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Chemo-mechanical model of cell polarization initiated by structural polarity

Soft Matter, 2024, 20,8407-8419
DOI: 10.1039/D4SM00800F, Paper
Hexiang Wang, Zhimeng Jia, Yuqiang Fang
We establish a multiscale model of a cell to explore the chemomechanical mechanisms of cell polarization initiated by structural polarity. The two-dimensional vertex model is built by coupling the cytoskeletal reorganization and the Cdc42 activation.
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Effective patchiness from critical points of a coarse-grained protein model with explicit shape and charge anisotropy

Soft Matter, 2024, 20,8455-8467
DOI: 10.1039/D4SM00867G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jens Weimar, Frank Hirschmann, Martin Oettel
Critical points of an anisotropic, coarse-grained protein model are used to detemine an “effective patchiness” by comparison to the Kern–Frenkel patchy model.
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The surface diffusivity of nanoparticles physically adsorbed at a solid–liquid interface

Soft Matter, 2024, 20,8446-8454
DOI: 10.1039/D4SM00992D, Paper
Troy Singletary, Nima Iranmanesh, Carlos E. Colosqui
This work proposes an analytical model considering the effects of hydrodynamic drag and energy barriers induced by liquid solvation forces to predict the in-plane translational diffusivity of a nanoparticle physically adsorbed on a wetted surface.
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Self-assembly of amphiphilic homopolymers grafted onto spherical nanoparticles: complete embedded minimal surfaces and a machine learning algorithm for their recognition

Soft Matter, 2024, 20,8385-8394
DOI: 10.1039/D4SM00616J, Paper
D. A. Mitkovskiy, A. A. Lazutin, A. L. Talis, V. V. Vasilevskaya
Amphiphilic macromolecules grafted onto spherical nanoparticles can self-assemble into morphological structures corresponding to the family of complete embedded minimal surfaces. They arise situationally, can coexist and transform into each other.
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Mechanical characterization of freestanding lipid bilayers with temperature-controlled phase

Soft Matter, 2024, 20,8524-8537
DOI: 10.1039/D4SM00706A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Arash Yahyazadeh Shourabi, Roland Kieffer, Djanick de Jong, Daniel Tam, Marie-Eve Aubin-Tam
Lipid membranes formed in a microfluidic device are studied with temperature-controlled optical tweezers, revealing how mechanical properties of ripple phase and gel-fluid phase-separated membranes change when heated above the transition temperature.
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Thickness-dependent response of aerosol-jet-printed ultrathin high-aspect-ratio electrochemical microactuators

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00886C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ji Zhang, Jeremy J. Baumberg, Sohini Kar-Narayan
Trilayer electrochemical actuators comprising an electrolyte layer sandwiched between two electrode layers have been shown to exhibit large deformations at low actuation voltages. Here we report aerosol-jet printing (AJP) of...
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Mapping deformation dynamics to composition of topologically-active DNA blends

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01065E, Paper
Karthik R. Peddireddy, Ryan McGorty, Rae M. Robertson-Anderson
We leverage in situ enzymatic topological conversion and OpTiDDM to map the deformation dynamics of DNA blends with over 70 fractions of linear, ring and supercoiled molecules that span the phase space of possible topological compositions.
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Scale-dependent interactions enable emergent microrheological stress response of actin–vimentin composites

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00988F, Paper
Julie Pinchiaroli, Renita Saldanha, Alison E. Patteson, Rae M. Robertson-Anderson, Bekele J. Gurmessa
The unique mechanical behaviors of actin–vimentin composites in both linear and nonlinear regimes are shaped by the complex interactions among actin entanglements, vimentin crosslinking, and poroelastic properties.
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Banana DNA derivatives as homeotropic alignment layers in optical devices

Soft Matter, 2024, 20,8561-8569
DOI: 10.1039/D4SM00322E, Paper
Rafał Węgłowski, Anna Spadło, Dorota Węgłowska
In this study, DNA extracted from bananas was functionalized and used as a homeotropic alignment layer for liquid crystals.
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Dynamical crossovers and correlations in a harmonic chain of active particles

