The OECD’s latest Environmental Performance Review of Spain finds the country has decreased the energy and carbon intensity of its economy, reduced industrial pollution and cut per-capita waste generation since 2000.

When it comes to labour and migration, global governance of almost any kind is missing. When it comes to labour, the International Labour Organization, which is the oldest among the institutions mentioned here, has little power and deals mostly with national labour rules.

The higher the level of education, the higher the salary cost of teachers per student. In Belgium (Flemish Community), France and Spain, the difference in the annual salary cost between the primary and upper secondary levels of education exceeds USD 1 800 in 2010.

Electric carmaker chief threatens to relocate to another state after request to restart production was denied

1. Elon Musk threatens to move Tesla headquarters, factory out of California  Livemint
2. Elon Musk Threatens Removing Tesla From California Over Virus Restrictions  NDTV
3. Elon Musk threatens to exit California over virus restrictions  The Hindu
4. Elon Musk threatens to close Fremont plant and sever ties with California  KTVU San Francisco
5. Tesla’s stock could see new peaks thanks to these 3 catalysts  MarketWatch
6. View Full coverage on Google News

Tesla filed a lawsuit Saturday against Alameda County in an effort to invalidate orders that have prevented the automaker from reopening its factory in Fremont, California. The lawsuit, which seeks injunctive and declaratory relief against Alameda County, was first reported by CNBC. The lawsuit was filed in U.S. District Court for California’s Northern District. Earlier […]

Elon Musk says Tesla may leave its Palo Alto headquarters and Fremont, California factory. In a tweet Saturday morning, the chief executive continued his outrage against shelter-in-place orders that have forced most non-essential businesses to close. Last week, Musk likened the rules to fascism, and urged leaders to "give people their goddamn freedom back." Visit Business Insider's homepage for more stories.After a week of decrying coronavirus shelter-in-place orders that have left Tesla's main factory shuttered and unable to produce vehicles, Elon Musk says the company may move its factory out of the state."Tesla is filing a lawsuit against Alameda County immediately," the chief executive said on Twitter Saturday morning. "The unelected & ignorant 'Interim Health Officer' of Alameda is acting

PETE JENSON IN SPAIN: Diario AS counted 41 players in Europe's top divisions who have come from the Valdebebas academy and there are 42 ex-Madrid youth system players playing in Spain.

It comes a day after France's PSA announced it would be temporarily mothballing Vauxhall's Ellesmere Port and Luton sites. Car manufacturers are reeling from a slump in demand.

The document outlines new measures, including temperature scans for all staff, requirements to wear face masks, working stations separated by 6 feet, and the closure of on-site gyms and canteens.

Judge Louis Walsh was filming scenes with his act, Love Actually star Olivia Olson, on a London street when George, who proclaimed himself a huge fan of the IITV show, turned up.  

PETE JENSON IN SPAIN: Diario AS counted 41 players in Europe's top divisions who have come from the Valdebebas academy and there are 42 ex-Madrid youth system players playing in Spain.

A fire broke out in a cardboard factory in outer Delhi's Bawana on Sunday morning, Delhi Fire Service officials said. However, no one is trapped or injured in the incident, they said. A call about the blaze was received around 7.25 am, following which 15 fire tenders were rushed to the spot. The fire fighting operations are underway, the officials said.

Elon Musk has been pushing to re-open Tesla's Fremont, California, factory after Alameda County's health department said the carmaker must not reopen because local lockdown measures to curb the spread of the coronavirus remain in effect.

On Monday, banks and NBFCs (non-banking finance companies) were among the biggest losers on the Indian stock exchanges. ICICI Bank ended 10.56 percent lower, HDFC 9.98 percent down, HDFC Bank 7.89 percent lower, SBI was down 5.88 percent and NSE's banking

A call about the blaze was received around 7.25 am on Sunday, following which 15 fire tenders were rushed to the spot.

A fire broke out in a cardboard factory in outer Delhi's Bawana today morning, Delhi Fire Service officials said.

