AMD has launched the Ryzen 7 9800X3D processor as part of the Ryzen 9000 series, promising a faster gaming experience

Long-time Slashdot reader blackbearnh writes: Since the COVID-19 pandemic has made Personal Protective Equipment worth it's weight in gold, Makers have been trying to help bridge the gap. While sewn masks have been the most common solution, the 3D printing community has been pitching in as well. The Montana Mask has been one of the most popular designs... Thursday, the group Make the Masks announced that the design files and STLs to print the mask have been released under the GNU General Public License v3, allowing anyone to print, sell, remix or improve the design, as long as they conform to the license. Importantly, the GPLv3 includes an international non-exclusive patent grant, meaning that even if the inventors decide to apply for a patent, it will not restrict anyone from using the design.

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Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

Apr. 13 - A team of self-described geeks in Taipei have taken to the streets on a bicycle equipped with a 3D printer which they're using to turn plastic waste into useful products. They call their printer the "Mobile Fab" and say it not only helps promote recycling, but also demonstrates how technology can be applied in a socially responsible way. Tara Cleary reports.

Say hello to the 3D printed Czinger 21C. It's been created by the LA-based auto maker and just 80 will be produced. Everything has been developed in-house, including a 1,233bhp drivetrain.

The two-storey 6,900 square foot structure will be used as an office for general administrative functions by the Dubai Municipality.It was designed in collaboration with Apis Cor, a 3D printing and construction company in Boston.

Following the recent demonstration of grazing-incidence X-ray fluorescence (GIXRF)-based characterization of the 3D atomic distribution of different elements and dimensional parameters of periodic nanoscale structures, this work presents a new computational scheme for the simulation of the angular-dependent fluorescence intensities from such periodic 2D and 3D nanoscale structures. The computational scheme is based on the dynamical diffraction theory in many-beam approximation, which allows a semi-analytical solution to the Sherman equation to be derived in a linear-algebraic form. The computational scheme has been used to analyze recently published GIXRF data measured on 2D Si3N4 lamellar gratings, as well as on periodically structured 3D Cr nanopillars. Both the dimensional and structural parameters of these nanostructures have been reconstructed by fitting numerical simulations to the experimental GIXRF data. Obtained results show good agreement with nominal parameters used in the manufacturing of the structures, as well as with reconstructed parameters based on the previously published finite-element-method simulations, in the case of the Si3N4 grating.

The in meso in situ serial X-ray crystallography method was developed to ease the handling of small fragile crystals of membrane proteins and for rapid data collection on hundreds of microcrystals directly in the growth medium without the need for crystal harvesting. To facilitate mounting of these in situ samples on a goniometer at cryogenic or at room temperatures, two new 3D-printed holders have been developed. They provide for cubic and sponge phase sample stability in the X-ray beam and are compatible with sample-changing robots. The holders can accommodate a variety of window material types, as well as bespoke samples for diffraction screening and data collection at conventional macromolecular crystallography beamlines. They can be used for convenient post-crystallization treatments such as ligand and heavy-atom soaking. The design, assembly and application of the holders for in situ serial crystallography are described. Files for making the holders using a 3D printer are included as supporting information.

The structural dimension of metal–organic frameworks (MOFs) is of great importance in defining their properties and thus applications. In particular, 2D layered MOFs are of considerable interest because of their useful applications, which are facilitated by unique structural features of 2D materials, such as a large number of open active sites and high surface areas. Herein, this work demonstrates a methodology for the selective synthesis of a 2D layered MOF in the presence of the competitive formation of a 3D MOF. The ratio of the reactants, metal ions and organic building blocks used during the reaction is found to be critical for the selective formation of a 2D MOF, and is associated with its chemical composition. In addition, the well defined and uniform micro-sized 2D MOF particles are successfully synthesized in the presence of an ultrasonic dispersion. Moreover, the laminated 2D MOF layers are directly synthesized via a modified bottom-up lamination method, a combination of chemical and physical stimuli, in the presence of surfactant and ultrasonication.

3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 min, but this begins to yield the α-form after only 1 min more. Both structures could be determined from continuous rotation electron diffraction data collected in less than 20 s on crystals of thickness ∼100 nm. Even though the γ-form is thermodynamically the most stable polymorph, kinetics favour the α-form, which dominates after prolonged standing. In the same sample, some β and one crystallite of the γ polymorph were also observed.

Serial crystallography has enabled the study of complex biological questions through the determination of biomolecular structures at room temperature using low X-ray doses. Furthermore, it has enabled the study of protein dynamics by the capture of atomically resolved and time-resolved molecular movies. However, the study of many biologically relevant targets is still severely hindered by high sample consumption and lengthy data-collection times. By combining serial synchrotron crystallography (SSX) with 3D printing, a new experimental platform has been created that tackles these challenges. An affordable 3D-printed, X-ray-compatible microfluidic device (3D-MiXD) is reported that allows data to be collected from protein microcrystals in a 3D flow with very high hit and indexing rates, while keeping the sample consumption low. The miniaturized 3D-MiXD can be rapidly installed into virtually any synchrotron beamline with only minimal adjustments. This efficient collection scheme in combination with its mixing geometry paves the way for recording molecular movies at synchrotrons by mixing-triggered millisecond time-resolved SSX.

