We analyse how Latvia secured a point against Germany at UEFA EURO 2004.

Integrating technology requires a significant investment of time and money, but the resources are well-spent if the focus is improving instruction, writes educational consultant Matthew Lynch.

About two dozen teachers from across the country spent a week wrestling with questions about how to remember the Confederacy.

Turkish President Recep Tayyip Erdogan rejected Riyadh’s account of the killing of dissident journalist Jamal Khashoggi at Saudi Arabia’s consulate in Istanbul, saying the murder was the result of a meticulously planned plot and calling on the Saudi king to hold all culprits to account.

β-lactam resistance in Staphylococcus aureus limits treatment options. Stp1 and Stk1, a serine-threonine phosphatase and kinase respectively, mediate serine-threonine kinase (STK) signaling. Loss of function point mutations in stp1 were detected among laboratory passaged, β-lactam resistant S. aureus strains lacking mecA and blaZ, the major determinants of β-lactam resistance in the bacteria. Loss of Stp1 function facilitates β-lactam resistance of the bacteria.

Ibrexafungerp (formerly SCY-078) is a semisynthetic triterpenoid and potent (1->3)-β-D-glucan synthase inhibitor. We investigated the in vitro activity, pharmacokinetics, and in vivo efficacy of ibrexafungerp (SCY) alone and in combination with anti-mould triazole isavuconazole (ISA) against invasive pulmonary aspergillosis (IPA). The combination of ibrexafungerp and isavuconazole in in vitro studies resulted in an additive and synergistic interactions against Aspergillus spp. Plasma concentration-time curves of ibrexafungerp were compatible with linear dose proportional profile. In vivo efficacy was studied in a well established persistently neutropenic NZW rabbit model of experimental IPA. Treatment groups included untreated rabbits (UC) and rabbits receiving ibrexafungerp at 2.5(SCY2.5) and 7.5(SCY7.5) mg/kg/day, isavuconazole at 40(ISA40) mg/kg/day, or combinations of SCY2.5+ISA40 and SCY7.5+ISA40. The combination of SCY+ISA produced in vitro synergistic interaction. There was significant in vivo reduction of residual fungal burden, lung weights, and pulmonary infarct scores in SCY2.5+ISA40, SCY7.5+ISA40, and ISA40-treatment groups vs that of SCY2.5-treated, SCY7.5-treated and UC (p<0.01). Rabbits treated with SCY2.5+ISA40 and SCY7.5+ISA40 had prolonged survival in comparison to that of SCY2.5-, SCY7.5-, ISA40-treated or UC (p<0.05). Serum GMI and (1->3)-β-D-glucan levels significantly declined in animals treated with the combination of SCY7.5+ISA40 in comparison to those treated with SCY7.5 or ISA40 (p<0.05). Ibrexafungerp and isavuconazole combination demonstrated prolonged survival, decreased pulmonary injury, reduced residual fungal burden, lower GMI and (1->3)-β-D-glucan levels in comparison to those of single therapy for treatment of IPA. These findings provide an experimental foundation for clinical evaluation of the combination of ibrexafungerp and an anti-mould triazole for treatment of IPA.

Resistance to amoxicillin-clavulanate, a widely used beta-lactam/beta-lactamase inhibitor combination antibiotic, is rising globally, yet susceptibility testing remains challenging. To test whether whole-genome sequencing (WGS) could provide a more reliable assessment of susceptibility than traditional methods, we predicted resistance from WGS for 976 E. coli bloodstream infection isolates from Oxfordshire, UK, comparing against phenotypes from the BD Phoenix (calibrated against EUCAST guidelines). 339/976 (35%) isolates were amoxicillin-clavulanate resistant. Predictions based solely on beta-lactamase presence/absence performed poorly (sensitivity 23% (78/339)) but improved when genetic features associated with penicillinase hyper-production (e.g. promoter mutations, copy number estimates) were considered (sensitivity 82% (277/339); p<0.0001). Most discrepancies occurred in isolates with peri-breakpoint MICs. We investigated two potential causes; the phenotypic reference and the binary resistant/susceptible classification. We performed reference standard, replicated phenotyping in a random stratified subsample of 261/976 (27%) isolates using agar dilution, following both EUCAST and CLSI guidelines, which use different clavulanate concentrations. As well as disagreeing with each other, neither agar dilution phenotype aligned perfectly with genetic features. A random-effects model investigating associations between genetic features and MICs showed that some genetic features had small, variable and additive effects, resulting in variable resistance classification. Using model fixed-effects to predict MICs for the non-agar dilution isolates, predicted MICs were in essential agreement (±1 doubling dilution) with observed (BD Phoenix) MICs for 691/715 (97%) isolates. This suggests amoxicillin-clavulanate resistance in E. coli is quantitative, rather than qualitative, explaining the poorly reproducible binary (resistant/susceptible) phenotypes and suboptimal concordance between different phenotypic methods and with WGS-based predictions.

