Some Democrats took "Believe Women" literally until Joe Biden was accused. Now they're relearning that guilt-by-accusation doesn't serve justice.

Stefan Klöppel
Mar 3, 2010; 30:3271-3275
BRIEF COMMUNICATION

Cristopher M. Niell
Jul 23, 2008; 28:7520-7536
BehavioralSystemsCognitive

Michael N. Shadlen
May 15, 1998; 18:3870-3896
Articles

Discurso del Dr. Agustín Carstens, Director General del Banco de Pagos Internacionales, en la Celebración del 25 Aniversario de la Autonomía del Banco de México, Ciudad de México, 22 de noviembre de 2019.

Adaptive coding of stimuli is well documented in perception, where it supports efficient encoding over a broad range of possible percepts. Recently, a similar neural mechanism has been reported also in value-based decision, where it allows optimal encoding of vast ranges of values in PFC: neuronal response to value depends on the choice context (relative coding), rather than being invariant across contexts (absolute coding). Additionally, value learning is sensitive to the amount of feedback information: providing complete feedback (both obtained and forgone outcomes) instead of partial feedback (only obtained outcome) improves learning. However, it is unclear whether relative coding occurs in all PFC regions and how it is affected by feedback information. We systematically investigated univariate and multivariate feedback encoding in various mPFC regions and compared three modes of neural coding: absolute, partially-adaptive and fully-adaptive.

Twenty-eight human participants (both sexes) performed a learning task while undergoing fMRI scanning. On each trial, they chose between two symbols associated with a certain outcome. Then, the decision outcome was revealed. Notably, in one-half of the trials participants received partial feedback, whereas in the other half they got complete feedback. We used univariate and multivariate analysis to explore value encoding in different feedback conditions.

We found that both obtained and forgone outcomes were encoded in mPFC, but with opposite sign in its ventral and dorsal subdivisions. Moreover, we showed that increasing feedback information induced a switch from absolute to relative coding. Our results suggest that complete feedback information enhances context-dependent outcome encoding.

SIGNIFICANCE STATEMENT This study offers a systematic investigation of the effect of the amount of feedback information (partial vs complete) on univariate and multivariate outcome value encoding, within multiple regions in mPFC and cingulate cortex that are critical for value-based decisions and behavioral adaptation. Moreover, we provide the first comparison of three possible models of neural coding (i.e., absolute, partially-adaptive, and fully-adaptive coding) of value signal in these regions, by using commensurable measures of prediction accuracy. Taken together, our results help build a more comprehensive picture of how the human brain encodes and processes outcome value. In particular, our results suggest that simultaneous presentation of obtained and foregone outcomes promotes relative value representation.

Microglial cells are considered as sensors of brain pathology by detecting any sign of brain lesions, infections, or dysfunction and can influence the onset and progression of neurological diseases. They are capable of sensing their neuronal environment via many different signaling molecules, such as neurotransmitters, neurohormones and neuropeptides. The neuropeptide VGF has been associated with many metabolic and neurological disorders. TLQP21 is a VGF-derived peptide and has been shown to signal via C3aR1 and C1qBP receptors. The effect of TLQP21 on microglial functions in health or disease is not known. Studying microglial cells in acute brain slices, we found that TLQP21 impaired metabotropic purinergic signaling. Specifically, it attenuated the ATP-induced activation of a K⁺ conductance, the UDP-stimulated phagocytic activity, and the ATP-dependent laser lesion-induced process outgrowth. These impairments were reversed by blocking C1qBP, but not C3aR1 receptors. While microglia in brain slices from male mice lack C3aR1 receptors, both receptors are expressed in primary cultured microglia. In addition to the negative impact on purinergic signaling, we found stimulating effects of TLQP21 in cultured microglia, which were mediated by C3aR1 receptors: it directly evoked membrane currents, stimulated basal phagocytic activity, evoked intracellular Ca²⁺ transient elevations, and served as a chemotactic signal. We conclude that TLQP21 has differential effects on microglia depending on C3aR1 activation or C1qBP-dependent attenuation of purinergic signaling. Thus, TLQP21 can modulate the functional phenotype of microglia, which may have an impact on their function in health and disease.

SIGNIFICANCE STATEMENT The neuropeptide VGF and its peptides have been associated with many metabolic and neurological disorders. TLQP21 is a VGF-derived peptide that activates C1qBP receptors, which are expressed by microglia. We show here, for the first time, that TLQP21 impairs P2Y-mediated purinergic signaling and related functions. These include modulation of phagocytic activity and responses to injury. As purinergic signaling is central for microglial actions in the brain, this TLQP21-mediated mechanism might regulate microglial activity in health and disease. We furthermore show that, in addition to C1qBP, functional C3aR1 responses contribute to TLQP21 action on microglia. However, C3aR1 responses were only present in primary cultures but not in situ, suggesting that the expression of these receptors might vary between different microglial activation states.

