Sangsan Warakkagun
Conform. Geom. Dyn. 28 (), 115-130.
Abstract, references and article information

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Sudan’s gold boom: Connections to conflict and transnational impacts 7 December 2022 — 2:00PM TO 3:30PM Anonymous (not verified) 24 November 2022 Online

At this event, experts will discuss Sudan’s gold sector, its connections to conflict, and transnational impacts. 

At this webinar panellists will discuss Sudan’s gold sector, its connections to conflict, and transnational impacts.

Sudan is one of the largest gold producers on the continent, with the industry constituting Sudan’s foremost source of hard currency since the secession of South Sudan in 2011 and resulting loss of oilfields.

The gold rush that has ensued has had important implications for domestic and transnational conflict dynamics. Military actors and armed groups have sought control of gold-producing areas in the peripheries and to capitalize on the flow of labour migrants, against a wider backdrop of conflict partly stemming from contestation for control between central and local actors.

International interests are prominent, including increased Russian involvement in the sector, while gold smuggling has also interlaced with mercenary activity in neighbouring CAR, Chad and Libya.
 
At this event, panellists will discuss Sudan’s gold trade, its connections to conflict, and transnational impacts, including the international politics of Sudan’s gold extraction and role of armed groups. It will also explore the environmental and socio-economic dimensions of gold in Sudan’s border areas. 
 
This roundtable is an output of the Cross-Border Conflict: Evidence, Policy and Trends (XCEPT) research programme, funded by UK Aid from the UK government.
 

Autophagy plays critical roles in the maintenance of endothelial cells in response to cellular stress caused by blood flow. There is growing evidence that both cell adhesion and cell detachment can modulate autophagy, but the mechanisms responsible for this regulation remain unclear. Immunoglobulin and proline-rich receptor-1 (IGPR-1) is a cell adhesion molecule that regulates angiogenesis and endothelial barrier function. In this study, using various biochemical and cellular assays, we demonstrate that IGPR-1 is activated by autophagy-inducing stimuli, such as amino acid starvation, nutrient deprivation, rapamycin, and lipopolysaccharide. Manipulating the IκB kinase β activity coupled with in vivo and in vitro kinase assays demonstrated that IκB kinase β is a key serine/threonine kinase activated by autophagy stimuli and that it catalyzes phosphorylation of IGPR-1 at Ser220. The subsequent activation of IGPR-1, in turn, stimulates phosphorylation of AMP-activated protein kinase, which leads to phosphorylation of the major pro-autophagy proteins ULK1 and Beclin-1 (BECN1), increased LC3-II levels, and accumulation of LC3 punctum. Thus, our data demonstrate that IGPR-1 is activated by autophagy-inducing stimuli and in response regulates autophagy, connecting cell adhesion to autophagy. These findings may have important significance for autophagy-driven pathologies such cardiovascular diseases and cancer and suggest that IGPR-1 may serve as a promising therapeutic target.

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A key point in achieving accurate intact glycopeptide identification is the definition of the glycan composition file that is used to match experimental with theoretical masses by a glycoproteomics search engine. At present, these files are mainly built from searching the literature and/or querying data sources focused on posttranslational modifications. Most glycoproteomics search engines include a default composition file that is readily used when processing MS data. We introduce here a glycan composition visualizing and comparative tool associated with the GlyConnect database and called GlyConnect Compozitor. It offers a web interface through which the database can be queried to bring out contextual information relative to a set of glycan compositions. The tool takes advantage of compositions being related to one another through shared monosaccharide counts and outputs interactive graphs summarizing information searched in the database. These results provide a guide for selecting or deselecting compositions in a file in order to reflect the context of a study as closely as possible. They also confirm the consistency of a set of compositions based on the content of the GlyConnect database. As part of the tool collection of the Glycomics@ExPASy initiative, Compozitor is hosted at https://glyconnect.expasy.org/compozitor/ where it can be run as a web application. It is also directly accessible from the GlyConnect database.

