Having just turned 50, I’ve been reflecting on my first half-century of late… many fun and impactful moments, a few regrets, and a life I’ve tried to live to the fullest. One thread that has run throughout it has been

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By Ivana Magovčević-Liebisch, CEO of Vigil Neuroscience, as part of the From The Trenches feature of LifeSciVC In an industry where boom and bust cycles occur regularly and 90 percent of drug candidates fail to reach the market, an outstanding

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By Jonathan Montagu, CEO of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC HotSpot’s trip to Barcelona for the recent European Society of Medical Oncology (ESMO) Annual Meeting was no ‘European Vacation,’ but it was certainly

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Surgical stitches that generate electricity can help wounds heal faster in rats, a new study from China finds.

In the body, electricity helps the heart beat, causes muscles to contract, and enables the body to communicate with the brain. Now scientists are increasingly using electricity to promote healing with so-called electroceuticals. These electrotherapies often seek to mimic the electrical signals the body naturally uses to help new cells migrate to wounds to support the healing process.

In the new study, researchers focused on sutures, which are used to close wounds and surgical incisions. Despite the way in which medical devices have evolved rapidly over the years, sutures are generally limited in capability, says Zhouquan Sun, a doctoral candidate at Donghua University in Shanghai. “This observation led us to explore integrating advanced therapeutics into sutures,” Sun says.

Prior work sought to enhance sutures by adding drugs or growth factors to the stitches. However, most of these drugs either had insignificant effects on healing, or triggered side-effects such as allergic reactions or nausea. Growth factors in sutures often degraded before they could have any effect, or failed to activate entirely.

The research team that created the new sutures previously developed fibers for electronics for nearly 10 years for applications such as sensors. “This is our first attempt to apply fiber electronics in the biomedical field,” says Chengyi Hou, a professor of materials science and engineering at Donghua University.

Making Electrical Sutures Work

The new sutures are roughly 500 microns wide, or about five times the width of the average human hair. Like typical sutures, the new stitches are biodegradable, avoiding the need for doctors to remove the stitches and potentially cause more damage to a wound.

Each suture is made of a magnesium filament core wrapped in poly(lactic-co-glycolic) acid (PLGA) nanofibers, a commercially available, inexpensive, biodegradable polymer used in sutures. The suture also includes an outer sheath made of polycaprolactone (PCL), a biodegradable polyester and another common suture material.

Previously, electrotherapy devices were often bulky and expensive, and required wires connected to an external battery. The new stitches are instead powered by the triboelectric effect, the most common cause of static electricity. When two different materials repeatedly touch and then separate—in the case of the new suture, its core and sheath—the surface of one material can steal electrons from the surface of the other. This is why rubbing feet on a carpet or a running a comb through hair can build up electric charge.

A common problem sutures face is how daily movements may cause strain that reduce their efficacy. The new stitches take advantage of these motions to help generate electricity that helps wounds heal.

The main obstacle the researchers had to surmount was developing a suture that was both thin and strong enough to serve in medicine. Over the course of nearly two years, they tinkered with the molecular weights of the polymers they used and refined their fiber spinning technology to reduce their suture’s diameter while maintaining strength, Sun says.

In lab experiments on rats, the sutures generated about 2.3 volts during normal exercise. The scientists found the new sutures could speed up wound healing by 50 percent over the course of 10 days compared to conventional sutures. They also significantly lowered bacteria levels even without the use of daily wound disinfectants, suggesting they could reduce the risk of post-operation infections.

“Future research may delve deeper into the molecular mechanisms of how electrical stimulation facilitated would healing,” says Hui Wang, a chief physician at Shanghai Sixth People’s Hospital.

Further tests are needed in clinical settings to assess how effective these sutures are in humans. If such experiments prove successful, “this bioabsorbable electrically stimulating suture could change how we treat injuries in the future,” Hou says.

The scientists detailed their findings online 8 October in the journal Nature Communications.

Imagine you’re a baby cocoa plant, just unfurling your first tentative roots into the fertile, welcoming soil.

Somewhere nearby, a predator stirs. It has no ears to hear you, no eyes to see you. But it knows where you are, thanks in part to the weak electric field emitted by your roots.

