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Guylaine Tanguay tiendra la vedette de la mouture québécoise de la comédie musicale «Ménopause»: «J’ai besoin de me mettre en danger»

Elle tiendra la vedette de l’adaptation québécoise du succès mondial Ménopause aux côtés de Claudine Mercier, Catherine Sénart et Geneviève Charest.




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Moldova cleans up its act to attract foreign businesses

Deputy PM admits former Soviet state was until recently a 'highly corrupt country' - but insists things are changing fast.




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Indian health, pharma companies invited to participate in Iraq's 'Medico Expo' from Feb 5─8, 2025

The Embassy of India in Iraq has extended an invitation to Indian businesses to participate in the "Medico Expo," officially known as the Erbil International Health Exhibition. This prestigious event, set to be the




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Nvision Biomedical 3D-printed PEEK Interbody System receives FDA clearance

Nvision Biomedical Technologies and Invibio Biomaterial Solutions have announced that the FDA has granted clearance of the first 3D-Printed PEEK Interbody System made from PEEK-OPTIMA.




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I Destroyed a Car to Explore Some Music Myths

Two years of experimentation taught a Nashville guitarist not every musical myth makes sense




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Informa Connnect's Pharma/Biotech GTN Summit

Informa Connnect's Pharma/Biotech GTN Summit
November 18-20, 2024 | W Philadelphia Hotel, Philadelphia, PA
Drug Channels Readers Receive 15% Off* with Code 24DGC15.

View the Complete Agenda

Book Your Place

The complex components of gross-to-net management requires cross-functional collaboration in order to effectively develop sound accrual estimates, proper forecasting, optimized pricing and contracting models and accurate financial reporting, all with minimal disruption to market access strategies.

The CPE-accredited Pharma/Biotech GTN Summit is the ideal opportunity to engage in comprehensive sessions for end-to-end GTN excellence, connect with peers to exchange experiences and solutions to common challenges, and participate in interactive discussions that address real-world scenarios to enhance GTN accuracy and efficiency.

Featured Thought-Leaders Leading the Dialogue Include:
  • Nancy Bell, Vice President, Head of US Patient Value & Access, Takeda Oncology
  • Chris Boneham, Vice President, Market Access US, Y-mAbs Therapeutics
  • Prakash Chainani, Vice President – Finance, HR & IT, Lifestar Pharma LLC (a Mankind Group Company)
  • George Kappus, Associate Director, M&S Controlling (GtN, Boehringer Ingelheim
  • Sherri Cirota, Executive Director, Contracts & Pricing, Alkermes
  • Chris Rocco, Senior Director, Market Access Data, Reporting & Analytics, GSK
  • Rosalind Davis, Director, Government Pricing & Contracts, CSL Vifor
  • Dan Sacchetta, Director Managed Markets Finance- Gross-to-Net, Novartis
  • Eckart Beuttenmueller, Director, Gross-to-Net Execution, Bayer
  • Kinneret Klein, Executive Director, Commercial Financial Planning & Analysis, Biocryst
  • James Engel, Controller, Finance, Collegium Pharmaceuticals
  • Brett Nussbaum, Head of Gross to Net Accounting, Novartis
  • Timothy Kocses, Executive Director, US Commercial Controller, Bristol Myers Squibb
  • Robert Lucchesi, Director, FP&A Sales Reporting & Forecasting, Novo Nordisk
  • Funso Olufade, PhD, MBA, Sr. Director – Head, Commercial Finance, Ascendis Pharma
  • Amy Ramazio, Contract Forecasting & Analytics Director, GSK US Market Access
  • Ranish Singhvi, Vice President, Finance, Accord Healthcare
  • Jeffrey Miller, Assistant Vice President & Corporate Controller, Lannett Company
  • Bal Ram, SVP Finance, US Operations, Indivior
  • Matthew Pellegrini, Sr. Director - Revenue Optimization Contracting & Compliance N.A, Teva Pharmaceuticals
  • Michael Domanico, Vice President Finance, Revenue, Sandoz
  • Christopher Wang, Corporate Controller, Revance Therapeutics
  • Melissa Norton, Assistant Controller, Revenue, Tolmar
  • Michael Christiano, Director, Revenue, Ardelyx
Learn more and see why the GTN Summit remains a great choice for education and benchmarking on strategic forecasting, estimates, analytics and reporting through best practices for gross-to-net management.

Drug Channels subscribers — Save 15% when you reserve your place using the VIP code 24DGC15.

*Offer applies to the current rate and maybe not be applied to existing registrations; additional terms may apply, see website for full details.


