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2025 Luis J. Alvarez and Admiral Grace M. Hopper Postdoc Fellowship in Computing Sciences

2025 Luis J. Alvarez and Admiral Grace M. Hopper Postdoc Fellowship in Computing Sciences - 102564 Division: AC-Computing Luis J. Alvarez Postdoctoral Fellowship and Admiral Grace M. Hopper Postdoctoral Fellowship in Computing Sciences The Computing Sciences Area (https://cs.lbl.gov/) at Lawrence Berkeley National Laboratory (https://www.lbl.gov) is now accepting applications for two distinguished postdoctoral fellowships in Computing Sciences: • Luis W. Alvarez Postdoctoral Fellowship, and • Admiral Grace M. Hopper Postdoctoral Fellowship. Researchers in computer science, mathematics, data science, or any computational science discipline who have received their Ph.D. no earlier than January 1, 2022 but no later than September 30, 2025 are encouraged to apply. Only one (1) application is needed and it will be considered for both postdoctoral fellowships. The successful candidates will participate in research activities in computer science, mathematics, data science, or any computational science discipline of interest to the Computing Sciences Area and Berkeley Lab. Alvarez Fellows apply advances in computer science, mathematics, computational science, data science, machine learning or AI to computational modeling, simulations, and advanced data analytics for scientific discovery in materials science, biology, astronomy, environmental science, energy, particle physics, genomics, and other scientific domains. Hopper Fellows concentrate on the development and optimization of scientific and engineering applications leveraging high-speed network capability provided by the Energy Sciences Network or run on next-generation high performance computing and data systems hosted by the National Energy Research Scientific Computing Center at Berkeley Lab. Since its founding in 2002, Berkeley Lab’s Luis W. Alvarez Postdoctoral Fellowship (go.lbl.gov/alvarez) has cultivated exceptional early career scientists who have gone on to make outstanding contributions to computer science, mathematics, data science, and computational sciences. The Admiral Grace Hopper Postdoctoral Fellowship (go.lbl.gov/hopper) was first awarded in 2015 with the goal of enabling early career scientists to make outstanding contributions in computer science and high performance computing (HPC) research. About Computing Sciences at Berkeley Lab: Whether running extreme-scale simulations on a supercomputer or applying machine-learning or data analysis to massive datasets, scientists today rely on advances in and integration across applied mathematics, computer science, and computational science, as well as large-scale computing and networking facilities, to increase our understanding of ourselves, our planet, and our universe. Berkeley Labs Computing Sciences Area researches, develops, and deploys new tools and technologies to meet these needs and to advance research in our core capabilities of applied mathematics, computer science, data science, and computational science. In addition to fundamental advances in our core capabilities, we impact such areas as astrophysics and cosmology, accelerator physics, chemical science and materials science, combustion, fusion energy, nuclear physics, biology, climate change, and HPC systems and network technology. Research areas in Computing Sciences include but are not limited to: • Developing scientific applications and software technologies for extreme-scale and energy-efficient • Developing mathematical modeling for complex scientific problems • Designing algorithms to improve the performance of scientific applications • Researching digital and post-digital computer architectures for science • Developing and advancing extreme-scale scientific data management, analysis, and visualization • Developing and advancing next-generation machine learning, AI, and data science approaches for science • Advancing quantum computing and networking technologies, software, algorithms and applications • Evaluating or developing new and promising HPC systems and networking technologies • Researching methods to control and manage next-generation networks • Managing scientific data and workflows in distributed environments Qualifications: • Requires a Ph.D. in computer science, mathematics, computational science, or related discipline. • Candidates must have no more than 3 years of Postdoctoral Researcher or similar experience. • Expertise with advanced algorithms, software techniques, HPC systems and/or networking in a related research field. • Demonstrated creativity and the ability to perform independent research. • Demonstrated excellence in a related research field. • Ability to develop new cross-disciplinary partnerships that use advanced computational and/or mathematical techniques to produce unique lab capabilities. • Excellent communication skills with the ability to facilitate communications and collaborations with internal and external stakeholders. Additional Desired Qualifications: • Knowledge of advanced computing and high-performance computing. Application Process: 1. As part of your application process, you must upload and submit the following materials with your online application. 1. Cover letter 2. CV, with publication list included 3. Research Statement (no more than five (5) pages in length when printed using standard letter-size (8.5 inch x 11 inch) paper with 1-inch margins (top, bottom, left, and right) and a font size not smaller than 11 point; figures and references cited, if included, must fit within the five-page limit) 4. Contact information (name, affiliation, and email address) of at least three (3) individuals who will be able to provide letters of reference. 2. Application deadline: October 31, 2024. * It is highly advisable that you have all the required application materials and information ready and available prior to completing and submitting your application. Your application will not be considered complete if any of the above information is missing. Tentative Application Timeline: The Computing Sciences Fellowship Selection Committee is made up of a diverse representation of scientists and engineers across Berkeley Lab’s Computing Sciences Area who will conduct a thorough review of all applications received. • Application deadline: October 31, 2024 • Review and Selection: October 2024 - December 2024 • Decisions made: January/February 2025 Want to learn more about working at Berkeley Lab? Please visit: careers.lbl.gov How To Apply Apply directly online at http://50.73.55.13/counter.php?id=290341 and follow the on-line instructions to complete the application process. Berkeley Lab is committed to inclusion, diversity, equity and accessibility and strives to continue building community with these shared values and commitments. Berkeley Lab is an Equal Opportunity and Affirmative Action Employer. We heartily welcome applications from women, minorities, veterans, and all who would contribute to the Labs mission of leading scientific discovery, inclusion, and professionalism. In support of our diverse global community, all qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Equal Opportunity and IDEA Information Links: Know your rights, click here (http://www.dol.gov/ofccp/regs/compliance/posters/ofccpost.htm) for the supplement: Equal Employment Opportunity is the Law and the Pay Transparency Nondiscrimination Provision (https://www.dol.gov/sites/dolgov/files/ofccp/pdf/pay-transp_%20English_formattedESQA508c.pdf) under 41 CFR 60-1.4.




