Transport / Logistic issues / Storage capacity issues

Commercial Changes / Commercial viability

Commercial Changes / Commercial viability

Custom designing proteins — a breakthrough recognized by the latest Nobel Prize in chemistry — could yield treatments that stop the worst of COVID-19 before it begins.

The post Stanford Medicine experts help Nobel winner custom design proteins for COVID-19 therapy appeared first on Scope.

WARSAW, 19 April 2016 – The OSCE Chairperson-in-Office, German Foreign Minister Frank Walter Steinmeier, today visited the headquarters of the OSCE Office for Democratic Institutions and Human Rights (ODIHR), in the context of the 25th anniversary of the establishment of the Office.

Chairperson-in-Office Steinmeier, who was joined for the visit by Witold Waszczykowski, Foreign Minister of Poland, met with ODIHR Director Michael Georg Link, before addressing guests and ODIHR Staff. In his address, he highlighted the background to the decision for the establishment of ODIHR in Warsaw, while stressing the continued importance of the Office’s work.

“The first democratic elections in 1989 in Poland marked the start of great change in Europe. It was not by coincidence that Warsaw was chosen as the seat of ODIHR – with this the OSCE paid tribute to the important role of the first Polish non-communist government since 1947 in the democratic re-shaping of Europe,” the German Foreign Minister said. “Today, 25 years later, I am in Warsaw to commend ODIHR, with its team of 150 people from 34 OSCE states, for its outstanding work: You are the chief promoters and defenders of the OSCE’s principles and commitments in the Human Dimension.”

“This task is never easy – it builds on your dedication to human rights and fundamental freedoms, it requires a reliable budget and it deserves the full support of all OSCE participating States,” he added. “ODIHR can count on Germany’s commitment, as OSCE Chairmanship, but also beyond.”

Director Link took the opportunity to express his thanks to both guests for their countries’ support for the Office.

“Over the past 25 years, ODIHR has grown into the OSCE’s principal human rights body, and this work is more important today than ever,” he said. “We are grateful for our host country’s continued support and appreciate the Chairperson-in-Office’s commitment to ODIHR and its mandate to promote human rights and democracy throughout the OSCE region.”

“ODIHR plays a major role not only in the process of monitoring human rights, but also in providing assistance with the implementation of commitments undertaken in the OSCE area,” said Polish Foreign Minister Waszczykowski. “ODIHR is an institution that truly makes a difference and, therefore, we fully support the work of every member of its highly devoted team.”

ODIHR was established in 1991 – originally as the OSCE Office for Free Elections – by a decision of OSCE heads of state and government at the Paris Summit in November of the previous year. The name was changed to its current form and its mandate significantly expanded in 1992, to providing assistance to governments and civil society in OSCE participating States in improving democratic governance, guaranteeing human rights and fundamental freedoms, and promoting tolerance and non-discrimination. 

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CHISINAU, 25 July 2016 – OSCE Chairperson-in-Office and German Federal Minister for Foreign Affairs Frank-Walter Steinmeier, is traveling to Moldova and will have talks in Chisinau and Tiraspol on 26 July 2016.

As the Spokesperson of the German Federal Foreign Office said in Berlin today, the visit to Moldova aims at strengthening the momentum that has recently been reinvigorated in the negotiation process on the settlement of the Transdniestrian conflict. On 2-3 June 2016 in Berlin the negotiators of the 5+2 Process met for the first time after a period of two years, and committed to undertaking concrete steps, including in the fields of ecology, education, transportation and telecommunications.

“We hope that there is a chance to bring this long-standing conflict step by step closer to a settlement,” said the Spokesperson.

In Chisinau, Steinmeier will meet with Speaker of Parliament Andrian Candu, Prime Minister Pavel Filip, Deputy Prime Minister and Minister of Foreign Affairs and European Integration Andrei Galbur, and Deputy Prime Minister for Reintegration and Moldovan Political Representative Gheorghe Balan.

In Tiraspol, the Chairperson-in-Office will meet a representative of the Transdniestrian leadership, Pavel Prokudin, Speaker of the Supreme Soviet, Vadim Krasnoslesky and the Transdniestrian Political Representative, Vitaly Ignatiev.