Soft Matter, 2024, 20,8638-8653
DOI: 10.1039/D4SM00350K, Paper
Subhajit Paul, Abhishek Dhar, Debasish Chaudhuri
We explore the dynamics of a tracer in a harmonic chain of active particles, investigating the influence of interactions. Depending upon the time-scales governed by the interaction and the persistence of activity, we explore crossovers between different scaling behaviors of its dynamics.
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Entropically and enthalpically driven self-assembly of a naphthalimide-based luminescent organic π-amphiphile in water

Soft Matter, 2024, 20,8684-8691
DOI: 10.1039/D4SM00986J, Paper
Sk Mursed Ali, Sujauddin Sk, Shuvajyoti Sarkar, Sayani Das, Nayim Sepay, Mijanur Rahaman Molla
Entropically and enthalpically favourable vesicular self-assembly of a naphthalimide based water soluble luminescent organic dipolar building block is reported.
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Mechanical properties soft hydrogels: assessment by scanning ion-conductance microscopy and atomic force microscopy

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00966E, Paper
Tatiana Tikhonova, Yuri M. Efremov, Vasilii Kolmogorov, Aleksei Iakovlev, Nikolay Sysoev, Peter S. Timashev, Victor Fadeev, Alexander Tivtikyan, Sergey Salikhov, Petr Gorelkin, Yuri Korchev, Alexandr Erofeev, Evgeny Shirshin
The growing interest in biomimetic hydrogels is due to their successful applications in tissue engineering, 3D cell culturing and drug delivery. Major characteristics of hydrogels include swelling, porosity, degradation rate,...
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Supramolecular chiroptical sensing of chiral species based on circularly polarized luminescence

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00960F, Review Article
Panyang Chen, Huahua Fan, Sifan Du, Xin Wen, Li Zhang, Minghua Liu
Chiral analytes can bind to an achiral fluorescent system to generate circularly polarized luminescence (CPL). Subsequently, the CPL signal can be employed to determine the absolute configuration of the chiral substrate.
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A dynamical system approach to relaxation in glass-forming liquids

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00976B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jack F. Douglas, Qi-Lu Yuan, Jiarui Zhang, Hao Zhang, Wen-Sheng Xu
We adapt a dynamical system approach to the practical matter of estimating relaxation times in both cooled liquids and crystals at elevated temperatures, which we identify as weakly non-integrable dynamical systems.
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Biomimetic mineralization of positively charged silica nanoparticles templated by thermoresponsive protein micelles: applications to electrostatic assembly of hierarchical and composite superstructures

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00907J, Paper
Nada Y. Naser, William C. Wixson, Helen Larson, Brandi M. Cossairt, Lilo D. Pozzo, François Baneyx
Exploiting the ability of a solid-binding elastin-like peptide to micellize, we mineralize monodisperse silica nanoparticles whose positive surface charge enables one-step electrostatic assembly of various mono- and bi-material superstructures.
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The influence of active agent motility on SIRS epidemiological dynamics

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00864B, Paper
Open Access
R. Kailasham, Aditya S. Khair
Motility induced phase separation of active disks with SIRS epidemiological dynamics.
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Jawed Habib: Clinical salons, with a doctor on board, are the future

Hair stylist Jawed Habib talks about his new book ‘Beautiful Hair, Beautiful You’ and says, despite the information overload pertaining to hair care, he observes a general lack of awareness




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Editorial. Clinical trials waiver for some drugs raises questions

The Centre should not relax its clinical trials norms unless the situation is exceptional or dire




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Five arrested in attack case; police deny political angle in attack on YSRC activist

The attacker was a tenant of the victim and had a grudge as he had been asked to vacate the by the victim, the police said




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Mental health is a moral and ethical issue

The greatest gap in mental health interventions has been in understanding the lived experiences of suffering




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A critical message for the urban elite

Our technology-enabled ecosystem could be making our cities unliveable




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Bernoulli's fallacy [electronic resource] : statistical illogic and the crisis of modern science / Aubrey Clayton.

New York : Columbia University Press, [2021]




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Tropical algebraic geometry [electronic resource] / Ilia Itenberg, Grigory Mikhalkin, Eugenii Shustin

Basel ; Boston : Birkhauser, 2007




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Growing mathematical minds [electronic resource] : conversations between developmental psychologists and early childhood teachers / edited by Jennifer S. McCray, Jie-Qi Chen, and Janet Eisenband-Sorkin.

New York, NY : Routledge, 2019.