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HPC System Administrator

HPC System Administrator University of California Los Angeles Budgeted Pay Scale: Full Salary Range: USD $76,200.00/Yr. - USD $158,800.00/Yr. Department Summary UCLAs Office of Advanced Research Computing (OARC) melds expert staff and technical infrastructure to amplify and accelerate the impact of UCLA research in the age of networked data and computation. OARC expertise and resources are available to all UCLA researchers, who are engaged in digital research and scholarship. We work with faculty, student, and postdoctoral researchers; instructors; and staff and administrators. OARC is a relationship-building organization. We enable digital scholarship through collaborations, partnerships, and networked communities to advance cutting-edge research capabilities at UCLA and beyond. OARC supports and enhances the university mission of education, research, and service through the development and execution of innovative and sustainable technology practices, programs, services, infrastructure, policies, and partnerships. Position Summary HPC System Administrator UCLAs Office of Advanced Research Computing (OARC) supports and enhances the university mission of education, research, and service through the development and execution of innovative and sustainable technology practices, programs, services, infrastructure, policies, and partnerships. The OARC High Performance Computing (HPC) Systems Research Technology Group (RTG) supports thousands of UCLA researchers and over 300 research groups through consultation and the operation of the Hoffman2 High Performance Research Cluster. More information on the Hoffman2 cluster may be found at Hoffman2 Cluster Documentation The Hoffman2 cluster environment consists of approximately 1000 compute nodes, GPU nodes, high speed networking, high-performance storage, backup equipment, and extensive hardware and software support infrastructure, spread across multiple data centers. The HPC System Administrator, as part of the HPC team, will serve as a technical expert supporting OARCs HPC environment in the areas of systems and application software development, HPC cluster system administration and management of the backup system environment. Requires the ability to work from UCLAs Westwood campus as operational demands dictate. FlexWork / hybrid schedules will be considered based on work demands and operational needs. Salary & Compensation *UCLA provides a full pay range. Actual salary offers consider factors, including budget, prior experience, skills, knowledge, abilities, education, licensure and certifications, and other business considerations. Salary offers at the top of the range are not common. Visit https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html to discover benefits that start on day one, and https://ucnet.universityofcalifornia.edu/compensation-and-benefits/total-compensation-calculator.html to calculate the total compensation value with benefits. Qualifications • 3 years Experience with software and applications development, Linux system administration, and two or more modern programming languages (e.g. Python, C++, Java). (Required) • Expert knowledge of Python, SQL, bash, git, and associated build systems, libraries, and development tools. Demonstrated knowledge of common programming paradigms (e.g., asynchronous, concurrent, and object-oriented). Demonstrated ability to create high-quality system tools and software. (Required) • Ability to work independently or in a development team, and effectively estimate time and effort required to complete tasks. Ability to analyze, benchmark, debug, and test software in a technically sound manner and to generate clear, readable reports and summaries. (Required) • Demonstrated working knowledge of HPC cluster architectures and concepts (e.g., provisioning, benchmarking, scalability, and parallelizing code) and ability to stay current with industry best practices. (Required) • Detailed knowledge of Red Hat Enterprise Linux and related distributions. Solid system administration skills including scripting, pipelines, and UNIX operating system fundamentals. (Required) • Working knowledge of protocols, applications, and formats including, but not limited to, TCP/IP, HTTP, DHCP, SSH, NFS, JSON, XML, and HTML. (Required) • Demonstrated ability to troubleshoot and debug computing problems including, corrupted data, file management, application software, and operating system problems. Accurately, and independently respond to production problems in multiple complex operating systems and software components. (Required) • Knowledge of validation, verification, and disaster recovery capabilities for both hardware and