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CHISINAU / TIRASPOL, 26 July 2016 – OSCE Chairperson-in-Office, German Foreign Minister Frank-Walter Steinmeier, in Moldova today had talks with high-level Moldovan officials as well as with representatives from the Transdniestrian leadership. Steinmeier also visited the offices of the OSCE Mission in Moldova on both sides of the Dniester/Nistru River, in Chisinau and Tiraspol, and acknowledged their valuable work towards the Transdniestrian conflict settlement process. 

In Chisinau, Steinmeier met with Speaker of Parliament Andrian Candu, Prime Minister Pavel Filip, Deputy Prime Minister and Minister of Foreign Affairs and European Integration Andrei Galbur, and Deputy Prime Minister for Reintegration and Moldovan Political Representative Gheorghe Balan. During these talks Steinmeier was joined by his Special Representative for the Transdniestrian Settlement Process Ambassador Cord Meier-Klodt and the Acting Head of the OSCE Mission in Moldova Stephen Young.

Speaking to the media at a joint press conference with Prime Minister Filip, Steinmeier stressed the importance of the role of the OSCE and the unified approach of all international partners, while calling on the sides to remain fully committed to the settlement of this long-standing conflict. “The success in the settlement process fundamentally depends on the resolve of the sides to achieve progress to the benefit of the people. But it is also a result of the remarkable unity of international partners.” Besides the OSCE, the international partners are the Russian Federation, Ukraine, the European Union and the United States of America.

“With a view to the Transdniestrian conflict we have recently made considerable efforts to inject new momentum to the negotiation process between the sides which had come to a standstill for quite some time,” Steinmeier said. He continued that it was a priority now to ensure a sustainable effect of the 5+2 talks which resumed in Berlin on 2 and 3 June 2016.

“We must now, as a first step, tackle those problems that can be solved pragmatically in order to enhance the trust between the sides that is necessary for more far-reaching measures.” As examples of such confidence-building measures, Steinmeier referred to the re-connection of telecommunication networks, the apostilisation of Transdniestrian university diplomas and progress on the car license plate issue.

At his talks in Tiraspol with representatives of the Transdniestrian leadership, Pavel Prokudin and Vitaly Ignatiev as well as with the speaker of the Supreme Soviet Vadim Krasnoselsky, Steinmeier called on the sides to implement the Berlin Protocol from June 2016 in a swift and comprehensive manner. Steinmeier, during his visit, also re-affirmed the parameters of the settlement process, which is the territorial integrity and sovereignty of Moldova with a special status for Transdniestria. 

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YEREVAN, 30 June 2016 – OSCE Chairperson-in-Office and German Foreign Minister Frank-Walter Steinmeier visited the premises of the OSCE Office in Yerevan on 30 June to discuss its work and activities and to meet with civil society representatives, while in Armenia as part of his official visit to the three countries of the South Caucasus.

Steinmeier was welcomed by Ambassador Argo Avakov, Head of the OSCE Office in Yerevan.  “The Office in Yerevan is closely co-operating with state structures and civil society in Armenia and welcomes this visit by the Chairperson-in-Office,” said Avakov. “Civil society plays an important role in enhancing public confidence in the electoral process, improving police-public partnership as well as promoting women and youth engagement and the freedom of the media in Armenia.”

The Chairperson-in-Office underlined his appreciation for the Office’s activities in all three dimensions and commended its good co-operation with Armenian institutions.

The OSCE Office in Yerevan works closely with government partners, civil society and other actors in Armenia to support activities in a variety of areas including legislative and criminal justice reform, anti-corruption, migration policy, economic integration, environmental activities, raising awareness on human rights, media freedom, access to information, gender equality, assistance to police and security sector reform.  

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BERLIN / VIENNA, 15 July 2016 – OSCE Chairperson-in-Office and Germany’s Foreign Minister Frank-Walter Steinmeier and OSCE Secretary General Lamberto Zannier today condemned the deadly terror attack in Nice, France. 

“A day dedicated to joy and the pride of the French Nation ended in tragedy,” said Minister Steinmeier. “Many people were cruelly and senselessly taken from peaceful celebrations to death, many are struggling for their lives.  Our thoughts and our compassion lie with the victims, their families, the French people. We share the grief of France, in these dark hours we stand shoulder to shoulder.”

