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Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation

RSC Med. Chem., 2024, 15,3778-3794
DOI: 10.1039/D4MD00281D, Research Article
Carolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. Pilli
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers

It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students




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Southern Railway refuses to share inquiry report of Perumon train tragedy

105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988




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Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators

It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion




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Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan




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India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield

In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months




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Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur

Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka




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Byelections: Polling passes off peacefully in Sandur




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After hosting World Cup, Qatar praised by U.N. rights body for labour law reforms but urged to do more

In Qatar, better labour law protections have been passed in recent years relating to a minimum wage, freedom to change employers and combating forced labor and trafficking




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Manipur stuns defending champion Punjab




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Punjab Finance Minister bats for cooperative federalism, structural reforms




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Bypolls to three Assembly seats in State passes off peacefully




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HC refuses to restrain police from arresting Omkar Balaji

Justice A.D. Jagadish Chandira simply adjourns his anticipatory bail plea by a week without granting any interim protection




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Rajasthan Assembly bypolls: 65% voter turnout recorded; largely peaceful

Highest voter turnout of 75.27% was recorded in Ramgarh; independent candidate slaps government officer




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Demanding security, Tamil Nadu government doctors begin indefinite strike

Federation of Government Doctors’ Association will decide on the next course of action at an executive committee meeting to be held on November 17, 2024.




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ED files Prosecution Complaint against Jaffer Sadiq before Additional CBI Court

A release said 20 persons had been arraigned as accused in the case, and Jaffer Sadiq was identified as the mastermind




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Trump taps former Democrat Tulsi Gabbard as US intel chief; Senator Marco Rubio as Secretary of State

Tulsi Gabbard demanded U.S. military withdrawal from Iraq and Syria during her 2020 Presidential run; Marco Rubio would be the first Hispanic as the top U.S. diplomat




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Defence Space Agency conducts maiden tabletop exercise ‘Antariksha Abhyas’

One of the aims of the exercise was also to identify vulnerabilities in conduct of operations in the event of denial or disruptions of space-based services




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Tax evasion rampant as only 23% of transactions being traced, says Chief Commissioner of IT




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Eight injured in fire at IndianOil’s Mathura refinery 

All injured individuals are reported to be in stable condition, according to the company statement




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Ram Ratna Wires acquires 60% stake in fabrication specialist Tefabo

This marks Ram Ratna Wires’ entry into the fabrication components and assemblies’ sector, particularly targeting opportunities in renewable energy and railways




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Google Reveals Election Security Efforts

Google has revealed a series of measures aimed to better inform US voters while reducing the risk of malicious misinformation. It includes restrictions on its AI tools and better protection against cyber attacks for election and campaign officials. The measures broadly break down into three categories. The first is better information for users who are trying to find out more about elections. For example, users who search YouTube for the name of an election candidate will get an information panel detailing official website and video channel links for the candidate. (Source: engadget.com ) ... (view more)




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Android 15 Boosts Security, Theft Detection Lock

Google has announced a range of security and privacy boosts for Android 15. It's also rolling out a key feature called Theft Detection Lock to older handsets. The new version of Android is coming to Google's own Pixel handsets almost immediately and then will go out to other manufacturers. The release date and which handsets it works on depends on the manufacturer. Theft Detection Lock Explained Unlike some previous new versions of Android which have often seemed more focused on appearance and style, the focus this time is much more practical. The most high-profile change is Theft Detection ... (view more)




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Good Grief - Real Grief and Christian Hope

Fr. Barnabas is joined by Fr. James and Kh. Linda Ellison who have experienced personal grief beyond most. How do we grieve and maintain our Christian hope and how can we help those who are grieving?




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Orthodoxy and the Reformation

Fr. Panayiotis Papageorgiou joins Fr. Barnabas to talk about the Reformation and its effects on the Christian Church.




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Rock and Sand - 500 Years After the Reformation

Fr. Barnabas welcomes Fr. Josiah Trenham, author of Rock and Sand, as they discuss the Protestant Reformation 500 years later.




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Dogecoin soars as Trump announces government efficiency group nicknamed DOGE

Dogecoin, the cryptocurrency whose mascot is a super-cute dog that muses things like "much wow," has been racing higher in value since Donald Trump won the presidential election last week. It got another bump after Trump named Tesla's Elon Musk as one of the heads of a new "Department of Government Efficiency," which is not a government agency but does have the acronym DOGE.