software. (Required) • Demonstrated skill in writing well-organized, complete, and technically and grammatically correct documents and procedures to be used by technical and non-technical personnel of diverse backgrounds at various levels in the organization, including researchers, peers, and management. (Required) • Demonstrated oral communication and presentation skills sufficient to effectively obtain and impart technical information and explain concepts on a one-to-one basis as well as in meetings with or presentations to multiple clients. (Required) • Demonstrated problem-solving skills and the ability to break down and define complex problems, formulate solutions, identify cause and effect relationships, make appropriate decisions, and communicate concepts clearly and appropriately with researchers and peers. (Required) • Ability to prioritize tasks, prepare project plans, schedules, effectively manage projects in areas of responsibility, complete tasks, projects in a timely manner. Work effectively both independently and as part of a team, follow through follow through on assignments with minimal direction. (Required) • Demonstrated skill in establishing and maintaining cooperative working relationships with staff, students, and vendors. Ability to communicate and interact effectively with persons of diverse backgrounds. (Required) Education, Licenses, Certifications & Personal Affiliations • Bachelors Degree Bachelors degree in computer science, software engineering, or a related field. (Required) And • Masters Degree Masters degree in computer science, software engineering or a related field . (Preferred) Special Conditions for Employment • Background Check: Continued employment is contingent upon the completion of a satisfactory background investigation. • Live Scan Background Check: A Live Scan background check must be completed prior to the start of employment. • COVID and Flu Vaccinations: The position is subject to providing evidence of inoculation. Schedule 8:00 am to 5:00 pm Union/Policy Covered 99-Policy Covered To apply, please visit: https://apptrkr.com/5770145 Application Deadline: 8:50 p.m. on Copyright ©2024 Jobelephant.com Inc. All rights reserved. https://www.jobelephant.com/




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Go (Mountain) West, Quantum Workers! CU, CUbit, and Elevate Quantum Issue Workforce Roadmap

Last week the University of Colorado (Boulder), the CUbit Quantum Initiative, and the Elevate Quantum consortium released workforce roadmap for educating and building a quantum workforce. “This roadmap provides a […]

The post Go (Mountain) West, Quantum Workers! CU, CUbit, and Elevate Quantum Issue Workforce Roadmap appeared first on HPCwire.




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An Admired Personality Trait Linked To Higher Suicide Risk

This positive personality trait linked to more suicidal thoughts and suicide itself.




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Selective Virginia Public High School to Drop Standardized Admissions Test

Thomas Jefferson High School for Science and Technology will see a new test-free admissions process by November, district leaders say.




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Report finds Loudoun school's admission policy discriminates




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Intracranially Administered Anti-A{beta} Antibodies Reduce {beta}-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

Donna M. Wilcock
May 1, 2003; 23:3745-3751
Development Plasticity Repair




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Wrongfully Admitted to Sunbury Asylum

In 1945, Maraquita Sargeant was admitted to a mental institution in Australia against her will and remained their for 22 years - produced by Matt Cleaves and George Clipp




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Admire the World's Largest Collection of Fossilized Poop at the New 'Poozeum' in Arizona

Owner George Frandsen has some 8,000 coprolites from dinosaurs, sharks and other creatures




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Watch Vampire Bats Run on a Tiny Treadmill to Shed Light on Their Blood-Fueled Metabolism

In a rare technique among mammals, the bats burn proteins from blood, rather than carbs or fat, to power their pursuits of prey, according to a new study




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Education Programs Would Be Spared Under Trump Administration's Green Card Proposal

While the Trump administration proposal would not strip student eligibility for Head Start, the federal school lunch program, or the Individual with Disabilities Education Act, it could still affect millions of school-aged children who live with immigrant parents.