Ambassador Zannier said: “I am saddened and shocked by the terror attack in Nice. We at the OSCE stand in solidarity with the families of the victims, and with the people of France. OSCE participating States and Partners will not be intimidated by murder and violence. We will work together to tackle this scourge.”

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NYC Weekend Watch is our weekly round-up of repertory offerings. Roxy CinemaIn honor of Ken Kelsch, Abel Ferrara’s The Blackout and The Addiction screen on 35mm; prints of Douglas Buck’s Family Portraits: A Trilogy of America and the 2006 Sisters remake screen Saturday and Sunday, respectively. Film ForumA 4K restoration of Michelangelo Antonioni’s Il Grido begins; 42 screens on Sunday. […]

The post NYC Weekend Watch: Ken Kelsch, Il Grido, Flesh for Frankenstein 3D & More first appeared on The Film Stage.

The Orlando Philharmonic debuted "Seventeen," which gives young people a voice, and paid tribute to Leonard Bernstein in weekend concerts.

U4SSC - City Snapshot - Ulstein, Norway

Radio Liechtenstein acapara más del 70% de la financiación del estado para los medios, lo que le da una ventaja injustificada Leer

What are design principles and tools for innovation? How can they help government executives transform how government does business? What strategies can leaders employ to achieve a design mindset? Join host Michael Keegan as he explores these questions and more with Sarah Stein Greenberg, Author of Creative Acts for Curious People: How to Think, Create, and Lead in Unconventional Ways.

The post Creativity and curiosity in government: A conversation with Sarah Stein Greenberg first appeared on Federal News Network.

Massachusetts Air National Guard member Jack Teixeira is expected to face a military court-martial for leaking highly classified military documents.

The post Pentagon leaker Jack Teixeira to face a military court-martial, Air Force says first appeared on Federal News Network.

Location: Electronic Resource- 

Location: Electronic Resource- 

Compartmentalized protein expression in the spider silk gland provides clues to spinning more sustainable materials. 

Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular architecture.1?

Hora 20Panelistas señalaron que la polémica plantea de nuevo la politización de las FFMM y su efecto en garantizar confianza a la ciudadanía. Acore plantea que no hubo participación en política.

Mike Monteiro returns to the show to talk about the Capitol insurrection and riot, Twitter and Facebook permanently banning Donald Trump, the shutdown of Parler, the fate of liberal democracy, and Mike’s new book, “The Collected Angers”.

En este episodio, La Luciérnaga se enciende para revisar que reveló en su informe final la Comisión de la Verdad. Además, analizamos la salida del General Eduardo Zapateiro. También,  le contamos por qué 7 de cada 10 jefes quieren renunciar.La Luciérnaga un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

El médico argentino Miguel Glatstein, radicado en Israel desde hace más de dos décadas, habló sobre su vivencia y la situación humanitaria en medio de la guerra entre Israel y Palestina

En 10AM de Caracol radio estuvo Miguel Glatstein, médico argentino radicado en Israel, quien está en la ciudad de Nahariya, a unos 10 kilómetros de la frontera con Líbano, para hablar un poco sobre cómo está la situación en la zona.

The former Massachusetts Air National Guard member, Jack Teixeira, has been sentenced to 15 years in a federal prison for leaking classified documents about the war in Ukraine.

On Explorations this week Dr. Michio Kaku answers emails on air.  One persistent email is the question of God.  Is there a God? The Einstein God letter has been auctioned.  […]

The post ON EXPLORATIONS – Scientists look to find roots of religion; Einstein’s view of a creator appeared first on KKFI.

"The Einstein Show" marked 100 years since his publication of four papers that changed the laws of physics

Grote merken, zoals Jack Daniel’s, draaien de diversiteitsklok terug. De anti-woke-trend is tekenend voor de polarisering in de VS, die steeds meer tot uiting komt in reclame en communicatie. Overigens niet alleen voor Marketing the Rainbow, maar ook voor andere vormen van diversiteit. Het ingevoerde beleid na Black Lives Matter wordt hiermee óók deels teruggedraaid. […]

Teri Garr, the quirky comedy actor who rose from background dancer in Elvis Presley movies to co-star of such favorites as “Young Frankenstein” and “Tootsie,” has died. She was 79.

