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Method for producing ring-halogenated N,N-dialkylbenzylamines

The invention relates to a method for preparing ring-halogenated N,N-dialkylbenzylamines and intermediates obtainable therefrom for preparing agrochemicals and pharmaceutically active ingredients.




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Matching metadata sources using rules for characterizing matches

Processing metadata includes storing, in a data storage system, a specification for each of multiple sources, each specification including information identifying one or more data elements of the corresponding source; and processing, in a data processing system coupled to the data storage system, data elements from the sources, including generating a set of rules for each source based on a corresponding one of the stored specifications, and matching data elements of different sources and determining a quality metric characterizing a given match between a first data element of a first source and a second data element of a second source according to the set of rules generated for the first source and the set of rules generated for the second source.




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Techniques for evaluation, building and/or retraining of a classification model

Techniques for evaluation and/or retraining of a classification model built using labeled training data. In some aspects, a classification model having a first set of weights is retrained by using unlabeled input to reweight the labeled training data to have a second set of weights, and by retraining the classification model using the labeled training data weighted according to the second set of weights. In some aspects, a classification model is evaluated by building a similarity model that represents similarities between unlabeled input and the labeled training data and using the similarity model to evaluate the labeled training data to identify a subset of the plurality of items of labeled training data that is more similar to the unlabeled input than a remainder of the labeled training data.




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Modeling of time-variant threshability due to interactions between a crop in a field and atmospheric and soil conditions for prediction of daily opportunity windows for harvest operations using field-level diagnosis and prediction of weather conditions an

A modeling framework for evaluating the impact of weather conditions on farming and harvest operations applies real-time, field-level weather data and forecasts of meteorological and climatological conditions together with user-provided and/or observed feedback of a present state of a harvest-related condition to agronomic models and to generate a plurality of harvest advisory outputs for precision agriculture. A harvest advisory model simulates and predicts the impacts of this weather information and user-provided and/or observed feedback in one or more physical, empirical, or artificial intelligence models of precision agriculture to analyze crops, plants, soils, and resulting agricultural commodities, and provides harvest advisory outputs to a diagnostic support tool for users to enhance farming and harvest decision-making, whether by providing pre-, post-, or in situ-harvest operations and crop analyzes.




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Apparatus and method for selecting motion signifying artificial feeling

An apparatus for selecting a motion signifying artificial feeling is provided. The apparatus includes: an feeling expression setting unit configured to set probabilities of each feeling expression behavior performed for each expression element of a robot for each predetermined feeling; a behavior combination generation unit configured to generate at least one behavior combination combined by randomly extracting the feeling expression behaviors in each expression element one by one; and a behavior combination selection unit configured to calculate an average for the probabilities of the feeling expression behaviors included in each behavior combination for each feeling of a robot and select behavior combinations in which the average of the probabilities of the feeling expression behaviors most approximates the predetermined feeling value of a robot from each behavior combination.




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Using dotplots for comparing and finding patterns in sequences of data points

Embodiments of the invention provide systems and methods for analyzing sequential data. The sequential data can comprise a sequence of data points arranged in a particular order and thus representing a sequence. A number of such sequences can be analyzed, for example, to identify patterns or commonalities within the sequences or portions of sequences represented by the data. According to one embodiment, a method of identifying patterns in sequences of data points can comprise reading a set of sequential data. The sequential data can comprises a plurality of sequences and each of the plurality of sequences can represent an ordered sequence of tokens. A dotplot representing matches between each sequence of the plurality sequences can be generated. One or more patterns within the sequential data can then be identified based on the dotplot.




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Method for generating visual mapping of knowledge information from parsing of text inputs for subjects and predicates

A method for performing relational analysis of parsed input is employed to create a visual map of knowledge information. A title, header or subject line for an input item of information is parsed into syntactical components of at least a subject component and any predicate component(s) relationally linked as topic and subtopics. A search of topics and subtopics is carried out for each parsed component. If a match is found, then the parsed component is taken as a chosen topic/subtopic label. If no match is found, then the parsed component is formatted as a new entry in the knowledge map. A translation function for translating topics and subtopics from an original language into one or more target languages is enabled by user request or indicated user preference for display on a generated visual map of knowledge information.