The tuberal hypothalamus is comprised of the dorsomedial, ventromedial, and arcuate nuclei, as well as parts of the lateral hypothalamic area, and it governs a wide range of physiologies. During neurogenesis, tuberal hypothalamic neurons are thought to be born in a dorsal-to-ventral and outside-in pattern, although the accuracy of this description has been questioned over the years. Moreover, the intrinsic factors that control the timing of neurogenesis in this region are poorly characterized. Proneural genes, including Achate-scute-like 1 (Ascl1) and Neurogenin 3 (Neurog3) are widely expressed in hypothalamic progenitors and contribute to lineage commitment and subtype-specific neuronal identifies, but the potential role of Neurogenin 2 (Neurog2) remains unexplored. Birthdating in male and female mice showed that tuberal hypothalamic neurogenesis begins as early as E9.5 in the lateral hypothalamic and arcuate and rapidly expands to dorsomedial and ventromedial neurons by E10.5, peaking throughout the region by E11.5. We confirmed an outside-in trend, except for neurons born at E9.5, and uncovered a rostrocaudal progression but did not confirm a dorsal-ventral patterning to tuberal hypothalamic neuronal birth. In the absence of Neurog2, neurogenesis stalls, with a significant reduction in early-born BrdU⁺ cells but no change at later time points. Further, the loss of Ascl1 yielded a similar delay in neuronal birth, suggesting that Ascl1 cannot rescue the loss of Neurog2 and that these proneural genes act independently in the tuberal hypothalamus. Together, our findings show that Neurog2 functions as a classical proneural gene to regulate the temporal progression of tuberal hypothalamic neurogenesis.

SIGNIFICANCE STATEMENT Here, we investigated the general timing and pattern of neurogenesis within the tuberal hypothalamus. Our results confirmed an outside-in trend of neurogenesis and uncovered a rostrocaudal progression. We also showed that Neurog2 acts as a classical proneural gene and is responsible for regulating the birth of early-born neurons within the ventromedial hypothalamus, acting independently of Ascl1. In addition, we revealed a role for Neurog2 in cell fate specification and differentiation of ventromedial -specific neurons. Last, Neurog2 does not have cross-inhibitory effects on Neurog1, Neurog3, and Ascl1. These findings are the first to reveal a role for Neurog2 in hypothalamic development.

We will only achieve zero hunger if we speak on behalf of those unable to represent themselves. That was a key message during an event titled “Zero Hunger: are we ready?” at FAO headquarters in Rome, Italy, on Friday, 11 October. “Hungry people have no voice, they are different from all others,” said FAO Director-General José Graziano da Silva (pictured, left). “We [...]

The California landmark is closed, but you can explore its bizarre architectural features from afar

Blending marshmallows with scientific rigor, the contest offers levity during a difficult time

The "lost" apples will help restore genetic, culinary diversity to a crop North America once produced in astonishing variety

The sites include the 5,000-year-old tomb of Meresankh III, the Red Monastery and the Mosque-Madrassa of Sultan Barquq

The 20th-century architect defined a uniquely American style that used nature-inspired motifs and horizontal lines

The virus tweaks bee behavior to infect new hives and may also spread other hive-killing pathogens and pests

Catch the musical event, featuring Sting, Death Cab for Cutie front man Ben Gibbard and other artists, on YouTube tonight at 8 p.m. Eastern time

Do some armchair traveling and see the breathtaking vistas of all 50 states while learning about their histories

This photo was taken from the Tunnel View at Yosemite National Park. The photo is of Bridalveil Fall consumed by smoke due to controlled burning on the Yosemite Valley floor.

Bacterial artificial chromosome (BAC) clones are rendered electrocompetent and transformed with the recombinant shuttle vector, pLD53SCAB/AB-box. Cointegrates are selected by growth on chloramphenicol and ampicillin to ensure recombination of the shuttle vector into the BAC.

Plasmid DNA is prepared from the recombinant shuttle vector pLD53.SCAB/A-B created by cloning of the A and B homology arms for two-step bacterial artificial chromosome (BAC) engineering. To confirm that the A-box and B-box arms have been successfully incorporated into pLD53.SCAB, the pattern of enzyme digestion of the modified plasmid is compared with that of the unmodified pLD53.SCAB. Once the shuttle vector is shown to carry the proper sequences, it is ready for transfer into the BAC host.

This protocol describes the preparation of the shuttle vector before its introduction into bacterial artificial chromosome (BAC) host cells for BAC two-step engineering. The homology arm sequences, prepared previously, are introduced by ligation into the digested shuttle vector DNA to provide sites for recombination within the BAC clone. Crude lysates of individual bacterial transformants serve as templates in polymerase chain reaction (PCR) analysis to confirm the presence of the homology arms in the recombinant shuttle vector.

In two-step bacterial artificial chromosome (BAC) engineering, a single plasmid is introduced into the BAC-carrying cell lines. The shuttle vector pLD53.SCAB (or pLD53.SCAEB) carries the recA gene and the R6K origin, which requires the protein to replicate. PIR2 cells, expressing , are typically used for the amplification of the vector and maintain about 15 copies/cell of the donor vector, which is relatively stable in this host.

