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Academic Achievement of Children and Adolescents With Oral Clefts

Previous studies that reported learning deficits among children with oral clefts mostly used small, clinic-based samples prone to ascertainment bias. No previous studies in the United States have used a population-based sample and direct testing of academic achievement.

Using a large population-based sample from the United States and standardized school tests for achievement, we found that children with oral clefts scored significantly lower than their classmates on all evaluated domains of achievement and had higher rates of learning disability. (Read the full article)




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Survival of Children With Hypoplastic Left Heart Syndrome

Hypoplastic left heart syndrome (HLHS) is a critical congenital heart defect with high mortality. With advances in surgical intervention in recent years, survival of infants with HLHS has improved, but information on long-term survival using population-based data is limited.

In this population-based study, survival to adolescence of children with HLHS has significantly improved in recent years. Among infant survivors, >90% survived up to 18 years. Gestational age, birth weight, and neighborhood poverty may affect survival. (Read the full article)




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Three Testing Issues to Watch in Rewriting No Child Left Behind

Both the House and Senate ESEA bills keep annual tests, but they go very different ways on a lot of other assessment issues.




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Bernie Sanders' Record on Testing and No Child Left Behind: A Brief History

The Democratic presidential candidate likes to highlight his vote against the No Child Left Behind Act in 2001, although his record on the issue of high-stakes standardized testing isn't black and white.




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Bishops’ meeting in Baltimore left much work to be done

By Bishop W. Shawn McKnight

The November General Assembly of Bishops in Baltimore was a difficult but perhaps unavoidable experience for us to move forward as a Church. I was very disappointed to learn that the Holy See found it necessary to insist that the USCCB not take action at this time on the proposals presented by our conference leadership. My frustration, shared with many other people, is this: We have known about the scandal of Archbishop McCarrick since the end of June, and our Church must take immediate, decisive and substantive action in light of the deep wound the scandal has caused.

I am not so concerned about the time it is taking to punish the perpetrator. Pope Francis immediately required the Archbishop to resign from the College of Cardinals when Cardinal Dolan announced the New York review board found a credible and substantiated allegation of sexual abuse of a minor against him. I’m okay with the fact that further penalties (which could include McCarrick’s return to the lay state) will take more time for a complete canonical process. McCarrick isn’t going anywhere and he is already living a life of imposed prayer and penance.

But much more is needed than simply meting out a just punishment. How could his rise to such an influential position in the Church have happened? I am concerned how the national conference of bishops and the Holy See answer that question. An internal investigation of the McCarrick scandal without the use of competent and qualified lay investigators will hardly be considered transparent and credible. We need and must utilize the best and brightest people to do a top-notch investigation and study of the problem. Archbishop Charles Scicluna of Malta is the most qualified Catholic clergy to lead such an investigation, but without knowing that his collaborators include competent laity, the public may not perceive his eventual report as independent and complete enough to be believed.

At the time of this writing, there has not been one bishop, archbishop or cardinal in either the Holy See or the United States who has come forward on his own to repent publicly of his sins of omission or commission with regard to Archbishop McCarrick’s series of promotions over decades. Please, be men, not cowards, and come clean on your own! There doesn’t have to be a formal and long, drawn out investigation for a bishop to exercise a little compunction and concern for the well-being of the whole Church. An independent and transparent investigation is all the more necessary when culpable hierarchs exhibit an incapacity to do the right thing on their own.

The laity are the only ones who can keep the hierarchy accountable and get us out of the mess we bishops got ourselves into. My singular focus throughout the Baltimore meeting was to advocate and push for greater public involvement of the laity at all levels of the Church. Why can’t we have well qualified, nationally known and trusted lay experts named to the special task force announced by the president of the USCCB? We are too insular and closed in as a hierarchy, and so are some of our processes at the USCCB. The Second Vatican Council gave us not only the freedom but the obligation to utilize and engage the gifts and talents of the laity in the life and mission of the Church.