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Systems and methods for classifying documents for data loss prevention

A computer-implemented method for classifying documents for data loss prevention may include 1) identifying training documents for a machine learning classifier configured for data loss prevention, 2) performing a semantic analysis on training documents to identify topics within the set training documents, 3) applying a similarity metric to the topics to identify at least one unrelated topic with a similarity to the other topics within the plurality of topics, as determined by the similarity metric, that falls below a similarity threshold, 4) identifying, based on the semantic analysis, at least one irrelevant training document within the set of training documents in which a predominance of the unrelated topic is above a predominance threshold, and 5) excluding the irrelevant training document from the set of training documents based on the predominance of the unrelated topic within the irrelevant training document. Various other methods, systems, and computer-readable media are also disclosed.




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Learning rewrite rules for search database systems using query logs

Methods and arrangements for conducting a search using query logs. A query log is consulted and query rewrite rules are learned automatically based on data in the query log. The learning includes obtaining click-through data present in the query log.




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Apparatus and method for recognizing representative user behavior based on recognition of unit behaviors

An apparatus for recognizing a representative user behavior includes a unit-data extracting unit configured to extract at least one unit data from sensor data, a feature-information extracting unit configured to extract feature information from each of the at least one unit data, a unit-behavior recognizing unit configured to recognize a respective unit behavior for each of the at least one unit data based on the feature information, and a representative-behavior recognizing unit configured to recognize at least one representative behavior based on the respective unit behavior recognized for each of the at least one unit data.




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Systems and methods for analysis of network equipment command line interface (CLI) and runtime management of user interface (UI) generation for same

Systems and methods are disclosed that may be implemented for network management system (NMS) configuration management support for network devices using a learning and natural language processing application to capture the usage and behavior of the Command Line Interface (CLI) of a network device with the aid of a CLI knowledge model, which in one example may be ontology-based.




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Optimization to identify nearest objects in a dataset for data analysis

In one embodiment, a plurality of objects associated with a dataset and a specified number of nearest objects to be identified are received. The received objects are sorted in a structured format. Further, a key object and a number of adjacent objects corresponding to the key object are selected from the sorted plurality of objects, wherein the number of adjacent objects is selected based on the specified number of nearest objects to be identified. Furthermore, distances between the key object and the number of adjacent objects are determined to identify the specified number of nearest objects, wherein the distances are determined until the specified number of nearest objects is identified. Based on the determined distances, the specified number of nearest objects in the dataset is identified for data analysis.




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Systems and methods for recommending media content items

Systems and methods for recommending media content items are provided. In some implementations, a method includes, identifying a first set of media items selected by a first plurality of users; causing a second set of media items to be displayed to a second user not included in the first plurality of users in accordance with the first set of media items. The first set of media items and the second set of media items are associated with a same media item category. In some implementations, the method optionally includes, identifying the second set of media items without regard to media content item selection history associated with the second user. In some implementations, the first and second sets of media items are news items.




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Method and apparatus for contextual content suggestion

An approach is provided for contextual content suggestion. A recommendation platform processes and/or facilitates a processing of contextual information associated with at least one device to determine one or more locations, one or more contextual parameter values, or a combination thereof. The recommendation platform also determines popularity data associated with one or more content items with respect to the one or more locations, the one or more contextual parameter values, or a combination. The popularity data is determined from one or more other devices sharing at least substantially the one or more locations, the one or more contextual parameter values, or a combination thereof. The recommendation platform then causes, at least in part, a recommendation of the one or more content items to the at least one device based, at least in part, on the popularity information.




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Information providing apparatus for vehicle, and method therefor

An information providing apparatus for vehicle has a remaining capacity detecting section 110 that detects a remaining capacity of a battery; a power consumption amount detecting section 130 that detects a power consumption amount of the battery; a power consumption amount history generating section 130 that generates a power consumption amount history on the basis of the power consumption amount detected by the power consumption amount detecting section 130; a charge necessity judgment information generating section 130 that generates, on the basis of the power consumption amount history generated by the power consumption amount history generating section 130, charge necessity judgment information which is information for user's judgment about whether or not charging of the battery is necessary; and a providing section 150 that provides information of the remaining capacity of the battery and the charge necessity judgment information with these information correlated with each other to the user. The information providing apparatus can properly provide the information for user's judgment about whether or not charging of the battery to the user.




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Systems and methods for control reliability operations using TMR

In one embodiment, a system includes a data collection system configured to collect a data from a control system by using an offline mode of operations. The system further includes a configuration management system configured to manage a hardware configuration and a software configuration for the control system based on the data. The system additionally includes a rule engine configured to use the data as input and to output a health assessment by using a rule database, and a report generator configured to provide a health assessment for the control system.