The content of Sponsored Posts does not necessarily reflect the views of HMP Omnimedia, LLC, Drug Channels Institute, its parent company, or any of its employees. To find out how you can promote an event on Drug Channels, please contact Paula Fein (paula@DrugChannels.net).
       




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Informa Connect's Copay, Reimbursement and Access Congress

Informa Connect's Copay, Reimbursement and Access Congress
November 18-20, 2024 | Hilton Penn’s Landing in Philadelphia, PA
Drug Channels readers save 10% with code USAVE24*

The access and affordability landscape is undergoing a seismic shift. Evolving legislation, disruptive market forces and the ever-growing complexities of cost sharing programs threaten patient adherence and commercialization strategies. Are you ready?

A program driven by marketplace insights and led by industry trailblazers, Copay, Reimbursement and Access Congress is back November 18-20 and will deliver up-to-date insights necessary to enhance patient affordability, ensure program sustainability and navigate the regulatory landscape. In a time where remaining compliant has never been more complex and program innovation has never been more important, be sure to join your industry counterparts to drive adherence, access and commercialization forward.

Why attend the Copay, Reimbursement and Access Congress?

Keeping up with shifting market dynamics in the midst of maximizing access, while also meeting business objectives is a challenging task and brings about many questions for access professionals.
  • Is your program sustainable and innovative to better support patients?
  • Accumulators, maximizers, AFPs – What are your next steps to ensure effective reimbursement strategies?
  • In an election year, what is the future of health policy?
Experts will tackle these questions and more as the industry comes together to benchmark best practices to accelerate access and commercialization. Do not miss your chance to join seasoned leaders, your peers and leading solution providers as they navigate marketplace trends and dive into the impact coupons, benefit design, accumulators, maximizers, alternative funding programs and drug pricing legislation have on patient affordability and out-of-pocket costs. This is your chance to gain critical insights on industry standards, forward-thinking strategies to optimize your copay and cost sharing programs and so much more.

Content highlights:
  • Over 20 hours of content, including 7+ dedicated sessions to help decipher copay legislation
  • Crucial perspectives from Pfizer, Sanofi, Janssen, Teva, Ascendis Pharma, Melinta Therapeutics, GSK, HIV + Hepatitis Policy Institute and more
  • Insights direct from enforcement agents on the top trends and actions within the copay and patient services space
  • Illuminating case study, Navigating the Patient Journey in a Shifting Copay Landscape from Spark Therapeutics
  • 465 minutes of valuable in-person networking with colleagues and counterparts to expand your network and establish powerful partnerships
  • Additional content access through Streamly, a platform that gives you 12-month access to all of the available conference content** to review at your leisure
  • And more!
Download the agenda and register today—Be sure to use your exclusive promo USAVE24 to save 10% off* of your registration

See you there!

*Cannot be combined with other offers, promotions or applied to an existing registration. Other restrictions may apply.
**Pending speaker permissions



The content of Sponsored Posts does not necessarily reflect the views of HMP Omnimedia, LLC, Drug Channels Institute, its parent company, or any of its employees. To find out how you can promote an event on Drug Channels, please contact Paula Fein (paula@DrugChannels.net).

       




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Informa Connect’s PBM Contracting Summit

Informa Connect’s PBM Contracting Summit
December 10-11, 2024 | Chicago, IL
Drug Channels readers save 10% with code 24DRCH10*

Experts from across the US come together each year at the PBM Contracting Summit to gain innovative and practical contracting strategies, master PBM innovation and design, improve patient care management and rising costs, understand the current legislative issues impacting contract negotiations and more. Join us in Chicago (or virtually) where you’ll benefit from two days of learning, education and networking, and will return to the office having mastered the complex PBM landscape.

You’ll hear from Matthew Gibbs, Pharm.D., Pharmacy Transformation Leader of Blue Shield of California as he leads a comprehensive discussion on the PBM landscape over the last year, and delves into the evolving trends and emerging challenges shaping the current industry today.

Other expert and thought leaders from within the industry are slated to present deep dive sessions, workshops and panels that will answer your most pressing questions:
  • What are the latest legislative updates and proposed federal bills impacting PBM operations?
  • What's on the horizon for alternative PBMs? What are the top intricacies of rebate eligibility? What are the market impacts of innovative models such as Mark Cuban's Cost Plus Drugs and Amazon's pharmacy model?
  • What can be learned from the J&J lawsuit? Review the expansion of data access and the importance of employer's fiduciary duties.
  • What are the challenges of vertical integration?
  • How do PBMs manage their contracting processes with plan sponsors to create successful contracts?
  • What are the most effective strategies for spread pricing and reimbursement models?
  • What is the best solution to navigate the challenges of the 340B drug pricing program and PBM contracting?
  • What is the best way to design and optimize benefits for covering GLP-1s?
  • How can I ensure compliance with ERISA requirements?
  • What are the latest developments in copay maximizer and accumulator programs?
  • What market dynamics and barriers are impacting pricing and demand?
  • What can be learned from the economic landscape of biosimilars and specialty therapeutics?
  • And much more!