Holland America and Princess cruise lines issued notices this week cancelling the remainder of the season in Atlantic Canada, citing global health concerns, and that's taking a huge bite out of the Port of Sydney's budget.

Carmen Figueroa Sotelo has been interpreting all the news conferences for English audiences since the beginning of the pandemic in Quebec

Remarks by Benoît Cœuré, Head of the Bank for International Settlements Innovation Hub, at the Reinventing Bretton Woods Committee - Chamber of Digital Commerce webinar on "The world economy transformed", 17 April 2020.

The string of pratfalls that was the comedic highlight of this year's New Waterford Coal Bowl Classic in Nova Scotia will be seen by millions of TV viewers.

The battle for humanity and solidarity in the post-American world.

Magical thinking won’t protect us.

God carries missionary friends through ‘a dark night of the soul’ in Hungary.

The post The Value of Simulation: Which Design is the Best? appeared first on The SOLIDWORKS Blog.

The post The Value of a “Body Double” During the Coronavirus Pandemic appeared first on The SOLIDWORKS Blog.

The post Learn the Value of Simulation in our Webinar Series appeared first on The SOLIDWORKS Blog.

OM Malawi begins construction on a ministry base they hope will impact the Malawian people for the Lord.

Chiyembekezo School is aptly named. Meaning “hope” in Chichewa, the school brings hope to orphans and vulnerable children in Ntaja, Malawi.

CNA Staff, Apr 30, 2020 / 05:00 am (CNA).- The bishops of England and Wales have urged parishes to help domestic abuse victims after a surge in requests for aid during the coronavirus crisis. 

Since the lockdown began in the U.K. March 23 there has been a 49% increase in calls and online pleas for assistance related to domestic abuse, the bishops said in a statement April 29. 

Bishop John Sherrington, chairman of the bishops’ domestic abuse group, said: “Catholic parishes can play an important role in fighting the scourge of domestic abuse, especially during the COVID-19 pandemic where we are seeing some shocking statistics from leading domestic abuse organisations.”

Guidance provided by the bishops’ domestic abuse group encourages pastors to raise the issue of domestic violence during livestreamed Masses and in homilies published on parish websites. 

The group also asks parishes to establish local domestic abuse support groups. Teams of volunteers should keep in regular contact with vulnerable parishioners, and collect and deliver donations to those living in refuges and other safe locations, the group advises.

It adds that team leaders ought to be “in a non-vulnerable COVID-19 category, and not living with any vulnerable people.” They should also have been checked by the Disclosure and Barring Service, which informs employers about applicants’ criminal records.

“Every local situation will differ and so our new guidance is designed to be used as an introduction to start a local project,” Bishop Sherrington said. “I hope that Catholics and parishes will be inspired to take this up in their local area.”

“Violence of this kind should never be tolerated or justified. It is an offence against the dignity of the human person.”
 

OM workers share how God answered prayers for visas to stay in North Africa.

Workers encourage new believers to persevere in their faith despite facing persecution from their families.

The world’s largest floating book fair welcomes its five millionth visitor as the tour of Asia comes to a conclusion.

Acne vulgaris is an extraordinarily common skin condition in adolescents. The mainstays of acne treatment have remained largely unchanged over recent years. In the context of increasing antibiotic resistance worldwide, there is a global movement away from antibiotic monotherapy toward their more restrictive use. Classically reserved for nodulocystic acne, isotretinoin has become the drug of choice by dermatologists for moderate to severe acne. Given the virtually ubiquitous nature of acne in teenagers, there remains an appreciable need for novel therapies. In this article, we will cover the currently used acne treatments, evaluate the issues and data supporting their use, explore the issues of compliance and the mental health implications of acne care, and recommend directions for the field of acne management in adolescents in the years ahead.

Words: Abbie Lyall

Your iPhone may be well protected against malware, but it can't protect your data as it travels the internet. Installing one of the best iPhone VPN apps can keep your information safe and private, even when you're connected to the web through an insecure Wi-Fi hotspot.

It’s been a nerve-wracking few years for the traditional auto industry. One Silicon Valley VC firm speculates on its future in an interview with Bloomberg.

One week before Ramadan, 17 participants share God’s love with hundreds of Arab tourists in Zell am See, Austria.

If you can't see elderly parents, or friends with medical conditions, what can you do to keep in touch? You can send a letter, of course, or make a landline phone call, but video calls allow you to speak and see each other.

From Thursday 16 January to Sunday 2 February 2020, musicians from across the world will take part in over 300 events in venues throughout Glasgow for the UK's premier celebration of celtic music.

YOU could call it state-sponsored sanctimony. In times of crisis or national emergency we’re all urged to pull in the same direction and put partisan politics behind us. How dare you talk about inequality and the plight of the disadvantaged at a time like this? Those who tend to be loudest in rebuking these social pariahs are often those who stand to benefit most from any suspension of scrutiny.