If there is one nutrient that you need to support your training and recovery, protein would be it! All the exercise in the world won’t help you build muscle or get lean if it is not supported with proper nutrition, which should always include a good dose of some high-quality protein or high quality protein powder.
Read the full article here==>How Much Protein?

Earlier this year, I started working through the online book Ray Tracing In One Weekend (Book 1). I have been following along with it in Common Lisp, and I have been extending it all from 3-dimensional to n-dimensional.

I reproduced 4-dimensional versions of all of the book images which you can see on my weekend-raytracer github page.

Here is the final image. This is a 250-samples-per-pixel, 640x360x10 image plane of three large hyperspheres (one mirrored, one diffuse, one glass) atop a very large, diffuse hypersphere. Also atop this very large hypersphere are a bunch of smaller hyperspheres of varying colors and materials. The image is rendered with some defocus-blur.

Caveat: This depends on a patched version of the policy-cond library that is not in the current Quicklisp distribution but should be in the next.

1. Peter Vandenbempt neemt praktijk op de korrel die steeds meer aan populariteit wint: "Gewoon geel geven, en een paar keer na elkaar"  Voetbalkrant.com
2. "Je lacht gewoon iedereen uit": Peter Vandenbempt hekelt "blessures bij doelmannen" en komt met oplossing  sporza.be
3. Delanghe onder vuur na acteren tegen RSC Anderlecht: “Lacht iedereen uit”  VoetbalPrimeur.be
4. Alle middelen zijn goed: de 'gouden' truc die Cercle Brugge toepaste tegen RSC Anderlecht krijgt (voorlopig) geen staartje  Voetbalkrant.com
5. Loopje met de sportiviteit, Delanghe faket blessure tegen Anderlecht  VoetbalPrimeur.be

1. Amerikaanse militair Jack Teixeira (22), die geheime informatie over oorlog lekte, krijgt 15 jaar cel  Het Nieuwsblad
2. Jonge Amerikaanse militair die Pentagon-documenten lekte veroordeeld tot 15 jaar cel  VRT.be
3. Live - Oorlog in Oekraïne. Jack Teixeira, die geheime documenten over oorlog lekte, veroordeeld tot 15 jaar cel • Noord-Koreaanse soldaten betrokken bij gevechten, zeggen VS  De Morgen
4. 15 jaar cel voor Amerikaanse militair die geheime documenten lekte  NOS
5. 15 jaar cel voor Amerikaanse militair die geheime informatie op internet deelde  NU.nl

RAMMSTEIN the only real reason most of us want to learn german

Research by Princeton scholars at the Atacama Cosmology Telescope collaboration has culminated in a significant breakthrough in understanding the evolution of the universe.

The underlying cause of multiple sclerosis is not yet known, but Epstein-Barr virus is a possible culprit, Harvard researchers say.

Teixeira leaked highly classified Pentagon documents to an online platform popular with gamers.

1. 9 protein-packed Indian breakfasts to fuel your day  Business Insider India
2. 6 Protein-Packed Breakfast Without Eggs  HerZindagi
3. 8 High-Protein Indian Breakfast Recipes to Fuel Your Day  Recipes
4. Wholesome Indian breakfasts that boost energy  Business Insider India
5. Have a protein-rich breakfast every day for these 7 benefits  Hindustan Times

Illustrator, writer, and filmmaker Mordicai Gerstein died earlier this month. He leaves behind an amazing body of work which is sure to be read and appreciated; several have already been anointed as modern classics.