View the agenda for the PBM Contracting Summit to see the complete picture – the program, speakers, and more, visit www.informaconnect.com/pbm-contracting for further details and to register. Drug Channels readers will save 10% off when they use code 24DRCH10 and register prior to November 8, 2024.*

*Cannot be combined with other offers or used towards a current registration. Cannot be combined with special category rates or other offers. Other restrictions may apply.


The content of Sponsored Posts does not necessarily reflect the views of HMP Omnimedia, LLC, Drug Channels Institute, its parent company, or any of its employees. To find out how you can promote an event on Drug Channels, please contact Paula Fein (paula@DrugChannels.net).
       




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Informa Connect’s Trade and Channel Strategies

Informa Connect’s Trade and Channel Strategies
December 10-12, 2024 at the W Hotel in Philadelphia, PA
Drug Channels readers save 10% with code 24DC10*

Pharmacy and distribution models are growing increasingly complex. Stop running in circles—It’s time to unlock proven strategies to propel market access.

What is the secret to success? Trade and Channel Strategies is bringing together industry experts to deliver specific strategies and talk best practices in tackling the latest industry challenges.

As the landscape rapidly evolves, there are only two choices—Adapt or risk falling behind. With policy changes and market fluctuations, specifically surrounding the DSCSA and IRA, the loss of exclusivity wave, adoption of low-WAC products affecting GTN and the rise of innovations within the pharmacy sector, there has never been a more important time for industry to unite. A program driven by market dynamics and led by champions of channel strategy, join your peers now to master the complexities of pharmacy and distribution models to accelerate market access—It's all happening December 10-12.

Why do trade and channel professionals choose this pivotal event?

The challenge of staying viable among shifting market dynamics while meeting business objectives is heavy. Professionals are left with many questions, including:
  • How will the new administration affect the distribution channel?
  • Is my organization haemorrhaging money to stay afloat with the shift to alternative distribution and pharmacy models?
  • Does the DSCSA deadline change affect my organization? Am I still prepared?
Join the experts for three dedicated days of collaborative discussions that will give you the answers to these questions and so many more. Leaders in the landscape are uniting and will dive into the top trends for innovative distribution, integrated pharmacy models and talk the truth about the future of trade.

WHAT CAN YOU EXPECT?

Vital insights from industry’s leading pharmacy and distribution experts, including:
  • Bill Roth, Senior Vice President of Consulting, Blue Fin Group, An IntegriChain Company
  • Patrick Lupo Group Vice President, Pharmacy Trade and Specialty, Walgreens
  • Amanda Salindong, Associate Director, Channel & Distribution, Alnylam Pharmaceuticals
  • Chris Rocco, Senior Director, Market Access Data, Reporting & Analytics, GSK
  • Eliane Maalouf, Director Trade and Fulfillment, Mass General Brigham Specialty Pharmacy
  • Stephanie Wirkes, Head of Distribution and Strategy Execution, Bayer
  • John Harlow, Chief Commercial Officer, Melinta Therapeutics
  • Aria Cohen, Vice President, Head of Market Access, Alkeus Pharmaceuticals, Inc.
  • Elizabeth Cherry, Program Director for Trade Relations, Vanderbilt Specialty Pharmacy
  • Danielle Bryan, PharmD, CSP, Program Director, Specialty Pharmacy Trade Relations, Vanderbilt University Medical Center
  • Thomas Scalone, Director, Trade Strategy and Operations, Bristol Myers Squibb
  • Dina Lynch, VP, Market Access and Reimbursement, Renibus Therapeutics
  • And more!
Tackle the hottest topics facing industry right now, including:
  • Keynote Address: Access and Channel 2024 In-Review and Preview of 2025
  • Pharmacy Evolved—Aligning Commercialization to the Changing Pharmacy Channel
  • Advanced Trade Leaders Executive Session
  • Navigate and Operationalize the IRA
  • Focused Multi-Track Offerings:
    • Supply Chain, Distribution and Logistics
    • Pharmacy Models and Reimbursement Strategies
    • Data, Innovation and Analytics
    • Health Systems and Pharma Partnering Symposium
  • Balancing the GTN Bubble with Market Access Priorities
  • What’s Happening in Retail—Brick and Morter, Home Delivery and Cash Pay Pharmacies
  • Navigating Post Deadline Challenges—DSCSA Compliance and Serialization Updates
  • Four Roundtable Breakout Discussions:
    • What Good Looks Like in a 3PL/Manufacturer Partnership
    • Optimizing Healthcare Partnerships
    • Women in Trade
    • GLP-1s and New Product Archetypes
  • Actions Needed to Mitigate and Prevent Drug Shortages
  • Case Study: Master Your Organization Chart—Ensuring Higher Cross Functional Interactions
  • Three Interactive Workshops:
    • Trade 101
    • Advanced Trade Leaders Executive Session
    • Health Systems Fundamentals
  • And more!
Exclusive Offer—Download the agenda and register today—Be sure to use your exclusive promo 24DC10 to save 10% off* of your registration.

