The human diseases caused by the fungal pathogens Cryptococcus neoformans and C. gattii are associated with high indices of mortality, and toxic and/or cost-prohibitive therapeutic protocols. The need for affordable antifungals to combat cryptococcal disease is unquestionable. Previous studies suggested benzimidazoles as promising anti-cryptococcal agents combining low cost and high antifungal efficacy, but their therapeutic potential has not been demonstrated so far. In this study, we investigated the antifungal potential of fenbendazole, the most effective anti-cryptococcal benzimidazole. Fenbendazole was inhibitory against 17 different isolates of C. neoformans and C. gattii at a low concentration. The mechanism of anti-cryptococcal activity of fenbendazole involved microtubule disorganization, as previously described for human parasites. In combination with fenbendazole, the concentrations of the standard antifungal amphotericin B required to control cryptococcal growth were lower than those required when this antifungal was used alone. Fenbendazole was not toxic to mammalian cells. During macrophage infection, the anti-cryptococcal effects of fenbendazole included inhibition of intracellular proliferation rates and reduced phagocytic escape through vomocytosis. Fenbendazole deeply affected the cryptococcal capsule. In a mice model of cryptococcosis, the efficacy of fenbendazole to control animal mortality was similar to that observed for amphotericin B. These results indicate that fenbendazole is a promising candidate for the future development of an efficient and affordable therapeutic tool to combat cryptococcosis.

Security researchers are demonstrating how you can use the Windows 10 flaw, CVE-2020-0601, to spoof the trusted digital certificates for official website domains on Google's Chrome browser. These same certificates can warn you about hacking attempts.

'As CEO of Avast, I feel personally responsible and I would like to apologize to all concerned,' wrote Ondrej Vlcek following a PCMag-Motherboard investigation into the privacy risks around the data harvesting.

Stock markets plunged on Thursday after economic growth data confirmed fears of Covid-19's bruising impact on the world economy.

Deep losses were recorded across most European benchmarks except the FTSE 100 which managed to trade relatively flat on the day.

New research has found that inequality in SA has increased, with wealth becoming ever more concentrated among the rich.

Reducing indebtedness and improving savings in South Africa is a major socio-economic challenge, warns an industry expert.

Even with the increase in streaming competitors, Netflix remains at the top of the pack—but how long will its dominance last?

Philip M. Farrell
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Cesar Gomes Victora
Mar 1, 2010; 125:e473-e480
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Richard A. Ehrenkranz
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Richard A. Ehrenkranz
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Cynthia L. Ogden
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Juan Roberto Meléndez-Colón was exonerated, in 2002, after nearly 18 years on death row for a crime he did not commit. He visited Penn State Fayette, The Eberly Campus to share his story on March 5.

A multi-disciplinary collaborative relationship, developed between Penn State EMS Energy Institute researchers and a Pittsburgh-based start-up company, may hold the answer to reducing global greenhouse gas (GHG) emissions while also paving the way to disrupt the chemical and material industries.

Former Vice President Joe Biden has approved a series of new hires that will significantly expand his campaign ahead of the general election fight with President Trump.

The Japanese company is building the 'Woven City' in 2021, which will be used to test robotics, personal mobility, smart homes and artificial intelligence in a real-world environment populated by 2000 of its employees and researchers.

The reason young people fail to vote is not because they don't care about politics or policy, but because they don't know how to translate their ideals into action, a new book argues.

All the results and highights from Switzerland as Spain won the Women's U19 title for the second year in a row.

A competition-record crowd of 32,510 watched Krasnodar take Real Madrid to penalties in their UEFA Youth League play-off, the Spanish side eventually winning 3-0 on spot-kicks.

A Neto double, including the extra-time winner 19 seconds from time, secured back-to-back FIFA Futsal World Cup triumphs for Brazil at the expense of regular rivals Spain.

Somerset West stands out as one of the fastest growing property areas – commercial, residential and industrial - in the Western Cape, according to a new report on the state of the property sector in the Western Cape.

House prices in SA could increase on average by 2.3% this year, but a more pessimistic scenario could see them decline by 1.3%, according to analytics company Lightstone.

