Might be best to shut up for a bit.

You can add this cheese to pasta, pizza, or charcuterie boards. READ MORE...

ARCH, the National Respite Network and Resource Center in the United States of America identified that evidence-based research on respite care has, to large extent, been lacking. Across ages, needs and settings, respite is based upon the premise that providing caregivers periodic relief from daily, ongoing caregiving responsibilities will directly benefit them in terms of their physical health, immediate and long-term psychological health, and social-emotional relationships with family members. These benefits are assumed to result in secondary benefits for care receivers and even larger societal benefits in the form of cost benefits or improved employee productivity. Some research studies point to the merits of these assumptions. However, evidence-based research supporting this premise - or going beyond it to demonstrate how to best provide respite care that results in maximum benefits - has not been available. This report presents the findings of an expert panel composed of academics, researchers, service providers, advocates, policymakers and administrators representing a range of age groups, disabilities and professional disciplines. Over a period of 18 months the panel explored the current status of respite research, proposed strategies to overcome barriers to research, and developed a plan to encourage rigorous research in key areas.

New on NextDoorStudios, an ASGMax site: Colt Spence would do anything to just relax today. He’s been beyond stressed out from work and his wife won’t stop calling him incessantly just to check in and see how he’s doing. Finally thinking he has some alone time, he ends up getting a surprise visitor when Andrew... View Article

The post ASGMax | NextDoorStudios: Andrew Delta and Colt Spence – “No Time to Relax” appeared first on QueerClick.

By Carly Tennes Published: November 10th, 2024

By Carly Tennes Published: November 12th, 2024

I've been gradually adding new and older BookADay posts to my new Bookstagram. One of the most recent:

SOUP DAY by Melissa Iwai (Henry Holt): Celebrates the importance of making a nutritious meal and sharing in the process as a famly. Also be sure to check out Melissa's newest book, DUMPLINGS FOR LILI (Norton Young Readers).

Cybersecurity researchers have disclosed six security flaws in the Ollama artificial intelligence (AI) framework that could be exploited by a malicious actor to perform various actions, including denial-of-service, model poisoning, and model theft. "Collectively, the vulnerabilities could allow an attacker to carry out a wide-range of malicious actions with a single HTTP request, including

Former President Donald Trump posted to social media an unsupported claim about "massive CHEATING" in Philadelphia, which he claimed had drawn the attention of law enforcement. The Philadelphia Police Department, the Philadelphia district attorney, a Republican city council member and the Pennsylvania Department of State all refuted the claim.

The post Trump Makes Unsupported Claim About ‘Massive CHEATING’ in Philadelphia appeared first on FactCheck.org.

From 1997 to 2012 just 1% of VC funded companies had female founders. Three of those companies were mine. People tell me it’s much better for women now, but statistically, this is BS. I raised money for a startup recently, and here’s what I found works best for female founders: Get a male cofounder. Women raising money without […]

The post How to get funding from deluded, self-congratulating investors appeared first on Penelope Trunk Careers.

Update: Now available in the UK store too, but only until midnight tonight (Nov. 7th).

It's now available in the EU and AU shops as well.

Available from The Cure shop (US only, but there are ways around that):

THE CURE SONGS OF A LOST WORLD (DELUXE) DIGITAL DOWNLOAD (MP3 & FLAC)

US $4.99

DELUXE DIGITAL ALBUM FEATURES SONGS OF A LOST WORLD STANDARD TRACKLIST PLUS FIVE LIVE BONUS TRACKS RECORDED AT SHORELINE AMPHITHEATER IN 2023.

TRACKLIST:

1.ALONE

2.AND NOTHING IS FOREVER

3.A FRAGILE THING

4.WARSONG

5.DRONE:NODRONE

6.I CAN NEVER SAY GOODBYE

7.ALL I EVER AM

8.ENDSONG

9.ALONE : LIVE @ SHORELINE AMPHITHEATER 2023

10.AND NOTHING IS FOREVER : LIVE @ SHORELINE AMPHITHEATER 2023

11.A FRAGILE THING : LIVE @ SHORELINE AMPHITHEATER 2023

12.I CAN NEVER SAY GOODBYE : LIVE @ SHORELINE AMPHITHEATER 2023

13.ENDSONG : LIVE @ SHORELINE AMPHITHEATER 2023

LIVE @ SHORELINE AMPHITHEATER 2023

Come one, come all! nycdevops does its first virtual meetup! All are invited!

