Noblesville has applied for a state grant to fund most of its section of the Nickel Plate trail, while Fishers and Indianapolis are pushing forward with their own plans.

Motorists crossing the soon-to-b-built Nickel Plate Train will face a safety feature drivers crossing the Monon Trail don't encounter: speed tables

The "Megatron" rapper is set to perform in the country next week despite calls to quit the gig over the government's alleged human rights violations.

The rapper said she wanted to support women's and LGTBQ rights.

Human rights advocates have urged artists not to perform in the country because of its dismal human rights record.

Karin Melnick of the University of Maryland, College Park, has been awarded the AMS Joan and Joseph Birman Fellowship for Women Scholars for the 2020–2021 academic year.

Melnick’s research is on differential-geometric aspects of rigidity. This work comprises global and local results relating the automorphisms of a differential-geometric structure with the geometric and topological properties of the space. Melnick also works in smooth dynamics, in which an invariant differential-geometric structure plays an important role in the proof of rigidity theorems. Melnick is a leader in research on the Lorentzian Lichnerowicz conjecture, a statement about conformal transformations of compact Lorentzian manifolds. Together with collaborators, she has developed new techniques in the setting of Cartan connections that have facilitated progress on this problem, as well as many results for other differential-geometric structures and general parabolic Cartan geometries.  

Brief Biography of Karin Melnick:

Melnick received her PhD at the University of Chicago in 2006 under the direction of Benson Farb. With an NSF Postdoctoral Research Fellowship, she went to Yale University as a Gibbs Assistant Professor. She received a Junior Research Fellowship from the Erwin Schrödinger Institute in the spring of 2009 and that fall began at the University of Maryland, where she is now an associate professor. Previously, Melnick has been awarded an AMS Centennial Fellowship and an NSF CAREER grant. She divides her time between the U.S. and Germany with her partner and their young child, and is very grateful for the flexibility provided by the Birman Fellowship and the opportunities it provides to advance her research and career goals.  

About the Fellowship:

Established in 2017, the AMS Joan and Joseph Birman Fellowship for Women Scholars seeks to give exceptionally talented women extra research support during their mid-career years. The primary selection criterion for the Birman Fellowship, which carries a stipend of US$50,000, is the excellence of the candidate’s research. Read an interview with Joan Birman about her decision to create the Fellowship with the goal of "helping more women mathematicians to develop their creative voices." See more information about the Fellowship.

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The American Mathematical Society is dedicated to advancing research and connecting the diverse global mathematical community through our publications, meetings and conferences, MathSciNet, professional services, advocacy, and awareness programs.

Cas12a (Cpf1) is an RNA-guided endonuclease in the bacterial type V-A CRISPR-Cas anti-phage immune system that can be repurposed for genome editing. Cas12a can bind and cut dsDNA targets with high specificity in vivo, making it an ideal candidate for expanding the arsenal of enzymes used in precise genome editing. However, this reported high specificity contradicts Cas12a's natural role as an immune effector against rapidly evolving phages. Here, we employed high-throughput in vitro cleavage assays to determine and compare the native cleavage specificities and activities of three different natural Cas12a orthologs (FnCas12a, LbCas12a, and AsCas12a). Surprisingly, we observed pervasive sequence-specific nicking of randomized target libraries, with strong nicking of DNA sequences containing up to four mismatches in the Cas12a-targeted DNA-RNA hybrid sequences. We also found that these nicking and cleavage activities depend on mismatch type and position and vary with Cas12a ortholog and CRISPR RNA sequence. Our analysis further revealed robust nonspecific nicking of dsDNA when Cas12a is activated by binding to a target DNA. Together, our findings reveal that Cas12a has multiple nicking activities against dsDNA substrates and that these activities vary among different Cas12a orthologs.

A single tweet on the weekend about a possible collaboration between dancehall princess Shenseea and US rap sensation Nicki Minaj has left fans of the Romeich Entertainment singer bursting with excitement. Rumours of a pending project between...

Astros outfielder Josh Reddick vows to start hitting to the opposite field more this year, which is something he did well in 2017, but not '18. Reddick hit .242 with 17 homers and 47 RBIs last year after hitting .314 with 13 homers and 82 RBIs to help the Astros to the World Series title in '17.

