FDI by firms moving from China to India will help offset damage: Kotak’s Shah

The district administration and the Corporation has asked all banks to ensure security guards at the ATMs so that they can provide hand sanitisers to the people visiting the kiosks.

Roland Garros could be behind closed doors, says French tennis boss

Tamil Nadu government rushes to SC against Madras HC ruling on Tasmac closure

White House economic adviser Kevin Hassett said the unemployment rate was likely to climb to around 20% this month

Tesla said the county's position left it no choice but to take legal action to ensure Tesla and its employees can go back to work

Bharti Airtel added Rs 8,537.95 crore to its m-cap to stand at Rs 2,89,144.54 crore

Arti Singh remembered her first letter to mother on the occasion of Mothers' Day

The title compound, C24H18FNO3, crystallizes in the monoclinic centrosymmetric space group P21/n and its mol­ecular conformation is stabilized via C—H⋯O intra­molecular inter­actions. The supra­molecular network mainly comprises C—H⋯O, C—H⋯F and C—H⋯π inter­actions, which contribute towards the formation of the crystal structure. The different inter­molecular inter­actions have been further analysed via Hirshfeld surface analysis and fingerprint plots.

Many biologists are now routinely seeking to determine the three-dimensional structures of their proteins of choice, illustrating the importance of this knowledge, but also of the simplification and streamlining of structure-determination processes. Despite the fact that most software packages offer simple pipelines, for the non-expert navigating the outputs and understanding the key aspects can be daunting. Here, the structure determination of the type IV pili (TFP) protein PilA1 from Clostridioides difficile is used to illustrate the different steps involved, the key decision criteria and important considerations when using the most common pipelines and software. Molecular-replacement pipelines within CCP4i2 are presented to illustrate the more commonly used processes. Previous knowledge of the biology and structure of TFP pilins, particularly the presence of a long, N-terminal α-helix required for pilus formation, allowed informed decisions to be made during the structure-determination strategy. The PilA1 structure was finally successfully determined using ARCIMBOLDO and the ab initio MR strategy used is described.

Book review

The proton-conducting material (NH4)4H2(SeO4)3 is examined to check whether its conductivity spectra are sensitive to subtle changes in the crystal structure and proton dynamics caused by external pressure. The AC conductivity was measured using impedance spectroscopy, in the frequency range from 100 Hz to 1 MHz, at temperatures 260 K < T < 400 K and pressures 0.1 MPa < p < 500 MPa. On the basis of the impedance spectra, carefully analyzed at different thermodynamic conditions, the p–T phase diagram of the crystal is constructed. It is found to be linear in the pressure range of the experiment, with the pressure coefficient value dTs/dp = −0.023 K MPa−1. The hydrostatic pressure effect on proton conductivity is also presented and discussed. Measurements of the electrical conductivity versus time were performed at a selected temperature T = 352.3 K and at pressures 0.1 MPa < p < 360 MPa. At fixed thermodynamic conditions (p = 302 MPa, T = 352.3 K), the sluggish solid–solid transformation from low conducting to superionic phase was induced. It is established that the kinetics of this transformation can be described by the Avrami model with an effective Avrami index value of about 4, which corresponds to the classical value associated with the homogeneous nucleation and three-dimensional growth of a new phase.

The proton-conducting crystal (NH4)4H2(SeO4)3 is examined to check whether its conductivity spectra and the phase transition to the superprotonic phase are sensitive to subtle changes in the crystal structure and proton dynamics caused by various thermodynamic conditions. It is established that the kinetics of this transformation can be described using the Avrami model with an effective Avrami index value associated with homogeneous nucleation and three-dimensional growth of a new phase.

The true identity of the protein found in the crystals reported by Bondoc et al. [(2019), Acta Cryst. F75, 646–651] is given.

In a recent study of the mating behavior of these Asian spiders, researchers found that 87.5 percent of males had both palps amputated during copulation.

The post Don’t pick a fight with a eunuch spider. It has nothing to lose appeared first on Smithsonian Insider.

A new study has revealed information about the way tungara frogs in the tropical rain forest hear, sort, and process sounds which is very similar to the way humans do. The knowledge could be applicable to communication disorders associated with hearing loss and attention deficits or difficulties.

The post Research on tungara frogs may be applicable to hearing loss/attention deficits in humans appeared first on Smithsonian Insider.