See you there!

* Cannot be combined with other offers, promotions or applied to an existing registration. Other restrictions may apply.


The content of Sponsored Posts does not necessarily reflect the views of HMP Omnimedia, LLC, Drug Channels Institute, its parent company, or any of its employees. To find out how you can promote an event on Drug Channels, please contact Paula Fein (paula@DrugChannels.net).
       




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A COVID-19 Cardiac MRI Study: What Went Wrong?

We still don’t know what COVID-19 is doing to the heart or how we should be investigating it and treating it. Last month JAMA Cardiology published a German cohort study of 100 patients recently recovered from COVID-19… A number of striking problems with the study were noted on Twitter…...

Click here to continue reading...




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Brazen Scofflaws? Are Pharma Companies Really Completely Ignoring FDAAA?

Results reporting requirements are pretty clear. Maybe critics should re-check their methods?

Ben Goldacre has rather famously described the clinical trial reporting requirements in the Food and Drug Administration Amendments Act of 2007 as a “fake fix” that was being thoroughly “ignored” by the pharmaceutical industry.

Pharma: breaking the law in broad daylight?
He makes this sweeping, unconditional proclamation about the industry and its regulators on the basis of  a single study in the BMJ, blithely ignoring the fact that a) the authors of the study admitted that they could not adequately determine the number of studies that were meeting FDAAA requirements and b) a subsequent FDA review that identified only 15 trials potentially out of compliance, out of a pool of thousands.


Despite the fact that the FDA, which has access to more data, says that only a tiny fraction of studies are potentially noncompliant, Goldacre's frequently repeated claims that the law is being ignored seems to have caught on in the general run of journalistic and academic discussions about FDAAA.

And now there appears to be additional support for the idea that a large percentage of studies are noncompliant with FDAAA results reporting requirements, in the form of a new study in the Journal of Clinical Oncology: "Public Availability of Results of Trials Assessing Cancer Drugs in the United States" by Thi-Anh-Hoa Nguyen, et al.. In it, the authors report even lower levels of FDAAA compliance – a mere 20% of randomized clinical trials met requirements of posting results on clinicaltrials.gov within one year.

Unsurprisingly, the JCO results were immediately picked up and circulated uncritically by the usual suspects.

I have to admit not knowing much about pure academic and cooperative group trial operations, but I do know a lot about industry-run trials – simply put, I find the data as presented in the JCO study impossible to believe. Everyone I work with in pharma trials is painfully aware of the regulatory environment they work in. FDAAA compliance is a given, a no-brainer: large internal legal and compliance teams are everywhere, ensuring that the letter of the law is followed in clinical trial conduct. If anything, pharma sponsors are twitchily over-compliant with these kinds of regulations (for example, most still adhere to 100% verification of source documentation – sending monitors to physically examine every single record of every single enrolled patient - even after the FDA explicitly told them they didn't have to).

I realize that’s anecdotal evidence, but when such behavior is so pervasive, it’s difficult to buy into data that says it’s not happening at all. The idea that all pharmaceutical companies are ignoring a highly visible law that’s been on the books for 6 years is extraordinary. Are they really so brazenly breaking the rules? And is FDA abetting them by disseminating incorrect information?

Those are extraordinary claims, and would seem to require extraordinary evidence. The BMJ study had clear limitations that make its implications entirely unclear. Is the JCO article any better?

Some Issues


In fact, there appear to be at least two major issues that may have seriously compromised the JCO findings:

1. Studies that were certified as being eligible for delayed reporting requirements, but do not have their certification date listed.