The development of the HUPO-PSI's (Proteomics Standards Initiative) standard data formats and MIAPE (Minimum Information About a Proteomics Experiment) guidelines should improve proteomics data sharing within the scientific community. Proteomics journals have encouraged the use of these standards and guidelines to improve the quality of experimental reporting and ease the evaluation and publication of manuscripts. However, there is an evident lack of bioinformatics tools specifically designed to create and edit standard file formats and reports, or embed them within proteomics workflows. In this article, we describe a new web-based software suite (The ProteoRed MIAPE web toolkit) that performs several complementary roles related to proteomic data standards. Firstly, it can verify the reports fulfill the minimum information requirements of the corresponding MIAPE modules, highlighting inconsistencies or missing information. Secondly, the toolkit can convert several XML-based data standards directly into human readable MIAPE reports stored within the ProteoRed MIAPE repository. Finally, it can also perform the reverse operation, allowing users to export from MIAPE reports into XML files for computational processing, data sharing or public database submission. The toolkit is thus the first application capable of automatically linking the PSI's MIAPE modules with the corresponding XML data exchange standards, enabling bidirectional conversions. This toolkit is freely available at http://www.proteored.org/MIAPE/.

HANOVER, Md., Nov. 5, 2024 — Ciena has announced that its optical and routing and switching innovations will once again support the SCinet network at SC24, taking place November 17–22 […]

The post Ciena Powers SC24’s SCinet with High-Speed Connectivity and Advanced Optical Solutions appeared first on HPCwire.

BEAVERTON, Ore., Oct. 29, 2024 — Ultra Accelerator Link (UALink) Consortium, led by Board Members from AMD, Amazon Web Services (AWS), Astera Labs, Cisco, Google, Hewlett Packard Enterprise (HPE), Intel, Meta […]

The post Ultra Accelerator Link Consortium Launches with Industry Leaders, Opens Membership to Drive AI Connectivity Standards appeared first on HPCwire.

A black bear with a sweet tooth visited the front porch of a Connecticut home to raid a bowl of Halloween candy and steal a pumpkin.

What if AI could bring the past to life? Cartoonist Amy Kurzweil shares how she helped train an AI chatbot on her late grandfather’s archives, allowing her to connect with a family member she never met — and discover family history she never knew. Backed by her own original drawings, she reveals the profound impact art and AI can have in keeping memories alive.

The rocky shift to remote learning has exacerbated inequities for the nation's 5 million English-learners. An army of multilingual liaisons work round the clock to plug widening gaps.

The switch to remote learning in rural New Mexico has left some students profoundly isolated—cut off from others and the grid by sheer distance.

A statewide survey of educators in Tennessee provides critical insights into connections that exist between standards, curriculum, professional development, and ultimately student success.

The U.S. Department of Education's office for civil rights says that Connecticut's interscholastic sports governing body violates Title IX with its transgender participation policy.

A federal judge dismissed most claims in a lawsuit challenging Connecticut's restrictions on magnet schools, charter schools, and school choice programs, saying there is no fundamental right to equal education opportunity under the U.S. Constitution.

Gov. Rell this month unveiled a revised budget that represents an increase of $114.4 million over last year’s K-12 allocation.

The state's highest court allowed some claims brought on behalf of relatives of victims of the 2012 mass shooting at Sandy Hook Elementary School to proceed against the firearms industry.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

Gov. Dannel Malloy will seek to dramatically adjust the way Connecticut distributes more than $4 billion of state aid, he told legislators in his annual address, as the legislature gets back to business for the 2017 session.

These tools encourage school administrators to gather as much information as possible about the students who will be entering kindergarten and the early-learning offerings in their communities.

The state, which earned a B, is one of the nation’s wealthiest and turned in strong performances in the school finance arena and in areas such as preschool and kindergarten enrollment.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

The rocky shift to remote learning has exacerbated inequities for the nation's 5 million English-learners. An army of multilingual liaisons work round the clock to plug widening gaps.