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A Roadmap for Reparations in Education

Breaking the cycle of institutional racism includes a quality education for Black students, writes Khalilah M. Harris. Here’s how that could look.




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Yes, Colleges Can Rescind Admission Offers. Here's What Educators Need to Know

In a recent high-profile case, Harvard College rescinded its offer to a school-shooting survivor after racist comments he’d written online surfaced. But how common is it for colleges to take back offers? And do students have any recourse?




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Special Ed. Administrators Press Congress for IDEA Waivers During Pandemic

The requests put the nation's special education administrators in conflict with disability rights advocates who fear waivers will place millions of special education students at risk.




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WATCH: Harris cheered on by administration staff as she arrives at the White House

Vice President Kamala Harris received a grand welcome to the White House on Tuesday afternoon — cheered on by hundreds of administration staff as her SUV pulled up to the West Wing.




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Iran Open To Talks With Trump Administration If Interests Align

Iran will pursue whatever secures its interest, government spokesperson Fatemeh Mohajerani said on Tuesday, when asked if there could be direct talks with the Trump administration.




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TV Actor Amit Tandon Admits He Cheated On His Wife Ruby: "I Let My Impulses Get The Better Of Me"

Amit said, "In that moment, I let parts of my past carry forward"




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Jennings announces settlement with Universal Health Services regarding allegations of improper admissions, discharges

Attorney General Kathy Jennings announced Friday that Universal Health Services, Inc. (“UHS, Inc.”) and a subsidiary of UHS, Inc., UHS of Delaware, Inc., have agreed to a settlement of which $34,338.73 will go to the Division of Medicaid and Medicaid Assistance (DMMA) within the Delaware Department of Health and Social Services (DHSS). “We expect all […]



  • Department of Justice
  • Department of Justice Press Releases
  • News

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Attorney General Jennings Fights Trump Administration’s Attempts to Reduce Census Efforts

Suit comes at a time when Delaware response rates are lagging. Attorney General Kathy Jennings has joined a large coalition of attorneys general, cities, counties, and the bipartisan U.S. Conference of Mayors in taking legal action against the Trump Administration’s impairment of the 2020 Decennial Census. The coalition filed an amicus brief in National Urban League v. […]



  • Department of Justice
  • Department of Justice Press Releases
  • News

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High Court Upholds Privacy, Declines Admission Of Illegally Recorded Phone Conversation As Evidence In Matrimonial Dispute




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DHSS Anuncia Organizaciones Seleccionadas para Operar el Programa de Atención Administrada de Medicaid

NEW CASTLE (Julio 12, 2022) – El Departamento de Salud y Servicios Sociales (DHSS) anunció hoy que ha seleccionado tres compañias para operar su Programa de Atención Administrada de Medicaid. La División de Medicaid y Asistencia Médica (DMMA) del DHSS continuará su asociación de MCO con Highmark Health Options Blue Cross Blue Shield, que empezó […]




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Mark Short Named Administrator of Delaware Standardbred Breeders’ Fund

The Delaware Department of Agriculture announced today that Mark Short has been named the new Delaware Standardbred Breeders’ Fund (DESBF) administrator. He will begin his new role as the DESBF administrator on November 1.




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Carney Administration Prioritizes Farmland Preservation, Preserving Highest Number of Farms

The Delaware Department of Agriculture announced the 28th round of easement selections by the Delaware Agricultural Lands Preservation, preserving 40 farms and 2,262 acres of farmland. With this announcement, the Carney administration has preserved 403 farms, the highest number in the program’s history.