Mosbach, Germany :: New crewmembers participate in OM’s GO Conference in Mosbach, Germany before heading for the ship.

Apple reported a whopping $65 billion in revenue in Q3. The tech giant's growth is largely due to its Apple Watch and AirPods sales, along with recurring subscriptions from its ever-expanding portfolio of services.

Brazil’s mission training programme provides practical experience and cross-cultural knowledge for participants heading overseas.

Although cash should still be seen as a "trashy" asset class, investors do not have many other places to park their money, says an analyst.

DOVER, DE – Delaware Insurance Commissioner Trinidad Navarro is pleased to announce that there will be another decrease in workers’ compensation insurance rates, effective December 1, 2019. “I am delighted to approve a decrease in workers’ compensation rates in Delaware for the third year in a row,” stated Commissioner Navarro. “These continued decreases mean significant […]

Wilmington, DE – For the third year in a row, the Small Business Administration (SBA) has granted a State Trade and Export Promotion (STEP) award to Delaware’s Department of State. This year’s award totals $221,713 and will be used to support the state’s efforts to assist Delaware companies in entering and developing markets overseas. The […]

The two funds are designed to spur job growth in Delaware Community and business leaders came together today to celebrate the success of a small business initiative which began in Wilmington a few years ago and to announce a complimentary effort that will support small businesses and job growth throughout Delaware. Facilitated by West End […]

NEWARK, DE – Up-and-coming Delaware small businesses will now have a potential new source of capital to help them expand. As part of National Small Business Week (May 5 to May 11), the Division of Small Business on Monday launched a competitive, matching grant program to assist Delaware entrepreneurs who want to grow their small […]

As tough taskmasters, challenges have a way of helping us expand the horizons of what we believe to be possible, and put our creativity to the best use while navigating around a tense situation.

Indian tea brands want a piece of this steaming hot business.

Virat Kohli posted a throwback picture of him posing with Anushka in a balcony with snow-clad mountains in the background.

<strong>New Delhi:</strong> Gauri Khan took a stroll down her memory lane and shared a throwback family picture from their vacation featuring husband and megastar Shah Rukh Khan and their two kids. However, it is the doting father and a husband's response over the adorable picture which will just melt

Yuvraj Singh had one of the finest arrays of shots during his playing days, making him one of the most attractive batsmen to watch.

The ECB took to Twitter to share a throwback video of Virat Kohli's dismissal from India's 2018 tour of England.

CSK's cheeky dig at Shikhar Dhawan on his throwback picture with Suresh Raina left fans in splits.

Analysts across the board have been certain about the heavy economic toll that the pandemic will take on the country.

The government resorts to market borrowing to make up for the mismatch between its revenue and expenditure.

Government will now borrow Rs 30,000 crore via a sale of bonds each week, sharply higher than the Rs 19,000-21,000 crore scheduled earlier.

"In remembrance of the two that have left us," wrote Amitabh Bachchan

The picture also features Alia Bhatt, Abhishek Bachchan, Neetu Kapoor and others

The picture also features Alia Bhatt, Abhishek Bachchan, Neetu Kapoor and others

Senior Congress leader P Chidambaram today welcomed the Centre's decision to borrow additional 4.2 lakh crore and said it should be used to provide relief to the poor and re-start the economy.

Delaware One Stop is a convenient, centralized transactional platform created to help business owners work through the necessary steps to begin operation in Delaware.

Governor Jack Markell unveiled a balanced budget proposal that invests in jobs, education and the safety and well-being of our children. His budget keeps the focus on core commitments such as healthcare and public safety and ensures continued fiscal responsibility.

Delaware jockeys are continuing their support of a nutrition program to help improve jockey health and safety on the state’s racetracks with a recent donation.

More than 30 Delaware farmers have Christmas trees available for First State merrymakers this holiday season, with firs, spruces and pines in abundance – and easy to find and buy with the Delaware Fresh mobile app. The app and a related website, de.gov/christmastrees, feature locations, hours and other shopping information.