Academic and health offerings have increased in McDowell County, W.Va., due to a private-public partnership.

The switch to remote learning in rural New Mexico has left some students profoundly isolated—cut off from others and the grid by sheer distance.

Hannah Grotzinger
May 29, 2024; 44:e1856232024-e1856232024
BehavioralSystemsCognitive

Martijn P. van den Heuvel
Nov 2, 2011; 31:15775-15786
BehavioralSystemsCognitive

Estimating the direction of functional connectivity (FC) can help further elucidate complex brain function. However, the estimation of directed FC at the voxel level in fMRI data, and evaluating its performance, has yet to be done. We therefore developed a novel directed seed-based connectivity analysis (SCA) method based on normalized pairwise Granger causality that provides greater detail and accuracy over ROI-based methods. We evaluated its performance against 145 cortical retrograde tracer injections in male and female marmosets that were used as ground truth cellular connectivity on a voxel-by-voxel basis. The receiver operating characteristic (ROC) curve was calculated for each injection, and we achieved area under the ROC curve of 0.95 for undirected and 0.942 for directed SCA in the case of high cell count threshold. This indicates that SCA can reliably estimate the strong cellular connections between voxels in fMRI data. We then used our directed SCA method to analyze the human default mode network (DMN) and found that dlPFC (dorsolateral prefrontal cortex) and temporal lobe were separated from other DMN regions, forming part of the language-network that works together with the core DMN regions. We also found that the cerebellum (Crus I-II) was strongly targeted by the posterior parietal cortices and dlPFC, but reciprocal connections were not observed. Thus, the cerebellum may not be a part of, but instead a target of, the DMN and language-network. Summarily, our novel directed SCA method, visualized with a new functional flat mapping technique, opens a new paradigm for whole-brain functional analysis.

The looming sculpture features a small camera above an eight-foot-tall screen, which displays live video from Lithuania, Poland and Ireland

Steve Lazarides' personal collection of prints, original works, handwritten press releases and burner phones sold at auction for around $1.4 million

A Whitehorse homeowner has been charged in connection with an explosion last year that destroyed his home and killed a man in a neighbouring house. 

What would you do if you'd just been dealt a devastating, extremely public defeat? If your answer is "drink wine in leggings," then Vice-President and former Democratic U.S. presidential candidate Kamala Harris can do you one better: Drink wine in leggings, sporting a messy bun, while playing Connect 4.

U.K.-based electrical connector manufacturer speeds product development with 3D mechanical design and product data management software

New Web destination lets visitors play with functionality, experience innovation, and influence product direction

An incorrect GPS coordinate leads a worship team to the end of the road, yet God has another route planned.

Teens in Europe are gathered this week to connect with Jesus and each other. A month ago, teenagers in Australia had this experience.

"How can we honour these 'mothers and fathers' [of OM]," asks David Greenlee. "Inclusion is one way, encouraging their ongoing participation, not forgetting them in our concern."

The district is reconnecting high school dropouts by focusing on life goals, academic gaps, social-emotional challenges, and personal commitments.

Despite freezing temperatures and snow, ministry with Café Hope has been both challenging and exciting for Michelle from Singapore.

Students are invited to expand their professional network and connect with businesses during the second annual Pittsburgh Connect: Penn State Student Networking Summit at the Energy Innovation Center in Pittsburgh from 11 a.m. to 3 p.m. on Monday, Nov. 25.

Faculty and staff from Penn State Lehigh Valley were among the slate of presenters and panelists at the annual Commonwealth Connections Instructor Days, a virtual event whose goal is to share strategies and tools for success in teaching.

Alumna Tanya Seyfert’s estate commitment will create scholarships for students who are affiliated with the military or who participate in work-study at the University Libraries, as well as funding urgent priorities set by Libraries leadership.

While reaching out to Turks in France, one long-term worker feels like Apostle Paul: preaching in house churches and getting kicked out of a mosque.