Beyond the McCarrick scandal, we have more work cut out for us with regard to putting into place protocols and institutional structures to build credibility in the hierarchy’s handling of sexual abuse cases going forward. History proves that we bishops are not capable of policing ourselves adequately on the issue of clergy sexual abuse. Why not include the laity to assist us with this problem? The document the Missouri Province of Bishops presented to the Committee for the Protection of Children and Young People on Oct. 6 was intended to offer a set of principles for the USCCB to consider as it was developing proposals for the full body of bishops, including the involvement of the laity. We Missouri bishops wanted something valuable to come from our November meeting.

And so, I was disappointed that even the mild proposals up for consideration at the Baltimore meeting had to be pulled from a vote. It was a rather harsh reminder to me of what many lay people have been saying throughout our Diocese: We bishops are ineffectual in our attempts to address the problem of abuse of power by the hierarchy. The Charter for the Protection of Children and Young People has had a marked impact on lowering the number of incidents of abuse by clergy since 2003. But with the aggravation of the McCarrick scandal, the laity and clergy are now rightfully asking that we get it all out, once and for all, and respond with an urgency that this crisis deserves. We literally have people dying because of the harm caused by predator clergy, and survivors of abuse are further victimized when we fail to take swift action. Seeing certain retired bishops who were notoriously responsible for covering up clergy sexual abuse at this year’s General Assembly in Baltimore as welcome guests was a slap in the face to all who have been wounded by the clergy. This example of episcopal arrogance and clericalism evidences the fact that we still don’t get the problem.

The whole Church is needed to solve our problem which the whole world knows about. What more do we have to hide? If we are going to move forward, we need to have authentic communion and a genuine synodal process. And this requires transparency and better communication between the clergy and the laity, between the USCCB and its own members, and between the USCCB and the Holy See. We need to become the Church Christ founded us to be.

Some of the most poignant comments I heard during the listening sessions in our Diocese were in response to the question asking for people’s dreams for their children and grandchildren. People spoke of a Church where their children and grandchildren would find the love, mercy and hope of Jesus Christ, a community filled by God’s graces and led by holy priests. Despite our current lethargy, I believe we are witnessing the rebirth and renewal of our Church in our day. And I feel very blessed to be part of that renewal with each of you. We are better together.

 

 

Bishop McKnight's column was first published at Making Connections, his column on the website of the Diocese of Jefferson City.



  • CNA Columns: From the Bishops

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What Irrfan Khan and Rishi Kapoor left behind for the lawyers and people to learn?

What Irrfan Khan and Rishi Kapoor left behind for the lawyers and people to learn?




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Cooking Tips: Prepare This Quick And Easy Bengali-Style Bhaat Bhaja With Leftover Rice In A Busy Day

Bhaat literally means rice and bhaja means fry; bhaat bhaja is the home-style fried rice among Bengalis. This recipe needs almost nothing for preparation; tastes best with leftover rice.



  • Food & Drinks

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TRAFFIC ALERT - Median Barrier Replacement Will Require the Closure of Left Lane on US 13 Southbound -- Route 71

Bear --

Location: US 13 Southbound, at Route 71/Red Lion Road, Bear.

Dates and Times: 8:00 p.m. until 4:00 p.m. Sunday through Friday. [More]




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TRAFFIC ALERT - Overhead Sign Structure Will Require Left Lane Closure on Route 141 SB

Newport --

Location: Route 141 southbound at Newport Ramp to Old Airport Road, Newport.

Time and Date: 9:00 a.m. until 3:00 p.m. on Thursday, March 26, 2020

Traffic Information: DelDOT announces to motorists that the left lane will be closed on Route 141 southbound for the foundation of an overhead sign structure.

Motorists should anticipate a lane shift and slow down in work zones. [More]




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TRAFFIC ALERT - Closure of Left Turn Lane on US 13 NB for Median Barrier Replacement

Bear --

Location: US 13 Northbound at Red Lion Road, Bear.

Times and Dates: 8:00 p.m. starting on Tuesday, May 5, 2020 until 8:00 pm. on Thursday, June 5, 2020, pending weather.