Tryptophan synthase catalyzes the last two steps of tryptophan biosynthesis in plants, fungi and bacteria. It consists of two protein chains, designated α and β, encoded by trpA and trpB genes, that function as an αββα complex. Structural and functional features of tryptophan synthase have been extensively studied, explaining the roles of individual residues in the two active sites in catalysis and allosteric regulation. TrpA serves as a model for protein-folding studies. In 1969, Jackson and Yanofsky observed that the typically monomeric TrpA forms a small population of dimers. Dimerization was postulated to take place through an exchange of structural elements of the monomeric chains, a phenomenon later termed 3D domain swapping. The structural details of the TrpA dimer have remained unknown. Here, the crystal structure of the Streptococcus pneumoniae TrpA homodimer is reported, demonstrating 3D domain swapping in a TIM-barrel fold for the first time. The N-terminal domain comprising the H0–S1–H1–S2 elements is exchanged, while the hinge region corresponds to loop L2 linking strand S2 to helix H2'. The structural elements S2 and L2 carry the catalytic residues Glu52 and Asp63. As the S2 element is part of the swapped domain, the architecture of the catalytic apparatus in the dimer is recreated from two protein chains. The homodimer interface overlaps with the α–β interface of the tryptophan synthase αββα heterotetramer, suggesting that the 3D domain-swapped dimer cannot form a complex with the β subunit. In the crystal, the dimers assemble into a decamer comprising two pentameric rings.

It is shown that the 2p3d resonant inelastic X-ray scattering intensity is distorted by saturation and self-absorption effects, i.e. by incident-energy-dependent saturation and by emission-energy-dependent self-absorption.

A method for reconstructing the three-dimensional grain structure from data collected with a recently introduced laboratory-based X-ray diffraction contrast tomography system is presented. Diffraction contrast patterns are recorded in Laue-focusing geometry. The diffraction geometry exposes shape information within recorded diffraction spots. In order to yield the three-dimensional crystallographic microstructure, diffraction spots are extracted and fed into a reconstruction scheme. The scheme successively traverses and refines solution space until a reasonable reconstruction is reached. This unique reconstruction approach produces results efficiently and fast for well suited samples.

Two methods for reconstructing intragranular strain fields are developed for scanning three-dimensional X-ray diffraction (3DXRD). The methods are compared with a third approach where voxels are reconstructed independently of their neighbours [Hayashi, Setoyama & Seno (2017). Mater. Sci. Forum, 905, 157–164]. The 3D strain field of a tin grain, located within a sample of approximately 70 grains, is analysed and compared across reconstruction methods. Implicit assumptions of sub-problem independence, made in the independent voxel reconstruction method, are demonstrated to introduce bias and reduce reconstruction accuracy. It is verified that the two proposed methods remedy these problems by taking the spatial properties of the inverse problem into account. Improvements in reconstruction quality achieved by the two proposed methods are further supported by reconstructions using synthetic diffraction data.

The design and assembly of two 3D-printed holders for high-throughput in meso in situ fixed-target crystallographic data collection are described.

Using 2-dimensional and 3-dimensional CT scans, Natural History Museum anthropologists found that the brain and major organs were removed and rolls of linen filled out the abdominal cavity. This mummification method is evidence of superior embalming, indicating a person of higher status.

The post Video: A mummy ‘grows’ with CT scans and 3D digital technology appeared first on Smithsonian Insider.

The Sloan Digital Sky Survey III (SDSS-III) has released the largest three-dimensional map of massive galaxies and distant black holes ever created.

The post Largest ever 3D map of the sky released by astronomers appeared first on Smithsonian Insider.

Using new numerical simulations and observations, scientists may now be able to explain why the Sun’s magnetic field reverses every eleven years. This significant discovery […]

The post 3D simulations reveals why the Sun flips its magnetic field every 11 years appeared first on Smithsonian Insider.

Björn Eismann, Teresa G. Krieger, Jürgen Beneke, Ruben Bulkescher, Lukas Adam, Holger Erfle, Carl Herrmann, Roland Eils, and Christian Conrad

3D cell cultures enable the in vitro study of dynamic biological processes such as the cell cycle, but their use in high-throughput screens remains impractical with conventional fluorescent microscopy. Here, we present a screening workflow for the automated evaluation of mitotic phenotypes in 3D cell cultures by light-sheet microscopy. After sample preparation by a liquid handling robot, cell spheroids are imaged for 24 hours in toto with a dual-view inverted selective plane illumination microscope (diSPIM) with a much improved signal-to-noise ratio, higher imaging speed, isotropic resolution and reduced light exposure compared to a spinning disc confocal microscope. A dedicated high-content image processing pipeline implements convolutional neural network based phenotype classification. We illustrate the potential of our approach by siRNA knock-down and epigenetic modification of 28 mitotic target genes for assessing their phenotypic role in mitosis. By rendering light-sheet microscopy operational for high-throughput screening applications, this workflow enables target gene characterization or drug candidate evaluation in tissue-like 3D cell culture models.