Chagas diseases (CD) is a silent yet life-threatening disease caused by a protozoan parasite named Trypanosoma cruzi (T.cruzi). The disease is also known as American trypanosomiasis as it is found mainly in rural areas of America where there is a lack

Thyroid cancer is the cancer of the thyroid gland which is found at the neck's front just below Adam's apple. The thyroid gland is a butterfly-shaped gland with two lobes, one at each side joined by a narrow tissue called the

Thalassemia is a group of inherited blood disorders that has a similar characteristic: defective and reduced production of haemoglobin, the iron-containing protein in red blood cells that helps in carrying oxygen throughout the body. Beta-thalassemia (BT) is one of

Tesla Inc sued local authorities in California on Saturday as the electric carmaker pushed to re-open its factory there and Chief Executive Elon Musk threatened to move Tesla's headquarters and future programs from the state to Texas or Nevada.

Archives, Room Use Only - UG607.U55 1905

McKinnon appears to be on pace for a strong recovery, but 49ers general manager John Lynch is taking a wait-and-see approach.

Work resumes in Greater Noida’s Oppo mobile factory

‘Management violated all norms’

The electric car company told employees to report to work Friday, but a county official said Tesla did not meet the requirements for resuming production.

Tesla said the county's position left it no choice but to take legal action to ensure Tesla and its employees can go back to work

A fire broke out in a cardboard factory in outer Delhi’s Bawana on Sunday morning, Delhi Fire Service officials said. However, no one is trapped or in

The bond-valence method was performed on 51 crystal data sets from nitrogenase proteins, indicating the presence of molybdenum(III) in FeMo cofactors and vanadium(III) with more reduced iron complements in FeV cofactors.

Transforming growth factor β-1 (TGFβ-1) is a secreted signalling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. The primary endogenous activity regulatory mechanism for TGFβ-1 is sequestration by its pro-peptide, latency-associated peptide (LAP), which sterically prohibits receptor binding by caging TGFβ-1. As such, recombinant LAP is promising as a protein-based therapeutic for modulating TGFβ-1 activity; however, the mechanism of binding is incompletely understood. Comparison of the crystal structure of unbound LAP (solved here to 3.5 Å resolution) with that of the bound complex shows that LAP is in a more open and extended conformation when unbound to TGFβ-1. Analysis suggests a mechanism of binding TGFβ-1 through a large-scale conformational change that includes contraction of the inter-monomer interface and caging by the `straight-jacket' domain that may occur in partnership through a loop-to-helix transition in the core jelly-roll fold. This conformational change does not appear to include a repositioning of the integrin-binding motif as previously proposed. X-ray scattering-based modelling supports this mechanism and reveals possible orientations and ensembles in solution. Although native LAP is heavily glycosylated, solution scattering experiments show that the overall folding and flexibility of unbound LAP are not influenced by glycan modification. The combination of crystallography, solution scattering and biochemical experiments reported here provide insight into the mechanism of LAP sequestration of TGFβ-1 that is of fundamental importance for therapeutic development.

The Y128F single mutant of p-hydroxymandelate oxidase (Hmo) is capable of oxidizing mandelate to benzoate via a four-electron oxidative decarboxylation reaction. When benzoylformate (the product of the first two-electron oxidation) and hydrogen peroxide (an oxidant) were used as substrates the reaction did not proceed, suggesting that free hydrogen peroxide is not the committed oxidant in the second two-electron oxidation. How the flavin mononucleotide (FMN)-dependent four-electron oxidation reaction takes place remains elusive. Structural and biochemical explorations have shed new light on this issue. 15 high-resolution crystal structures of Hmo and its mutants liganded with or without a substrate reveal that oxidized FMN (FMNox) possesses a previously unknown electrophilic/nucleophilic duality. In the Y128F mutant the active-site perturbation ensemble facilitates the polarization of FMNox to a nucleophilic ylide, which is in a position to act on an α-ketoacid, forming an N5-acyl-FMNred dead-end adduct. In four-electron oxidation, an intramolecular disproportion­ation reaction via an N5-alkanol-FMNred C'α carbanion intermediate may account for the ThDP/PLP/NADPH-independent oxidative decarboxylation reaction. A synthetic 5-deaza-FMNox cofactor in combination with an α-hydroxyamide or α-ketoamide biochemically and structurally supports the proposed mechanism.

