No sooner had Broncos coach Vic Fangio walked over to the deep end of the pool when NFL Commissioner Roger Goodell ran over, unseen, and shoved him straight into the water.

No sooner had Broncos coach Vic Fangio walked over to the deep end of the pool when NFL Commissioner Roger Goodell ran over, unseen, and shoved him straight into the water.

No sooner had Broncos coach Vic Fangio walked over to the deep end of the pool when NFL Commissioner Roger Goodell ran over, unseen, and shoved him straight into the water.

No sooner had Broncos coach Vic Fangio walked over to the deep end of the pool when NFL Commissioner Roger Goodell ran over, unseen, and shoved him straight into the water.

The Effects of Left-Turn Traffic-Calming Treatments on Conflicts and Speeds in Washington, D.C. , released by the Insurance Institute for Highway Safety

Several groups of reptiles persisted in Jurassic Africa even as volcanism ruined their habitat

Have you ever observed the mating dance of the birds of paradise? The male moves dramatically, and in response, the female inches away, but ultimately the male conquers the female, and achieves the purpose of this ritualistic, instinctive dance. Well, … Continue reading →

There's got to be a reason for the Democrats to suppose to exist. And the reason the Democrats are supposed to exist is to be an opposition party to the Republicans. If you're in bed with the same people, taking money from the same people, you're no longer an opposition party. There's no reason for you to exist. And guess what? Don't be surprised that people don't vote for you. Continue reading →

Tucker: There’s no value more American than free speech Liberals working to crack down on the First Amendment, ban speech they don’t like. GOOD EVENING, AND WELCOME TO “TUCKER CARLSON TONIGHT.” It’s hard to think of an ideal more American … Continue reading →

Photos by Sara Lando and David Hobby except where noted.

Just as most of us are either right- or left-handed, it is said that we all have a dominant side of our brain as well. Left-brained people are supposed to be more analytical and methodical, whereas right-brained people are more artistic and creative.

For most photographers, one of these two areas is probably a relative strength; the other a weakness. But ideally, you need the whole package. Which is something we were exploring earlier this month in Porto, Portugal. Read more »

When Nets owner Joe Tsai pledged to continue paying the Barclays Center workers who make game day experiences possible through the end of May, it was a relief to many. One group has been left out in the cold, however, and is now speaking up for itself.

When Nets owner Joe Tsai pledged to continue paying the Barclays Center workers who make game day experiences possible through the end of May, it was a relief to many. One group has been left out in the cold, however, and is now speaking up for itself.

Kawhi Leonard was having one of the best statistical seasons in Clippers history, a feat done only 15 times by five players, before the season stopped.

Ryan Buchter was signed to a minor league deal after being non-tendered by the Oakland Athletics. He could fill an essential role in the Angels' bullpen

The Angels removed Mark Langston with a no-hitter intact after seven innings in 1990, in what could serve as a cautionary tale for the 2020 season.

When Nets owner Joe Tsai pledged to continue paying the Barclays Center workers who make game day experiences possible through the end of May, it was a relief to many. One group has been left out in the cold, however, and is now speaking up for itself.

The luckiest traveller in Europe in the past nine days? Andrew Gardner, an engineer from Milton Keynes. On Thursday morning, 15 April, he flew from Stansted to Oslo. About 10 minutes after he landed, the air-traffic control shutters came down over northern Europe, and remained closed for the next six days.

Something sketchy this way comes: "30 Rock" alum Jack McBrayer hosts "The Second City Presents: The Last Show Left on Earth."

PARTICK THISTLE were left baffled after a goal was disallowed despite hitting the net during their clash with Greenock Morton.

Chelsea have entered negotiations with Leicester over Ben Chilwell after the left-back reportedly told his agent he wants a transfer to London.

PHILLIP SCHOFIELD - a host on This Morning alongside Holly Willoughby - has addressed claims that he "moved out of his family home" he shared with wife Steph Lowe following the announcement he is gay.

Four boys were executed in a Parke County, Indiana, mobile home on Feb. 14, 1977. There was only one survivor: Betty Jane Spencer.

Colts legend Robert Mathis rebuilt Kemoko Turay into a tactical, calculated missile instead of a grenade lobbed into the dark.

It's illegal to leave a pet outside in Indianapolis when temperatures drop below 20 degrees Fahrenheit or during a wind chill advisory.

A union representing taxi drivers estimates 80,000 "are in danger of becoming destitute" in lockdown.

Many people who started jobs in March cannot get furlough payments despite the scheme being extended.

The game teeters over the line between childlike and childish.

They have big dreams, but the plans aren’t backed up.

oscon: There's still time left to apply for #OSCON scholarships from @github + @newrelic. Deadline is 6/15 http://t.co/xQwx30jnaN

oscon: Just 1 week left to take advantage of #OSCON early registration prices. Register by 6/6 to save http://t.co/E0JKpcj1Rp #opensource

oscon: Only 48 hours left to get discounted tickets to #OSCON. Early registration prices end tomorrow at midnight http://t.co/E0JKpcj1Rp

After Mmusi Maimane's resignation as DA leader, Buccus recycled the madcap mutterings of Herman Mashaba, warning that the DA had been captured by the "right-wing zealots of the Institute of Race Relations".

