In my first couple of years of garden mothing, almost everything species that appeared was new to me, there were dozens and dozens. Well over 120 moths I’d never knowingly seen before. In subsequent years, there were the dozens of regulars, but even then still a few dozen species that were new to the garden … Continue reading "Moth of the Moment – Black-spotted Chestnut"

The 2024 Good Furry Awards were presented this Tuesday, 15 October, at Biggest Little Fur Con.

This year saw the Award divided into three categories, the winners of which were:

• Image Award: Finn the Panther
• Furtastic Award: Spottacus Cheetah
• Good Egg Award: Shutter Karelian

Meanwhile, 2024's Lifetime Achievement award was presented to Albedo creator Steve Gallacci.

Catch this once-in-a-lifetime comet over the next few days.

Bitcoin fell 3.4% in the past 24 hours to trade at $86,855, potentially indicating profit-taking by investors, according to a BRN analyst.

When your 2020 wrapped congratulates you on all four episodes of content you produced this year, it must be PotterCast!

Welcome to season 16, in which we are, we swear, on the edge of actually producing this thing at a normal clip. See how it's going to start to work in this episode in which we introduce a few new segments — a bit of opening chatter (including an IN-Depp conversation as Frankie puts it) with your gang, then two new segments: POTTER PONDERINGS (in this episode, we wonder what it takes to make a Hufflepuff go dark) and HEY NETFLIX (in which we pitch spinoff shows about the Potter universe — today, what would we want from a show about the Ministry of Magic?). Then join us to chat in the drums as usual!

~*~

Here are ways to support the show!
Join our patreon! patreon.com/pottercast - Now, you can also join our Discord community there!

You can also buy PotterCast-related merch at mischiefmerch.com!

You can add this cheese to pasta, pizza, or charcuterie boards. READ MORE...

When I first started working in the big city, my friends and I rented a house. I always tried to make my little room as cozy and personal as possible, beyond the basic bed and wardrobe that came with the place. And I made sure to leave it in as good, if not better, condition than when I moved in. Later in life, I had the opportunity to rent out a property. Unfortunately, I experienced the frustration of having my […]

The post 17 Sneaky Ideas for a Rental Makeover Your Landlord Won’t Spot appeared first on IKEA Hackers.

The Leonid meteor shower peaks in North America overnight from Nov. 17 to 18, with fast-moving fireballs possible in US skies.

If you’re an avid coffee connoisseur and celebrity-spotter, you’re in for a treat. There are coffee shops globally frequented by stars who enjoy a good cup of joe. Let’s explore 12 coffee shops where you might bump into your favorite celebrity. 1. Alfred Coffee, Los Angeles LA is the home of Hollywood stars, and one ... Read more

The post 12 Coffee Shops Where You Might Just Spot a Celebrity appeared first on Star Two.