A 3-D rendering of the Apollo 11 Command Module with a view inside the hatch. The seats inside are where astronauts Neil Armstrong, Buzz Aldrin […]

The post Apollo 11 Command Module in 3D! appeared first on Smithsonian Insider.

Click photo to take a tour of the 1903 Wright Flyer with Smithsonian X 3D Explorer. The Smithsonian X 3D Collection features objects from the […]

The post Take a 3D tour of the 1903 Wright Flyer! appeared first on Smithsonian Insider.

How 3D technology is used at the Smithsonian to create world class exhibits!

The post Smithsonian X 3D – Exhibits appeared first on Smithsonian Insider.

To mark the 47th anniversary of the Apollo 11 moon-landing mission, the Smithsonian has made available a high-resolution 3-D scan of the command module “Columbia,” […]

The post Apollo 11 Command Module in 3D appeared first on Smithsonian Insider.

When it comes time to eat, Abyssinian ground hornbills pick up prey with their beak, toss it into the air and swallow it whole. But […]

The post Building 3D prosthetic beak for Karl, a hornbill appeared first on Smithsonian Insider.

By charting the slopes and crags on animals’ teeth as if they were mountain ranges, scientists at the Smithsonian’s National Museum of Natural History have […]

The post 3D study of teeth in modern mammals opens window to extinct animal diets appeared first on Smithsonian Insider.

Björn Eismann
Apr 15, 2020; 0:jcs.245043v1-jcs.245043
TOOLS AND RESOURCES

As 3D printing, also known as additive manufacturing (AM), begins to replace conventional manufacturing, the environmental impacts of its implementation must be assessed. This study conducted a life cycle assessment (LCA) to investigate the environmental and resource implications of using AM to manufacture the metal parts of an engine in a light distribution truck. In the LCA, the impacts of both present and possible future states of AM technology were compared with current conventional manufacturing. The results suggest that there are potential environmental and resource benefits1 to AM technologies, but that these benefits rely on the achievement of a clean energy source and further technological development.

Desktop three-dimensional (3D) printers, available for use in offices and homes, can release between 20 and 200 billion ultra-fine particles (UFPs) per minute, finds new research. UFPs may pose a risk to health, and the study’s authors recommend caution when operating 3D printers inside unventilated or unfiltered indoor environments.

A nanoscale 3D printing technique could be useful for nanomanufacturing processes with environmental applications. The authors of a new study have found a way to control their printing process by incorporating a simple pattern into the printing surface. They say their technique could reduce costs for nanoscale printing.

Initial batches have been supplied in Chennai, while some were in the process of being scaled up towards mass production for use in hospitals and clinics across the country.

The post 3D-printed body parts set for surgical training ramp up appeared first on The Lead SA.

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MARS spectral X-ray scanning technology will bring unprecedented detail and versatility to doctors seeking a window into the human body.

A great pied hornbill at Jurong Bird Park developed cancer, and doctors used 3D printing to make a prosthetic casque for it.

SwimCity is a housing concept for young Swedes who don't mind donning goggles or hopping in a canoe as part of their commute.

Located in northwest London, it's the first optical illusion-y pedestrian crossing in the U.K.

Following purchases earlier this year for their Palo Alto and New York locations, Equinox has purchased a Fit3D ProScanner to enhance their E and T4 Membership offering in their Chicago location.

Over 100 participants lost upwards of 150 inches through digitally driven wellness challenge

The first one in the world for robo-delivery

FunFlicks Outdoor Movies revives anaglyphic 3d for a nationwide social media campaign and pre-movie entertainment. The largest outdoor movie company in the U.S.A. is making 3D cool again and bringing back the red and blue glasses for the kids!

Free for a Limited Time

Despite the fact that 3D printing has already become extremely popular worldwide, majority of people associate this technology with desktop 3D printers able to fabricate object with use of synthetic polymers commonly known as plastics.

Mr Killian McNabb of Wheelcare Ltd. is delighted to be fitting out one of Dublin's leading dealerships with the Ravaglioli 3D wheel alignment system.

A modular and flexible gaming system, Gridopolis's innovations allow users to change the 3D playing space during gameplay and even design their own game from scratch.

New features support enhanced driver behaviour and rating, KPI tracking and mobile vehicle allocation for service providers

Air Force Win Signals New Era for Glasses-Free 3D Display Company.