The study authors make what I believe to be a completely unwarranted assumption:

In trials for approval of new drugs or approval for a new indication, a certification [permitting delayed results reporting] should be posted within 1 year and should be publicly available.

It’s unclear to me why the authors think the certifications “should be” publicly available. In re-reading FDAAA section 801, I don’t see any reference to that being a requirement. I suppose I could have missed it, but the authors provide a citation to a page that clearly does not list any such requirement.

But their methodology assumes that all trials that have a certification will have it posted:

If no results were posted at ClinicalTrials.gov, we determined whether the responsible party submitted a certification. In this case, we recorded the date of submission of the certification to ClinicalTrials.gov.

If a sponsor gets approval from FDA to delay reporting (as is routine for all drugs that are either not approved for any indication, or being studied for a new indication – i.e., the overwhelming majority of pharma drug trials), but doesn't post that approval on the registry, the JCO authors deem that trial “noncompliant”. This is not warranted: the company may have simply chosen not to post the certification despite being entirely FDAAA compliant.

2. Studies that were previously certified for delayed reporting and subsequently reported results

It is hard to tell how the authors treated this rather-substantial category of trials. If a trial was certified for delayed results reporting, but then subsequently published results, the certification date becomes difficult to find. Indeed, it appears in the case where there were results, the authors simply looked at the time from study completion to results posting. In effect, this would re-classify almost every single one of these trials from compliant to non-compliant. Consider this example trial:


  • Phase 3 trial completes January 2010
  • Certification of delayed results obtained December 2010 (compliant)
  • FDA approval June 2013
  • Results posted July 2013 (compliant)


In looking at the JCO paper's methods section, it really appears that this trial would be classified as reporting results 3.5 years after completion, and therefore be considered noncompliant with FDAAA. In fact, this trial is entirely kosher, and would be extremely typical for many phase 2 and 3 trials in industry.

Time for Some Data Transparency


The above two concerns may, in fact, be non-issues. They certainly appear to be implied in the JCO paper, but the wording isn't terribly detailed and could easily be giving me the wrong impression.

However, if either or both of these issues are real, they may affect the vast majority of "noncompliant" trials in this study. Given the fact that most clinical trials are either looking at new drugs, or looking at new indications for new drugs, these two issues may entirely explain the gap between the JCO study and the unequivocal FDA statements that contradict it.

I hope that, given the importance of transparency in research, the authors will be willing to post their data set publicly so that others can review their assumptions and independently verify their conclusions. It would be more than a bit ironic otherwise.

[Image credit: Shamless lawlessness via Flikr user willytronics.]


Thi-Anh-Hoa Nguyen, Agnes Dechartres, Soraya Belgherbi, and Philippe Ravaud (2013). Public Availability of Results of Trials Assessing Cancer Drugs in the United States JOURNAL OF CLINICAL ONCOLOGY DOI: 10.1200/JCO.2012.46.9577




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Online yoga classes prove helpful for back pain in new study

Participant reported relief from chronic low back pain and reduced need for pain-relief medications.




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Cat's Eye Camera Can See Through Camouflage



Did that rock move, or is it a squirrel crossing the road? Tracking objects that look a lot like their surroundings is a big problem for many autonomous vision systems. AI algorithms can solve this camouflage problem, but they take time and computing power. A new camera designed by researchers in South Korea provides a faster solution. The camera takes inspiration from the eyes of a cat, using two modifications that let it distinguish objects from their background, even at night.

“In the future … a variety of intelligent robots will require the development of vision systems that are best suited for their specific visual tasks,” says Young Min Song, a professor of electrical engineering and computer science at Gwangju Institute of Science and Technology and one of the camera’s designers. Song’s recent research has been focused on using the “perfectly adapted” eyes of animals to enhance camera hardware, allowing for specialized cameras for different jobs. For example, fish eyes have wider fields of view as a consequence of their curved retinas. Cats may be common and easy to overlook, he says, but their eyes actually offer a lot of inspiration.

This particular camera copied two adaptations from cats’ eyes: their vertical pupils and a reflective structure behind their retinas. Combined, these allowed the camera to be 10 percent more accurate at distinguishing camouflaged objects from their backgrounds and 52 percent more efficient at absorbing incoming light.

Using a vertical pupil to narrow focus

While conventional cameras can clearly see the foreground and background of an image, the slitted pupils of a cat focus directly on a target, preventing it from blending in with its surroundings. Kim et al./Science Advances

In conventional camera systems, when there is adequate light, the aperture—the camera’s version of a pupil—is small and circular. This structure allows for a large depth of field (the distance between the closest and farthest objects in focus), clearly seeing both the foreground and the background. By contrast, cat eyes narrow to a vertical pupil during the day. This shifts the focus to a target, distinguishing it more clearly from the background.