It is microscopic, but it’s not alone. By the thousands, the creatures converge, slithering through the waterlogged soil, propelled by their flagella. If they reach you, they will use fungal-like hyphae to penetrate and devour you from the inside. They’re getting closer. You’re a plant. You have no legs. There’s no escape.

But just before they fall upon you, they hesitate. They seem confused. Then, en masse, they swarm off in a different direction, lured by a more attractive electric field. You are safe. And they will soon be dead.

If Eleonora Moratto and Giovanni Sena get their way, this is the future of crop pathogen control.

Many variables are involved in the global food crisis, but among the worst are the pests that devastate food crops, ruining up to 40 percent of their yield before they can be harvested. One of these—the little protist in the example above, an oomycete formally known as Phytophthora palmivora—has a US $1 billion appetite for economic staples like cocoa, palm, and rubber.

There is currently no chemical defense that can vanquish these creatures without poisoning the rest of the (often beneficial) organisms living in the soil. So Moratto, Sena, and their colleagues at Sena’s group at Imperial College London settled on a non-traditional approach: They exploited P. palmivora’s electric sense, which can be spoofed.

All plant roots that have been measured to date generate external ion flux, which translates into a very weak electric field. Decades of evidence suggests that this signal is an important target for predators’ navigation systems. However, it remains a matter of some debate how much their predators rely on plants’ electrical signatures to locate them, as opposed to chemical or mechanical information. Last year, Moratto and Sena’s group found that P. palmivora spores are attracted to the positive electrode of a cell generating current densities of 1 ampere per square meter. “The spores followed the electric field,” says Sena, suggesting that a similar mechanism helps them find natural bioelectric fields emitted by roots in the soil.

That got the researchers wondering: Might such an artificial electric field override the protists’ other sensory inputs, and scramble their compasses as they tried to use plant roots’ much weaker electrical output?

To test the idea, the researchers developed two ways to protect plant roots using a constant vertical electric field. They cultivated two common snacks for P. palmivora—a flowering plant related to cabbage and mustard, and a legume often used as a livestock feed plant—in tubes in a hydroponic solution.

Two electric-field configurations were tested: A “global” vertical field [left] and a field generated by two small nearby electrodes. The global field proved to be slightly more effective.Eleonora Moratto

In the first assay, the researchers sandwiched the plant roots between rows of electrodes above and below, which completely engulfed them in a “global” vertical field. For the second set, the field was generated using two small electrodes a short distance away from the plant, creating current densities on the order of 10 A/m². Then they unleashed the protists.

With respect to the control group, both methods successfully diverted a significant portion of the predators away from the plant roots. They swarmed the positive electrode, where—since zoospores can’t survive for longer than about 2 to 3 hours without a host—they presumably starved to death. Or worse. Neil Gow, whose research presented some of the first evidence for zoospore electrosensing, has other theories about their fate. “Applied electrical fields generate toxic products and steep pH gradients near and around the electrodes due to the electrolysis of water,” he says. “The tropism towards the electrode might be followed by killing or immobilization due to the induced pH gradients.”

Not only did the technique prevent infestation, but some evidence indicates that it may also mitigate existing infections. The researchers published their results in August in Scientific Reports.

The global electric field was marginally more successful than the local. However, it would be harder to translate from lab conditions into a (literal) field trial in soil. The local electric field setup would be easy to replicate: “All you have to do is stick the little plug into the soil next to the crop you want to protect,” says Sena.

Moratto and Sena say this is a proof of concept that demonstrates a basis for a new, pesticide-free way to protect food crops. (Sena likens the technique to the decoys used by fighter jets to draw away incoming missiles by mimicking the signals of the original target.) They are now looking for funding to expand the project. The first step is testing the local setup in soil; the next is to test the approach on Phytophthora infestans, a meaner, scarier cousin of P. palmivora.

P. infestans attacks a more varied diet of crops—you may be familiar with its work during the Irish potato famine. The close genetic similarities imply another promising candidate for electrical pest control. This investigation, however, may require more funding. P. infestans research can be undertaken only under more stringent laboratory security protocols.