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Opioid Fund Co-Chairs Release Roadmap to Recalibrate Use of Settlement Funds

WILMINGTON, Del. – As the first year of grantmaking comes to a close, Co-Chairs Attorney General Kathy Jennings and Lt. Governor Bethany Hall-Long shared the results of the third-party report from independent contractor Social Contract with recommendations to maximize the impact of the governing body overseeing Delaware’s opioid settlement funds.     The report, Enhancing Use […]




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Carney Administration Outlines Investments in Electric Vehicle Infrastructure

DOVER, Del. – Governor Carney joined Lieutenant Governor Bethany Hall-Long, Department of Transportation Secretary Nicole Majeski, Department of Natural Resources and Environmental Control Secretary Shawn Garvin, elected officials and advocates on Friday afternoon to outline investments in the state’s electric vehicle infrastructure. With a combination of state and federal funding, charging stations for electric vehicles will be […]



  • Department of Natural Resources and Environmental Control
  • Department of Transportation
  • Governor John Carney
  • News
  • Office of the Governor
  • Bipartisan Infrastructure Law
  • electric vehicles
  • National Electrical Vehicle Infrastructure

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5200 Board of Examiners of Nursing Home Administrators

DEPARTMENT OF STATE: Division of Professional Regulation




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Biden Administration Faces Daunting Task of Rebuilding US Economic Diplomacy

Biden Administration Faces Daunting Task of Rebuilding US Economic Diplomacy Biden Administration Faces Daunting Task of Rebuilding US Economic Diplomacy
ferrard Wed, 12/09/2020 - 14:49

East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

Explore

East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

Explore




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South Sudan: Alarming Spike in Admissions of Children With Malaria At Aweil State Hospital

[MSF] An alarming number of children suffering from severe malaria have been admitted to Aweil state hospital, where Médecins Sans Frontières (MSF) runs the paediatric and maternity wards, in Northern Bahr El-Ghazal state, South Sudan, over the past three months. Malaria admissions to the children's ward began to increase in June and, by September, up to 400 children a week were being admitted to the paediatric department with severe malaria - more than double the numbers compared to September the




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Excess campaign funds used for drug war reward system, Duterte admits

MANILA, Philippines — The excess campaign funds of then-president Rodrigo Duterte were used for the reward system of police officers during his administration’s brutal war on drugs.  Duterte himself admitted this to Santa Rosa City Rep. Dan Fernandez during the House of Representatives quad committee during its 11th probe on his controversial anti-drug campaign.  “I still remember that you mentioned na yung pera galing sa donation ng inyong campaign funds will be utilized for the reward system, that’s private money,” Fernandez said.  (I still remember you mentioned that the money from the donation for your campaign funds would be utilized […]...

Keep on reading: Excess campaign funds used for drug war reward system, Duterte admits





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Netanyahu admits Israel behind pager attack in Lebanon

Netanyahu admits Israel behind pager attack in Lebanon




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Ariana Grande expresses admiration for 'amazing' beau Ethan Slater

Ariana Grande praises her ‘adorable’ beau Ethan SlaterAriana Grande has recently expressed her admiration for beau and adorable Wicked co-star Ethan Slater.Speaking to Entertainment Tonight at Wicked press tour in Los Angeles over the weekend, the pop star praised Ethan for his...




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Tom Brady admits “screwing up” as a father, “a lot”

Tom Brady on fatherhoood Tom Brady finds being a father the “hardest job,” one he admits he is not good at.The former NFL star accepted the fact that he didn't always give his best being a father to son Jack, 17, whom he shares with ex Bridget Moynahan, as well as son Benjamin,...




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Senior Administration and Communications Assistant

ADB has a vacancy for the position of Senior Administration and Communications Assistant in the Strategy, Policy and Partnerships Department. The deadline for submitting applications is on 26-NOV-2024.




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alm administrator guide

alm administrator guide




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bladesystem onboard administrator user guide version

bladesystem onboard administrator user guide version




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Energizing Gender Equality: A Roadmap to Inclusive Energy in Vanuatu

Outlining the energy access disparity women face in Vanuatu, this brief shows how it impacts their health and economic opportunities and explains why mainstreaming gender can increase financial inclusion and drive an equitable green transition.




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South Asia Subregional Economic Cooperation Customs Administration Reform and Modernization Project




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Vampire bats run on a treadmill to reveal their strange metabolism

Experiments where vampire bats were made to run on a treadmill have revealed how they extract energy from protein in their latest blood meal




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Vampire bats run on a treadmill to reveal their strange metabolism

Experiments where vampire bats were made to run on a treadmill have revealed how they extract energy from protein in their latest blood meal




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Readmission Rates for Children May Not Reflect Hospital Performance

Title: Readmission Rates for Children May Not Reflect Hospital Performance
Category: Health News
Created: 8/27/2013 9:35:00 AM
Last Editorial Review: 8/27/2013 12:00:00 AM




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Obama Administration Offers New Rules for Religious Objections to Health Care Law