The researchers 3D printed a vertical slit to use as an aperture for their camera. They tested the vertical slit using seven computer vision algorithms designed to track moving objects. The vertical slit increased contrast between a target object and its background, even if they were visually similar. It beat the conventional camera on five of the seven tests. For the two tests it performed worse than the conventional camera, the accuracies of the two cameras were within 10 percent of each other.

Using a reflector to gather additional light

Cats can see more clearly at night than conventional cameras due to reflectors in their eyes that bring extra light to their retinas.Kim et al./Science Advances

Cat eyes have an in-built reflector, called a tapetum lucidum, which sits behind the retina. It reflects light that passes through the retina back at it, so it can process both the incoming light and reflected light, giving felines superior night vision. You can see this biological adaptation yourself by looking at a cat’s eyes at night: they will glow.

The researchers created an artificial version of this biological structure by placing a silver reflector under each photodiode in the camera. Photodiodes without a reflector generated current when more than 1.39 watts per square meter of light fell on them, while photodiodes with a reflector activated with 0.007 W/m2 of light. That means the photodiode could generate an image with about 1/200th the light.

Each photodiode was placed above a reflector and joined by metal electrodes to create a curved image sensor.Kim et al./Science Advances

To decrease visual aberrations (imperfections in the way the lens of the camera focuses light), Song and his team opted to create a curved image sensor, like the back of the human eye. In such a setup, a standard image sensor chip won’t work, because it’s rigid and flat. Instead it often relies on many individual photodiodes arranged on a curved substrate. A common problem with such curved sensors is that they require ultrathin silicon photodiodes, which inherently absorb less light than a standard imager’s pixels. But reflectors behind each photodiode in the artificial cat’s eye compensated for this, enabling the researchers to create a curved imager without sacrificing light absorption.

Together, vertical slits and reflectors led to a camera that could see more clearly in the dark and isn’t fooled by camouflage. “Applying these two characteristics to autonomous vehicles or intelligent robots could naturally improve their ability to see objects more clearly at night and to identify specific targets more accurately,” says Song. He foresees this camera being used for self-driving cars or drones in complex urban environments.

Song’s lab is continuing to work on using biological solutions to solve artificial vision problems. Currently, they are developing devices that mimic how brains process images, hoping to one day combine them with their biologically-inspired cameras. The goal, says Song, is to “mimic the neural systems of nature.”

Song and his colleague’s work was published this week in the journal Science Advances.

This article appears in the November 2024 print issue.




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For this Stanford Engineer, Frugal Invention Is a Calling



Manu Prakash spoke with IEEE Spectrum shortly after returning to Stanford University from a month aboard a research vessel off the coast of California, where he was testing tools to monitor oceanic carbon sequestration. The associate professor conducts fieldwork around the world to better understand the problems he’s working on, as well as the communities that will be using his inventions.

This article is part of our special report, “Reinventing Invention: Stories from Innovation’s Edge.”

Prakash develops imaging instruments and diagnostic tools, often for use in global health and environmental sciences. His devices typically cost radically less than conventional equipment—he aims for reductions of two or more orders of magnitude. Whether he’s working on pocketable microscopes, mosquito or plankton monitors, or an autonomous malaria diagnostic platform, Prakash always includes cost and access as key aspects of his engineering. He calls this philosophy “frugal science.”

Why should we think about science frugally?

Manu Prakash: To me, when we are trying to ask and solve problems and puzzles, it becomes important: In whose hands are we putting these solutions? A frugal approach to solving the problem is the difference between 1 percent of the population or billions of people having access to that solution.

Lack of access creates these kinds of barriers in people’s minds, where they think they can or cannot approach a kind of problem. It’s important that we as scientists or just citizens of this world create an environment that feels that anybody has a chance to make important inventions and discoveries if they put their heart to it. The entrance to all that is dependent on tools, but those tools are just inaccessible.

How did you first encounter the idea of “frugal science”?

Prakash: I grew up in India and lived with very little access to things. And I got my Ph.D. at MIT. I was thinking about this stark difference in worlds that I had seen and lived in, so when I started my lab, it was almost a commitment to [asking]: What does it mean when we make access one of the critical dimensions of exploration? So, I think a lot of the work I do is primarily driven by curiosity, but access brings another layer of intellectual curiosity.

How do you identify a problem that might benefit from frugal science?