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Methods and systems for constructing intelligent glossaries from distinction-based reasoning

A computer implemented method of constructing formal definitions in intelligent glossaries for interpreting text, comprising the steps of: providing at least one Distinction having a Boundary, an Indication, a Counter-indication and a Frame; modeling each Distinction as a diagram to provide a Distinction Model; verifying each distinction model as being an instantiation of a generic Distinction Pattern; providing at least one Arrangement made of nonintersecting Marks of Distinction containing Indications from the verified Distinction Model; writing at least one Formulation for each Indication appearing in verified Distinction model and Arrangement, providing well-founded Indications; calculating precise Formulations in Natural Language from well-founded Indications by substituting Variables symbols and/or replacing Constants symbols to transform imprecise Formulations into precise Formulations; selecting a Definition type and embedding at least one precise Formulation and Definition type as a formal Definition in an Intelligent Glossary to provide computerized Semantic Systems of Intelligent Glossaries.




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Method and apparatus for declarative data warehouse definition for object-relational mapped objects

A data warehouse is constructed using the relational mapping of a transactional database without reconstructing the data relationships of the transactional database. First, an application programmer analyzes an object model in order to describe facts and dimensions using the objects, attributes, and paths of the object model. Each of the dimensions has an identifier that correlates an item in the transactional database to a dimension record in the data warehouse. The fact and dimension descriptions are saved to a description file. Second, a Data Warehouse Engine (DWE) then access the description file and uses the object model, fact and dimension descriptions, and object-relational mapping to map transactional data to the data warehouse.




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System and method for using cluster level quorum to prevent split brain scenario in a data grid cluster

A system and method is described for use with a data grid cluster, which uses cluster quorum to prevent split brain scenario. The data grid cluster includes a plurality of cluster nodes, each of which runs a cluster service. Each cluster service collects and maintains statistics regarding communication flow between its cluster node and the other cluster nodes in the data grid cluster. The statistics are used to determine a status associated with other cluster nodes in the data grid cluster whenever a disconnect event happens. The data grid cluster is associated with a quorum policy, which is defined in a cache configuration file, and which specifies a time period that a cluster node will wait before making a decision on whether or not to evict one or more cluster nodes from the data grid cluster.




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Systems and methods for making bioproducts

Processes for continuous preparation of bioproducts are described herein. The processes include contacting fatty acid glycerides with alcohols in the presence of an acidic heterogeneous catalyst and separating the fatty acid alkyl esters from the reaction products.




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Process for fractionating crude triglyceride oil

The present invention relates to an improved process for fractionating triglyceride oil. The process according to the present invention attains a reproducible crystallization by introducing a controlled temperature profile and ensuing crystal development that reduce the amount of entrapped olein inside the crystals or crystal aggregates. The process of the present invention may be used to fractionate vegetable oils such as palm oil or its blends with other palm oil products or edible vegetable oils.




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Surfactant composition for agricultural chemicals

A surfactant composition for agricultural chemicals, containing fatty acid polyoxyalkylene alkyl ether expressed by the following general formula (I), R1CO(EO)m(PO)nOR2 (I) wherein the fatty acid polyoxyalkylene alkyl ether has a narrow ratio of 55% by mass or more, where the narrow ratio is expressed by the following formula (A): Narrow ratio=Σi=nMAX−2i=nMAX+2Yi (A).




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Process for the production of bio-oil from municipal solid waste

A process for producing bio-oil from municipal solid waste, the process including: a) liquifying municipal solid waste, to obtain a mixture containing an oily phase containing bio-oil, a solid phase, and a first aqueous phase; b) treating the first aqueous phase from a) with an adsorbing material, to obtain a second aqueous phase; c) fermenting the second aqueous phase from b), to obtain a biomass; d) subjecting the biomass obtained in c) to the liquification a). The bio-oil obtained is advantageously used in the production of biofuels for motor vehicles or for the generation of electric energy or heat.




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Catalytic processes for preparing estolide base oils

Provided herein are processes for preparing estolides and estolide base oils from fatty acid reactants utilizing catalysts. Further provided herein are processes for preparing carboxylic esters from at least one carboxylic acid reactant and at least one olefin.