Cas12a (Cpf1) is an RNA-guided endonuclease in the bacterial type V-A CRISPR-Cas anti-phage immune system that can be repurposed for genome editing. Cas12a can bind and cut dsDNA targets with high specificity in vivo, making it an ideal candidate for expanding the arsenal of enzymes used in precise genome editing. However, this reported high specificity contradicts Cas12a's natural role as an immune effector against rapidly evolving phages. Here, we employed high-throughput in vitro cleavage assays to determine and compare the native cleavage specificities and activities of three different natural Cas12a orthologs (FnCas12a, LbCas12a, and AsCas12a). Surprisingly, we observed pervasive sequence-specific nicking of randomized target libraries, with strong nicking of DNA sequences containing up to four mismatches in the Cas12a-targeted DNA-RNA hybrid sequences. We also found that these nicking and cleavage activities depend on mismatch type and position and vary with Cas12a ortholog and CRISPR RNA sequence. Our analysis further revealed robust nonspecific nicking of dsDNA when Cas12a is activated by binding to a target DNA. Together, our findings reveal that Cas12a has multiple nicking activities against dsDNA substrates and that these activities vary among different Cas12a orthologs.

"Researchers of DETCRC 3.1 project acquired substantial experience in seismic exploration of Nickel deposits across Yilgarn craton, Western Australia. There are many lessons learnt and various approaches trialled. The validity of the research conducted and the outputs achieved were verified against real field data provided by the sponsors and affiliates to DET CRC. Research quality was scrutinised by publishing in high level journals. In general high quality images are achieved over nickel rich Kambalda province that allowed for an accurate structural interpretation. Rock identification and characterisation is still challenging particularly due to lack of calibration of seismic images with borehole logs and borehole seismic. Several case histories are documented and briefly analysed. The difference between Komatiitic nickel deposit of Australia and Canada is also commented in light of seismic response and required technology for its detection" -- Executive summary.

Science fiction -- History and criticism.

Food security -- Australia.

Commonwealth Railways (Australia) -- History.

Loneliness.

Data protection -- Law and legislation -- Australia.

Organized crime -- New South Wales -- Sydney -- History -- 20th century.

A SUNDAY shift on The Herald’s Politics Watch tends to begin the same way, with an early trip to buy the papers. Usually it is just myself, a couple of other larks, and the woman who keeps an eye on the self-checkout area. All quiet on the supermarket front.

Bria Nickerson turned her love of true crime television into a passion for criminal justice. During her time at Penn State Schuylkill, this administration of justice major has distinguished herself in the classroom and as a campus leader, earning her this year's Student Life Chancellor's Award for Student Leadership for contributions to the improvement and advancement of campus life.

Injury-plagued former champ Dominick Cruz makes his return from another extended absence from the cage to challenge Henry Cejudo for bantamweight gold at UFC 249, knowing that a win will mark him out as the best of all time.
Read Full Article at RT.com

Several of the works honored in the arts explored race in American culture, including the music winner, Anthony Davis’ opera The Central Park Five. It tells of the wrongful conviction of five black and Latino teenagers for the 1989 assault on a white female jogger in Central Park. Five adult singers depicted the group as boys and men in Davis’ opera

Nickel is a ubiquitous metal added to jewelry and metallic substances for its hardening properties and because it is inexpensive. Estimates suggest that at least 1.1 million children in the United States are sensitized to nickel. Nickel allergic contact dermatitis (Ni-ACD) is the most common cutaneous delayed-type hypersensitivity reaction worldwide. The incidence among children tested has almost quadrupled over the past 3 decades. The associated morbidities include itch, discomfort, school absence, and reduced quality of life. In adulthood, individuals with Ni-ACD may have severe disabling hand eczema. The increasing rate of Ni-ACD in children has been postulated to result from early and frequent exposure to metals with high amounts of nickel release (eg, as occurs with ear piercing or with products used daily in childhood such as toys, belt buckles, and electronics).

To reduce exposure to metal sources with high nickel release by prolonged and direct contact with human skin, Denmark and the European Union legislated a directive several decades ago with the goal of reducing high nickel release and the incidence of Ni-ACD. Since then, there has been a global reduction in incidence of Ni-ACD in population-based studies of adults and studies of children and young adults being tested for allergic contact dermatitis. These data point to nickel exposure as a trigger for elicitation of Ni-ACD and, further, provide evidence that legislation can have a favorable effect on the economic and medical health of a population.

