The latest design in Bernews’ weekly Wallpaper Wednesday series features a sea turtle cartoon, with the colourful animal depicted amongst other sea life. The design is available in two sizes; a Facebook profile cover image and also in a vertical format, ideally sized for use as a mobile phone wallpaper, WhatsApp status image or Instagram […]

Předsedou Pirátů se dnes stal bývalý pražský primátor a nynější primátorův náměstek Zdeněk Hřib. Chce stranu reformovat, bez čehož se jí podle něj nepodaří uspět ve sněmovních volbách v příštím roce. Hřib ve finále porazil bývalého senátora Lukáše Wagenknechta, který se o zvolení do čela strany neúspěšně pokoušel už před dvěma lety.

A much less famous, but just as squee, story than "The Tortoise and The Hare".

In this episode of the Arsenal Women Arsecast, Tim and Jamie talk about Arsenal’s 1-0 win over Leicester at the King Power. Tim and Jamie discuss a rotated starting line-up, how much the packed early season schedule contributed to a leggy performance, whether the game can be taken in isolation or whether concerns about the attack in particular persist and the performances of Daphne van Domselaar, Alessia Russo, the midfield partnership of Lia Walti and Kyra Cooney-Cross, defensive injuries and a lack of creativity without Mariona and Kafaji starting the game.

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Juston Gordon-Montgomery's action-packed series with a lot of big ideas will debut this weekend on Adult Swim and Max.

The project is from Mattel Films, Shadowmachine, Jennifer Lopez’s Nuyorican Productions, and actor-producer Anthony Ramos.

Watch our livestream starting 11am Pacific / 2pm Eastern.

All architecture is great architecture after sunset; perhaps architecture is really a nocturnal art, like the art of fireworks.

A capital espanhola inaugura um espaço para enterrar bebês que não chegaram a nascer.

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Gabriel Bortoleto, 20, will make his Formula One debut for the Audi-owned Sauber next season.

Over the past decade, parent advocacy groups led a grassroots movement resulting in most states adopting dyslexia-specific legislation, with many states mandating the use of the Orton-Gillingham (OG) approach to reading instruction. Orton-Gillingham is a direct, explicit, multisensory, structured, sequential, diagnostic, and prescriptive approach to reading for students with or at risk for word-level reading disabilities (WLRD). Evidence from a prior synthesis and What Works Clearinghouse reports yielded findings lacking support for the effectiveness of OG interventions.

A.F. Branco Cartoon – The Media (CBS, MSNBC, CNN, ABC, etc. are showing their complete bias in support of Kamala..

A.F. Branco and Joe Dan Gorman discuss Tony’s recent toons and related issues, along with some videos and a few..

A.F. Branco Cartoon – The DOJ is Suing Virginia over purging illegal registrations from their voter rolls. The Biden DOJ..

A.F. Branco Cartoon – Gov Walz trying to load his shotgun was emblematic of his entire reign in Minnesota. Now,..

A.F. Branco Cartoon – Free Market Capitalism is great, but when big corporations merge with the Government, it begins to..

A.F. Branco Cartoon – Democrats, the party of child genital mutilation and late-term abortion, are outraged at Trump for his comments alluding to..

A.F. Branco and Joe Dan Gorman discuss Tony’s recent toons and related issues like the 2024 election, along with some..

A.F. Branco Cartoon – It’s been a lousy week for Kamala and a great week for Trump as he surges..

A.F. Branco Cartoon — Harris-Biden’s last four years in office have been a total wreck on the American people, and..

A.F. Branco Cartoon — Desperation has consumed the Harris campaign, which has brought out the “Trump is Hitler” card just..

A.F. Branco Cartoon – Gov Walz and the Minnesota Democrats are in a war with police and the people of Minnesota, well documented in..

A.F. Branco Cartoon – Mainstream leftist media, along with the Democrats (The Party of the KKK), are trying their best..

A.F. Branco Cartoon – After years of Democrat lawfare, phony impeachments, attempted assassinations, and media-biased lies against Trump, he is..

A.F Branco Cartoon – The choice in this election is clear: Sleight-of-hand leftist Tricks or the abrasive truth in the..

A.F. Branco’s Cartoon – The Legend of the Headless President, has seeded its place in American history. Biden is now..

A.F. Branco Cartoon – Some say Gov. Walz is celebrating a bit too early on winning the 2024 election despite..

A.F. Branco Cartoon – Compare and contrast. Fight, Fight, Fight against Kamala’s Marxist tyrannical government. It’s what’s at stake in..