The work at Imperial ties into the broader—and somewhat charged—debate around electrostatic ecology; that is, the extent to which creatures including ticks make use of heretofore poorly understood electrical mechanisms to orient themselves and in other ways enhance their survival. “Most people still aren’t aware that naturally occurring electricity can play an ecological role,” says Sam England, a behavioral ecologist with Berlin’s Natural History Museum. “So I suspect that once these electrical phenomena become more well known and understood, they will inspire a greater number of practical applications like this one.”

Complicating the PPP decision-making are growing indications of a leadership struggle.

Pakistan is one of a handful of countries (including India, Brazil, and South Africa) that routinely oppose the United States in multilateral debates despite strong bilateral ties to the U.S.

The AIADMK spent the highest share in spreading the party’s propaganda (99.5%) and relied only on media and advertisements

As leaders mull over who will head the party next, the Congress Working Committee announced that elections will be held on October 17.

National parties’ unknown income rose from 66% to 71% in the three years before and after the scheme’s introduction

Polling was held on December 4 and the results were announced on Wednesday.

As many as 3.32 crore voters will cast their votes in 37,809 polling stations across State

Jul 17, 2023

Apekshya Prasai, a political science doctoral candidate at the Massachusetts Institute of Technology, was recently named a 2023 Harry Frank Guggenheim Foundation Emerging Scholar.   The Emerging Scholars (nine in all) are doctoral candidates who are in the final year of writing dissertations on the nature of and responses to violence around the world.

Jun 10, 2024

As India concluded the world’s largest election on June 5, 2024, with over 640 million votes counted, observers could assess how the various parties and factions used artificial intelligence technologies – and what lessons that holds for the rest of the world.

Aug 8, 2023

Energy economist Karen Palmer, renowned for her research on the nation’s electric power sector, shared her insights on electricity regulation and deregulation, carbon pricing, and climate change policy in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”

Sep 8, 2023

Energy economist Severin Borenstein, Professor of the Graduate School at the Haas School of Business at the University of California, Berkeley, discussed the many significant challenges facing the nation’s electricity power sector in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.

Jul 28, 2024

The Africa in Focus series is a forum for the intellectual and critical analysis of processes and policies from the continent and its engagement with the international community. Through thoughtful and dynamic programming, Africa in Focus brings greater African perspectives into broader policy conversations at HKS.

Apr 8, 2024

Behavioral economist Hunt Allcott, Professor of Global Environmental Policy at the Doerr School of Sustainability at Stanford University, questioned the impact of new and used electric vehicle (EV) subsidies in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”

May 8, 2024

Electric vehicles (EVs) can challenge or support electricity systems depending on how they are charged. Controlled charging that combines technical solutions with heterogenous EV user behaviors can reduce peak demand to avoid grid constraints and support the integration of renewable energy.

Jun 12, 2024

Deploying renewable energy sources is the most promising approach to decarbonizing the power sector in China. However, the intermittency and non-dispatchable nature of wind and solar power pose significant challenges to grid stability, particularly when these sources reach high penetration rates. This study applies a unit commitment model to investigate the economic and environmental performance of load shaving strategies across different scenarios.

The �Design Smart, Live Beautifully� Home Tour coincides with the launch of the 2014 model of Blu�s award-winning�Breezehouse, which is�packed with luxurious features and an even more spacious floor plan

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Eyeglass World launches first retail collection of smart glass technologies in the U.S., including specially designed prescription lens options and hardware for Recon, Vuzix and Epson wearable devices.

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Just after the New Year, I spent some time in Vermont.

I go to Vermont to write, but ever since the start of the pandemic, I also go there for some clarity of thought. Sometimes it's easier to figure out how you're doing if you can get some distance from everything. Where I go, I have no cell service, internet, or email. I keep my fingers crossed that when I arrive, I won't discover frozen pipes. I haul a lot of wood (so much wood! Wood is heavy!). I start a fire in the stove and hole up for a while, blessed with the great good fortune to be allowed to turn briefly into a hermit.

Occasionally I'm able to talk to Kevin on the phone, and our conversations go something like this: Hi! How have you been? Could you please tell me the names of Henry VIII's wives in order and also which ones were executed? 

Because, again, I have no internet. So I keep a running list of all the things I've been wondering. And when you're listening to the audiobook of Wolf Hall while staring out the window,

sometimes you realize you want some spoilers. (The answer, if you're interested: (1) Catherine of Aragon. (2) Anne Boleyn, beheaded. (3) Jane Seymour. (4) Anne of Cleves. (5) Catherine Howard, beheaded. (6) Catherine Parr.) 

