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Union Education Minister Dharmendra Pradhan urges states to support exam reforms for zero-error entrance test




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Fifth storm in a month bears down on the Philippines

The local government also reported knee-high floods across Santiago, a city of 1,50,000 people along an upper bank of the Cagayan river




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Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics

RSC Med. Chem., 2024, 15,3639-3651
DOI: 10.1039/D4MD00183D, Review Article
Abdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke Hisamatsu
TRAIL induced apoptosis signalling by death receptors (DR4/DR5).
The content of this RSS Feed (c) The Royal Society of Chemistry




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New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3759-3777
DOI: 10.1039/D4MD00498A, Research Article
Lucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. Enriz
A diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site

RSC Med. Chem., 2024, 15,3704-3710
DOI: 10.1039/D4MD00552J, Research Article
Jaeyong Jung, Jeong Soo Sung, Soonil Kwon, Hyung Eun Bae, Min-Jung Kang, Joachim Jose, Misu Lee, Jae-Chul Pyun
Fv-antibodies targeting the PPC region of SARS-CoV-2 to prevent infection, screened from an Fv-antibody library (displayed on outer membrane of E. coli cell).
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry




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T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers

It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students




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Water supply from Pampa Reservoir to be paused this rabi

IAB makes decision to allow reservoir gate repairs and aqueduct construction works; water to affected lands to be supplied from the Eastern Godavari Delta, Pithapuram Branch Canal and Yeleru Reservoir instead




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117 applications received at Kuppam’s first ‘Praja Darbar’




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India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield

In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months




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Synthesis of MOF-supported Pt catalyst with high electrochemical oxidation activity for methanol oxidation

RSC Adv., 2024, 14,36370-36377
DOI: 10.1039/D4RA06393G, Paper
Open Access
Merve Akin, Hatice Kars, Muhammed Bekmezci, Aysenur Aygun, Mert Gul, Guray Kaya, Fatih Sen
In this study, Pt and Pt@Ti-MOF NPs catalysts were synthesized by chemical reduction method. Ti-MOF structure was synthesized using the solvothermal method, and the effect of Ti-MOF on methanol oxidation was investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Satish Jarkiholi supporter to lead Belagavi DCC bank

Before the election, the three Jarkiholi brothers — Satish (Congress MLA), Ramesh (BJP MLA), and Balachandra (BJP MLA) — met in a private hotel in Belagavi to discuss the names of candidates




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KEA opposes fee reduction for recruitment examinations in Karnataka

Points out that the government does not provide any grant for conducting recruitment examinations




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PUCL condemns opposition to Dalits’ entry into temple in Mandya village




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CCI starts buying cotton at minimum support price




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Villagers oppose proposal for quarry near Sathanur dam at a public hearing

Tiruvannamalai Collector D. Bhaskara Pandian chaired the hearing organised by the TNPCB on Wednesday. The black granite quarry is proposed to be set up on about 8.46 hectares of government land in Sathanur




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China, Philippines spar over new maritime laws, baseline drawings in South China Sea

The move follows China's definition on Sunday of the baseline for "territorial waters" around the shoal, which Beijing claims as Huangyan Island




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UPPSC aspirants protest continues for third day over exam format 

The job aspirants protest multiple shifts and score normalisation in exams, demanding a fair and unified testing process




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Village Administrative Officer arrested in DVAC trap in Tiruppur




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Tambaram Corporation begins population survey and area mapping for improved coverage of UPHCs




pp

64.98% cast votes in Malappuram in Wayanad bypoll

While Eranad and Wandoor registered 69.42% and 64.43% polling respectively, voting percentage in Nilambur stood at 61.91%




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L-G approves proposal to deploy former bus marshals on anti-pollution duties




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If 23andMe goes bust, what happens to its DNA database?