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Binghamton University Expands Efforts to Protect Birds From Deadly Collisions

Glass windows are an invisible killer, resulting in billions of bird deaths in the U.S. each year. To prevent collisions on campus. Binghamton University, State University of New York has installed bird-safe windows.




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Jumio teams up with LatticeFlow AI to scale fraud prevention and compliance

US-based Jumio has entered into a collaboration with




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Participants of OSCE-supported discussion in Bosnia and Herzegovina called to unite efforts in addressing online content that incites violence

Addressing online content that incites violence was in the focus of a two-day OSCE-supported roundtable discussion that concluded today in Sarajevo, Bosnia and Herzegovina (BiH).




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OSCE Mission to BIH supports meeting of the Inter-Agency Working Group on election reform

Among other issues discussed at the meeting was the implementation of recommendations stipulated in the final report by election observers of the OSCE Office for Democratic Institutions and Human Righ




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Maid sentenced to 235 years for gold thefts

A maid has been sentenced to 235 years in jail for dozens of thefts of gold ornaments worth about 25 million baht from her employer’s shop in Khon Kaen.




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Models of deformation processes within subglacial tills - the application of microsedimentology

Menzies, J; Paulen, R C. Geoconvention 2020 abstracts; 2020 p. 1-3
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20190526.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20190526.jpg" title="Geoconvention 2020 abstracts; 2020 p. 1-3" height="150" border="1" /></a>




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Investigating the relationship between the elemental composition of coprolites and trophic level: a brief digest of Late Carboniferous coprolites from the Joggins Formation

Bingham-Koslowski, N; Grey, M; Ehrman, J M; Pufahl, P. The Atlantic Geoscience Society (AGS), 47th Colloquium and Annual Meeting, program with abstracts/La Société Géoscientifique de l'Atlantique, 47th Colloquium and Annual Meeting, program with abstracts; 2021 p. 14
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200688.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200688.jpg" title="The Atlantic Geoscience Society (AGS), 47th Colloquium and Annual Meeting, program with abstracts/La Société Géoscientifique de l'Atlantique, 47th Colloquium and Annual Meeting, program with abstracts; 2021 p. 14" height="150" border="1" /></a>




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Palaeoecology of the Hiraiso Formation (Miyagi Prefecture, Japan) and implications for the recovery following the end-Permian mass extinction.

Foster, W J; Godbold, A; Brayard, A; Frank, A; Grasby, S E; Twitchett, R J; Oji, T. PeerJ 2022 p. 1-45, https://doi.org/10.7717/peerj.14357
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220547.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220547.jpg" title="PeerJ 2022 p. 1-45, https://doi.org/10.7717/peerj.14357" height="150" border="1" /></a>




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Deformation history and tectonic significance of the Sanagak Lake shear zone, Boothia Peninsula, Nunavut

Drayson, D; Camacho, A; Sanborn-Barrie, M; Regis, D; Larson, K; Osinchuk, A; DuFrane, S A. Canadian Journal of Earth Sciences 2022 p. 1-22, https://doi.org/10.1139/cjes-2022-0046
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220231.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220231.jpg" title="Canadian Journal of Earth Sciences 2022 p. 1-22, https://doi.org/10.1139/cjes-2022-0046" height="150" border="1" /></a>




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A review of the Jurassic dinoflagellate cyst genus Gonyaulacysta Deflandre 1964 emend. nov.

Riding, J B; Mariani, E; Fensome, R A. Review of Palaeobotany and Palynology vol. 299, 104605, 2022 p. 1-37, https://doi.org/10.1016/j.revpalbo.2022.104605
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210363.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210363.jpg" title="Review of Palaeobotany and Palynology vol. 299, 104605, 2022 p. 1-37, https://doi.org/10.1016/j.revpalbo.2022.104605" height="150" border="1" /></a>




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Glacial history and limits of Cordilleran and Laurentide ice sheets in the Mackenzie Mountains, foothills, and plains, Northwest Territories: a brief overview

Duk-Rodkin, A; Barendregt, R W. Surficial geology of northern Canada: a summary of Geo-mapping for Energy and Minerals program contributions; by McMartin, I (ed.); Geological Survey of Canada, Bulletin 611, 2023 p. 113-143, https://doi.org/10.4095/331422
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_331422.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_331422.jpg" title="Surficial geology of northern Canada: a summary of Geo-mapping for Energy and Minerals program contributions; by McMartin, I (ed.); Geological Survey of Canada, Bulletin 611, 2023 p. 113-143, https://doi.org/10.4095/331422" height="150" border="1" /></a>




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SF: we have been repeatedly impressed by how resourceful GLS is in the European market

GLS and SF, China's largest integrated logistics service provider, are excited to announce a bilateral network partnership.