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ZnO nanoparticle catalysts for use in transesterification and esterification reactions and method of making

A method of forming a product from an oil feedstock, such as a biodiesel product, and a heterogeneous catalyst system used to form said product is disclosed. This catalyst system, which has a high tolerance for the presence of water and free fatty acids (FFA) in the oil feedstock, may simultaneously catalyze both the esterification of FAA and the transesterification of triglycerides present in the oil feedstock. The catalyst system is comprised of a mixture of zinc oxide and a second metal oxide. The zinc oxide includes a mixture of amorphous zinc oxide and zinc oxide nanocrystals, the zinc nanocrystals having a mean grain size between about 20 and 80 nanometers with at least one of the nanocrystals including a mesopore having a diameter of about 5 to 15 nanometers. Preferably, the second metal oxide is a lanthanum oxide, the lanthanum oxide being selected as one from the group of La2CO5, LaOOH, and combinations or mixtures thereof.




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Process for separation of renewable materials from microorganisms

Methods of separating renewable materials, such as lipids, from microorganisms, such as oleaginous yeasts, may include conditioning cell walls of the microorganisms to form, open or enlarge pores, and removing at least a portion of the renewable material through the pores. These methods may result in delipidated microorganisms with cell walls that are substantially intact and with mesopores. These delipidated microorganisms may be used to produce biofuels.




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Lipid compositions for the treatment of gastro-intestinal disorders and the promotion of intestinal development and maturation

The present invention provides a use of a lipid composition for the preparation of a nutritional, pharmaceutical or nutraceutical composition or a functional food, for the prevention and treatment of gastrointestinal diseases and disorders, and for promoting intestinal development, maturation, adaptation and differentiation.




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Process for producing biodiesel through lower molecular weight alcohol-targeted cavitation

A method for producing fatty acid alkyl esters from biolipids through transesterification and/or esterification reactions uses a flow-through cavitation device for generating cavitation bubbles in a fluidic reaction medium. The fluidic medium is passed through sequential compartments in the cavitation device having varying diameters and inner surface features to create localized reductions in fluid pressure thus vaporizing volatile alcohols and creating an increased surface area and optimized conditions for the reaction to occur at the gas-liquid interface around the bubbles.




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Process for making esters

The invention relates to a process for making esters, in particular biodiesel, using heterogeneous catalysts. The invention provides a process for making biodiesel, in particular FAME, which process is versatile and robust. The process of the invention can be carried out continuously, in particular in a fixed bed reactor or a slurry reactor and may be operated in a continuous fashion. In accordance with the invention, the transesterification reaction of triglycerides is carried out using a heterogeneous catalyst that comprises a Group 4 silicate and less than 3 wt. % Na in the presence of at least one acid compound.




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Method for producing a concentrate of eicosapentaenoic and docosahexaenoic acids

The current invention describes processes for obtaining of concentrates of esters of eicosapentaenoic acid and docosahexaenoic acid for their use in massive and regular human consumption either as a pharmaceutical ingredient or as a food ingredient, which are characterized by having neutral and stable organoleptic properties, free of side effects, which are typical from marine oils derivatives, and with low content of Persistent Organic Pollutants (POP).




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Method for fractionating Jatropha seeds

A method for the solvent-free fractionation of jatropha seeds having a phorbol ester content and at least one fraction.




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Method for removing phosphorus-containing compounds from triglyceride-containing compositions

The present invention relates to a method for removing phosphorus-containing compounds from triglyceride-containing compositions.




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Process for producing monobranched fatty acids or alkyl esters

A process for producing C10-C26 monobranched fatty acids or alkyl esters thereof which includes isomerizing unsaturated C10-C26 fatty acids or alkyl esters thereof in the presence of a catalyst which comprises both a zeolite and a Lewis base. The zeolite can be reused after simple separation from the reaction products without having to regenerate. The process is particularly suitable for producing highly monobranched fatty acids or alkyl esters thereof.




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Quality control bioassays for nutriceutical and medicinal products

Bioassays for detecting the ability of one sample of a food substance, nutritional supplement, therapeutic agent and/or disease preventive agent relative to that of a second sample of such a substance, supplement and/or agent to inhibit, upregulate or otherwise modulate translation initiation, and thereby demonstrate a disease curative and/or preventive effect in a human and/or animal that consumes a such substance, supplement and/or agent or to whom a such substance, supplement and/or agent is administered are provided.