Despite the worldwide re-emergence of the chikungunya virus (CHIKV) and the high morbidity associated with CHIKV infections, there is no approved vaccine or antiviral treatment available. We here aim to identify the target of a novel class of CHIKV inhibitors i.e. CHVB series. CHVB compounds inhibit the in vitro replication of CHIKV isolates with 50% effective concentrations in the low micromolar range. A CHVB-resistant variant (CHVB^res) was selected that carried two mutations in the gene encoding nsP1 (responsible for viral RNA capping), one mutation in nsP2 and one mutation in nsP3. Reverse genetics studies demonstrated that both nsP1 mutations were necessary and sufficient to achieve ~18-fold resistance, suggesting that CHVB targets viral mRNA capping. Interestingly, CHVB^res was cross-resistant to the previously described CHIKV capping inhibitors from the MADTP series, suggesting they share a similar mechanism of action. In enzymatic assays, CHVB inhibited the methyltransferase and guanylyltransferase activities of alphavirus nsP1 proteins. To conclude, we identified a class of CHIKV inhibitors that targets the viral capping machinery. The potent anti-CHIKV activity makes this chemical scaffold a potential candidate for CHIKV drug development.

In number 10 in our countdown, I tried to offer a few thoughts to funders as they embraced new agendas and looked to avoid repeating yesterday's missteps.

BACKGROUND:

Pediatricians are less frequently sued than other physicians. When suits are successful, however, the average payout is higher. Little is known about changes in the risk of litigation over time. We sought to characterize malpractice lawsuit trends for pediatricians over time.

Many teachers scrapped their lesson plans on Monday and gave their students space to talk about Kobe Bryant.

Penn State Campus Recreation is now offering a library of more than 50 workouts online through YouTube as well as live classes that are held every business day on the Penn State Campus Recreation Instagram. Group fitness instructor Alexis "Lexi" Neimeyer talked about her experience on the transition to virtual fitness classes.

The Education Department says federal law should not be used to prevent schools from offering online learning to all students, including those with disabilities.

RANGERS vice-chairman John Bennett last night dismissed a claim that Ibrox chairman Douglas Park had threatened SPFL chief executive Neil Doncaster as “unfounded”.

Falkirk chairman Gary Deans tonight slammed Ladbrokes Premiership clubs for scuppering league reconstruction hopes - and called for change at the top of Scottish football.

Already home to a thriving ecosystem of private school choice, the state’s lawmakers want vouchers for thousands of new students.

History teacher Bill Tolley offers tips on adapting to learning environments that combine face-to-face instruction with self-directed online experiences.

The champion of disruptive innovation in business and education passed away this month. One of Christensen's co-authors of "Disrupting Class," Michael B. Horn, assesses the impact his late colleague had on schools.

"With unparalleled technology support, digital and curriculum innovation, a flexible structure including our Commonwealth and University Park campuses, effective outreach programming, and a wide array of top-ranked academic programs, Penn State is uniquely prepared for the arrival of the Class of 2024," wrote President Eric J. Barron in a message inviting accepted students to attend a four-part virtual series titled "Welcome to the Penn State Community."

Media literacy belongs in science class, insists Media Literacy Now’s Andy Zucker. Here’s how to bring it there.

The OnePlus 7T Pro 5G McLaren is a wickedly powerful Android phone which falls just short of the Galaxy S20 series on performance, for considerably less coin.

051 - Decision on 13 final tournament hosts to be taken in September 2014

A Holyrood committee has called on the Scottish Government to include a “sunset clause” in legislation that will enable the Common Agricultural Policy (CAP) to continue to operate during a post-Brexit transition period

The UK and Scottish Governments must work more closely together to ensure people get the benefits they are entitled to, a new report by the Scottish Parliament’s Social Security Committee has said.

Adobe's Photoshop Lightroom remains the gold standard in pro photo workflow software. It's a complete package, with top-notch organization tools, state of-the-art adjustments, and all the output and printing options you'd want.

Penn State's College of Education and the State College Area School District have joined forces for 22 years to conduct the Professional Development School.

An education professor at Penn State is investigating how educators can adopt mindfulness practices to keep stress and anxiety at bay.

Google's quantum computer performed a computation in 200 seconds that would have taken the world's fastest supercomputer 10,000 years to calculate. But IBM is dismissing Google's claim that it achieved quantum supremacy.

And in some districts, shorter school weeks hurt the bottom line.