Numerous iron-sulfur (Fe-S) proteins with diverse functions are present in the matrix and respiratory chain complexes of mitochondria. Although [4Fe-4S] clusters are the most common type of Fe-S cluster in mitochondria, the molecular mechanism of [4Fe-4S] cluster assembly and insertion into target proteins by the mitochondrial iron-sulfur cluster (ISC) maturation system is not well-understood. Here we report a detailed characterization of two late-acting Fe-S cluster-carrier proteins from Arabidopsis thaliana, NFU4 and NFU5. Yeast two-hybrid and bimolecular fluorescence complementation studies demonstrated interaction of both the NFU4 and NFU5 proteins with the ISCA class of Fe-S carrier proteins. Recombinant NFU4 and NFU5 were purified as apo-proteins after expression in Escherichia coli. In vitro Fe-S cluster reconstitution led to the insertion of one [4Fe-4S]2+ cluster per homodimer as determined by UV-visible absorption/CD, resonance Raman and EPR spectroscopy, and analytical studies. Cluster transfer reactions, monitored by UV-visible absorption and CD spectroscopy, showed that a [4Fe-4S]2+ cluster-bound ISCA1a/2 heterodimer is effective in transferring [4Fe-4S]2+ clusters to both NFU4 and NFU5 with negligible back reaction. In addition, [4Fe-4S]2+ cluster-bound ISCA1a/2, NFU4, and NFU5 were all found to be effective [4Fe-4S]2+ cluster donors for maturation of the mitochondrial apo-aconitase 2 as assessed by enzyme activity measurements. The results demonstrate rapid, unidirectional, and quantitative [4Fe-4S]2+ cluster transfer from ISCA1a/2 to NFU4 or NFU5 that further delineates their respective positions in the plant ISC machinery and their contributions to the maturation of client [4Fe-4S] cluster-containing proteins.

The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a pandemic and caused global public health crisis. Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2. As a carboxypeptidase, ACE2 cleaves many biological substrates besides angiotensin II to control vasodilatation and vascular permeability. Given the nanomolar high affinity between ACE2 and SARS-CoV-2 spike protein, we investigated how this interaction would affect the enzymatic activity of ACE2. Surprisingly, SARS-CoV-2 trimeric spike protein increased ACE2 proteolytic activity ∼3-10 fold against model peptide substrates, such as caspase-1 substrate and Bradykinin-analog. The enhancement in ACE2 enzymatic function was mediated by the binding of SARS-CoV-2 spike RBD domain. These results highlighted the potential for SARS-CoV-2 infection to enhance ACE2 activity, which may be relevant to the cardiovascular symptoms associated with COVID-19.

IQGAP1 is a key scaffold protein that regulates numerous cellular processes and signaling pathways. Analogous to many other cellular proteins, IQGAP1 undergoes post-translational modifications, including phosphorylation. Nevertheless, very little is known about the specific sites of phosphorylation or the effects on IQGAP1 function. Here, using several approaches, including MS, site-directed mutagenesis, siRNA-mediated gene silencing, and chemical inhibitors, we identified the specific tyrosine residues that are phosphorylated on IQGAP1 and evaluated the effect on function. Tyr-172, Tyr-654, Tyr-855, and Tyr-1510 were phosphorylated on IQGAP1 when phosphotyrosine phosphatase activity was inhibited in cells. IQGAP1 was phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src signaling, including in human lung cancer cell lines. This phosphorylation was significantly reduced by chemical inhibitors of MET or c-Src or by siRNA-mediated knockdown of MET. To investigate the biological sequelae of phosphorylation, we generated a nonphosphorylatable IQGAP1 construct by replacing Tyr-1510 with alanine. The ability of hepatocyte growth factor, the ligand for MET, to promote AKT activation and cell migration was significantly greater when IQGAP1-null cells were reconstituted with IQGAP1 Y1510A than when cells were reconstituted with WT IQGAP1. Collectively, our data suggest that phosphorylation of Tyr-1510 of IQGAP1 alters cell function. Because increased MET signaling is implicated in the development and progression of several types of carcinoma, IQGAP1 may be a potential therapeutic target in selected malignancies.

Alfred C. O. Vertegaal
Dec 1, 2006; 5:2298-2310
Research

Lars Jønson
May 1, 2007; 6:798-811
Research

Michal Bassani-Sternberg
Mar 1, 2015; 14:658-673
Research

Ileana M. Cristea
Dec 1, 2005; 4:1933-1941
Research

Ilka Wittig
Jul 1, 2007; 6:1215-1225
Research

Hasmik Keshishian
Dec 1, 2007; 6:2212-2229
Research

M. Wang
Aug 1, 2012; 11:492-500
Technological Innovation and Resources