Traffic Information: DelDOT announces to motorists that as part of the US 13 Median Barrier Replacement project, the left-turn lane will be closed on US 13 northbound. [More]




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Stocks for just a week: Only 3 lakh RNA extraction kits left

The Group of Ministers (GoM), headed by health minister Harsh Vardhan, met to review the preparations and deliberate on the way ahead.




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COVID-19 Lockdown: Govt revises own orders, stakeholders left clueless

In fact, the BJP-JDU government in Bihar has protested against students being allowed to move out of Rajasthan and wrote to the Centre recently calling it an “utter violation of guidelines issued by the MHA”.




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SR 1, TYBOUTS CORNER LEFT EXIT SIGNING

SR 1, TYBOUTS CORNER LEFT EXIT SIGNING




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Why do migrant workers who left for their homes want to return to Haryana?

Amidst Coronavirus breakdown, a reverse trend of people wanting to get back to work has been noticed in Haryana.




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OnePlus devices are swapping left and right audio channels when connecting headphones

In what seems like a rather weird glitch, it appears that there is a growing number of complaints amongst OnePlus users who are finding that their headphones audio channels are being wrongly swapped when connected.








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Rape survivor left with huge legal bill after losing court case against cops

Businesswoman and activist Andisiwe “Andy” Kawa sued police for damages after accusing them of failing to find her during a 15-hour rape she endured in 2010 but lost the case.




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China Is Happy to Fill the Leadership Vacuum Left by the U.S.

In the global jostling amid the coronavirus crisis, Beijing is extending its influence while U.S. President Donald Trump continues to squander America's leadership role. The pandemic could mark the beginning of a new Chinese era.




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Conflict, flood left thousands displaced in Somalia: UN

More than 220,000 Somalis have been internally displaced due to armed conflict and natural disasters while facing deadly coronavirus since the start of 2020, the UN Refugee Agency said Friday. “UNHCR, the UN Refugee Agency, fears these multiple, compounding emergencies will lead to devastating consequences unless there is a strong and coordinated response from the […]

The post Conflict, flood left thousands displaced in Somalia: UN appeared first on Horseed Media • Somali News.



  • News in English

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RNC Launches 'Protect the Vote' to Fight Left's Vote-by-Mail Scheme

The Republican National Committee...




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NATO ships left the Barents Sea

A NATO squadron of three US destroyers Porter, Donald Cook and Roosevelt, the British frigate Kent and the American supply ship Sapplay left the Barents Sea. This was reported on the website of the Sixth Fleet of the United States. Ships entered...




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Coronavirus response: China’s military may have filled the gap left by the US but it’s only temporary, experts say

As the United States has taken a step back from world affairs to focus on an unprecedented health crisis at home, China has made full use of its massive military power to promote itself as a leader in the global fight against Covid-19.In the latest of a slew of recent overseas aid efforts carried out by the People’s Liberation Army (PLA), a Chinese medical team put the finishing touches to a testing laboratory in Yangon, Myanmar’s largest city, which they had helped to build from the ground up…




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COVID-19: Developing Countries Must Not be Left Behind

Globalization has been a driver for increased prosperity world-wide, but it has been in reverse in the last years due to the growth of populism in the USA and Europe. The COVID-19 pandemic may well provide further momentum to increasingly national-interest oriented policies in the west. Nevertheless, a common response to COVID-19 is needed, where […]

The post COVID-19: Developing Countries Must Not be Left Behind appeared first on Inter Press Service.