Title: Obama Administration Offers New Rules for Religious Objections to Health Care Law
Category: Health News
Created: 8/25/2014 9:35:00 AM
Last Editorial Review: 8/25/2014 12:00:00 AM




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Hospital Admission Day Tied to Outcomes for Children With Leukemia

Title: Hospital Admission Day Tied to Outcomes for Children With Leukemia
Category: Health News
Created: 8/25/2014 4:35:00 PM
Last Editorial Review: 8/26/2014 12:00:00 AM




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Alternative Reinforcers Enhance the Effects of Opioid Antagonists, but Not Agonists, on Oxycodone Choice Self-Administration in Nonhuman Primates [Behavioral Pharmacology]

Clinical reports suggest that the most effective strategies for managing opioid use disorder comprise a comprehensive treatment program of both pharmacological and nonpharmacological approaches. However, the conditions under which these combinations are most effective are not well characterized. This study examined whether the presence of an alternative reinforcer could alter the efficacy of Food and Drug Administration–approved opioid antagonist or agonist medications, as well as the nonopioid flumazenil, in decreasing oxycodone choice self-administration in nonhuman primates. Adult squirrel monkeys (n = 7; four females) responded under concurrent second-order fixed-ratio (FR)-3(FR5:S);TO45s schedules of reinforcement for intravenous oxycodone (0.1 mg/kg) or saline on one lever and 30% sweetened condensed milk or water on the other. Doses of naltrexone (0.00032–1.0 mg/kg), nalbuphine (0.32–10 mg/kg), buprenorphine (0.0032–0.032 mg/kg), methadone (0.32–1.0 mg/kg), or flumazenil (1–3.2 mg/kg) were administered intramuscularly prior to oxycodone self-administration sessions that occurred with either milk or water as the alternative. Naltrexone, a μ-opioid receptor antagonist, was >30-fold more potent when milk was available compared with water and abolished oxycodone intake (injections/session) while concomitantly increasing milk deliveries at the highest dose tested. Pretreatment with the low-efficacy μ-agonist nalbuphine was most effective in the presence of milk compared with water, decreasing oxycodone preference to <50% of control values. The higher efficacy μ-agonists, methadone and buprenorphine, and the benzodiazepine antagonist flumazenil did not appreciably alter the reinforcing potency of oxycodone under either condition. These results suggest that antagonist medications used in combination with alternative reinforcers may be an effective strategy to curtail opioid abuse–related behaviors.

SIGNIFICANCE STATEMENT

Clinical treatment programs for opioid use disorder use a combination of pharmacological and nonpharmacological approaches. However, the conditions under which these combinations are most effective have not been fully characterized. This study examined whether the effectiveness of μ-opioid medications to decrease oxycodone self-administration is altered in the presence of an alternative reinforcer. The results suggest that alternative reinforcers enhance the effects of antagonist or low-efficacy partial agonists, suggesting they may be a more effective strategy to curtail opioid use.




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Chronic Administration of Cannabinoid Agonists ACEA, AM1241, and CP55,940 Induce Sex-Specific Differences in Tolerance and Sex Hormone Changes in a Chemotherapy-Induced Peripheral Neuropathy [Special Section: Cannabinoid Signaling in Human Health and Dise

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy treatment, routinely manifesting as increased pain sensitivity (allodynia) in distal extremities. Despite its prevalence, effective treatment options are limited. Cannabinoids are increasingly being evaluated for their ability to treat chronic pain conditions, including CIPN. While previous studies have revealed sex differences in cannabinoid-mediated antinociception in acute and chronic pain models, there is a paucity of studies addressing potential sex differences in the response of CIPN to cannabinoid treatment. Therefore, we evaluated the long-term antiallodynic efficacy of cannabinoid receptor type 1 (CB1)-selective, cannabinoid receptor type 2 (CB2)-selective, and CB1/CB2 mixed agonists in the cisplatin CIPN model, using both male and female mice. CB1 selective agonism was observed to have sex differences in the development of tolerance to antiallodynic effects, with females developing tolerance more rapidly than males, while the antiallodynic effects of selective CB2 agonism lacked tolerance development. Compound-specific changes to the female estrous cycle and female plasma estradiol levels were noted, with CB1 selective agonism decreasing plasma estradiol while CB2 selective agonism increased plasma estradiol. Chronic administration of a mixed CB1/CB2 agonist resulted in increased mRNA expression of proinflammatory cytokines and endocannabinoid regulatory enzymes in female spinal cord tissue. Ovarian tissue was noted to have proinflammatory cytokine mRNA expression following administration of a CB2 acting compound while selective CB1 agonism resulted in decreased proinflammatory cytokines and endocannabinoid regulatory enzymes in testes. These results support the need for further investigation into the role of sex and sex hormones signaling in pain and cannabinoid-mediated antinociceptive effects.