Over a dozen flights cancelled or delayed between Bali and Australia

Ibiza, a stunning island in the Mediterranean Sea, is globally renowned for its electric nightlife and vibrant party scene. This picturesque island has become the epitome of summer party destinations. It attracts visitors from all corners of the world with its beautiful beaches, mesmerizing sunsets, and, most notably, its unparalleled nightlife. Clubs in Ibiza are not just venues; they are the beating heart of the island’s culture as they showcase world-class DJs, groundbreaking music, and unforgettable experiences to define the essence of a perfect summer getaway. The purpose of this article is to guide you through the exhilarating nightlife of Ibiza. Whether you’re a seasoned club-goer or a first-time visitor, this comprehensive guide to the top 10 must-visit nightclubs will ensure you hit the hottest spots and make the most of your nights in Ibiza. From iconic institutions to cutting-edge clubs, we’ve curated a list that captures the diversity and vibrancy of Ibiza’s nightlife. These places promise unforgettable nights filled with music, dance, and celebration. Why Ibiza? Ibiza stands as a beacon for nightlife enthusiasts from around the globe. It’s celebrated for its unmatched party scene and vibrant atmosphere. But what exactly catapults this Balearic Island into the spotlight as a world-renowned destination for nightlife? Diverse Music Scene: Ibiza’s music landscape is as varied as it is electrifying. From techno and house to EDM and indie rock, the island offers something for every taste, hosted across an array of clubs and venues. Vibrant Atmosphere: There’s an infectious energy that permeates Ibiza’s nightlife. Whether you’re dancing under the stars at an outdoor beach club or losing yourself in the immersive environment of an underground venue, the atmosphere is always charged with excitement. Stunning Venues: Ibiza’s nightclubs are more than just places to dance; they’re architectural wonders and sensory experiences. From clubs with breathtaking views of the Mediterranean to venues that push the boundaries of interior design, Ibiza offers stunning settings that elevate the party experience to new heights. Criteria for Selection When it comes to pinpointing the top 10 nightclubs in Ibiza, our selection is driven by a carefully considered set of criteria. We aim to showcase venues that not only dominate the nightlife scene but also offer unique experiences that leave a lasting impression. The following factors play a crucial role in our selection: Music Genres: A club’s musical offerings are pivotal. We look for diversity and quality, favoring venues that host world-renowned DJs to suit a wide range of musical tastes. Atmosphere: The vibe of a nightclub is its soul. We seek out places that offer more than just a dance floor. In fact, we prioritize those who create an immersive experience through their energy, design, and crowd.  Reputation: A club’s reputation is built on years of delivering exceptional nights out. We consider the esteem in which venues are held by both locals and international visitors, as well as their recognition within the global nightlife community. Overall Experience: Finally, we factor in the overall experience, including the quality of sound and lighting systems, the presence of unique features (like outdoor terraces or poolside dance floors), and the level of service provided. A club that offers an unforgettable night out, from entry to exit, makes our list.  Club 1: Amnesia Ibiza Location San Rafael, Ibiza Music Genres Techno House EDM Atmosphere Amnesia Ibiza stands out for its high-energy ambiance which makes it a sanctuary for dance music enthusiasts. The club’s iconic terrace offers an immersive experience that draws partygoers into a world of euphoric beats and rhythms. Notable Features Famous Foam Parties: These unique and wildly entertaining parties are a signature Amnesia experience. State-of-the-Art Sound System: Delivers crystal-clear audio that enhances the musical journey. Spectacular Light Shows: Visually stunning displays complement the sonic experience, creating unforgettable moments.  Highlights Legends of the electronic music scene, such as Carl Cox and Marco Carola, are regulars here, guaranteeing an unmatched lineup of performances. Club 2: Pacha Ibiza Location Ibiza Town, Ibiza Music Genres House Techno EDM Atmosphere Pacha Ibiza exudes a glamorous and chic vibe and offers a luxurious nightclub experience. Its atmosphere attracts a stylish crowd to dance the night away in one of the island’s most iconic settings. Notable Features Iconic Cherry Logo: A symbol of the club’s heritage and prestige. VIP Sections: For those seeking a more exclusive experience, with stunning views of Ibiza Town. Elegant Decor: Pacha’s interior design combines style with comfort, creating a uniquely sophisticated environment. Highlights Hosting world-renowned DJs like David Guetta and Martin Solveig, Pacha remains at the forefront of Ibiza’s nightlife scene. Club 3: DC-10 Location Sant Josep de sa Talaia, Ibiza Music Genres Techno House Atmosphere DC-10 is celebrated for its raw and underground atmosphere. This club offers an intimate setting where the focus is squarely on the music and the communal experience of dance. Notable Features Open-Air Terrace: Provides a unique outdoor clubbing experience. Industrial Vibe: The club’s minimalist, warehouse-style setup enhances its gritty, authentic feel. Immersive Experiences: DC-10’s events are designed to create a deep connection between the DJs and the crowd. Highlights Home to the legendary Circoloco parties, DC-10 attracts top DJs such as Seth Troxler and The Martinez Brothers to ensure an unparalleled lineup and vibe. Club 4: Ushuaïa Ibiza Beach Club Location Playa d’en Bossa, Ibiza Music Genres EDM House Atmosphere Ushuaïa Ibiza Beach Club is the epitome of an extravagant outdoor party experience. With its poolside setting, it invites guests to dance under the sun and stars in one of the most breathtaking venues on the island. Notable Features Massive Stage: Hosts some of the biggest names in the music industry. Stunning Visuals: Offers a sensory feast with its impressive light shows and stage