This policy statement reviews the epidemiology, history, and appearances of Ni-ACD. Examples of sources of high nickel release are discussed to highlight how difficult it is to avoid this metal in modern daily lives. Treatments are outlined, and avoidance strategies are presented. Long-term epidemiological interventions are addressed. Advocacy for smarter nickel use is reviewed. The American Academy of Pediatrics supports US legislation that advances safety standards (as modeled by the European Union) that protect children from early and prolonged skin exposure to high–nickel-releasing items. Our final aim for this article is to aid the pediatric community in developing nickel-avoidance strategies on both individual and global levels.

Patients in China were found to have evidence of COVID-19 in their semen several days after they stopped displaying symptoms of the coronavirus

Nicki wed Kenneth Petty last year.

Broadway star Nick Cordero's wife said coronavirus complications have led the star to need a leg amputation.

Nicki Minaj (37) sent fans into a frenzy after sparking pregnancy rumors on Twitter. A fan asked her about morning sickness and often toilet visits. The tweet sparked her fans, dubbed Barbz, to tweet out at her with endless questions about a possible pregnancy. Lmao. No throwing up. But nausea and peeing non stop. Omg […]

The post Nicki Minaj Sparks Rumors About Possible Pregnancy appeared first on Chart Attack.

Taraji P. Henson, Jonathan Van Ness, Selma Blair, Justin Bieber and more have embraced ongoing health issues, encouraging fans to do the same.

Follow our live coronavirus updates HERE Coronavirus: The symptoms

Malorie Blackman, Lee Child and Philip Pullman are among the first five essayists published

The Leeds legend and 1966 World Cup winner​ has died at the age of 76 having contracted coronavirus

Former Manchester United head of academy Nicky Butt has defended Jose Mourinho and Louis van Gaal's ill-fated spells as manager.

Actor Nick Cordero’s wife, Amanda Kloots, has once again posted on her husband’s condition as he battles the COVID-19 virus. Cordero has had horrible complications since being hospitalized more than a month ago. His struggle has been memorialized by Kloots on Instagram, and she has again updated his health status. Kloots shared in an Instagram […]

With the Olympics being postponed until 2021, UCLA softball stars Rachel Garcia and Bubble Nickles plan to play for the Bruins next season.

Prof. ZHONG Zhicheng's team at the Ningbo Institute of Materials Technology and Engineering has investigated the electronic structure of the recently discovered nickelate superconductors NdNiO₂. They successfully explained the experimental difficulties in synthesizing superconducting nickelates, in cooperation with Prof. Karsten Held at Vienna University of Technology.

Dancer Amanda Kloots offered a hopeful update Wednesday on her husband, Nick Cordero, who has been in a medically induced coma after contracting COVID-19.

ViacomCBS' first-quarter earnings beat expectations, leading to a stock rally.

"When a bank allows its customers, and even its customers’ customers, access to the national banking system, it should endeavor to understand the true nature of the business that it will allow to access the payment system, and the risks posed to consumers and society regarding criminal or other unlawful conduct," said Executive Director Bresnick.

The Justice Department announced today that the Executive Director of the Financial Fraud Enforcement Task Force (FFETF) Michael Bresnick will be leaving the department on Thursday, August 1, 2013.

UCLA, the NCAA champion in 2019 and the No. 1 team in 2020 when the COVID-19 pandemic hit, got a boost with the return of Rachel Garcia and Bubba Nickles.

Nov 8, 2019

An exclusive interview with Lord Nicholas Stern, one of the world’s foremost experts on climate change.

Nov 8, 2019

An exclusive interview with Lord Nicholas Stern, one of the world’s foremost experts on climate change.

Nov 8, 2019

An exclusive interview with Lord Nicholas Stern, one of the world’s foremost experts on climate change.

Nov 8, 2019

An exclusive interview with Lord Nicholas Stern, one of the world’s foremost experts on climate change.

Nov 8, 2019

An exclusive interview with Lord Nicholas Stern, one of the world’s foremost experts on climate change.

Nov 8, 2019

An exclusive interview with Lord Nicholas Stern, one of the world’s foremost experts on climate change.

Nov 8, 2019

An exclusive interview with Lord Nicholas Stern, one of the world’s foremost experts on climate change.