(California Court of Appeal) - Reversed and remanded to enter summary adjudication for Plaintiff as to her retaliation claim and punitive damages, but denied discrimination and harassment claims.

(California Court of Appeal) - Affirming the trail court's denial of a motion for a new trial in the case of a serially absent defendant who had secured an opportunity to have his motion heard due to the ineffective assistance of counsel upon the motion's first presentation, but when he failed to appear for the new hearing, represented by the same lawyer as previously, the court held that the lawyer's previous ineffective assistance afforded sufficient grounds for the appointment of a new lawyer, but that the trial court needn't do so unless and until the defendant requested.

(California Court of Appeal) - In a case in which a minority shareholder sued a majority shareholder, reversed and remanded with directions to reinstitute a special proceeding under Corporations Code section 2000.

(California Court of Appeal) - Affirmed order denying anti-SLAPP motion. Plaintiffs sought to assign leasehold interest in shopping center. Defendant refused to consent to assignment. Plaintiff brought suit alleging Defendant improperly withheld assignment. Defendant brought an anti-SLAPP motion which the trial court denied because the assignment request was not a settlement communication or litigation-related conduct.

(California Court of Appeal) - Affirmed. Plaintiffs, rural, privately-owned telephone companies, brought suit against Defendant, California Public Utilities Commission, challenging the PUC’s decision establishing “cost of capital” as component in rate making. Plaintiff argued Defendant failed to adequately consider circumstances for rural telephone companies and that the PUC decision was unconstitutional. Appeals court held Plaintiff failed to demonstrate that the PUC decision was arbitrary, capricious, lacking in evidentiary support, or fell short of constitutional standards.

(United States Fifth Circuit) - Partially affirmed, partially reversed. The removal of children from a home under investigation for abuse did not result in substantive due process violation, but did result in procedural due process rights violation.

Ms Veronica Cordier, a 419 loan offer scammer that's by the book.

(United States DC Circuit) - Granted in part. In a petition to review an order loosening regulations to allow microcell transmission towers supporting cell phone reception to be built on or near Native American cultural sites, the FCC's determination that it wasn't in the public interest to review small cell deployment was arbitrary and capricious.

(United States Fifth Circuit) - Partially affirmed, partially reversed. The removal of children from a home under investigation for abuse did not result in substantive due process violation, but did result in procedural due process rights violation.

Amnesty advocates are working overtime to portray illegal migrants as heroic essential workers in the national campaign to contain China's coronavirus.

"How did Michael Moore become a hero to climate deniers and the far right?" asks a disturbed and tearful George Monbiot in the Guardian. Simple: by speaking the truth, for a change.

(United States Ninth Circuit) - Vacated an award of attorney fees but otherwise affirmed the district court's approval of a class action settlement resolving claims that an online retailer enrolled consumers in a membership rewards program without their consent and mishandled their billing information. Held that the district court should not have counted the full face value of $20 coupons provided to class members when it performed the percentage-of-recovery and lodestar calculations.

(US 1st Circuit) - No. 19-1390

Analysts and industry officials were searching for new adjectives Monday to describe the cataclysmic fall of oil prices into sub-zero territory for the first time ever, prompting analysts to predict the idling of wells and bankruptcies.

Mara Brock Akil, Salim Akil are back with "Black Lightning."

Find out what kind of superhero you are.

The rapper and Tiny blame today’s music for relationships.

Flipp Dinero has fans wanting an encore.

“I should be dead.”

Flipp Dinero has fans wanting an encore.

It’s family first for one of the newest Miami Dolphins.

25 female athletes get super makeovers as IMPACT25 honorees.

Airports worldwide are setting aggressive zero- or low-emissions targets. To meet these targets, airports are deploying new strategies, adopting innovative financing mechanisms, and harnessing the collective influence of voluntary emissions and reporting programs. In tandem, new and affordable zero- or low-emissions technologies are rapidly becoming available at airports. The TRB Airport Cooperative Research Program's pre-publicaton draft of ACRP Research Report 220: Guidebook for Developing a Zero- or L...

Switchzilla issues a whopping 30+ patches in time for the long UK weekend

Cisco has emitted a fresh round of software updates to address nearly three dozen security holes in its products.…

Hayabusa 2 expected to return with out-of-this-world material in December

Video Close-up footage of asteroid Ryugu, taken by the Hayabusa 2 spacecraft as it touched down to retrieve a sample, reveals the near-Earth object’s surface may have been torched by the Sun as its orbit changed over time.…

Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin of 35 untreated patients with early diffuse SSc and here show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates. We also observed an accumulation of apoptotic cells in SSc tissues, suggesting that recurring cell death may contribute to tissue damage and remodeling in this fibrotic disease. HLA-DR–expressing endothelial cells were frequent targets of apoptosis in SSc, consistent with the prominent vasculopathy seen in patients with this disease. A circulating effector population of cytotoxic CD4+ T cells, which exhibited signatures of enhanced metabolic activity, was clonally expanded in patients with systemic sclerosis. These data suggest that cytotoxic T cells may induce the apoptotic death of endothelial and other cells in systemic sclerosis. Cell loss driven by immune cells may be followed by overly exuberant tissue repair processes that lead to fibrosis and tissue dysfunction.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

New experience reports published by Erowid on May 01 2020

New experience reports published by Erowid on May 02 2020

New experience reports published by Erowid on May 04 2020

New experience reports published by Erowid on May 05 2020

New experience reports published by Erowid on May 06 2020

New experience reports published by Erowid on May 08 2020

Tucker Carlson: Elizabeth Warren's enemies on Wall Street and Big Tech are not really her enemies. Elizabeth Warren is really just this season's Hillary Clinton -- faithful party robot, stalwart defender of the prerogatives of the establishment. Continue reading →

A fundraising initiative spearheaded by Canadian comic retailers and creators aims to auction off items in order to support their struggling industry.

The post Zdarsky, Fabok, & more ask you to “Be Our Heroes” for Canadian retailers appeared first on The Beat.

Real heroes deserve their own comics/Los héroes reales merecen sus propios comics

The post Heroes always come home in David Rubín’s free COVID-19 SUPERMAN story (version en español incluída) appeared first on The Beat.

IBM Security anunció hoy los resultados de su informe 2018 IBM X-Force Threat Intelligence Index, en donde se muestra que la cantidad de registros infringidos cayó casi un 25% en 2017 a medida que los cibercriminales cambiaron el enfoque en el lanzamiento de ransomware y ataques destructivos que buscaban retener o destruir información a menos que la víctima pagara algún rescate.

Na jednorázový příspěvek 500 korun denně budou mít nově nárok i malé společnosti s ručením omezeným postižené šířením koronaviru. „Čekáme na schválení Senátem a prezidentem, žádosti budou moci podávat zřejmě do týdne,“ uvedla ve čtvrtek ministryně financí Alena Schillerová.

Každá krize znamená příležitost.Takovým heslem se řídí egyptský miliardář Naguib Sawiris. Podle něj se bude ropa do roku a půl obchodovat za sto dolarů za barel. Zatímco jiní miliardáři se podílů v leteckých společnostech zbavují, Sawiris je chce nakupovat. Potenciál vidí i v turismu.