productions. Celebrity Appearances: A hotspot for celebrities, adding to the club’s allure. Highlights Iconic pool parties featuring world-class performances by artists like Calvin Harris and Avicii are the heart of Ushuaïa’s appeal. Club 5: Hï Ibiza Location Playa d’en Bossa, Ibiza Music Genres Techno House EDM Atmosphere Hï Ibiza offers a sophisticated and futuristic nightclub experience. Its immersive atmosphere is crafted through cutting-edge sound and stunning visuals that make every night a journey into the future of nightlife. Notable Features Cutting-Edge Sound System: Delivers unparalleled audio quality. Immersive Production: Engages all senses for a complete clubbing experience. Stunning Visuals: The club’s design and lighting create a mesmerizing environment. Highlights Glitterbox parties at Hï Ibiza shine with disco and house music vibes, featuring top DJs and a vibrant, inclusive atmosphere. Club 6: Privilege Ibiza Location San Rafael, Ibiza Music Genres House Techno EDM Atmosphere Privilege Ibiza is recognized for its massive scale and extravagant atmosphere. Holding the Guinness World Record for the world’s largest club, it offers an immersive experience with panoramic views of Ibiza. Notable Features World’s Largest Club: A title that adds to its legendary status. Panoramic Views: The club’s location and design provide breathtaking views of the island. Highlights Resistance parties at Privilege are a highlight, featuring top techno and house DJs like Adam Beyer and Charlotte de Witte to create unforgettable nights. Club 7: Eden Ibiza Location San Antonio, Ibiza Music Genres House Techno EDM Atmosphere Eden Ibiza strikes a perfect balance between lively and intimate as it creates an energetic atmosphere for music lovers to enjoy themselves up close with the performers. Notable Features Renovated Venue: A recent makeover has injected new life into Eden, enhancing its appeal. Impressive LED Screens: Add to the visual experience, complementing the beats with captivating displays. Intimate Dance Floor: Despite its size, Eden maintains an intimate feel, making every night more personal. Highlights Toolroom parties at Eden are a standout, with house music legends like Mark Knight behind the decks. Club 8: Heart Ibiza Location Ibiza Town, Ibiza Music Genres Eclectic Avant-garde Live performances Atmosphere Heart Ibiza offers an artistic and immersive experience with a blend of music, art, and gastronomy into a unique nightlife adventure to tantalize all senses. Notable Features Fusion of Music, Art, and Gastronomy: A unique concept that stands out in Ibiza’s nightlife. Stunning Interior Design: Adds to the immersive experience with its beauty and creativity. Highlights Heart Factory events are particularly notable for their live performances and DJ sets by international artists, making each night a unique journey. Club 9: Ibiza Rocks Hotel Location San Antonio, Ibiza Music Genres Indie Rock EDM Atmosphere Ibiza Rocks Hotel is known for its lively and vibrant environment, where the poolside setting adds a refreshing twist to the traditional nightclub experience. Notable Features Outdoor Stage: Offers a unique venue for live music under the Ibiza sun and stars. Pool Parties: Bring an energetic and fun atmosphere, perfect for daytime reveling. Live Music Events: Unlike many other clubs focusing solely on DJs, Ibiza Rocks hosts live bands and performances. Highlights The Ibiza Rocks Pool Party series is a summer highlight, featuring an eclectic mix of live performances by indie bands and DJs. It offers something different from the typical club scene. Club 10: Octan Ibiza Location Playa d’en Bossa, Ibiza Music Genres Techno House Atmosphere Octan Ibiza brings a raw and underground vibe to the forefront of Ibiza’s nightlife. Its intimate setting allows for an immersive clubbing experience that’s both intense and personal. Notable Features Intimate Dance Floors: Designed to create a close connection between the DJs and the crowd. Immersive Experiences: Focused on delivering cutting-edge underground parties. Legacy: Carrying the torch from the famed Sankeys Ibiza, Octan continues to push the boundaries of the electronic music scene. Highlights The club is a haven for enthusiasts of techno and house music, and it hosts cutting-edge underground parties with leading DJs in the genre. Frequently Asked Questions (FAQ) What is the legal drinking age in Ibiza? The legal drinking age in Ibiza is 18 years old. Is there a dress code for Ibiza nightclubs? Dress codes can vary. While some clubs are more relaxed, others might require a more upscale attire. It’s best to check the specific club’s policy before going. How much does it cost to enter Ibiza nightclubs? Entrance fees can range widely from club to club and depending on the event or DJ playing. Prices can vary from €20 to over €50. VIP services and tables will cost significantly more. Are there any age restrictions for entry into nightclubs? Yes, most nightclubs in Ibiza have an age restriction of 18 years and above. Is it necessary to book tickets in advance for Ibiza nightclubs? It’s highly recommended to book tickets in advance, especially for popular events, to ensure entry and often at a lower price. What are the typical opening hours for Ibiza nightclubs? Nightclubs usually open around midnight and can go on till dawn, with peak hours from 1 AM to 4 AM. Are there any safety tips for clubbing in Ibiza? Stay hydrated, especially if dancing for long periods. Keep an eye on your belongings. Never accept drinks from strangers. Stick with your friends and plan how to get back to your accommodation safely. Conclusion We’ve explored the top 10 must-visit nightclubs in Ibiza, and each offers its unique vibe. From the extravagant and glamorous to the raw and underground, Ibiza’s nightlife is unparalleled. Its diverse music scenes and world-renowned DJs provide an unforgettable experience for every partygoer. Whether you’re drawn to the legendary foam parties of Amnesia, the sophisticated atmosphere of Hï Ibiza, or the intimate underground vibes of Octan, the island caters to all. We encourage you to dive into the vibrant energy of Ibiza’s nightlife scene and experience the magic of these iconic clubs firsthand.  