Good prior estimates of the effective root-mean-square deviation (r.m.s.d.) between the atomic coordinates of the model and the target optimize the signal in molecular replacement, thereby increasing the success rate in difficult cases. Previous studies using protein structures solved by X-ray crystallography as models showed that optimal error estimates (refined after structure solution) were correlated with the sequence identity between the model and target, and with the number of residues in the model. Here, this work has been extended to find additional correlations between parameters of the model and the target and hence improved prior estimates of the coordinate error. Using a graph database, a curated set of 6030 molecular-replacement calculations using models that had been solved by X-ray crystallography was analysed to consider about 120 model and target parameters. Improved estimates were achieved by replacing the sequence identity with the Gonnet score for sequence similarity, as well as by considering the resolution of the target structure and the MolProbity score of the model. This approach was extended by analysing 12 610 additional molecular-replacement calculations where the model was determined by NMR. The median r.m.s.d. between pairs of models in an ensemble was found to be correlated with the estimated r.m.s.d. to the target. For models solved by NMR, the overall coordinate error estimates were larger than for structures determined by X-ray crystallography, and were more highly correlated with the number of residues.

Most articles dealing with R2TSi3 compounds are only interested in one specific composite or in a series of composites with varying T elements while keeping R fixed (or vice versa). The present work gives an overview of the complete range of 2:1:3 silicides, similar those of Hoffmann & Pöttgen (2001) and Pan et al. (2013). In contrast to the work of Hoffmann & Pöttgen (2001), reasons for formation of the different symmetries and superstructures are discussed. Here, crystallographic properties are in[the] focus, whereas physical and magnetic properties are omitted because those are given by Pan et al. (2013). READS LIKE AN ABSTRACT, please re-write and remove references if possible. Should be two sentences max.

A local supernova factory has recently started production, according to a wealth of new data from NASA's Chandra X-ray Observatory on the Carina Nebula.

The post The Carina Nebula, a local supernova factory, is ramping up production appeared first on Smithsonian Insider.

With its homely featherless head, undertaker’s charcoal coloring and association with death and decay, the turkey vulture (Cathartes aura) tops few lists as a favorite […]

The post Scientists in awe of huge olfactory bulb found in turkey vulture brain appeared first on Smithsonian Insider.

The bond-valence method has been used for valence calculations of FeMo/V cofactors in FeMo/V proteins using 51 crystallographic data sets of FeMo/V proteins from the Protein Data Bank. The calculations show molybdenum(III) to be present in MoFe7S9C(Cys)(HHis)[R-(H)homocit] (where H4homocit is homocitric acid, HCys is cysteine and HHis is histidine) in FeMo cofactors, while vanadium(III) with a more reduced iron complement is obtained for FeV cofactors. Using an error analysis of the calculated valences, it was found that in FeMo cofactors Fe1, Fe6 and Fe7 can be unambiguously assigned as iron(III), while Fe2, Fe3, Fe4 and Fe5 show different degrees of mixed valences for the individual Fe atoms. For the FeV cofactors in PDB entry 5n6y, Fe4, Fe5 and Fe6 correspond to iron(II), iron(II) and iron(III), respectively, while Fe1, Fe2, Fe3 and Fe7 exhibit strongly mixed valences. Special situations such as CO-bound and selenium-substituted FeMo cofactors and O(N)H-bridged FeV cofactors are also discussed and suggest rearrangement of the electron configuration on the substitution of the bridging S atoms.