SIGNIFICANCE STATEMENT

CIPN is a common side effect of chemotherapy. We have found that both CB1 and CB2 receptor agonism produce antinociceptive effects in a cisplatin CIPN model. We observed that tolerance to CB1-mediated antinociception developed faster in females and did not develop for CB2-mediated antinociception. Additionally, we found contrasting roles for CB1/CB2 receptors in the regulation of plasma estradiol in females, with CB1 agonism attenuating estradiol and CB2 agonism enhancing estradiol. These findings support the exploration of cannabinoid agonists for CIPN.




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Best Patient Care Practices for Administering PSMA-Targeted Radiopharmaceutical Therapy

Optimal patient management protocols for metastatic castration-resistant prostate cancer (mCRPC) are poorly defined and even further complexified with new therapy approvals, such as radiopharmaceuticals. The prostate-specific membrane antigen (PSMA)–targeted agent 177Lu vipivotide tetraxetan ([177Lu]Lu-PSMA-617), approved after the phase III VISION study, presents physicians with additional aspects of patient management, including specific adverse event (AE) monitoring and management, as well as radiation safety. Drawing on our experience as VISION study investigators, here we provide guidance on best practices for delivering PSMA-targeted radiopharmaceutical therapy (RPT) to patients with mCRPC. After a comprehensive review of published evidence and guidelines on RPT management in prostate cancer, we identified educational gaps in managing the radiation safety and AEs associated with [177Lu]Lu-PSMA-617. Our results showed that providing sufficient education on AEs (e.g., fatigue and dry mouth) and radiation safety principles is key to effective delivery and management of patient expectations. Patient counseling by health care professionals, across disciplines, is a cornerstone of optimal patient management during PSMA-targeted RPT. Multidisciplinary collaboration is crucial, and physicians must adhere to radiation safety protocols and counsel patients on radiation safety considerations. Treatment with [177Lu]Lu-PSMA-617 is generally well tolerated; however, additional interventions may be required, such as dosing modification, medications, or transfusions. Urinary incontinence can be challenging in the context of radiation safety. Multidisciplinary collaboration between medical oncologists and nuclear medicine teams ensures that patients are monitored and managed safely and efficiently. In clinical practice, the benefit-to-risk ratio should always be evaluated on a case-by-case basis.




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Correction to "Validity of diagnoses of SARS-CoV-2 infection in Canadian administrative health data: a multiprovince, population-based cohort study"




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Billionaire Bill Ackman Admits Debate Conspiracy He Pushed Is Fake

Jared Siskin/Patrick McMullan via Getty

Billionaire Bill Ackman spent days after the ABC presidential debate promoting false claims that a network “whistleblower” had allegedly uncovered collusion between ABC and Kamala Harris’ campaign. Now, a month and multiple denials later, he sees the claims differently.

“It seems pretty clear that the alleged @abc whistleblower debate story claiming that @KamalaHarris was given questions in advance and other advantages was a fake,” Ackman posted on X alongside a blog post by Megyn Kelly discussing the dubious claims.

What Ackman, CEO of Pershing Square Capital Management, did not acknowledge, however, is that he was one of falsehood’s early boosters. After an X account named “Black Insurrectionist” claimed it had been in touch with a whistleblower who alleged the Harris campaign had been given debate topics ahead of the showdown with Donald Trump and had demanded Trump—and Trump alone—be fact-checked.

Read more at The Daily Beast.




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Trump Builds New Administration

Friday on the RealClearPolitics radio show -- weeknights at 6:00 p.m. on SiriusXM's POTUS Channel 124 and then on Apple, Spotify, and here on our website -- Tom Bevan, Andrew Walworth, and Carl Cannon look at the latest count to determine the final popular vote and House majority.




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Call of Duty fans hail 'packed' Season 1 roadmap with fan-favourite skin



Call of Duty fans are impressed by Black Ops 6 Season 1 already, calling it the 'best Season 1 roadmap' since 2019's Modern Warfare reboot and you can find out below why they're saying it