The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

Methods and apparatus for correlating event notifications between agents in a management network are provided. An agent constructs a network notification in response to receiving an event notification. If the received event notification is associated with a prior notification already received and stored by the agent, a correlation attribute is added to the constructed network notification. If the received notification matches a peer agent notification category that another agent in the management network is interested in receiving, the constructed network notification is sent to the other agent.

A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof:Z(Y-Triazole-CH2—X—CH2—(FP)n)m (Formula 1), wherein Z is a magnetic particle smaller than 1 mm; n and m are independently integers; Y includes a first linker having an alkyl and/or aryl linked to the magnetic particle; X is CH2 or a heteroatom; FP is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the magnetic particle through the Y-Triazole-CH2—X—CH2 linker; and one or more monomeric units each including a second structure derived from a second norbornene compound, where one of the monomeric units is linked to the first structure through a saturated or unsaturated alkyl, each monomeric unit includes a functional group capable of binding with another substance.

An ion conducting membrane for fuel cells involves coupling a compound having a sulfonic acid group with a polymeric backbone. Each of the compounds having a sulfonic acid group and the polymeric backbone are first functionalized with a halogen.

An instrument is configured to receive a staple cartridge to staple tissue and expel a fluid from within a container in the staple cartridge. The staple cartridge has an upper deck including staple apertures and orifices formed therein. The orifices are in fluid communication with the containers. The staple cartridge includes staple drivers having a driver body to translate a staple and a container protrusion to expel the fluid out the orifices. The fluid may be expelled while driving the staples out through the staple apertures. The container may be vertically compressible container or, in one alternative, may be a container having a channel and a sealant that is configured to be pierced as the fluid is expelled. Some configurations for the fluid include a hemostatic agent, thrombin, a gel, or a medicament. The containers may also be formed as reservoirs defined within the upper deck and/or cartridge body.

A system and method for controlling an application of a friction modifying agent to an area of contact between a railway wheel and a railway rail over which the wheel is traversing to selectively modify the coefficient of friction at the contact area. A sensor is used for detecting a parameter relating to the operation of the railway train. A controller is responsive to the sensor for selecting one or more of a plurality of friction modifying agents and controls the application of the agent to the rail as a function of the parameter. An applicator is responsive to the controller and applies the friction modifying agent to the area of contact between the railway wheel and rail. A second application of the agent may be predicated upon the effectiveness of a first application of the agent. The selection of the appropriate agent may include a consideration of a current location of the railway vehicle.

Disclosed are apparatus and method for decontaminating and sterilizing chemical and biological agents, which can efficiently decontaminate and sterilize high precision electronic devices, communication devices, computers or inside of vehicles and air planes contaminated with chemical and biological agent by using mixture of non-thermal atmospheric pressure air plasma and oxidizing peroxide vapor. The apparatus according to the present invention comprises a decontamination and sterilization chamber 10; a first fluid supplying line L1 and a second fluid supplying line L2, which are installed in the form of closed circuit between the inlet 11 and outlet 12 of the decontamination and sterilization chamber 10; a peroxide vapor supplier which is installed on the first fluid supplying line; and a non-thermal atmospheric pressure air plasma reactor 70 which is installed on the second fluid supplying line L2.

The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

An apparatus for safety-compliant emptying and filling of a reagent container (24, 40) for a tissue processor (20) comprises a suction line (30, 42) for aspirating a reagent out of the reagent container (24, 40) and a delivery line (32, 44) for filling the reagent container (24, 40) with the reagent, a terminating opening (31, 43) of the suction line (30, 42) being spaced away from a terminating opening (33, 45) of the delivery line (32, 44).

An exemplary embodiment provides a cardanol-modified silane coupling agent, which can improve strength and toughness by improving adhesion at an interface between a filler and a cellulose resin when being used as a surface-treatment agent, a resin additive, or the like; a cardanol-modified filler subjected to a surface treatment with the cardanol-modified silane coupling agent; and a cellulose resin composition having excellent toughness. More specifically, the exemplary embodiment provides a cardanol-modified silane coupling agent obtained by reacting cardanol or a derivative thereof with an epoxy silane coupling agent or an isocyanate silane coupling agent; a cardanol-modified filler obtained by subjecting a filler to a surface treatment with the cardanol-modified silane coupling agent; a cellulose resin composition comprising the cardanol-modified filler and a cellulose resin; and a cellulose resin composition comprising the cardanol-modified silane coupling agent, a filler and a cellulose resin.

