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Vijay's maiden political entry was successful: Tamil megastar Rajinikanth




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Bengal govt to bring exams in medical colleges under CCTV surveillance, live-streaming




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NIH clinical trial will test precision medicine treatments for myeloid cancers

NCI has launched myeloMATCH, a precision medicine treatment trial that will test treatment combinations targeting specific genetic changes in people with acute myeloid leukemia and myelodysplastic syndromes.




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Manipur Police accuse radical outfit Arambai Tengol of extortion, assault

Terming the abduction of an officer “unprecedented”, police in valley and hill districts ask for more forces of Assam Rifles, fearing a breach of peace due to the movement of armed civilians, underground outfits  




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Parliamentary Panel highlights significant delays in installation of telemetry systems in critical flood-prone areas

The Committee's report on the performance audit of schemes for flood control and forecasting underscores the need for urgent action to ensure timely and effective flood management




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 Political instability, economic woes stare at Germany 

The German economy, the largest in Europe, has not been performing well and is looking at a second consecutive year of contraction; Germany was the only G-7 country to contract in 2024, with its economy expected to shrink by 0.2%




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Political differences crop up between TDP-JSP leaders in Nellimarla constituency in Vizianagaram district

Karrotu Bangarraju and his followers are up in arms against MLA Lokam Madhavi, who allegedly ignored TDP leaders and cadres and gave priority to YSRCP leaders in the constituency




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Eluru Government Medical College named after biochemist Yellapragada SubbaRow

SubbaRow, born in 1895 in Bhimavaram, is credited with discovering drugs for Filariasis and the role of ATP in muscular activity




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Practical data analysis with JMP [electronic resource] / Robert Carver.

Cary, NC : SAS Institute, 2019.




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Response strategies and biological applications of organic fluorescent thermometry: cell- and mitochondrion-level detection

Anal. Methods, 2024, 16,1968-1984
DOI: 10.1039/D4AY00117F, Minireview
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Shuai Li, Yaoxuan Li, Shiji Zhang, Haixiao Fang, Ze Huang, Duoteng Zhang, Aixiang Ding, Kajsa Uvdal, Zhangjun Hu, Kai Huang, Lin Li
In this review, we primarily summarized four temperature-response strategies. Then, we further analyzed the chemical modifications and biological applications of the probes. Finally, we have provided a prospective on the future development of probes.
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P3MOT-decorated metal-porphyrin-based zirconium-MOF for the efficient electrochemical detection of 4-nitrobenzaldehyde

Anal. Methods, 2024, 16,2093-2100
DOI: 10.1039/D4AY00152D, Paper
Wen-yi Chen, Xin-yu Huang, Qian Sun, En-qing Gao
Developed a novel hybrid P3MOT@PCN-222(Fe) via in situ polymerization for 4-NBA detection. Showcased broad detection range, high sensitivity, selectivity and stability, laying groundwork for environmental monitoring.
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Surface charge-induced electrospray for high-throughput analysis of complex samples and electrochemical reaction intermediates using mass spectrometry

Anal. Methods, 2024, 16,2002-2008
DOI: 10.1039/D4AY00276H, Communication
Yajie Huang, Yajun Zheng, Qianqian Zuo, Zhiming Zhang, Lixuan Zhu, Yun Li, Zhiping Zhang
A novel surface charge induced electrospray ionization is proposed due to its features of no contact between sample solution and metal electrode, fast analytical process (less than 40 s), and high analytical sensitivity.
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Electrochemical aptasensor based on silver-thiolated graphene for high-sensitive detection of Pb2+

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00322E, Paper
Jie Zhou, Changchun Hu, Shuo Li, Chuanxiang Zhang, Yuan Liu, Zhu Chen, Song Li, Hui Chen, Yan Deng
The presence of lead ions (Pb2+) not only leads to environmental contamination but also poses a significant risk to public health through their migration into food and drinking water. Therefore,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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An on-line SPE-LC-MS/MS method for quantification of nucleobases and nucleosides present in biological fluids

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00100A, Paper
Yi-Ming Liu, Shuguan Wang, Amani Dickenson, Jinghe Mao, Xiaolin Bai, Xun Liao
A facile on-line SPE-LC-MS/MS method for quantification of nucleobases and nucleosides in urine and saliva.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00236A, Paper
Gasser M. Khairy, Rania M. Goda, Zeinab M. Anwar, Mohamed M. Aboelnga, Axel Duerkop
A new luminescent europium probe for the determination of the antibiotic gemifloxacin is presented. Time-resolved luminescence enables its quantitation in pharmaceutical formulations and blood samples.
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An efficient electrochemical sensor based on the Ce-MOF/g-C3N5 composite for the detection of nitrofurazone