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Fuchsian reduction [electronic resource] : applications to geometry, cosmology and mathematical physics / Satyanad Kichenassamy

Boston : Birkhauser, 2007




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Topological and bivariant K-theory [electronic resource] / Joachim Cuntz, Ralf Meyer, Jonathan M. Rosenberg

Basel ; Boston : Birkhauser, 2007




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Problems and theorems in classical set theory [electronic resource] / Peter Komjath, Vilmos Totik

New York ; Berlin : Springer, 2006




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Vorticity, statistical mechanics, and Monte Carlo simulation [electronic resource] / Chjan Lim, Joseph Nebus

New York : Springer, 2007




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Algebraic graph algorithms [electronic resource] : a practical guide using Python / K. Erciyes.

Cham, Switzerland : Springer, 2021.




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Game theory basics / Bernhard von Stengel, London School of Economics and Political Science.

Cambridge, United Kingdom ; New York, NY : Cambridge University Press, 2022.




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Address problems in accident black spots scientifically, Udupi DC tells officials




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Govt. Wenlock Hospital’s new surgical super speciality block begins functioning in Mangaluru

The building was constructed at the cost of ₹56 crore with grants from the Mangaluru Smart City Mission




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Number of MBBS seats in UP have doubled, 17 new medical colleges opened this year: Adityanath




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Amazon launches its first free facility to impart technological skills to underserved students in Bengaluru

The Amazon Future Engineer Makerspace aims to empower students with hands-on learning in robotics, AI, and 3D printing




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Visible-light heterogeneous photocatalysis with an ionic porous organic polymer (IPOP): synthesis of β-keto sulfoxides and benzothiophene diesters by tandem radical addition–oxidation reactions

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01382D, Research Article
Ajay Kumar Sahoo, Parag Tamuly, Jarugu Narasimha Moorthy
An IPOP, constructed constructed from cyanuric chloride and the readily accessible 2,5-di(pyridin-4-yl)thiazolo[5,4-d]thiazole (BpyTzTz), is shown to exhibit excellent visible light absorption and serve as a metal-free heterogeneous photocatalyst.
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Unravelling the different pathways of cyclohexene oxidation via a peroxyl radical generated from tert-butyl hydroperoxide (TBHP) by various metal salts

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01681E, Research Article
Lu-Jian Zhou, Xiao-Hui Liu, Han-Wen Zhang, Can Xue, Han-Kang Zhong, Xian-Tai Zhou
Two different mechanisms were obtained in the selective oxidation of cyclohexene catalyzed by CuCl2 and VCl3 respectively in presence of TBHP. The two opposed mechanisms are mainly caused by the roles of the t-BuOO˙ radical in catalytic oxidations.
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Intermediate diradical character and thermal cis–trans isomerization of near-infrared absorbing thionated squaraine dyes

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01722F, Research Article
Open Access
Taishi Oka, Takeshi Maeda, Daisuke Sakamaki, Naoya Suzuki, Shigeyuki Yagi, Shintaro Kodama, Hideki Fujiwara
Near-infrared absorbing squaraine dyes incorporating 4-membered thionated oxocarbon and chalcogenopyrylium moieties exhibit intermediate diradical character, which impacts thermal cis–trans isomerization.
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Synergy of prediction rule and total synthesis in solving the stereochemical puzzle of eucalactam B

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01777C, Research Article
Chenqi Wang, Junyang Liu, Tao Ye
The absolute configurations of the fungal-derived reduced polyketide eucalactam B were initially predicted using the “Biochemistry-based rule” and later confirmed through its first successful total synthesis.
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Visible-light excited copper activating unactivated alkyl iodides for radical addition/cyclization to access oxindole derivatives

Org. Chem. Front., 2024, 11,6380-6384
DOI: 10.1039/D4QO01329H, Research Article
Hang Luo, Fangnian Yu, Luqing Lin
The photocopper catalyst facilitates halogen atom transfer to give unactivated alkyl radicals, which is critical for achieving radical cyclization in the absence of an exogenous photocatalyst.
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Theoretical insights into Pd-catalyzed dual γ-1,1-C(sp3)–H activation of aliphatic carboxylic acids: mechanistic pathways, substituent influence on product selectivity, diastereoselectivity, and additive effects