A highly alkalized humic and fulvic filter reagent for the removal of multiple contaminants from a gas is provided. The contaminants removed from the gas stream may include, but are not limited to, Carbon Dioxide, Sulfur Oxide, Nitrogen Oxides, Hydrogen Sulfides, radionuclides, mercaptans, ammonia, toxic metals, particulates, volatile vapors, and organics. The present invention further includes the disposal of the filter reagent by way of using the highly alkalized humic and fulvic filter for soil fertility, releasing the carbon dioxide from the filter reagent, converting the liquid filter reagent into a solid for disposal or for use as a contaminant removal filter for waters, wastes, and chemicals.

Disclosed is a water and oil resistant agent comprising a fluorine-containing copolymer obtained by copolymerizing a (meth)acrylate monomer having a polyfluoroalkyl group having 1 to 6 carbon atoms, the agent being able to afford a superior water and oil resistance to a paper. The invention also discloses a composition comprising the water and oil resistant agent, a process for treating a paper thereby and a treated paper thereby.

Resin systems and methods for making and using same are provided. The method for making a paper product can include contacting a plurality of pulp fibers with a resin system. The resin system can include a first polyamidoamine-epihalohydrin resin and a second resin that can include a second polyamidoamine-epihalohydrin resin, a urea-formaldehyde resin, or a mixture thereof to produce a paper product. The first resin and the second resin can be sequentially or simultaneously contacted with the plurality of pulp fibers. The period for sequential addition between the first resin and the second resin is about 1 second to about 1 hour.

[Object] To provide an anti-soiling agent compound that can sufficiently prevents adhesion of pitch to a dry part region. [Solution] The present invention provides an anti-soiling agent composition for preventing pitch contamination in a dry part of a paper-making process, and the composition has a polysiloxane compound represented by the following formula (1), wherein the number of amino-modified groups per molecule of the polysiloxane compound is in a range from 0.5 to 5.[wherein, a substituent R1 represents a methyl group or an amino-modified group represented by the following formula (2), and the number n of repeating siloxane units represents an integer in a range from 50 to 1000, andwherein, each of a substituent R2 and a substituent R3 independently represents an alkylene group having carbon atoms of 1 to 6, and the number m of repeating amino-alkylene units represents an integer in a range from 0 to 2].

A dishwasher includes a shiftable rack provided with a washing agent dispersal system including a housing into which washing fluid is delivered. When the rack is shifted to a retracted position within a tub of the dishwasher, a tube feed system is employed to selectively distribute washing fluid from a pump assembly to each of multiple spray arms, the housing of the washing agent dispersal system and an auxiliary spray unit carried by the upper rack.

The present invention includes a novel method capable of identifying a compound as an imaging agent using a DAZAX-based scaffold or derivative thereof. The present invention further includes novel imaging agents. The present invention further includes a method of modifying a DAZAX-based scaffold or derivative thereof. The present invention further includes a method for imaging a sample.

A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents; and related methods.

Provided is a method of decreasing blood sugar level or preventing and/or treating a hyperglycemia-related disease, including administering an anti-Ang2 antibody or an antigen-biding fragment thereof to a subject in need thereof.

Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

The invention relates to polynucleotide agents targeting the complement component C5 gene, and methods of using such polynucleotide agents to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.

The present invention is directed to an explosive composition comprised of heavy ANFO and expanded polymeric beads that have a density that is less than the density of the heavy ANFO. The expanded polymeric beads have a size that is determined or based on the size of ammonium nitrate prills used in the heavy ANFO portion of the composition. In one embodiment, the expanded polymeric beads that are utilized in the composition are at least 70% of the lower limit of the mesh size of the predominant ammonium nitrate prill mesh size. In another embodiment, the expanded polymeric beads are at least 70% of the a size that is related to the average mesh size of the ammonium nitrate prills.

An aqueous dispersion for use as a finishing agent for textiles, wherein the dispersion contains a pyrogenically produced, aggregated silicon dioxide powder and a cationic polymer which is soluble in the dispersion, wherein the cationic polymer is present in a quantity such that the particles of the silicon dioxide powder exhibit a positive zeta potential.

The present document describes methods of use of photo activated compositions for oral disinfection and/or treatments which comprise at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmacologically acceptable carrier.