The post Top 10 Must-Visit Ibiza Nightclubs: Your Ultimate Guide to the Island’s Hottest Spots appeared first on Geeky Traveller.

If you have Spotify's soon-to-be-bricked Car Thing, there are a few ways you can give it a new lease on life. YouTuber Dammit Jeff has showcased modifications to Car Thing that makes the device useful as a desktop music controller, customizable shortcut tool, or a simple digital clock. Ars Technica's Kevin Purdy reports: Spotify had previously posted the code for its uboot and kernel to GitHub, under the very unassuming name "spsgsb" and with no announcement (as discovered by Josh Hendrickson). Jeff has one idea why the streaming giant might not have made much noise about it: "The truth is, this thing isn't really great at running anything." It has half a gigabyte of memory, 4GB of internal storage, and a "really crappy processor" (Amlogic S905D2 SoC) and is mostly good for controlling music. How do you get in? The SoC has a built-in USB "burning mode," allowing for a connected computer, running the right toolkit, to open up root access and overwrite its firmware. Jeff has quite a few issues getting connected (check his video description for some guidance), but it's "drag and drop" once you're in. Jeff runs through a few of the most popular options for a repurposed Car Thing: - DeskThing, which largely makes Spotify desk-friendly, but adds a tiny app store for weather (including Jeff's own WeatherWave), clocks, and alternate music controls - GlanceThing, which keeps the music controls but also provides some Stream-Deck-like app-launching shortcuts for your main computer. - Nocturne, currently invite-only, is a wholly redesigned Spotify interface that restores all its Spotify functionality.

Read more of this story at Slashdot.

“A huge fish in the Mekong River thought to be extinct has been spotted three times in recent years,” reports the Associated Press: “The giant salmon carp is like a symbol of the Mekong region,” said Chheana Chhut, a researcher at the Inland Fisheries Research Institute in Cambodia. The predatory fish can grow up to […]

The post Giant fish believed to be extinct is spotted in the Mekong River appeared first on Liberty Unyielding.

A fair number of Mac users have discovered that Spotlight Search is not working well in MacOS Sequoia, either missing files, apps, and sometimes not working at all to find any local file. For some users the issues with Spotlight happens right after they update to MacOS Seqouia, and for others it may happen later ... Read More

President-elect Donald Trump is reportedly considering lawyer Alina Habba to be the White House press secretary. Habba often spoke to the media while she was on the legal team representing […]

The post Report Shows New Front-Runner for Trump's Press Secretary Spot: The Media Should Be Terrified appeared first on The Western Journal.

Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: Gs, Gi/o, Gq/11, and G12/13. Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncogenic transformation in experimental systems. With the advent of next-generation sequencing, activating hotspot mutations in Gs, Gi/o, or Gq/11 proteins have also been identified in patient tumor samples. In contrast, patient tumor-associated G12/13 mutations characterized to date lead to inactivation rather than activation. By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associated hotspot mutations in Arg-200 of Gα13 (encoded by GNA13) as potent activators of oncogenic signaling. First, we found that components of a G12/13-dependent signaling cascade that culminates in activation of the Hippo pathway effectors YAP and TAZ is frequently altered in bladder cancer. Up-regulation of this signaling cascade correlates with increased YAP/TAZ activation transcriptional signatures in this cancer type. Among the G12/13 pathway alterations were mutations in Arg-200 of Gα13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-dependent (SRE.L) transcriptional activity. We further showed that this mechanism relies on the same RhoGEF-RhoGTPase cascade components that are up-regulated in bladder cancers. Moreover, Gα13 Arg-200 mutants induced oncogenic transformation in vitro as determined by focus formation assays. In summary, our findings on Gα13 mutants establish that naturally occurring hotspot mutations in Gα subunits of any of the four families of heterotrimeric G-proteins are putative cancer drivers.

Food system transformation: A blind spot for climate and biodiversity action? 20 October 2022 — 12:00PM TO 1:00PM Anonymous (not verified) 5 October 2022 Chatham House and Online

How can COP27 and COP15 accelerate the agenda for sustainable food systems and land use?

Tackling the dual crises of climate change and biodiversity loss requires extraordinary levels of action at an unprecedented speed. Agriculture is the biggest user of land, the biggest source of methane emissions, a major contributor to total greenhouse gas emissions and the leading driver of biodiversity loss.

Anything short of a food system transformation puts climate and biodiversity objectives in peril. However, governments have not yet produced credible pathways and strong policies for tackling our growing ‘foodprint’ – the negative impacts of what we grow and eat.

In advance of COP27 in Sharm El-Sheikh for climate and COP15 in Montreal for biodiversity, Chatham House has published a new briefing paper which examines aligning food systems with climate and biodiversity targets.

The paper reviews the climate and biodiversity policy landscape to 2030, with a focus on land-based aspects and the inclusion of food and agriculture. The paper highlights serious conflicts between the impacts of the food system and goals to protect and restore biodiversity and mitigate climate change.

In light of this, opportunities for joined-up action on food, climate and biodiversity are identified, including three key steps for countries to take this decade to produce suitably ambitious and effective policies across the climate–biodiversity–food nexus.

This event brings together leading voices from the international policy arenas for climate and biodiversity to react to the briefing paper and discuss how COP27 and COP15 can accelerate the agenda for sustainable food systems and land use.

Lawford Hatcher
Proc. Amer. Math. Soc. 152 (), 5191-5205.
Abstract, references and article information

Alison B. Ross
Nov 30, 2020; 0:R120.002190v1-mcp.R120.002190
Review

In all cells, proteins are continuously synthesized and degraded in order to maintain protein homeostasis and modify gene expression levels in response to stimuli. Collectively, the processes of protein synthesis and degradation are referred to as protein turnover. At steady state, protein turnover is constant to maintain protein homeostasis, but in dynamic responses, proteins change their rates of synthesis and degradation in order to adjust their proteomes to internal or external stimuli. Thus, probing the kinetics and dynamics of protein turnover lends insight into how cells regulate essential processes such as growth, differentiation, and stress response. Here we outline historical and current approaches to measuring the kinetics of protein turnover on a proteome-wide scale in both steady-state and dynamic systems, with an emphasis on metabolic tracing using stable-isotope-labeled amino acids. We highlight important considerations for designing proteome turnover experiments, key biological findings regarding the conserved principles of proteome turnover regulation, and future perspectives for both technological and biological investigation.