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02221H, Paper
Jianxia Gu, Yiqiong Jia, Zhanbin Jin, Tingting Wei, Yongxia Li
The Ce-MOF/g-C3N5 composite was first constructed using a simple reflux method in an oil bath, and the electrochemical sensor fabricated based on this composite shows excellent detection performance in nitrofurazone detection in practical samples.
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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
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LAMP-based hydrogen ion selective electrochemical sensor for highly sensitive detection of Mycoplasma pneumoniae

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00341A, Paper
Huiqing Wang, Yang Li, Lin Tian, Xinyi Li, Qian Gao, Yaru Liu, Cuiping Ma, Qing Wang, Chao Shi
An urgent need for a concise and rapid detection method for Mycoplasma pneumoniae is required due to its severe impact on human’s health. To meet such a need, this study...
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Statistical approaches to Raman imaging: principal component score mapping

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00171K, Paper
Open Access
Elia Marin, Davide Redolfi Bristol, Alfredo Rondinella, Alex Lanzutti, Pietro Riello
We propose and benchmark test a universal protocol for the analysis of huge Raman imaging datasets, by applying PCA on raw, unprocessed data.
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Resolving phytosterols in microalgae using offline two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry

Anal. Methods, 2024, 16,2278-2285
DOI: 10.1039/D3AY02261G, Paper
Magali Batteau, Elodie Bouju, Adriana Ramirez-Romero, Sylvie Nuccio, René De Vaumas, Florian Delrue, Karine Faure
Development of an off-line LC-SFc-MS method, separation of sterol isomers in algal unsaponifiable fractions, elution pattern helping in the reduction of structural candidates.
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Heparin-stabilized gold nanoparticles embedded in graphene for the electrochemical determination of esculetin

Anal. Methods, 2024, 16,2256-2266
DOI: 10.1039/D4AY00229F, Paper
Vinicius José da Silva, Luan Gabriel Baumgarten, Juliana Priscila Dreyer, Edson Roberto Santana, Almir Spinelli, João Paulo Winiarski, Iolanda Cruz Vieira
A conductive nanocomposite consisting of heparin-stabilized gold nanoparticles embedded in graphene was prepared for esculetin determination in tea and jam samples.
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Direct solid sample analysis of low-cost jewelry using spectroanalytical techniques: exploratory chemical data evaluation and metal migration with synthetic sweat

Anal. Methods, 2024, 16,2286-2291
DOI: 10.1039/D4AY00325J, Paper
Thaila Lorena de Araújo, Fabiola Manhas Verbi Pereira, Edenir Rodrigues Pereira-Filho
Jewelry samples were directly analyzed using LIBS and XRF.
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Characterizing a visual lateral flow device for rapid SARS-CoV-2 virus protein detection: pre-clinical and system assessment

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02075D, Paper
Natpapas Wiriyachaiporn, Jetnapang Kongrueng, Kannika Sukkuea, Rattana Tanrattanawong, Jarunee Vanichtanankul, Thanaya Saeyang, Tararat Jantra, Deanpen Japrung, Weerakanya Maneeprakorn, Suwussa Bamrungsap, Pareena Janchompoo, Ekawat Pasomsub
Analytical and pre-clinical evaluation of a visual screening lateral flow device for SARS-CoV-2 virus protein detection and its system characterization.
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Analysing micro- and nanoplastics with cutting-edge infrared spectroscopy techniques: a critical review

Anal. Methods, 2024, 16,2177-2197
DOI: 10.1039/D3AY01808C, Critical Review
Open Access
Junhao Xie, Aoife Gowen, Wei Xu, Junli Xu
In this review, we discussed and compared the applications of Fourier transform infrared spectroscopy, quantum cascade laser infrared spectroscopy, atomic force microscopy-based infrared spectroscopy, and optical photothermal infrared spectroscopy in MNP research from multiple perspectives.
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An overview of electrochemical biosensors used for COVID-19 detection

Anal. Methods, 2024, 16,2164-2176
DOI: 10.1039/D3AY02042H, Minireview
Tatiana Lima Valerio, Raquel Anastácio, Stella Schuster da Silva, Carolina Camargo de Oliveira, Marcio Vidotti
This short review presents the latest advances in the field of electrochemical biosensors, focusing particularly on impedimetric biosensors for the direct measurement of analytes.
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A novel electrophoretic assisted hydrophobic microdevice for enhancing blood cell sorting: design and numerical simulation

