two adults were significantly impacted by learning to read and write in recent adult literacy classes run by OM in Bangladesh.

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.