• Speaker: Adarsh Shah
• Topic: "Continuous Delivery for Machine Learning"
• Time: Thursday, September 17, 2020, 5-630 PM
• Link: https://www.meetup.com/nycdevops/events/272914068/

Hope to see you there!

A Princeton-led team of astrophysicists has measured a surprising value for the “clumpiness” of the universe’s dark matter.

In this talk, Graham Neubig will discuss a new frontier in AI models, vision-language models that understand the world's cultures. The talk will be in two parts. First, Neubig will discuss training of multilingual multimodal multicultural models that understand images and text, and have increased ability to answer culture-specific questions about multimodal data. Second, he will discuss work on "image transcreation", where models have been developed that can transform images to make them more relevant to a particular culture. This work has applications in a number of areas, such as cultural localization of educational materials (to accompany translated text). While these methods cover many languages, African and not, the talk will focus on examples specifically from the African context, and challenges we currently face therein.

Though there are few comps for R-rated stop-motion films at the box office, 'Memoir of a Snail' is off to an excellent start.

The claustrum seems to act as a switchboard, telling different parts of the brain when to turn on and off. But what happens when the switchboard operator steps away?

Sam Koch looked like he was playing very, very badly. In fact, he was changing one of sport's strangest positions for ever.

Crews say they faced crucial delays trying to save dying patients because of the time it took to put on equipment.

Elizabeth line, Great Western Railway and Heathrow Express services are all being affected.

President Trump tweeted a four-minute video message updating the American public Saturday evening on his progress since being tested positive with the coronavirus, saying that he “feels much better now” but the next few days is going to be “the real test.” pic.twitter.com/gvIPuYtTZG — Donald J. Trump (@realDonaldTrump) October 3, 2020 “I came here, wasn’t […]

The post Trump Delivers Video Update From Walter Reed: ‘I Feel Much Better Now’ appeared first on Hispolitica.

Delhi woke up to a thick layer of smog on Wednesday morning as pollution levels soared in the city.

Lulu Delacre’s recent book, Cool Green (Candlewick) takes readers on a trip around the world, led by a grandfather with his granddaughter, introducing readers to a range of trees in lyrical text punctuated by fascinating information accompanied by informative and varied illustration. It’s a gorgeous book and Lulu has answered questions that I posed to her.

The best early Black Friday MacBook deals include all-time low prices on the latest MacBook Air models.

The Gauteng education department has postponed the appointment of new office-based staff as well as teachers who applied to be promoted as heads of department, deputy principals and principals until April because of budget constraints.

The following article, Lawfare Freeze: Judge Merchan Delays Decision On Trump Sentencing, was first published on Conservative Firing Line.

BREAKING: Justice Merchan has granted a request from prosecutions/defense to pause deadlines — including Trump's sentencing date — while they consider the effect of his election as president. https://t.co/LaeJlAyTDi pic.twitter.com/SAHVbo3HbG — Kyle Cheney (@kyledcheney) November 12, 2024 Developing … * * * Content created by the WND News Center is available for re-publication without charge …

Continue reading Lawfare Freeze: Judge Merchan Delays Decision On Trump Sentencing ...

I was excited to finally get the word that an article I wrote sharing my love for my hometown – San Jose, California – is out in Delta Sky Magazine this month! Time Out: San José – (Image / PDF) (Thanks to Deb L. and Ginni R. for sending copies for me!)    

The article EIT Elsewhere | “Time Out: San José” in Delta Sky Magazine originated at EverInTransit.com

By Cynthia Farahat On Friday 27th, 2023 at 11:00 am EST, my sweet dear younger brother Amir Farahat passed away. Amir was the most loving father I have ever seen, a great brother, son, husband, and brother-in-law. My little Miró, my little prince, my soul is shattered by your loss. I will forever mourn your […]

Making the circular economy work for global development: how the UN Summit of the Future can deliver 23 September 2024 — 6:15PM TO 9:00PM Anonymous (not verified) 5 September 2024 Online

This policy roundtable focusses on how to advance implementation of a global approach and collaboration to an inclusive circular economy for an updated post-2030 SDG framework.