Su Ming Sun, Amandine Batte, Mireille Tittel-Elmer, Sophie van der Horst, Tibor van Welsem, Gordon Bean, Trey Ideker, Fred van Leeuwen, and Haico van Attikum

Eukaryotic chromosomes are replicated in interphase and the two newly duplicated sister chromatids are held together by the cohesin complex and several cohesin auxiliary factors. Sister chromatid cohesion is essential for accurate chromosome segregation during mitosis, yet has also been implicated in other processes, including DNA damage repair, transcription and DNA replication. To assess how cohesin and associated factors functionally interconnect and coordinate with other cellular processes, we systematically mapped genetic interactions of 17 cohesin genes centered on quantitative growth measurements of >52,000 gene pairs in budding yeast. Integration of synthetic genetic interactions unveiled a cohesin functional map that constitutes 373 genetic interactions, revealing novel functional connections with post-replication repair, microtubule organization and protein folding. Accordingly, we show that the microtubule-associated protein Irc15 and the prefoldin complex members Gim3, Gim4 and Yke2 are new factors involved in sister chromatid cohesion. Our genetic interaction map thus provides a unique resource for further identification and functional interrogation of cohesin proteins. Since mutations in cohesin proteins have been associated with cohesinopathies and cancer, it may also identify cohesin interactions relevant in disease etiology.

Relativistic electron diffraction depends on linear and quadratic terms in the electric potential, the latter being neglected in the frequently used relativistically corrected Schrödinger equation. The quadratic electric potential term modifies atomic scattering amplitudes in particular for large-angle scattering and backscattering. The respective correction increases with increasing scattering angle, increasing atomic number and increasing kinetic energy. Conventional tabulations for electron scattering and its large-angle extrapolations can be amended in closed form by a universal correction based on the screened Coulomb potential squared.

A new aspherical scattering factor formalism has been implemented in the crystallographic least-squares refinement program SHELXL. The formalism relies on Gaussian functions and can optionally complement the independent atom model to take into account the deformation of electron-density distribution due to chemical bonding and lone pairs. Asphericity contributions were derived from the electron density obtained from quantum-chemical density functional theory computations of suitable model compounds that contain particular chemical environments, as defined by the invariom formalism. Thanks to a new algorithm, invariom assignment for refinement in SHELXL is automated. A suitable parameterization for each chemical environment within the new model was achieved by metaheuristics. Figures of merit, precision and accuracy of crystallographic least-squares refinements improve significantly upon using the new model.

An error in an equation in the paper by Song et al. [Acta Cryst. (2019), C75, 1353–1358] is corrected.

Su Ming Sun
Apr 16, 2020; 0:jcs.237628v1-jcs.237628
Articles

Our ability to observe and predict severe weather events and other disasters has improved markedly over recent decades, yet this progress does not always translate into similar advances in the systems used in such circumstances to protect lives.

A new report from the National Academies of Sciences, Engineering, and Medicine examines to what extent and in which ways health care utilization -- such as in-patient hospitalizations, emergency department use, and hospital readmission -- reflects disease severity, disability, and ability to perform gainful activity.

New research has investigated the many ways in which technological transfer occurs for wind power projects in developing countries. These range from trading with developed countries, to local innovation. In India and China, successful transfer was found to depend more on existing capabilities in these countries than international projects, such as the Clean Development Mechanism (CDM).

Invasions of alien species are rising at an alarming rate, largely due to growing global trade and transport routes. Preventing the successful establishment of alien species by better understanding the factors determining success is a step toward limiting the threat of future biological invasions. Statistical modelling using observed bird invasion data — including location, event and species-level factors showed which factors were key to successful establishment by the alien species.

New research has investigated the many ways in which technological transfer occurs for wind power projects in developing countries. These range from trading with developed countries, to local innovation. In India and China, successful transfer was found to depend more on existing capabilities in these countries than international projects, such as the Clean Development Mechanism (CDM).

Two of the biggest barriers for organisations refurbishing waste electrical and electronic equipment (WEEE) for re-use are the availability of sufficient quantities of good quality used equipment and a lack of legislation that encourages or enforces re-use. These, and other barriers as well as success factors, were identified in a recent survey of re-use organisations in Africa, Latin America, North America and Europe.

A new study lists 10 factors to help create a closed-loop supply chain for critical materials. However, interviews with key actors in supply chains for photovoltaic (PV) panels and wind turbines suggest that manufacturers and recyclers hold different perspectives on these factors. The research highlights the importance of cooperation between supply-chain actors, as well as investment in technologies and infrastructure for closed-loop supply chains.

Industry executives say most plants will work at low capacity at least until the festive season