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Kareena Kapoor says Sara Ali Khan's London departure left her sad

Kareena Kapoor was left visibly upset when Sara Ali Khan was leaving for London after her vacation in Mumbai




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Brexit, 10,000 BC: The untold story of how Britain first left Europe

Megafloods, broken backstops and retreating ice sheets combine in a geological epic: the dramatic story of Britain's protracted original exit from Europe




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Study Recommends Putting Your Left Face Forward

Title: Study Recommends Putting Your Left Face Forward
Category: Health News
Created: 4/27/2012 6:06:00 PM
Last Editorial Review: 4/30/2012 12:00:00 AM




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Role of Plasmodium falciparum Protein GEXP07 in Maurers Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

ABSTRACT

The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to the surface of infected red blood cells (RBCs) via membranous organelles, known as the Maurer’s clefts. We developed a method for efficient enrichment of Maurer’s clefts and profiled the protein composition of this trafficking organelle. We identified 13 previously uncharacterized or poorly characterized Maurer’s cleft proteins. We generated transfectants expressing green fluorescent protein (GFP) fusions of 7 proteins and confirmed their Maurer’s cleft location. Using co-immunoprecipitation and mass spectrometry, we generated an interaction map of proteins at the Maurer’s clefts. We identified two key clusters that may function in the loading and unloading of PfEMP1 into and out of the Maurer’s clefts. We focus on a putative PfEMP1 loading complex that includes the protein GEXP07/CX3CL1-binding protein 2 (CBP2). Disruption of GEXP07 causes Maurer’s cleft fragmentation, aberrant knobs, ablation of PfEMP1 surface expression, and loss of the PfEMP1-mediated adhesion. GEXP07 parasites have a growth advantage compared to wild-type parasites, and the infected RBCs are more deformable and more osmotically fragile.

IMPORTANCE The trafficking of the virulence antigen PfEMP1 and its presentation at the knob structures at the surface of parasite-infected RBCs are central to severe adhesion-related pathologies such as cerebral and placental malaria. This work adds to our understanding of how PfEMP1 is trafficked to the RBC membrane by defining the protein-protein interaction networks that function at the Maurer’s clefts controlling PfEMP1 loading and unloading. We characterize a protein needed for virulence protein trafficking and provide new insights into the mechanisms for host cell remodeling, parasite survival within the host, and virulence.




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Effect of Low-Sodium versus Conventional Sodium Dialysate on Left Ventricular Mass in Home and Self-Care Satellite Facility Hemodialysis Patients: A Randomized Clinical Trial

Background

Fluid overload in patients undergoing hemodialysis contributes to cardiovascular morbidity and mortality. There is a global trend to lower dialysate sodium with the goal of reducing fluid overload.

Methods

To investigate whether lower dialysate sodium during hemodialysis reduces left ventricular mass, we conducted a randomized trial in which patients received either low-sodium dialysate (135 mM) or conventional dialysate (140 mM) for 12 months. We included participants who were aged >18 years old, had a predialysis serum sodium ≥135 mM, and were receiving hemodialysis at home or a self-care satellite facility. Exclusion criteria included hemodialysis frequency >3.5 times per week and use of sodium profiling or hemodiafiltration. The main outcome was left ventricular mass index by cardiac magnetic resonance imaging.

Results

The 99 participants had a median age of 51 years old; 67 were men, 31 had diabetes mellitus, and 59 had left ventricular hypertrophy. Over 12 months of follow-up, relative to control, a dialysate sodium concentration of 135 mmol/L did not change the left ventricular mass index, despite significant reductions at 6 and 12 months in interdialytic weight gain, in extracellular fluid volume, and in plasma B-type natriuretic peptide concentration (ratio of intervention to control). The intervention increased intradialytic hypotension (odds ratio [OR], 7.5; 95% confidence interval [95% CI], 1.1 to 49.8 at 6 months and OR, 3.6; 95% CI, 0.5 to 28.8 at 12 months). Five participants in the intervention arm could not complete the trial because of hypotension. We found no effect on health-related quality of life measures, perceived thirst or xerostomia, or dietary sodium intake.

Conclusions

Dialysate sodium of 135 mmol/L did not reduce left ventricular mass relative to control, despite improving fluid status.

Clinical Trial registry name and registration number:

The Australian New Zealand Clinical Trials Registry, ACTRN12611000975998.