As the world looks beyond the Sustainable Development Goals (SDGs) towards the post-2030 era, integrating the principles of the circular economy into the future global development agenda becomes imperative.  

A new Chatham House research paper about the role of the circular economy for the SDGs and their possible extension into the post-2030 development agenda will be launched in September 2024 during the UN Summit of the Future and the New York Climate Week. The paper outlines the rationale for the integration of circular economy goals into for the next crucial phase of international development and how to meet net-zero 2050 targets. It provides actionable recommendations on international cooperation mechanisms for policymakers and stakeholders at the UN Summit for the Future in 2024 and beyond.

The aim of the roundtable is to bring together stakeholders and leaders from intergovernmental organisations, business, governments and civil society. The focus of the roundtable meeting is: 

• Reflections on the Summit of the Future and the role of circularity for an updated post-2030 SDG framework.
• Discussion on key aspects of the institutional arrangements and international coordination that are needed for a globally coordinated approach to achieve an inclusive circular economy that supports SDG implementation. 
• Development of joint strategies on how to advance implementation of a global approach and collaboration to an inclusive circular economy as a follow-up from the Summit of the Future.

The objective is to emerge from the roundtable with a clearer roadmap for translating the recommendations for international coordination into concrete actions, with a shared commitment to driving meaningful change on the international level.

The event is co-hosted by Chatham House and partners from the Global Circular Economy Roadmap initiative including the African Circular Economy Network, the African Development Bank, Circular Change, Circular Innovation Lab, Circle Economy, EU CE Stakeholder Platform, Hanns Seidel Foundation, Institute of Global Environmental Strategies, Sitra, UNIDO, World Business Council on Sustainable Development, World Economic Forum and the Wyss Academy for Nature.

Further background information is available on the initiative website.

More speakers to be announced.

Hdac3 is a lysine deacetylase that removes acetyl groups from histones and additional proteins. Although Hdac3 functions within mesenchymal lineage skeletal cells are defined, little is known about Hdac3 activities in bone-resorbing osteoclasts. In this study we conditionally deleted Hdac3 within Ctsk-expressing cells and examined the effects on bone modeling and osteoclast differentiation in mice. Hdac3 deficiency reduced femur and tibia periosteal circumference and increased cortical periosteal osteoclast number. Trabecular bone was likewise reduced and was accompanied by increased osteoclast number per trabecular bone surface. We previously showed that Hdac3 deacetylates the p65 subunit of the NF-κB transcriptional complex to decrease DNA-binding and transcriptional activity. Hdac3-deficient osteoclasts demonstrate increased K310 NF-κB acetylation and NF-κB transcriptional activity. Hdac3-deficient osteoclast lineage cells were hyper-responsive to RANKL and showed elevated ex vivo osteoclast number and size and enhanced bone resorption in pit formation assays. Osteoclast-directed Hdac3 deficiency decreased cortical and trabecular bone mass parameters, suggesting that Hdac3 regulates coupling of bone resorption and bone formation. We surveyed a panel of osteoclast-derived coupling factors and found that Hdac3 suppression diminished sphingosine-1-phosphate production. Osteoclast-derived sphingosine-1-phosphate acts in paracrine to promote bone mineralization. Mineralization of WT bone marrow stromal cells cultured with conditioned medium from Hdac3-deficient osteoclasts was markedly reduced. Expression of alkaline phosphatase, type 1a1 collagen, and osteocalcin was also suppressed, but no change in Runx2 expression was observed. Our results demonstrate that Hdac3 controls bone modeling by suppressing osteoclast lineage cell responsiveness to RANKL and coupling to bone formation.