So anyway, I went to Vermont at the New Year. In previous years, I've loved the New Year. It's been a time of reflection and planning for me, a time to find balance and reconsider my intentions. Since the start of the pandemic, I've lost that New Year ritual to a certain extent, because time and its passage have gotten quite confusing. It doesn't seem possible, for example, that Winterkeep was released in 2021. Wasn't that eons ago? But also, I finalized a new book in 2021 (more on that, as soon as I'm allowed to say more) and am more than halfway through writing a new one, plus I have three other ideas begging to be written. How is that possible? Hasn't it been only a year? Didn't time used to be less springy than this? How old am I anyway? Did winter always used to make me this emotional? Why did I used to dislike my gray hair and now I love it? Why did I ever, EVER, put up with itchy tags in my clothes before now? Have my hands always been this cold? When will I see my friends' faces again?

It's really hard to sum up my last year and make plans for the next. I'm thinking in mushy blobs of time, rather than weeks, months, or years. But I am still hoping and planning. 

Here are three plans I have for the nearish future:

1. I will finish a draft of a new, contemporary book that I'm currently loving writing. (I actually think this will happen this spring!)

2. I will unveil a website. Finally, after more than a decade, I've hired someone to build me a website! I'm having so, so much fun making my own art for it. I think this will get sorted this summer.

3. I will make some strides in a project currently occupying me and some other family members: dual USA-Italian citizenship.

These are my plans. Of course, every new piece of news and frankly the world in general can gum up the works pretty easily these days. So, we'll see how everything goes. I'm trying to learn flexibility.

I hope you're able to find some flexibility too, and also some clarity of thought, as we move through the New Year.

We speak with former Ohio state senator and Bernie Sanders presidential campaign staffer Nina Turner about how the 2024 election has left her and many voters “frustrated” and “exhausted.” While she is not endorsing a candidate, she denounces the white supremacist rhetoric of the Trump campaign, which she notes is “as American as apple pie.” Turner pushes back on comparisons of the Trump movement to the rise of Nazi Germany, which she argues threaten to whitewash the United States’ own anti-democratic history. “The unfulfilled promises of this country, the undealt-with anti-Blackness and other types of racism and bigotry have not been dealt with sufficiently,” she explains. “It is us, and we need to deal with it and not push it off on some other nation.”

Kamala Harris is blasting Donald Trump for vowing to protect women whether they “like it or not” at the same time he is calling for Republican Liz Cheney to be shot in the face. We get response from The Nation's abortion access correspondent Amy Littlefield and talk about 10 states with abortion rights on the ballot, including Arizona, Nevada, Florida, South Dakota and Missouri. Trump's remarks are a “succinct and clear definition of patriarchy,” says Littlefield. She argues the 2024 election will be decided in large part by white women and whether they will vote for abortion rights. Trump is “laying out the bargain that white patriarchy has offered for white women in this country,” says Littlefield. “He is saying, 'White women, we will protect you from Brown and Black men.'”

With just days to go before the November 5 presidential election, fears are growing that Republicans intend to interfere with the official results in order to install Donald Trump as president. At Sunday’s Madison Square Garden rally, Trump said he had a “little secret” with House Speaker Mike Johnson that would have a “big impact” on the outcome, though neither he nor Johnson elaborated on what that entailed. Elie Mystal, the justice correspondent for The Nation, says the secret is almost certainly a plan to force a contingent election, whereby no candidate wins a majority of the Electoral College and the president is instead chosen by the House of Representatives, where Republicans hold a slim majority. Mystal notes that even if Democrats challenge such an outcome, the case would still end up before a Supreme Court with a conservative supermajority that is likely to side with Trump.

As Donald Trump and Kamala Harris campaign in Pennsylvania on the last day before the presidential election, false claims of voter fraud are spreading. “The truth is, none of these lies have been about election integrity. It’s always been about power,” says Neil Makhija, chair of the board of elections in Montgomery County, Pennsylvania — the battleground state that “could decide the election” — in a video essay featured by The New York Times. Makhija joins Democracy Now! to discuss his work expanding access to the vote and debunking the myth of mass voter fraud.