Anal. Methods, 2024, 16,2368-2377
DOI: 10.1039/D4AY00196F, Paper
Xinkun Chen, Xueye Chen
Microfluidic technology has great advantages in the precise manipulation of micro–nano particles, and the hybrid microfluidic separation technology has attracted much attention due to the advantages of both active and passive separation technology at the same time.
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A simple and rapid colorimetric detection of Staphylococcus Aureus relied on the distance-dependent optical properties of silver nanoparticles

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02189K, Paper
Ngoc Anh Thu Phan, Hoang Men Nguyen, Cam Duyen Thi Vo, Toi Vo Van, Phuoc Long Truong
The quick and accurate diagnosis of pathogens has appeared as a pressing issue in clinical diagnostics, environmental monitoring, and food safety. The current assays are suffering from limited capacities in...
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Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00264D, Paper
Mariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia Doss
Fabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.
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Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
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Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective

RSC Med. Chem., 2024, 15,3345-3370
DOI: 10.1039/D4MD00317A, Review Article
Meghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep Kumar
Semisynthetic phytochemicals in cancer treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
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Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation

RSC Med. Chem., 2024, 15,3529-3557
DOI: 10.1039/D4MD00481G, Research Article
Mohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai Adel
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
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Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate

RSC Med. Chem., 2024, 15,3485-3494
DOI: 10.1039/D4MD00246F, Research Article
Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng Xu
A novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.
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Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00297K, Research Article
Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea Nikolić
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
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Students and agriculture officials grapple with logistical, technical issues during digital crop survey




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581: DevRel, Musical Mics, Social Sharing, and 100 Years of WordPress

Dave calls a quick Luro branding meeting, some thoughts on DevRel, Chris tries to figure out musical instrument mics, follow up on WordPress from a previous episode, Chris' journey through the social graph options, 100 year hosting with WordPress, and the introduction of a new segment: Happy Project Share Time.




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604: VS Code Plugins, Git as a Radical Statement, Tailwind & Arc Drama

A follow up on jQuery conversation, Microsoft owning all the things, what VS Code plugins are your ride or die, the ability to Git from wherever you want, Tailwind drama, global design system follow up, Arc Search gets roasted, and Frontend Design Conference is back!




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623: Assigning Weight Dynamically, CoPilot vs Other AI, and Monorepos

We're talking about assigning a weight to items in a layout, differentiating between banger posts and regular blog posts, using social engineering to get PR's accepted, monorepo thoughts, using CoPilot vs other AI programming support bots, has TypeScript benefited from AI, and what happens if you turn off CoPilot?




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Provide medical aid to jailed separatist leader Yasin Malik: Delhi HC to Tihar jail

In his plea before the high court, Malik claimed to be a patient of “serious cardiac and kidney ailments”, currently facing a “life and death situation”




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Three juveniles held for murder in Delhi; political row erupts over city’s crime rate




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Delhi L-G approves recruitment of 701 nurses and 756 paramedical staff




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Policy prescription for economic and political maladies

Bimal Jalan delves deep into issues that are critical to the country with suggestions on how to overcome challenges 




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The chemical treasury in garlic




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FPIs take out ₹58,711 crore from equities in October on geopolitical crisis, strong Chinese stocks

The outflow came following a nine-month high investment of ₹57,724 crore in September




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Geometrical impacts of platonic particles on nematic liquid crystal dynamics

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00870G, Paper
Stiven Villada-Gil, Monirosadat Sadati, Juan D. Ospina-Correa, Daniel A. Olaya-Muñoz, Juan P. Hernández-Ortiz, José A. Martínez-González
In this work, we studied the defect dynamics of platonic-like colloidal particles immersed in a nematic liquid crystal under flow conditions, analyzing the behavior of disclinations for each of these polyhedra.
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A macroscopic magneto-optical response resulting from local effects in ferronematic liquid crystals

Soft Matter, 2024, 20,8363-8372
DOI: 10.1039/D4SM00577E, Paper
Xiangshen Meng, Xiaowei Li, Jian Li, Yueqiang Lin, Xiaodong Liu, Zhenghong He
The dynamic rotational behavior of composite chains under a rotating magnetic field was observed. The birefringence and dichroism variations in FNLCs mainly stem from the magnetic response of the composite chains, indicating local effects.
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