Jürgen Cox
Sep 1, 2014; 13:2513-2526
Technological Innovation and Resources

Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Here, we examined the cellular distribution of tau protein species in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of frontotemporal dementia. Line 66 mice express intracellular tau aggregates in multiple brain regions and exhibit sensorimotor and motor learning deficiencies. Using a series of anti-tau antibodies, we observed, histologically, that nonphosphorylated transgenic human tau is enriched in synapses, whereas phosphorylated tau accumulates predominantly in cell bodies and axons. Subcellular fractionation confirmed that human tau is highly enriched in insoluble cytosolic and synaptosomal fractions, whereas endogenous mouse tau is virtually absent from synapses. Cytosolic tau was resistant to solubilization with urea and Triton X-100, indicating the formation of larger tau aggregates. By contrast, synaptic tau was partially soluble after Triton X-100 treatment and most likely represents aggregates of smaller size. MS corroborated that synaptosomal tau is nonphosphorylated. Tau enriched in the synapse of line 66 mice, therefore, appears to be in an oligomeric and nonphosphorylated state, and one that could have a direct impact on cognitive function.

The break-up of Scholz’s coalition government signals the end of Germany’s old economic model Expert comment jon.wallace 12 November 2024

The coalition could not agree how to fund new support for Ukraine and failed to fully implement the ‘Zeitenwende’. A new government must push through reform.

As Europeans were still processing Donald Trump’s victory in the 2024 US presidential election, an acrimonious break up occurred 4000 miles east of Washington DC.

Reports had been circulating for weeks about the fragile state of Germany’s ‘traffic light’ coalition government led by German Chancellor Olaf Scholz, consisting of the centre-left Social Democratic Party (SPD), the Green Party, and liberal Free Democratic Party (FDP).

The expectation had been that the coalition would hold on for a few more weeks and might even be given a new lease of life by Trump’s re-election. Instead, it collapsed on the day Trump’s win was confirmed. An unusually angry Scholtz announced in a live address that he had fired FDP Finance Minister Christian Lindner, effectively breaking up the coalition.

At the heart of the dispute was the so-called ‘debt brake’ – a constitutional mechanism which restricts Germany’s annual public deficit to 0.35 per cent of GDP. Lindner proposed a set of reforms which were unpalatable to the SPD and the Greens. 

In response, Scholz suggested declaring an emergency, which would have suspended the debt brake. That in turn was unacceptable to Lindner, leading to his sacking by the Chancellor.

Practically, this means the SPD and the Greens are now in a minority coalition, without agreement on the 2025 budget or the votes in parliament to pass it. They also still face the challenge of the debt brake.

A vote of confidence will take place in December, with elections to be held before the end of February 2025 latest.

The end of Germany’s economic model

At the root of Germany’s political crisis is the country’s economic model. For decades, Germany relied on a system that depended on cheap Russian gas, cheap imports of consumer goods from China, high-value exports – particularly in the automotive sector – and the US security umbrella.

With Russian energy no longer viable, the global economic landscape shifting, and Donald Trump on his way back to the White House, that model is no longer workable. And Germany’s economy is expected to contract by 0.2 per cent in 2024 – a contraction for the second year running.

The ‘Zeitenwende’, announced by Scholz in the wake of Russia’s full-scale invasion of Ukraine, should have signalled a turnaround of both foreign and economic policy, given how much the two are interconnected. Yet on both fronts, too little changed.

Germany’s reliance on Russian gas did come to an abrupt end in 2022. And Germany is Ukraine’s second largest military aid donor after the US, while accepting the most Ukrainian refugees.

But the ‘Zeitenwende’ turnaround ended there. Scholz’s coalition government failed to prepare for long-term investment in defence at the levels required by creating an off-budget defence spending fund which would have run out in 2027. The draft budget for 2025 showed defence spending would have been cut, as would support for Ukraine.

Germany has also struggled to turn around its economic woes, with the car industry particularly affected. Cheap Chinese EVs and new energy technologies are competing with Germany’s most powerful companies. Volkswagen, the country’s largest car manufacturer, has announced plant closures and layoffs due to shrinking profit margins.  

To the west, Trump’s threat to impose 10 to 20 per cent tariffs on all EU imports meant share prices of Volkswagen, BMW, Mercedez-Benz and Porsche all dropped between 4 to 7 per cent following news of his re-election.