The present invention relates to oral and dental care and cleaning agents comprising an aqueous dispersion of a phosphate-containing and/or phosphonate-containing polyurethane polymer and anionic surfactant(s), to tooth cleaning methods using these agents, and to the use of oral and dental care and cleaning agents comprising an aqueous dispersion of a phosphate-containing and/or phosphonate-containing polyurethane polymer and anionic surfactant(s) to reduce the restaining of teeth and/or to reduce biofilm development on dental surfaces and/or to reduce the adhesion of bacteria to dental surfaces and/or to extend the antibacterial action of antibacterial substances.

A fabric cleaning composition comprising from 1% to 20% by weight of the fabric cleaning composition of an oxygen-based bleaching source and a hueing agent, and wherein the neat composition has a pH between 2.5 and 5.5, and a method of using said fabric cleaning composition.

The present disclosure therefore relates to a method for lightening keratin materials, in which the following are used: (a) a direct emulsion (A) comprising at least one fatty substance in an amount greater than 25% by weight, such as greater than 50%, at least one surfactant; at least one alkaline agent and an amount of water greater than 5% by weight, of the total weight of the emulsion, (b) a composition (B) comprising at least one oxidizing agent. It also relates to a multi-compartment device comprising, in one compartment, an emulsion (A), in another compartment a composition (B) comprising at least one oxidizing agent.

The present application provides preparations for changing the color of keratinic fibers, containing in a cosmetically acceptable carrier, at least one color-changing agent, at least one soap, at least one non-ionic surfactant of formula (I), in which R1 denotes an alkyl or alkenyl residue having 5 to 21 carbon atoms, R2 denotes a C2-C4 monohydroxyalkyl residue, and R3 denotes hydrogen, a C1-C4 alkyl residue or a C2-C4 monohydroxyalkyl residue, and at least one propellant wherein the preparation is in the form of a foam, and a proportion of gas in the foam is at least 50% by volume.

A processing agent containing five specified kinds of components including esters and ethers as required components is used in the production or fabrication process of synthetic fibers such that superior spinning property is maintained and synthetic fibers with superior yarn quality and dyeing property can be obtained. Aqueous liquids of such processing agents, processing methods using such liquids and synthetic fibers obtained by such methods are also presented.

Certain novel formulations of plant growth media additives that act in such a manner as to permit proper amounts of moisture to contact root systems in order to reduce hydrophobicity within said media. The inventive formulation comprising multi-branched surfactant compounds with both hydrophobic and hydrophilic constituents within each branch attached to a polyfunctional base compound permit effective moisture penetration through plant growth media for sustained seedling and plant growth therein. Such multi-branched wetting agents provide sustained moisture penetration over a sustained period of time, since the individual branches of such compounds may become dissociated from its base polyfunctional compound. Since such branches include both hydrophobic and hydrophilic constituents themselves, and thus act as wetting agents, even after degradation of the initial surfactant compound, repeated wetting and moisture penetration, at least, are permitted. Methods of treating plant growth media with such compounds and formulations thereof are also contemplated within this invention.

A process for producing granules containing one or more complexing agent salts of the general formula from an aqueous starting solution, containing the one or more complexing agent salts in a concentration of from 10 to 80% by weight, based on the total weight of the aqueous starting solution, in a jet apparatus.

To provide a liquid crystal display device, in which the vertical alignment property of the liquid crystal is high, favorable transparency when no voltage is applied and favorable scattering property when a voltage is applied are achieved, and the adhesion between the liquid crystal layer and the vertical liquid crystal alignment film is high. A liquid crystal display device, which comprises a liquid crystal layer formed by disposing a liquid crystal composition containing a polymerizable compound which undergoes a polymerization reaction by ultraviolet rays, between a pair of substrates provided with an electrode, and irradiating the liquid crystal composition with ultraviolet rays and curing it in such a state that the liquid crystal composition partly or entirely shows liquid crystallinity, and at least one of the substrates being provided with a liquid crystal alignment film to vertically align a liquid crystal, wherein the liquid crystal alignment film is a liquid crystal alignment film obtained from a liquid crystal aligning agent containing a polymer having a first side chain structure and a second side chain structure.