As online parties continue to rise, the question of how artistes and other musicians will get paid from these virtual sessions becomes even more pertinent. During an online forum held by the Jamaica Reggae Industry Association (JaRIA) yesterday...

Nora Linscheid
Apr 14, 2020; 0:RA119.001878v1-mcp.RA119.001878
Research

Background: Accurate definition of the extent and severity of left-ventricular assist device (LVAD) infection may facilitate therapeutic decision making and targeted surgical intervention. Here, we explore the value of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for guidance of patient management. Methods: Fifty-seven LVAD-carrying patients received 85 whole-body ¹⁸F-FDG PET/CT scans for the work-up of device infection. Clinical follow-up was obtained over a period of up to two years. Results: PET/CT showed various patterns of infectious involvement of the 4 LVAD components: driveline entry point (77% of cases), subcutaneous driveline path (87%), pump pocket (49%) and outflow tract (58%). Driveline smears revealed staphylococcus or pseudomonas strains as the underlying pathogen in a majority of cases (48 and 34%, respectively). At receiver-operating characteristics analysis, an ¹⁸F-FDG standardized uptake value (SUV) >2.5 was most accurate to identify smear-positive driveline infection. Infection of 3 or all 4 LVAD components showed a trend towards lower survival vs infection of 2 or less components (P = 0.089), while involvement of thoracic lymph nodes was significantly associated with adverse outcome (P = 0.001 for nodal SUV above vs below median). Finally, patients that underwent early surgical revision within 3 months after PET/CT (n = 21) required significantly less inpatient hospital care during follow-up when compared to those receiving delayed surgical revision (n = 11; p<0.05). Conclusion: Whole-body ¹⁸F-FDG PET/CT identifies the extent of LVAD infection and predicts adverse outcome. Initial experience suggests that early image-guided surgical intervention may facilitate a less complicated subsequent course.

16 April 2020

Genetic and genomic research has greatly advanced our understanding of heart disease. Yet, comprehensive, in-depth, quantitative maps of protein expression in hearts of living humans are still lacking. Using samples obtained during valve replacement surgery in patients with mitral valve prolapse (MVP), we set out to define inter-chamber differences, the intersect of proteomic data with genetic or genomic datasets, and the impact of left atrial dilation on the proteome of patients with no history of atrial fibrillation (AF).  We collected biopsies from right atria (RA), left atria (LA) and left ventricle (LV) of seven male patients with mitral valve regurgitation with dilated LA but no history of AF. Biopsy samples were analyzed by high-resolution mass spectrometry (MS), where peptides were pre-fractionated by reverse phase high-pressure liquid chromatography prior to MS measurement on a Q-Exactive-HF Orbitrap instrument. We identified 7,314 proteins based on 130,728 peptides. Results were confirmed in an independent set of biopsies collected from three additional individuals. Comparative analysis against data from post-mortem samples showed enhanced quantitative power and confidence level in samples collected from living hearts. Our analysis, combined with data from genome wide association studies suggested candidate gene associations to MVP, identified higher abundance in ventricle for proteins associated with cardiomyopathies and revealed the dilated LA proteome, demonstrating differential representation of molecules previously associated with AF, in non-AF hearts. This is the largest dataset of cardiac protein expression from human samples collected in vivo. It provides a comprehensive resource that allows insight into molecular fingerprints of MVP and facilitates novel inferences between genomic data and disease mechanisms. We propose that over-representation of proteins in ventricle is consequent not to redundancy but to functional need, and conclude that changes in abundance of proteins known to associate with AF are not sufficient for arrhythmogenesis.

16 April 2020

16 April 2020

A recent Washington Post article reminds us of this frightening statistic: the first 100,000 cases of COVID-19 occupied all of three months to reach that milestone. It also stated that the second 100,000 cases sprinted to that number in 12 days....

16 April 2020

OBJECTIVE

To determine the effects of dapagliflozin in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) on left ventricular (LV) remodeling using cardiac MRI.

Always something nice about discovering new dishes by utilising left overs from the night before . Seriously who doesn't love a bowl of pasta with a rich ragout of slow braised meat . Add a fresh twist with sweet seasonal peas from the markets .

The nation's largest tax-credit scholarship program doesn't seem to have hurt the academics of students who remain in public schools, a new study shows.

London (Braynes-Row, Spa-Fields) : Publish'd ... by R. Pollard printseller, Jany: 30th; 1797.

THE last day of term before recess saw MSPs attempt more jokes than usual at FMQs, some of them even bordering on approaching the mildly funny. Heady days.

“Scotland”, declared a young Alex Salmond in May 1975, “knows from bitter experience what treatment is in store for a powerless region of a common market.”