DSHA has partnered with the Department of Education (DOE) to offer reduced interest rates on mortgages for teachers in the Delaware Talent Cooperative, a group of high performing educators who have committed to work in schools with a significant proportion of disadvantaged students

In response to the growing coronavirus pandemic, orders from the state government and recommendations from global public health organizations, Penn State will hold its spring 2020 commencement ceremony via livestream on May 9. The virtual ceremony will recognize all Penn State undergraduate students and all graduate students in the Penn State Graduate School.

At 2 p.m. on Saturday, May 9, Penn State will host its first virtual commencement. The ceremony will be livestreamed, and available internationally, at https://spring2020.commencement.psu.edu/.

Teaching English by acting out Christian songs. Great fun, and surprisingly meaningful for Gabiel, a homeless man in Chile.

Many of education's most common questions skip a logical step or two, warns Alfie Kohn.

Flipped classrooms have been getting attention as a way for teachers to find more time for activities and individual support during the regular school day, but a new study cautions that the model could trade short-term gains for wider achievement gaps.

Delaware leads bipartisan coalition opposing attempt to weaponize class action settlements against state law enforcement actions Attorney General Kathy Jennings announced Monday that Delaware has filed an amicus brief in a Minnesota federal court opposing a corporation’s attempt to weaponize a class action settlement against a parallel law enforcement action by the Minnesota Attorney General. […]

Dover, DE   August 8, 2019 — A Wilmington woman was indicted by the New Castle County Grand Jury for insurance fraud and other felony charges. Theresa T. Milton, 44, of the 900 block of Clayton Street, was indicted on seven felony counts of insurance fraud, one felony count of theft by false pretense, and one […]

August 13, 2019  – The Delaware Department of Insurance has received inquiries from Medicare eligible citizens concerning  misunderstandings or misinformation they’ve received from some insurance agents and brokers regarding the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA).  As this act is rather complex, it has not been determined if consumers have been misinformed, or […]

The clock is ticking for Delaware companies that may wish to convert their abandoned and unclaimed property audits to a Voluntary Disclosure Agreement offered by the Secretary of State. Eligible firms have until Dec. 11, 2017 to choose a VDA conversion.

The bill has a provision for endorsers, under which they cannot be held liable for false and misleading ads if they are found to have done due diligence before signing the deal.

Force majeure on contracts in India during COVID-19

Bihar Water Minister Sanjay Kumar Jha hitout at the Delhi government after it claimed reimbursement over train fares paid for return of migrants stranded in the national capital amid the coronavirus...

Volker Grimm, Steven F. Railsback, Christian E. Vincenot, Uta Berger, Cara Gallagher, Donald L. DeAngelis, Bruce Edmonds, Jiaqi Ge, Jarl Giske, Jürgen Groeneveld, Alice S.A. Johnston, Alexander Milles, Jacob Nabe-Nielsen, J. Gareth Polhill, Viktoriia Radchuk, Marie-Sophie Rohwäder, Richard A. Stillman, Jan C. Thiele and Daniel Ayllón: The Overview, Design concepts and Details (ODD) protocol for describing Individual- and Agent-Based Models (ABMs) is now widely accepted and used to document such models in journal articles. As a standardized document for providing a consistent, logical and readable account of the structure and dynamics of ABMs, some research groups also find it useful as a workflow for model design. Even so, there are still limitations to ODD that obstruct its more widespread adoption. Such limitations are discussed and addressed in this paper: the limited availability of guidance on how to use ODD; the length of ODD documents; limitations of ODD for highly complex models; lack of sufficient details of many ODDs to enable reimplementation without access to the model code; and the lack of provision for sections in the document structure covering model design rationale, the model’s underlying narrative, and the means by which the model’s fitness for purpose is evaluated. We document the steps we have taken to provide better guidance on: structuring complex ODDs and an ODD summary for inclusion in a journal article (with full details in supplementary material; Table 1); using ODD to point readers to relevant sections of the model code; update the document structure to include sections on model rationale and evaluation. We also further advocate the need for standard descriptions of simulation experiments and argue that ODD can in principle be used for any type of simulation model. Thereby ODD would provide a lingua franca for simulation modelling.

All State of Delaware employees will be able to access a new online class, Focus on Ability. This class will provide information about hiring and retaining employees with disabilities, including responding to and requesting accommodations, understanding invisible disabilities, and interacting comfortably and respectfully with people who have disabilities.

Governor Jack Markell announced today that Friday, December 26, 2014, will be an additional holiday for state government.

Governor Jack Markell announced today that Thursday, December 24, 2015, will be an additional holiday for state government.

On Sunday, Delaware will lay to rest fallen firefighter Tim McClanahan. Mr. McClanahan passed away on Monday, July 11, 2016, following a Delaware Air Rescue Team training accident. He was a graduate of Cape Henlopen High School, was a past member of Milton and Rehoboth Beach Fire Departments, and a current member of the Lewes […]