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Methods for the synthesis of 13C labeled plasmalogen

A method for preparing 13C labeled plasmalogens as represented by Formula B: The method involves producing a 13C labeled cyclic plasmalogen precursor of Formula A: and conversion of the precursor to a plasmalogen of Formula B.




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Method for producing refined a fat or oil

A method for manufacturing a refined fat or oil, including: carrying out a first steam treatment of bringing a fat or oil into contact with water vapor; and subsequently carrying out a second steam treatment of bringing the fat or oil having a temperature lower by 10° C. or more than a temperature of the fat or oil in the first steam treatment into contact with water vapor in the presence of an organic acid.




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Process for the production of bio-oil from solid urban waste

A process for the production of bio-oil from solid urban waste, comprising the following steps: a) subjecting said solid urban waste to liquefaction, obtaining a mixture including an oily phase consisting of bio-oil, a solid phase and an aqueous phase; b) subjecting the aqueous phase obtained in the liquefaction step a) to fermentation, obtaining a fermented biomass; c) feeding the fermented biomass obtained in the fermentation step b) to the liquefaction step a). The bio-oil (or bio-crude) thus obtained can be advantageously used in the production of biofuels which can be used as such or mixed with other motor vehicle fuels. Alternatively, this bio-oil (or bio-crude) can be used as such (biocombustible) or mixed with fossil combustibles (combustible oil, coal, etc.) for the generation of electric energy or heat.




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Biodegradable lipids for the delivery of active agents

The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.




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Method and systems for enhancing oil recovery from ethanol production byproducts

Methods and related systems efficiently and effectively recover a significant amount of valuable, useable oil from byproducts formed during a dry milling process used for producing ethanol. The method may include forming a concentrate from the byproduct and recovering oil from the concentrate. The step of forming the concentrate may comprise evaporating the byproduct using a multi-stage evaporator, as well as recovering the oil before the final stage of the evaporator. Further, the step of recovering oil from the concentrate may comprise using a centrifuge and, in particular, a disk stack centrifuge. Other aspects include related methods and subsystems for recovering oil.




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Method for producing regenerated clay, regenerated clay, and method for producing purified fats and oils

The present invention provides a method for performing regeneration of a decolorization capacity of waste clay that has been used for purification of fats and oils, and production of a thermally recyclable compound as a biofuel from oily ingredients in the waste clay at the same time in a convenient manner. That is, a method for producing purified fats and oils of the invention includes: a method for producing regenerated clay including the steps of mixing waste clay that has been used for purification of fats and oils, lower alcohol, and an acidic catalyst; and performing extraction of oily ingredients from the waste clay, and an esterification reaction between the fats and oils and/or a free fatty acid in the oily ingredients and the lower alcohol at the same time so as to regenerate a decolorization capacity of the waste clay; regenerated clay that is produced by the method for producing the regenerated clay; and a process of decolorizing the fats and oils using the regenerated clay.




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Mixture of an amine alkoxylate ester and a quaternary ammonium compound as a collector for minerals containing silicate

The invention relates to the use of a composition of A) at least one quaternary ammonia compound comprising at least one organic radical bonded to the ammonia nitrogen atom and optionally comprising heteroatoms and having 1 to 36 carbon atoms, and B) at least one amine alkoxylate ester of formula (1) or a salt thereof, where A, B are, independently of each other, a C2- through C5-alkylene radical R1, a C8- through C24-alkyl radical or alkenyl radical R2, R3, R4 independent of each other, H, or a C8- through C24-acyl radical, with the stipulation that at least one of the radicals R2, R3 or R4 stands for a C8- through C24-acyl radical, and x, y, z, independently of each other, stand for a whole number from 0 through 50, with the stipulation that x+y+z is a whole number from 1 through 100, in quantities of 10 through 5000 g/tonne of ore as a collector in silicate floation.




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Composition for cosmetics, cosmetic, method for producing oil-in-water emulsion cosmetic, and two separate layer-type cosmetic

The present invention relates to a composition for cosmetics including a polyglycerol fatty acid ester, which is an ester of polyglycerol having an average degree of polymerization of 4 to 100 with a fatty acid having 2 to 18 carbon atoms, has a hydroxyl value equal to or less than 15 mgKOH/g, and has a specific gravity at 20° C. of 0.96 to 1.15; a cosmetic which includes the composition for cosmetics; a method for producing an oil-in-water emulsion cosmetic which includes mixing the composition for cosmetics; and a two-separate-layer-type cosmetic, which comprises the composition for cosmetics. The present invention relates to the composition for cosmetics which can be appropriately used in producing a cosmetic giving a highly excellent feel in using and having a very good texture, a cosmetic showing a very high stability over time as an emulsion, and a two-separate-layer-type cosmetic.