The 30 prospects below all are getting very long looks this spring with an eye toward breaking camp with the parent club. Even if they start the year in the Minors, they all should get the chance to contribute at some point in the very near future.

The 30 prospects below all are getting very long looks this spring with an eye toward breaking camp with the parent club. Even if they start the year in the Minors, they all should get the chance to contribute at some point in the very near future.

SAN ANTONIO, Nov. 5, 2024 — Rackspace Technology has announced the expansion of Rackspace Spot with a new geographic location and an on-demand GPU-as-a-Service powered by NVIDIA. The expansion comes […]

The post Rackspace Expands Spot Platform with On-Demand NVIDIA GPU-as-a-Service for AI Workloads appeared first on HPCwire.

ATLANTA, Nov. 7, 2024 — As the high-performance computing (HPC) community gathers in Atlanta for SC24, the world’s largest HPC conference, the event will feature presentations from thought leaders and […]

The post SC24 Invited Talks to Spotlight HPC’s Role in AI, Quantum Computing, and Sustainability appeared first on HPCwire.

Dougherty County, a largely black school district in an region heavily affected by coronavirus, is no longer subject to desegregation orders first imposed in 1963.

Nov. 12—PULLMAN — After two rounds of rankings, Washington State is still on the outside looking in on the College Football Playoff. That's the word from the second round of CFP rankings, which placed WSU at No. 18 in Tuesday's reveal show on ESPN, up three spots from last week. The Cougars (8-1) are six spots out of the 12-team field, which is expanding for the first time this season. New ...

The second College Football Playoff Top 25 rankings were revealed on Tuesday and the now-7-2

The Chesapeake Bay watershed is the winter home for a broad variety of birds, and avid bird watchers flock to the region to find the rarest species (Meredith Bragg)

The species may have been carried to the Sacramento–San Joaquin Delta in ballast water on ships

It's not clear how the juvenile male ended up so far north, but experts suggest he was motivated by his appetite

SolidWorks 3D CAD Software Helps Enable Launch of SideEyes, a Potentially Life-Saving Infrared Alert System

World's #1 mainstream analysis software adds 100-plus new features that put powerful design validation in easy-to-use packages

U.K. company cut weeks out of design time, eliminated prototyping, and increased innovation with SOLIDWORKS and CircuitWorks

More than 4,600 of the world's engineering experts witness astonishing new products

If you are uncertain whether you are dealing with a scammer, use these checklists to see your potential risk profile, and warning signs of possible scams.

A new digital guide aims to identify students missing out on special education services and supports during distance learning.

Om Trivedi is a second-year student at Penn State Brandywine with a major in computer science. He was attracted to Penn State by the University's 2+2 program, which will allow him to transition to University Park for his final two years.

Penn State Brandywine’s Student Spotlight series highlights the remarkable work being done by students in leadership, academics, service, athletics and more.

Penn State Brandywine’s Student Spotlight series highlights the remarkable work being done by students in leadership, academics, service, athletics and more.

Penn State Brandywine’s Student Spotlight series highlights the remarkable work being done by students in leadership, academics, service, athletics and more.

Penn State Brandywine’s Student Spotlight series highlights the remarkable work being done by students in leadership, academics, service, athletics and more.

Penn State Brandywine’s Student Spotlight series highlights the remarkable work being done by students in leadership, academics, service, athletics and more.

Asus ROG Phone 9 will be officially launched later this week. Following Qualcomm's unveiling of the Snapdragon 8 Elite chipset last month, Asus confirmed that the ROG Phone 9 would use the flagship SoC. Now, ahead of the launch, the handset has been reportedly spotted in the Geekbench ML online database suggesting key specifications.

NASA's Roman Space Telescope has successfully integrated the Roman Coronagraph, a vital step in detecting planets far beyond our solar system. This tool will help block starlight, enabling the telescope to capture faint planetary light. The coronagraph marks a significant advancement in exoplanet detection, allowing the telescope to observe planets 100 million times fainter than their stars. The mission will provide insights into dark energy, exoplanets, and more, paving the way for future observatories like the Habitable Worlds Observatory.