Millions of people have used 23andMe’s simple genetic testing service, which involves ordering a saliva test, spitting into a tube, and sending it back to the company for a detailed DNA analysis




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Centre approves widening of Rajahmundry-Anakapalli and Rayachoti-Kadapa national highways to six lanes, says MP




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Ganababu, Chiranjeevi Rao appointed Whips in Legislative Assembly and Council respectively




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VSEA expresses concern over iron ore supply to VSP due to proposed ArcelorMittal & Nippon Steel plant in Anakapalli

We have appealed to the governments to take a note of RINL’s iron ore issue before finalising anything on Mittal’s steel plant in Anakapalli, says association general secretary




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IRFC looks beyond Railways for lending opportunities

To focus on other sectors for improved margins and growth, with zero NPAs




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Day Trading Guide for November 14, 2024: Intraday supports, resistances for Nifty50 stocks

Here are the intraday supports and resistances for widely traded stocks such as Reliance Industries, ITC, ONGC, Infosys, HDFC Bank, TCS, and SBI



  • Day trading guide

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Today’s top tech news: Elon Musk to co-lead government department; Apple’s new AI wall tablet; Netflix grows on ad-supported tier




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Nazara teams up with ONDC to launch in-game shopping platform 

gCommerce, the new in-game platform, aims to help game developers overcome low in-app purchase conversion rates by creating additional revenue streams through affiliate marketing




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Children's Day 2024: 50 WhatsApp wishes, messages, quotes to share on bal diwas

Here are 50 WhatsApp messages and quotes you can share with your loved ones on this special occasion:




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Meet Tulsi Gabbard, Hindu American who is appointed by Donald Trump as US director of national intelligence

Gabbard, who has served in the Army National Guard for more than two decades, deploying to Iraq and Kuwait, would come to the role as somewhat of an outsider, compared to her predecessor.




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Upper-teens EPS growth likely for Gland Pharma

Gland Pharma beat muted expectations for Q2FY25. There was increased Ebitda (Earnings before interest, taxes, depreciation and amortisation) loss at Cenexi, the CRAM subsidiary. However, overall Ebitda margin was better than expectations at 21.1 per cent. But given two years of earnings decline in FY23 and FY24, the business may have bottomed and upper-teens EPS (earnings per share) growth looks possible over next two financial years.




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The Stair Step Method of Bootstrapping

Between this blog, my podcast, MicroConf and the TinySeed, I’ve had the privilege of watching hundreds of entrepreneurs launch products over the past decade (even into the thousands, depending on how you count). After a while, I started to notice a pattern emerging among the pool of bootstrappers who were able to successfully replace their income, buy back their time,Read More →

The post The Stair Step Method of Bootstrapping first appeared on Rob Walling - Serial Entrepreneur.




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My Next Act: The First Startup Accelerator for Bootstrappers

When you hear the term startup accelerator you likely think of YCombinator, TechStars or 500 Startups. Accelerators traditionally cater to “unicorns” – companies that have the potential to be worth at least a billion dollars. This focus has made them successful in launching startups like DropBox, AirBnB, Stripe and Instacart. But what about founders whoRead More →

The post My Next Act: The First Startup Accelerator for Bootstrappers first appeared on Rob Walling - Serial Entrepreneur.




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TinySeed Applications Open January 18th

Two-and-a-half months ago Einar Vollset and I announced TinySeed, the first startup accelerator designed for bootstrappers. The response was overwhelming. Hundreds and hundreds of tweets, re-tweets, likes, Hacker News upvotes, email responses…it was immediately obvious that there is pent up demand for this kind of alternative early-stage startup funding. Previously On..TinySeed To catch you up, here’s a briefRead More →

The post TinySeed Applications Open January 18th first appeared on Rob Walling - Serial Entrepreneur.