To the east, trade tensions between the EU and China are intensifying. Yet rather than choosing to diversify, German companies have doubled down on their bets in China, with German investment in the country rising from €6.5bn for the whole of 2023 to €7.3bn in the first half of 2024 alone – only exposing carmakers further.

Germany’s support for Ukraine

Like French President Emmanuel Macron, Scholz had already been weakened by the results of the European Parliamentary elections in June. With the collapse of his traffic light coalition, the EU’s Franco-German ‘engine’ is now well and truly stalled – until new leadership can be found. This weakness comes at a perilous moment when clear, united European leadership, and much increased funding, is needed to shore up support for Ukraine.

RK Tangirala
Nov 1, 1995; 36:2320-2328
Articles

Evolving evidence suggests that nicotine may contribute to impaired asthma control by stimulating expression of nerve growth factor (NGF), a neurotrophin associated with airway remodeling and airway hyperresponsiveness. We explored the hypothesis that nicotine increases NGF by reducing lung fibroblast (LF) microRNA-98 (miR-98) and PPARγ levels, thus promoting airway remodeling. Levels of NGF, miR-98, PPARγ, fibronectin 1 (FN1), endothelin-1 (EDN1, herein referred to as ET-1), and collagen (COL1A1 and COL3A1) were measured in human LFs isolated from smoking donors, in mouse primary LFs exposed to nicotine (50 μg/ml), and in whole lung homogenates from mice chronically exposed to nicotine (100 μg/ml) in the drinking water. In selected studies, these pathways were manipulated in LFs with miR-98 inhibitor (anti-miR-98), miR-98 overexpression (miR-98 mimic), or the PPARγ agonist rosiglitazone. Compared with unexposed controls, nicotine increased NGF, FN1, ET-1, COL1A1, and COL3A1 expression in human and mouse LFs and mouse lung homogenates. In contrast, nicotine reduced miR-98 levels in LFs in vitro and in lung homogenates in vivo. Treatment with anti-miR-98 alone was sufficient to recapitulate increases in NGF, FN1, and ET-1, whereas treatment with a miR-98 mimic significantly suppressed luciferase expression in cells transfected with a luciferase reporter linked to the putative seed sequence in the NGF 3'UTR and also abrogated nicotine-induced increases in NGF, FN1, and ET-1 in LFs. Similarly, rosiglitazone increased miR-98 and reversed nicotine-induced increases in NGF, FN1, and ET-1. Taken together, these findings demonstrate that nicotine-induced increases in NGF and other markers of airway remodeling are negatively regulated by miR-98.

Expert

A. V. Domrina
Trans. Moscow Math. Soc. 83 (), 201-215.
Abstract, references and article information

A. Kh. Khachatryan, Kh. A. Khachatryan and A. Zh. Narimanyan
Trans. Moscow Math. Soc. 83 (), 183-200.
Abstract, references and article information

A. G. Sergeev, A. Kh. Khachatryan and Kh. A. Khachatryan
Trans. Moscow Math. Soc. 83 (), 55-65.
Abstract, references and article information

Decarbonizing Heat: A New Frontier for Technologies and Business Models 27 February 2019 — 8:15AM TO 9:45AM Anonymous (not verified) 3 December 2018 Chatham House | 10 St James's Square | London | SW1Y 4LE

Building space and water heating accounts for over 35 percent of global energy consumption - nearly double that of transport. However, there has been limited progress in decarbonizing the sector to date. International cooperation is required to ensure harmonized policies drag low carbon heating technologies down the cost curve to the extent that low carbon heating is cost competitive and affordable. The initial presentations and discussion focus on:

• Demand reduction technologies and policies that speed up transformation of the sector.
• The different challenges for energy efficiency of retrofitting as opposed to new build.
• The impact of electrification on GHG emissions and the power sector.
• The comparative role of national and city level initiatives.

The meeting concludes by looking at the challenges and risks in accelerating the transformation of heating and the lessons that can be learned from other sectors.

Otto Overkamp
Trans. Amer. Math. Soc. 377 (), 5863-5903.
Abstract, references and article information

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