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FedEx Express Swiss Post to offer a range of time-definite services to its customers

FedEx Express Swiss Post, the joint venture between FedEx Express and Swiss Post, announced today that it will open a new facility in Gossau in the canton of St. Gallen next year.




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Australia Post “re-defining the customer experience and offering opportunities for local businesses to collaborate”

Australia Post has officially opened its fourth Community Hub @ Post in Williamstown - its first in Victoria - transforming the post office into a modern retail space with an extensive renovation.




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New approval to allow Prime Air to “effectively expand and scale” drone delivery operations

Amazon drones can now fly farther and deliver to more customers following The Federal Aviation Administration (FAA) approval.




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“With the introduction of the e-truck, Austrian Post is definitely going in the right direction”

Österreichische Post AG put its first two e-trucks into operation at the beginning of May. The two vehicles commute CO2-free between the logistics center in Vienna-Inzersdorf and Vienna Airport to pick up or deliver international shipments.




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parcelLab: Trending Late AI leverages the power of AI to predict potential delays before they occur

parcelLab, a global provider of post-purchase experience software, has announced the launch of "Trending Late AI," a new feature powered by artificial intelligence (AI)




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DHL research finds “AI unlocking unprecedented levels of efficiency and innovation”

DHL has published  the 7th edition of the DHL Logistics Trend Radar, a biennial report that highlights the foremost social, business, and technological trends impacting the industry.




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The Alaya Project defines Indo-jazz funk

Drawing on centuries-old rhythms and ragas from South Indian classical music and grooves honed in Oakland’s furnace of simmering funk, the Alaya Project is spreading the gospel of East Bay Indo-soul around the country. “Every time we perform on the East Coast it strikes me that what we’re doing is quintessentially Bay Area and Oakland,” […]




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Volleyball: Bermuda Defeat St. Eustatius

The Bermuda men’s national volleyball team were back in action competing in the 2024 ECVA senior men’s championships. Bermuda took on St. Eustatius and picked up a 3 – 0 victory to move to 1 & 1. Bermuda won the first set 25-11, before winning the second set 25-18, and then they closed it out […]




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Can Super Zhewitra Be Effective for Different Types of Premature Ejaculation?

Super Zhewitra is a medication designed to treat erectile dysfunction (ED). It combines two active ingredients, Vardenafil and Dapoxetine, to provide a dual-action treatment. Vardenafil is a PDE5 inhibitor, which enhances erectile function, while Dapoxetine, a selective serotonin reuptake inhibitor (SSRI), helps with premature ejaculation (PE). This combination is particularly beneficial for men who experience both ED and PE, as it improves erectile quality and delays ejaculation, allowing for more satisfying sexual experiences. How Super Zhewitra Works Vardenafil (20 mg): Vardenafil is a PDE5 inhibitor, which works by increasing blood flow to the penis when sexually stimulated. This helps achieve and maintain an erection. Vardenafil is known for its quick onset of action, typically taking effect within 30 to 60 minutes of consumption. Its effects can last for about 4 to 5 hours, providing a window of time for sexual activity. Dapoxetine (60 mg): Dapoxetine is an SSRI that helps delay ejaculation. It increases serotonin levels in the brain, improving control over ejaculation. Dapoxetine is typically used for treating premature ejaculation and helps men maintain sexual performance for longer durations. Benefits of Super Zhewitra Dual Action for ED and PE: Super Zhewitra combines two active ingredients to address both erectile dysfunction and premature ejaculation in a single pill, making it an efficient and convenient treatment for men facing both issues. Improved Sexual Confidence: By helping men achieve and maintain an erection while delaying ejaculation, Super Zhewitra can significantly boost sexual confidence and satisfaction. Longer Duration of Action: The effects of Vardenafil last for 4 to 5 hours, and with Dapoxetine's impact on ejaculatory control, men can enjoy more extended sexual activity without the worry of premature ejaculation. https://www.genericday.com/super-zhewitra.html