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Apple 'Distraction Control' Tool May Block Ads

iPhones and iPads could soon let users permanently hide parts of web pages including pop-up windows. The move has proven controversial with suggestions it could also be used as an ad-blocker. The new feature is called Distraction Control and is in the development beta stages (i.e. test version) of the Safari web browser in the upcoming iOS 18 update. It also appears to be on the way in Safari for Mac computers. The feature lets users tap a page menu button marked "Hide Distracting Items". That will bring up a list of elements on a web page such as pop-up windows, autoplay videos and banners ... (view more)




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Banking Scam Bypasses iOS, Android App Store Vetting

A useful web feature could be a serious phishing risk according to security researchers. They say scammers are using "progressive web apps" to bypass Android and iOS security features. In simple terms, a progressive web app is a mix of a website and a standalone application. It's technically a website and uses web technologies, allowing for instant updates. However, it looks and feels more like a standalone app and can often access more of a device's resources than a web browser. Security firm ESET says scammers are using progressive web apps as a way to overcome a major limitation in scams ... (view more)




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Android to Tackle Data Harvesting Scam Apps

A key change to Android could reduce the risk of scammers stealing personal data or money. The update will mean sensitive apps won't open unless potentially risky apps are closed first. The idea is to tackle rogue apps which are designed to either capture personal data from another app, or to take control of the phone unbeknownst to the owner. Developer Choice Google's new tactic aims to find a balance between restricting the activities of such rogue apps and keeping the freedom of users to choose what apps they install, including those from sources other than the official Play Store. The ... (view more)




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Infopackets to Launch YouTube Tech Support Pilot Program

Dear Infopackets Readers, I would like to introduce the launch of an exciting, new video-based tech support Q ... (view more)




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Necro Malware Infects 'Modified' Spotify, WhatsApp

"Modified" versions of popular apps have helped distribute a nasty piece of Android malware. The tactic expanded the reach of the Necro Trojan despite Google's security checks. Necro was able to survive for some time before discovery, largely because the infection wasn't obvious to users. Its main purpose was to hijack phones and use them to make money for the people behind the malware. This included displaying paid ads in the background so that users didn't see them, but the scammers were able to claim revenue from advertisers. The malware would also install apps on the phone to earn ... (view more)




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Google Pays Price for App Store 'Monopoly'

Google has suffered a major court defeat over its Play store. It will mean much greater access for third party app stores and apps, though could prompt a continuing argument about security. The ruling came in a case brought by Epic Games, makers of the popular game Fortnite. It's had similar battles with Apple and its possible this case will have an effect there too. Epic had argued that Google unfairly exploited a monopoly over access of app developers to the Android system by the way it controlled the official Play store. It said that monopoly existed despite the fact that Android users can ... (view more)




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Running App Revealed World Leaders' Location

Running app Strava made it possible to track the locations of world leaders and high-profile political candidates according to a newspaper investigation. Security services say the vulnerability did not put people at risk but are reviewing their guidelines on using the app. Le Monde investigated the movements of bodyguards for politicians including Joe Biden, Kamala Harris, Emannuel Macron and Vladimir Putin, Donald Trump plus partners Jill Biden and Melania Trump. (Source: lemonde.fr ) Secret Trip Revealed The newspaper was able to discover the names of the presidential bodyguards and find ... (view more)




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The War on the Hippocratic Oath

Bioethicist and Orthodox Christian Wesley J. Smith joins Fr. Barnabas to discuss medical ethics, end of life issues, and societal trending in the world of bioethics.




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Speaker Johnson wins unanimous support from GOP for another term as top House Republican

House Speaker Mike Johnson on Wednesday won a unanimous closed-door vote for his first, full term as Speaker, despite rumblings of a possible rebellion against him, after he received a full-throated endorsement from President-elect Donald Trump.




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Marygold & Co. partners with Griffin to support healthy financial habits

UK-based Marygold & Co. has...




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PUPPY GLOVE

PUPPY GLOVE by Will Bullas is a(n) Open Edition. The Edition is Limited to OPEN EDITION pcs




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ZIPPO THE FIRE-EATER

ZIPPO THE FIRE-EATER by Will Bullas is a(n) Open Edition. The Edition is Limited to Open Edition pcs