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Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects

Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited. To identify causal CHD genes that are associated with specific molecular functions, the study used prior knowledge to filter de novo variants from 2,881 probands with sporadic severe CHD. This approach enabled the authors to identify an association between left ventricular outflow tract obstruction lesions and genes associated with the WAVE2 complex and regulation of small GTPase-mediated signal transduction. Using CRISPR zebrafish knockdowns, the study confirmed that WAVE2 complex proteins brk1, nckap1, and wasf2 and the regulators of small GTPase signaling cul3a and racgap1 are critical to cardiac development.




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Lil Wayne's music was always being leaked through CDs he left in his car

The rapper detected the source of where his music was being released from - and tracked it down to when he would leave CDs in his car at the car wash.




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Fiona Phillips opens up on 'horrible' coronavirus symptoms which left her bedridden

Read our live updates on coronavirus HERE Cornavirus: The symptoms




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Homeless man with Covid-19 symptoms left sleeping on London buses

The man contacted several government-funded services tasked with helping the homeless, but was told there was "no space for him," human rights journalists at Liberty Investigates found.




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Former Olympic rower Kenny Dwan recalls emotional moment he left hospital after overcoming coronavirus

Former Olympic rower Kenny Dwan has recalled the emotional moment he left hospital after a three-week battle with coronavirus.




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Elderly residents left horrified after vandals ransack gardens and steal furniture

Elderly residents of a Staffordshire street woke up this morning to find their gardens had been ransacked by vandals.





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My partner left me before lockdown and I can't get over him

With so much time on our hands, it’s easy to dwell on loss, says Mariella Frostrup. Try distracting yourself with online dates, box sets and classic novels

The dilemma Several months ago my partner of five years left me very suddenly. He’d gone abroad to work, but as far as I knew everything was fine. I even had flights booked to go and visit. The break-up was a huge shock that left me in a low place. After a few weeks I felt I was beginning to come out of the fog and start moving on with my life, going out and seeing friends, going to classes, etc, but then the lockdown was imposed. Being shut away in my flat all day, alone with my thoughts, I seem to be going backwards.

I’m very aware that we are in the middle of a global crisis and it’s awful for everyone. Luckily, I’m in a good position regarding pay and I’m not paying rent, so I really don’t have any reason to complain. However, all I can think about is my ex. It’s driving me a little bit mad. Do you have any advice on dealing with non-Covid-related troubles during this crisis? Talking to others about it is hard, and I don’t want to make it all about myself.

Continue reading...




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Joe Cole left Peaky Blinders because 'it's Cillian Murphy's show'

The 31-year-old is set to star in new Sky drama Gangs of London




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Ellen DeGeneres crew left 'distressed and outraged' over pay amid coronavirus shutdown, report claims

US talk show host previously said she returned to the air to support her crew, who she said she 'loves and misses'




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Gogglebox's Jonathan Tapper left 'fighting for life' during coronavirus battle

52-year-old appeared on the series from 2013 until 2018




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Walking Dead star Tom Payne says he was 'kind of over' show by the time he left

Actor claimed everyone in the show is 'waiting for their time to shine'




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Last Dance viewers left 'emotional' as Kobe Bryant raves about 'big brother' Michael Jordan

Archive footage shows Jordan tell Bryant 'I'll see you down the road' after first match together





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Gary Neville suggests Harry Kane has intentionally left the door open for Tottenham exit this summer

Gary Neville claims Tottenham star Harry Kane has 'deliberately opened the door' for a move away from north London.




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Jose Mourinho's Chelsea exit left players 'crying on the floor', reveals Steve Sidwell

Steve Sidwell has revealed a number of Chelsea players were crying on the floor after learning of Jose Mourinho's departure from the club in 2007.




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Scott McTominay patience pays off as Manchester United star reveals he nearly left on loan

Scott McTominay has revealed he nearly left Manchester United on loan but believes his patience in waiting for his chance has paid off.




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Valencia left-back Jose Gaya explains why he turned down Real Madrid in 2015

Valencia left-back Jose Gaya has revealed why he turned down Real Madrid in 2015.




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Aaron Ramsey reveals why he left Arsenal for Juventus

Former Arsenal midfielder Aaron Ramsey has revealed he joined Italian giants Juventus in a bit to get out of his comfort zone.