Prakash: Frankly, it’s hard to find a problem that would not benefit from access. The question to ask is “Where are the neglected problems that we as a society have failed to tackle?” We do a lot of work in diagnostics. A lot [of our solutions] beat the conventional methods that are neither cost effective nor any good. It’s not about cutting corners; it’s about deeply understanding the problem—better solutions at a fraction of the cost. It does require invention. For that order of magnitude change, you really have to start fresh.

Where does your involvement with an invention end?

Prakash: Inventions are part of our soul. Your involvement never ends. I just designed the 415th version of Foldscope [a low-cost “origami” microscope]. People only know it as version 3. We created Foldscope a long time ago; then I realized that nobody was going to provide access to it. So we went back and invented the manufacturing process for Foldscope to scale it. We made the first 100,000 Foldscopes in the lab, which led to millions of Foldscopes being deployed.

So it’s continuous. If people are scared of this, they should never invent anything [laughs], because once you invent something, it’s a lifelong project. You don’t put it aside; the project doesn’t put you aside. You can try to, but that’s not really possible if your heart is in it. You always see problems. Nothing is ever perfect. That can be ever consuming. It’s hard. I don’t want to minimize this process in any way or form.




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Tools to Boost Beneficial Bacteria Can Help Poultry Farms Fight Salmonella

Chicken products cause an estimated 1 in 7 of the nation’s human Salmonella illnesses each year, partly because the pathogen can easily contaminate the environments where birds are raised. To reduce the risk that contaminated meat will reach consumers, poultry companies need measures that control the bacterium on farms where chickens are bred and raised.




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Indonesia says it has no overlapping South China Sea claims with China, despite joint agreement

JAKARTA — Indonesia said on Monday (Nov 11) it does not recognise China's claims over the South China Sea despite signing a joint maritime development deal with Beijing, as some analysts warned the agreement risked compromising the country's sovereign rights. Beijing has long clashed with its Southeast Asian neighbours over territory in the South China Sea, which it claims sovereignty over in almost its entirety via a "nine-dash line" on its maps that cuts into the exclusive economic zones (EEZ) of several countries. Joint agreements with China in the strategic waterway have for years been sensitive, with some claimant states wary of entering into deals they fear could be interpreted as legitimising Beijing's vast claims. An arbitral tribunal in 2016 said the Chinese claim, based on its old maps, has no basis under international law, a decision China refuses to recognise. A joint statement issued at the weekend during Indonesian President Prabowo Subianto's visit to Beijing mentioned the two countries had "reached important common understanding on joint development in areas of overlapping claims".




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A Couple and Their Country, The Telegraph

I have had a long-standing interest in South Africa, and in 1995 briefly contemplated moving there to work. The country had just had its first multi-racial election, and the great Nelson Mandela had been elected President. I was deeply curious to see, at first-hand, what the land and its people would make of their hard [...]




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The Faultlines Podcast: A Conversation with Ambassador Paula J. Dobriansky

A conversation hosted by the Faultlines Podcast with Ambassador Paula J. Dobriansky covering her career at the U.S. State Department and current geopolitical issues like the Russia-China strategic alignment.




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What Africa Can Learn from China about Growing its Agribusiness Sector

There is growing evidence that the Chinese economic miracle is a consequence of the rural entrepreneurship which started in the 1980s. This contradicts classical interpretations that focus on state-led enterprises and receptiveness to foreign direct investment....The lesson from China's experience is that development must be viewed as an expression of human potentialities, not as a product of external interventions.




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The Challenges Facing the Nation's Electricity Power Sector: A Conversation with Severin Borenstein

Energy economist Severin Borenstein, Professor of the Graduate School at the Haas School of Business at the University of California, Berkeley, discussed the many significant challenges facing the nation’s electricity power sector in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.




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Private Sector Solutions for Climate Change: A Conversation with Michael Toffel

Michael Toffel, Senator John Heinz Professor of Environmental Management and Professor of Business Administration at Harvard Business School (HBS), discusses the many ways in which business and governments can and are working together to address climate change in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.




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Previewing COP 28: A Conversation with Nat Keohane

With the start of the 28th Conference of the Parties (COP 28) of the United Nations Framework Convention on Climate Change just days away, environmental economist Nat Keohane is expressing optimism that the new global stocktake will incentivize participating nations to step up their collective efforts to slow the rise of global temperatures. Keohane is the guest in a special pre-COP episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.




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Analyzing COP 28: A Conversation with Jonathan Banks

With 28th Conference of the Parties (COP 28) of the United Nations Framework Convention on Climate Change well underway, Jonathan Banks, the global director of the Methane Pollution Prevention Program at the Clean Air Task Force (CATF), is the guest in a special mid-COP episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.