Org. Chem. Front., 2024, 11,6393-6410
DOI: 10.1039/D4QO01451K, Research Article
Jiaoyang Liu, Li-juan Huang, Zeang Sun, Juan Li
DFT calculations were employed to explore the detailed reaction mechanism and the origins of the experimentally observed product, regio-, and diastereoselectivities in the Pd-catalyzed dual-γ-1,1-C(sp3)–H activation of aliphatic carboxylic acids.
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Electrochemical approach for upgrading the pollutant CS2: three-component N–H thiocarbamylation of sulfoximines

Org. Chem. Front., 2024, 11,6477-6482
DOI: 10.1039/D4QO01310G, Research Article
Peng Qian, Wenjing Xiong, Qian Meng, Jinxiu Liu, Xiyuan Li, Liangquan Sheng
We report an electrochemical approach for upgrading the pollutant CS2via the thiocarbamylation of sulfoximines, in which CS2 and amines are incorporated as a readily available source of dithiocarbamate.
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Anomalous magnetic behaviour induced by a structural phase transition with anisotropic thermal expansion in a spirodiradical

Org. Chem. Front., 2024, 11,6495-6502
DOI: 10.1039/D4QO01098A, Research Article
Open Access
Takuya Kanetomo, Daigo Matsunaga, Shinichi Ogawa, Masaya Enomoto
A Ge-centred spirodiradical exhibited anomalous magnetic behaviour, influenced by two key structural factors: negative thermal expansion and a structural phase transition.
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Copper-catalyzed alkynyldisulfuration of arynes: an efficient access to unsymmetrical disulfides

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01844C, Research Article
Shuai Huang, Yumin Zhang, Yuekai Li, Chen-Ho Tung, Xin Li, Zhenghu Xu
This article investigates a copper-catalyzed alkynyl disulfuration reaction of aryne formed in situ to synthesize o‑alkynyl aryl disulfides. The transformation proceeds through the in situ generation of aryne, followed by...
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DABSO-Mediated Pummerer Reaction Enables One-Pot Synthesis of Pyrroloquinolines for Accessing Marinoquinolines: Mechanistic, Photophysical and Pharmacological Investigations

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01512F, Research Article
Rahimuddin Khan, Dipun Kumar Penthi, Aditi Chatterjee, Chandrakanta Sahoo, Shanti Gopal Patra, Viswanathan Arun Nagaraj, Tabrez Khan
A new one-pot acid- and exogenous oxidant-free synthesis of pyrrolo[2,3-c]quinolines has been developed. The strategy involves chemoselective reduction of the 3-(2-nitrophenyl)-1H-pyrroles (pyrrolnitrin derivatives) and subsequent DABSO-facilitated Pummerer reaction in the...
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Charge Transfer Complex Enabled Mechanochemical Synthesis of Chalcogenoacetylenes via Alkynyl Radicals

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01827C, Research Article
Open Access
Fang Tan, Chang-Zhen Fang, Bing-Sheng Qiu, He Sheng, Yong-Liang Tu, Xiang-Yu Chen
Mechanochemistry has become an appealing strategy to enable numerous organic transformations. While significant advances have been achieved, the radical coupling reaction under mechanochemical conditions is still in its infancy. In...
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Folding of a dynamic macrocyclic system to stabilize its cation radical state

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01566E, Research Article
Arnab Dutta, Krzysztof Dzieszkowski, Marco Farinone, Łukasz Orzeł, Krzysztof Kruczała, Monika Kijewska, Miłosz Pawlicki
A precisely designed π-extended system responds to different stimuli by folding the structure, which prevents overoxidation and stabilizes the cation radical.
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Telangana pharmaceutical industries logged 97 major fire accidents in past decade: Fire Services Director-General Y. Nagi Reddy

The new government would like to decentralise and set up pharma villages, in 10 clusters, Special Chief Secretary Jayesh Ranjan said




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Watch: ‘I am prepared to face political repercussions’: Revanth Reddy on HYDRAA

Telangana Chief Minister A. Revanth Reddy made it clear that the government is not going to spare encroachers and that HYDRAA has been given full powers 




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Three schoolgirls in Telangana tribal school hospitalised after suspected food poisoning, one critical

The girls, aged between 13 and 16, suffered acute gastroenteritis, dehydration, and kidney-related complications




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Creative meets critical

The Srishti school of New Humanities and Design hopes to question dominant thinking