A.F. Branco Cartoon – Families are at risk under the biden/HARRIS regime promoting taking away parental rights in the name of helping..

A.F. Branco and Joe Dan Gorman discuss The debate, Tony’s toons and related issues, along with some videos and some..

A.F. Branco Cartoon – Trump wins the 2024 presidential election. Now it’s time to clean up the mess and get..

A.F. Branco Cartoon – After almost four years of Democrats trying to shove Marxism down Americans’ throats, We, The People,..

A.F. Branco Cartoon – Gov. Tim Walz lost his own Blue Earth County in Minnesota. Trump also flipped three other..

A.F. Branco Cartoon – Revised from 2018 and revised for 2024 Veterans Day. Our Veterans are being left in the..

A.F. Branco Cartoon – Trump supporters are rooting for Rick Scott to be the next Senate Majority Leader, hoping he..

CD4+ T cell responses are crucial for inducing and maintaining effective anti-cancer immunity, and the identification of human leukocyte antigen class II (HLA-II) cancer-specific epitopes is key to the development of potent cancer immunotherapies. In many tumor types, and especially in glioblastoma (GBM), HLA-II complexes are hardly ever naturally expressed. Hence, little is known about immunogenic HLA-II epitopes in GBM. With stable expression of the class II major histocompatibility complex transactivator (CIITA) coupled to a detailed and sensitive mass spectrometry based immunopeptidomics analysis, we here uncovered a remarkable breadth of the HLA-ligandome in HROG02, HROG17 and RA GBM cell lines. The effect of CIITA expression on the induction of the HLA-II presentation machinery was striking in each of the three cell lines, and it was significantly higher compared to interferon gamma (IFN) treatment. In total, we identified 16,123 unique HLA-I peptides and 32,690 unique HLA-II peptides. In order to genuinely define the identified peptides as true HLA ligands, we carefully characterized their association with the different HLA allotypes. In addition, we identified 138 and 279 HLA-I and HLA-II ligands, respectively, most of which are novel in GBM, derived from known GBM-associated tumor-antigens that have been used as source proteins for a variety of GBM vaccines. Our data further indicate that CIITA-expressing GBM cells acquired an antigen presenting cell-like phenotype as we found that they directly present external proteins as HLA-II ligands. Not only that CIITA-expressing GBM cells are attractive models for antigen discovery endeavors, but also such engineered cells have great therapeutic potential through massive presentation of a diverse antigenic repertoire.

The pilot, which was initially one of the most buzzed about pieces of ESSA, allows states to try out new forms of testing in a handful of districts, with the goal of eventually taking them statewide.

From gender roles to etiquette to fashion, step back in time to learn more about the real lives of the Regency women who inspired 'Bridgerton.' --- To read more about the Regency era - and 'Bridgerton' - check out these articles from Smithsonian Magazine: What 'Bridgerton' Gets Wrong About Corsets: https://www.smithsonianmag.com/history/what-bridgerton-gets-wrong-about-corsets-180976691/ The Real History Behind 'Queen Charlotte: A Bridgerton Story' https://www.smithsonianmag.com/smart-news/the-real-history-behind-queen-charlotte-a-bridgerton-story-180982130/ Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Producer: Nicki Marko Video Editor: Sierra Theobald

A local fisherman talks about the uncertain future facing locals when the new bridge connecting Peru and Brazil is completed

Biographer David Maraniss says that in order to truly understand Clemente's importance to the sport, you have to look beyond his spectacular numbers

An exhibition in London is showcasing more than 600 artworks and artifacts—including costumes, props and sketches—from the famous filmmaker’s career

Families of Norton Elementary School won’t be seeing their kids return anytime soon. Repairs are going to take longer than expected and students are expected to be back in the school by the start of the next school year.

Paul Frank Baum, Evan Pugh University Professor of Mathematics at Penn State, has been honored by Penn State with the title of Atherton Professor. The University created the Atherton Professorship to recognize the continuing high level of scholarly or creative activity Evan Pugh Professors may pursue after their retirement.

All babies born at Bayhealth to receive first Imagination Library book WILMINGTON, Del.— Governor John Carney and the Delaware Division of Libraries announced on Wednesday that Bayhealth has partnered with Dover and Milford Public Libraries to ensure all babies born at Bayhealth Hospitals, as well as any eligible patients of Bayhealth Pediatrics in Milford, are […]

Since the public announcement of Dolly’s arrival in Delaware last week, more than 1,000 Delaware children have been signed up for the Imagination Library. As of last week, over 21,000 Delaware children are enrolled in the program.