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Examining the Outcomes of COP 28: A Conversation with Amy Harder

Amy Harder, the founding Executive Editor of the climate policy publication Cipher News, expressed her surprise with several positive outcomes from the recent 28th Conference of the Parties of the United Nations Framework Convention on Climate Change (COP 28) in Dubai during a special episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”




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Making the Case for Climate Adaptation: A Conversation with Richard Zeckhauser

Eminent Harvard economist Richard Zeckhauser presented arguments for additional climate adaptation measures in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.




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The Intersection of Trade and Climate Policy: A Conversation with Kim Clausing

UCLA Law School Professor Kimberly Clausing gives the Biden Administration high praise for its climate policies in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.








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US-Israel Relations Are at a Crossroads

This was originally published in The Hill on April 18, 2024.




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Making a Case for Investing in Nature: An Interview with Lydia Zemke

As a Predoctoral Research Fellow at the Belfer Center’s Environment and Natural Resources Program and Science, Technology, and Public Policy Program, Lydia Zemke has spent the last two years studying climate finance in developing countries. As she rounds out her time at the Belfer Center, Zemke she reflects on her research interests, her experience conducting fieldwork in Kenya and Costa Rica, and her advice for other early-career researchers. 




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Setting a Course for Arctic Research: Arctic Initiative at Arctic Science Summit Week 2024

The Arctic Initiative team helped kick off discussions for the International Conference on Arctic Research Planning Process 2022-2026 (ICARP IV) research priority teams at the Arctic Science Summit Week (ASSW) 2024 in Edinburgh, Scotland. 




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International Trade and Climate Change Policy: A Conversation with Robert Lawrence

The rise of political populism and economic protectionism are serious barriers impeding efforts to combat global climate change. Robert Lawrence, the Albert Williams Professor of International Trade and Investment at Harvard Kennedy School, expressed those concerns in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”




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Land Use Policy and Climate Change: A Conversation with Charles Taylor

The ways in which land use and environmental policies intersect with natural resource sustainability and climate change was the focus of discussion in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program” featuring Charles Taylor, assistant professor of public policy at Harvard Kennedy School. The podcast is produced by the Harvard Environmental Economics Program.




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US-China Cooperation Remains Possible

Joseph S. Nye advocates for identifying areas for cooperation between the United States and China such as climate change and public health.




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Impacts of Electric Vehicle Subsidies: A Conversation with Hunt Allcott

Behavioral economist Hunt Allcott, Professor of Global Environmental Policy at the Doerr School of Sustainability at Stanford University, questioned the impact of new and used electric vehicle (EV) subsidies in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”




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Energy, Geopolitics, and Climate Change: A Conversation with Meghan O'Sullivan

International relations expert Meghan O'Sullivan, the Jeane Kirkpatrick Professor of the Practice of International Affairs at Harvard Kennedy School, expressed her hopes for achieving successful international climate policy solutions in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”





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Nominate your Community NOW for a Chance to Win a $25,000 Grant - Join State Farm Neighborhood Assist to help improve neighborhoods with a $25k grant

Join State Farm Neighborhood Assist to help improve neighborhoods with a $25k grant





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Extended Stay America Partners With The Noerr Programs To Create The "Official Hotel of Santa Claus" - Santa Claus� Travel Secrets

Santa Claus and Extended Stay America, �Santa�s Official Hotel,� Partner to ease holiday travel woes. In time for the holiday season, the ultimate holiday travel guru shares holiday travel tips.




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Ziploc� Brand Helps Bring a Chaos-Free Holiday to Travelers across the Country - Ziploc� Brand Holiday Tollbooth Video (Extended)

Bad traffic, tired drivers and cranky kids; life makes holiday travel anything but a holiday. Watch what happens when Ziploc� takes over a tollbooth and surprises real holiday travelers with gifts.







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Clayton Celebrates a Culture of Craftsmanship - Clayton Factory Family

Clayton home building group team members share their stories of being part of the Clayton manufacturing family.





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Bior� Skincare Announces Shay Mitchell As New Brand Ambassador For Launch Of Baking Soda Cleansers - Don't just clean your face.....wash away dirt and oil

Brand Ambassador Shay Mitchell shows you how




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T-Mobile Arena Celebrates Grand Opening Tonight With The Killers, Wayne Newton and Shamir - T-Mobile Arena Opens Tonight

The newest entertainment venue on the Las Vegas Strip opens tonight with a concert from The Killers, Wayne Newton and Shamir.