As voters across the United States head to the polls on Election Day, many face “a choice between two unsatisfactory candidates,” says Democracy Now! co-host Juan González. This choice is especially “excruciating” for those “who are outraged by our government’s continued support for Israel’s yearlong genocidal assault on Gaza.” He says the 2024 election has echoes of 1968, when many progressives sat out the election because of anger over Vietnam, but Richard Nixon’s victory and ultimate expansion of the war proved to be disastrous. “It would take many years for some of us to realize we had made a big mistake in sitting out that election. … Making these decisions at the time of election may be difficult but sometimes necessary to do to open up the way for possible change in the future.

As voters across the United States head to the polls, we speak with New York Times writer Jim Rutenberg about how Donald Trump may try to preemptively declare victory and challenge election results. The former president has ramped up claims Democrats are “a bunch of cheats” and preemptively cast doubt on a win by Vice President Kamala Harris, following a similar playbook as 2020 when he baselessly claimed the election was stolen. Rutenberg spoke to pro-Trump election officials in battleground states of Arizona, Georgia, Nevada and Pennsylvania who say they are ready to refuse to certify local election results as part of a wide-ranging effort to throw the system into disarray. Rutenberg says after the failed insurrection of January 6, 2021, many in Trump’s orbit had a clear goal for 2024: “We have to go local.” He also discusses the Electoral Count Reform Act of 2022 that makes it harder to stop the final certification of results.

Ari Berman, the voting rights correspondent for Mother Jones, details how pro-Trump forces may try to throw out the results of the 2024 election if Kamala Harris wins, with a focus on the swing state of Georgia, the “epicenter” of Trump’s failed efforts to overturn the 2020 election results. “It’s very dangerous to imagine what people who don’t believe in free and fair elections can do when given the power to oversee those very elections,” says Berman.

In a major piece for Mother Jones magazine on “Why Ballot Measures Are Democracy’s Last Line of Defense,” voting rights correspondent Ari Berman discusses abortion ballot measures in 10 states, important down-ballot races in Wisconsin and elsewhere, and the movement to abolish or reform the Electoral College.

Donald Trump has been reelected president of the United States. Ahead of Kamala Harris’s expected concession speech, we speak to professors Carol Anderson and Michele Goodwin to discuss Harris’s historic campaign — and historic loss. “The Confederacy won,” says Anderson, a professor of African American studies at Emory University. “It paints a picture of what Americans are willing to embrace,” says Goodwin, a professor of constitutional law at Georgetown and an expert on healthcare law, who warns of the public health dangers of a second Trump administration and discusses the election’s implications for reproductive rights.

In the wake of the reelection of Donald Trump, some of the richest people in the world saw their net worths soar as stock prices rapidly shot up. “What was different about this election was how central billionaires were in the entire political discourse,” says The Lever's David Sirota, who joins Democracy Now! to discuss the outsized role of the super-rich in U.S politics, pointing out that both Trump and Kamala Harris campaigned heavily with billionaires, including Elon Musk and Mark Cuban. “These people are not giving money simply out of the goodness of their hearts. They want things. They have policy demands,” Sirota says. “The investors, the donors, like billionaires, are looking for a return on their investment.” Sirota, who previously worked as a communications adviser and speechwriter for the Bernie Sanders presidential campaign, also explains how Elon Musk's influence on Trump’s campaign is a preview of the power he could wield if he ends up appointed to the Trump administration.

The FBI is investigating a spate of racist text messages targeting Black Americans in the wake of Donald Trump’s election victory last week. The texts were reported in states including Alabama, North Carolina, Pennsylvania and Virginia, addressing recipients as young as 13 by name and telling them they were “selected to pick cotton at the nearest plantation” and other messages referencing slavery. For more, we speak with Robert Greene II, a history professor at Claflin University, South Carolina’s first and oldest historically Black university in Orangeburg, where many students were targeted. “Initially when I heard about the texts, I thought it was a bit of a hoax, but … it quickly became clear that this wasn’t just a Claflin problem, it was a national issue, as well,” says Greene. We also speak with Wisdom Cole, senior national director of advocacy for the NAACP, who says “this is only the beginning,” with a second Trump administration expected to attack civil rights and embolden hate groups.