A wax composition comprising various waxes and an organically modified polysiloxane (OMP). These materials are mixed and melted into a homogenous liquid state creating a molten blend. It is preferred that the slip agent be added to the blend at least 0.25 percent by weight, and more preferably at 0.50 percent by weight. By mixing OMP with known candle and wax potpourri waxes, the wax becomes much easier to remove from the wax container.

Methods and systems are provided for disinfecting water mains using ultraviolet (UV) light and advanced oxidation processes. One or more UV light sources are provided and secured to a movable device that moves axially in a pipe. The frequency and intensity of the UV light is determined based on characteristics of the pipe, such as its material and size. The rate at which the movable device moves through the pipe is also determined so that the interior surface of the pipe is properly disinfected. The movable device is remotely caused to move through the pipe. An oxidant supply component having a dispensing portion dispenses an oxidizing agent into the pipe. A portion of the emitted UV light may convert the dispensed oxidizing agent into additional oxidizing agents that further disinfect the pipe.

Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×104-fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

Provided are a detection agent for detecting hydroxy vitamin D, preparation method thereof, and use thereof in 25-hydroxy vitamin D immunological detection. The detection agent comprises a conjugate formed by a 25-hydroxy vitamin D antigen derivative and protein carrier, and magnetic spheres coated by the conjugate. Also provided is a 25-hydroxy vitamin D detection kit comprising the detection agent.

Copyright 2018 NPR. To see more, visit SCOTT SIMON, HOST: Finally, time for sports. (SOUNDBITE OF MUSIC) SIMON: The NFL suddenly powered by free agents. Are the Pats running out of gas? And the return of the Tiger (imitating tiger roar). Joined now by NPR sports correspondent Tom Goldman, who's somewhere in Minnesota - actually, Minneapolis. He's pretty easy to find. Tom, thanks so much for being with us. TOM GOLDMAN, BYLINE: Always a pleasure, Scott. How are you? SIMON: I'm fine, thanks. A little over three weeks into the season. Free agents are getting contracts. Among them, let me ask you about safety Eric Reid. This was kind of a surprise, yes. GOLDMAN: Sure is. And it is not just any free agent signing. Eric Reid, former San Francisco teammate of Colin Kaepernick's. He followed Kaepernick's lead and was the second player to take a knee during the national anthem protests. And he also filed a collusion grievance against the NFL, like Kaepernick, after he wasn't signed as a free

Dominick Polifrone, an undercover agent who worked at both the local and federal levels (for agencies such as the Attorney General's office and the ATF), calls in to talk with Joey Diaz and Lee Syatt about how Polifrone gained the trust of and eventually took down "The Iceman," one of the most notorious and feared serial killers and hitmen in history.

Steinberg has announced the immediate availability of the Marco Minnemann Studio Drums expansion pack for Groove Agent. With over 4 GB of samples and 12 MIDI styles that were recorded and played in his studio in Los Angeles, Marco Minnemann Studio Drums features his 19-piece DW Purpleheart wood kit, comprising one kick drum, two snares, […]

The post Steinberg releases Marco Minnemann Studio Drums for Groove Agent appeared first on rekkerd.org.

ROME, April 27 -- Dissatisfied with the results of a joint investigation with the United States, Italy on Wednesday began its own probe into the March 4 killing of one of its intelligence agents by U.S. troops in Baghdad.

Be cautious handling — and mixing — cleaning supplies, read labels and follow directions. Many of the accidental, and potentially dangerous, recent exposures reported to the Washington Poison Center have been from ordinary household cleaning supplies or the combination of them.

The Seahawks on Monday filled out their roster by announcing the official signing of 12 more undrafted rookie free agents while waiving four veterans.

Marshawn Lynch opened the door wide Monday for a potential return in 2020 when he talked tantalizingly about what his agent has been up to.

On a busy day of transactions, the Storm traded guard Kaleena Mosqueda-Lewis on Monday hours after signing free-agent guard Epiphanny Prince. Seattle sent Mosqueda-Lewis to Connecticut for a 2021 second-round WNBA draft pick. The five-year veteran was selected at No. 3 overall by the Storm in the 2015 draft.  She averaged 5.3 points, 1.1 rebounds […]

The King's grad is a finalist for the Julius Erving small forward of the year award.

The Seahawks on Monday filled out their roster by announcing the official signing of 12 more undrafted rookie free agents while waiving four veterans.

Marshawn Lynch opened the door wide Monday for a potential return in 2020 when he talked tantalizingly about what his agent has been up to.