Our studies of the genetic relationships between these bees tells us that they originated in the Amazon about 22 million years ago and that they moved north into Central America before 3 million years ago.

The post Two closely related bee species discovered far apart in Panama and northern Colombia appeared first on Smithsonian Insider.

Smithsonian Secretary Wayne Clough, left, talks with Carlos Jaramillo, scientist at the Smithsonian Tropical Research Institute in Panama, at a research site near the Panama […]

The post Wayne Clough & Carlos Jaramillo, at a research site near the Panama Canal. appeared first on Smithsonian Insider.

16,000 square kilometers of giant panda habitat will likely be lost by the year 2080

The post Panda habitat to be lost, shifted by climate change appeared first on Smithsonian Insider.

Imagine a gas giant planet spanning three times more sky than the Moon looming over the molten landscape of a lava world. This alien vista exists in the newly discovered two-planet system of Kepler-36.

The post Close encounters between planetary systems of Kepler-36 stun astrophysicists appeared first on Smithsonian Insider.

Save the Rhinos! Save the Elephants! Save the humans?! It seems strange to be connecting our own fate to that of wildlife but new research […]

The post Losing large mammals increases human risk from rodent-borne diseases appeared first on Smithsonian Insider.

A newly released study focusing on an extinct species, the Caribbean monk seal (Monachus tropicalis), has revealed just how evolutionarily unique its only two living […]

The post Too valuable to lose: Extinct relative reveals rarity of last two remaining monk seal species appeared first on Smithsonian Insider.

After eluding scientists for nearly 80 years, the Clarion nightsnake (Hypsiglena ochrorhyncha unaocularus), a nocturnal reptilian species that was initially discovered in the first half […]

The post Lost species of nightsnake rediscovered in Mexico appeared first on Smithsonian Insider.

Skygazers at northern latitudes are familiar with the W-shaped star pattern of Cassiopeia the Queen. This circumpolar constellation is visible year-round near the North Star. […]

The post CASSIOPEIA’S HIDDEN GEM: THE CLOSEST ROCKY, TRANSITING PLANET appeared first on Smithsonian Insider.

In the past 50 years, the amount of water in the open ocean with zero oxygen has increased more than fourfold. In coastal water bodies, […]

The post Earth’s oceans are losing their breath. Here’s the global scope appeared first on Smithsonian Insider.

The biological processes related to protein homeostasis in Mycobacterium tuberculosis, the etiologic agent of tuberculosis, have recently been established as critical pathways for therapeutic intervention. Proteins of particular interest are ClpC1 and the ClpC1–ClpP1–ClpP2 proteasome complex. The structure of the potent antituberculosis macrocyclic depsipeptide ecumicin complexed with the N-terminal domain of ClpC1 (ClpC1-NTD) is presented here. Crystals of the ClpC1-NTD–ecumicin complex were monoclinic (unit-cell parameters a = 80.0, b = 130.0, c = 112.0 Å, β = 90.07°; space group P21; 12 complexes per asymmetric unit) and diffracted to 2.5 Å resolution. The structure was solved by molecular replacement using the self-rotation function to resolve space-group ambiguities. The new structure of the ecumicin complex showed a unique 1:2 (target:ligand) stoichiometry exploiting the intramolecular dyad in the α-helical fold of the target N-terminal domain. The structure of the ecumicin complex unveiled extensive interactions in the uniquely extended N-terminus, a critical binding site for the known cyclopeptide complexes. This structure, in comparison with the previously reported rufomycin I complex, revealed unique features that could be relevant for understanding the mechanism of action of these potential antituberculosis drug leads. Comparison of the ecumicin complex and the ClpC1-NTD-L92S/L96P double-mutant structure with the available structures of rufomycin I and cyclomarin A complexes revealed a range of conformational changes available to this small N-terminal helical domain and the minor helical alterations involved in the antibiotic-resistance mechanism. The different modes of binding and structural alterations could be related to distinct modes of action.

Warner’s narrative covers the major natural sweeteners, including sugar, molasses from cane, beet sugar, corn syrup, honey and maple, as well as artificial sweeteners such as saccharin, cyclamate, aspartame and sucralose.

The post New Book: “Sweet Stuff: An American History of Sweeteners from Sugar to Sucralose” appeared first on Smithsonian Insider.