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Composition for cosmetics, cosmetic, method for producing oil-in-water emulsion cosmetic, and two separate layer-type cosmetic

The present invention relates to a composition for cosmetics including a polyglycerol fatty acid ester, which is an ester of polyglycerol having an average degree of polymerization of 4 to 100 with a fatty acid having 2 to 18 carbon atoms, has a hydroxyl value equal to or less than 15 mgKOH/g, and has a specific gravity at 20° C. of 0.96 to 1.15; a cosmetic which includes the composition for cosmetics; a method for producing an oil-in-water emulsion cosmetic which includes mixing the composition for cosmetics; and a two-separate-layer-type cosmetic, which comprises the composition for cosmetics. The present invention relates to the composition for cosmetics which can be appropriately used in producing a cosmetic giving a highly excellent feel in using and having a very good texture, a cosmetic showing a very high stability over time as an emulsion, and a two-separate-layer-type cosmetic.




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Castor oil derivatives and method for the production thereof

Novel compounds of formula (1) wherein: A is especially a linear or branched divalent alkylene radical having between 1 and 10 carbon atoms, and Y is especially a hydrogen atom.




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Process for the preparation of fatty acid alkyl esters (biodiesel) from triglyceride oils using eco-friendly solid base catalysts

This invention relates to an improved process for the preparation of green fatty acid methyl esters (FAME; commonly called as biodiesel) from different triglyceride oils using mixed metal oxides derived from layered double hydroxides (referred here as LDHs) as reusable solid heterogeneous base catalysts. This process uses very low alcohohoil molar ratio and catalyst and/or products are easily separable after the reaction through simple physical processes. The properties of thus obtained biodiesel meet the standard biodiesel values and can directly be used as transport fuel.




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Method for producing oil containing highly unsaturated fatty acid using lipase

A method for lowering content of a sterol in a highly unsaturated fatty acid-concentrated oil in a method to concentrate a highly unsaturated fatty acid by using a lipase reaction, may include removing the free form of the sterol from a raw material oil that includes a highly unsaturated fatty acid-containing glyceride prior to performing the lipase reaction; and thereafter concentrating the highly unsaturated fatty acid in the glyceride by using a lipase that is less reactive for the highly unsaturated fatty acid.




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Method and composition for modulating erythropoiesis

The invention generally relates to compositions and methods of their use. More specifically, the invention relates to the use of a compound in modulating erythropoiesis in a subject by mediating the activity and/or quantity of a member present in the LPA3-mediated signaling pathway, such as lysophosphatidic acid receptor subtype 3 (LPA3).




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Method for cleaving unsaturated fatty chains

The invention relates to a method for cleaving unsaturated fatty chains comprising a step of oxidative cleavage in which at least one fatty acid derivative having at least one unsaturation is reacted in the liquid phase with hydrogen peroxide in the presence of a catalyst for activating the reaction of oxidative cleavage and of molecular oxygen and in the absence of organic solvent.




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Processes for making compounds useful as inhibitors of ATR kinase

The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.




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Uracil derivative and use thereof for medical purposes

The present invention provides: an uracil derivative represented by general formula (I) or a physiologically acceptable salt thereof (in the formula, R1 represents a hydrogen atom, a C1-10 alkyl group, a C2-6 alkene group or a 3- to 6-membered saturated or 4- to 6-membered unsaturated aliphatic ring group which may contain 1 to 2 hetero atoms independently selected from the group consisting of N, O and S; R2 represents a hydrogen atom, a halogen atom, a cyano group, —NRcRd, —N═CHN(CH3)2, or an C1-3 alkyl group; Ar1 and Ar2 independently represent a 5- to 6-membered aromatic ring group which may contain 1 to 3 hetero atoms independently selected from the group consisting of N, O and S; and L represents a 6-membered aromatic ring group which may contain 1 to 4 nitrogen atoms, a pyrazole group, a triazole group, or an imidazole group); and a therapeutic agent or prophylactic agent for various inflammatory diseases associated with elastase, comprises the compound or the like as an active ingredient.