Expect ‘business as usual’ scenario returning from October; current operations at 60 per cent of pre-Covid levels

Did last night get away from you? You find the meaning of life in an enlightening grease-soaked bag of fries sometime around 230AM when the bars had finally closed, and your booze-blinded ass somehow made it home? Or did you fail to achieve such lofty goals, and just mindlessly empty whatever bottle was set before you? And now today you're stomaching all the fleeting bliss of last night. Well, sit back, refill that that water glass, prop your feet up, loathe life, and maybe even find yourself laughing at these funny, unintentionally ironic church signs.

Research Event

Event participants

Dr Maria Ângela Bragança, Secretary of State for Cooperation, Ministry of External Relations, Angola

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Amid lockdown crisis, Guwahati NGO lends helping hand to musicians  Northeast Now

Cairngorm National Park has moved online to give armchair visitors a flavour of a Highland spring, finds Sandra Dick

Barranquilla, Colombia :: Logos Hope’s community reflects on a key date in the Ship Ministry’s history – the shipwreck of the first vessel, Logos.

The board had been holding regular workshops with both farmers and buyers to encourage exports, he said, adding that the board had taken huge efforts to ensure that more mango growers register their orchards with MangoNet.

Researchers at Johns Hopkins University said Thursday work was ongoing at North Korean nuclear and missile sites, but no imminent threat is apparent.

Luanda -Deux autres patients ont �t� gu�ri de covid-19 au cours des derni�res 24 heures, a annonc� samedi le secr�taire d'�tat � la Sant� publique, Franco Mufinda. ......

The music of Little Richard, who died on Saturday at the age of 87, was one of the genuine architects of not only rock and roll but R&B, soul, hip-hop and other genres as well. Few artists can truly be said to have directly inspired the Beatles, James Brown, the Rolling Stones, Prince and countless […]

For the second time, a federal judge has issued a restraining order against Kentucky officials who moved to block church services during the coronavirus shutdown.

U.S. District Judge Gregory Van Tatenhove ruled Friday night in favor of Tabernacle Baptist Church of Nicholasville and against Democratic Kentucky Gov. Andy Beshear's order ...

1. Mahendra Singh Dhoni had requested me not to use Mongoose bat, reveals Mathew Hayden  Zee News
2. Dhoni turns up in video with daughter, his appearance inspires memes on social media  The Indian Express
3. MS Dhoni sports a new look during lockdown as meme fest ensues on social media - Republic World  Republic World
4. Hayden Says Dhoni Had Requested Him Not to Use Mongoose Bat  News18
5. I'm sure MS Dhoni would've had given retirement a thought a couple of years back itself: Anjum Chopra  CricTracker
6. View Full coverage on Google News

It seems that there is rampant poaching of pangolins taking place during the lockdown in the Konkan belt, and their scales are being illegally sold in the local black market. During the raids, the forest department recovered two kilograms of pangolin scales and six nails. The pangolin is one of the most trafficked wild animals across the world as there is a huge international demand for its scales.

Range Forest Officer (RFO), Vaibhav Borate, said, "Based on the tip-off received from our sources, our forest department team raided the house of Kalpesh Tukaram Balgude at Karanjali [Balgudewadi] village near Dapoli. During the search operation of the house, our team recovered one tortoise shell, one jungle hare, and 22 kg of pangolin scales and nails. We have taken the accused into custody and investigation is on."

As evidence related to wildlife trade have been found from the house of the accused, the forest department is exploring the possibility of him doing this regularly. The forest department team has registered an offence under various sections of the Wildlife Protection Act, 1972.

According to the Wildlife Crime Control Bureau (WCCB) website, "Major threats to pangolins in India are hunting and poaching for local consumptive use and international trade. Another reason for hunting pangolin is its meat. There is now greater evidence of its inclusion in illicit international trade, in particular its scales, from India through Myanmar to China and South-East Asian countries as the most likely, final destinations. Inadequate information on population and distribution further accentuates the threats arising from hunting and poaching."

The Indian Pangolin is found sporadically throughout the plains and lower slopes of hills from south of the Himalayas to Kanyakumari, except the north-eastern region. The Chinese Pangolin is found in India in Sikkim, Arunachal Pradesh, Meghalaya, Nagaland, Assam, Manipur, Tripura, Mizoram and the northern part of West Bengal.

Why Pangolins?

Pangolins are the most trafficked mammal in the world, for their scales [made of keratin], which are boiled off their bodies for use in traditional medicine. Their meat is a delicacy in Vietnam and China; and their blood, which is considered to be a healing tonic.

Pangolin could help find cure for COVID-19?

Soon after the outbreak of COVID-19 pandemic, there were many media reports that claimed that the endangered pangolin was linked to the initial outbreak of the disease in China. However, this hasn't been proven yet. Now, a research conducted by the Medical University of Vienna in Austria, has revealed that certain genes sense when a virus enters the body, and trigger an immune response in most mammals. They found that pangolins, which have been called the 'missing link' between bats and humans, lack two of those virus-sensing genes. This means that not only are the endangered animals carriers, but they also seem to be immune to it, via an unknown mechanism. This evolutionary advantage and its understanding may give way to possible treatment options for COVID-19.

Catch up on all the latest Mumbai news, crime news, current affairs, and a complete guide from food to things to do and events across Mumbai. Also download the new mid-day Android and iOS apps to get latest updates.

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Focused mainly on the Democratic Republic of the Congo, this report takes stock of 5 years of implementation of national and international programmes and initiatives designed to operationalise the recommendations of the OECD Due Diligence Guidance on Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas in the Great Lakes Region of Central Africa.

Mongolia should persist with systematic reforms in its struggle against corruption, says a new report by the Istanbul Anti-Corruption Action Plan (IAP).

Mongolia’s rapid economic and social development, fuelled by the discovery of significant mineral resources, has exacerbated governance and corruption challenges.

Mongolia has made significant progress in developing its anti-corruption policy, legislation and institutions over the past few years. However, progress has recently slowed and there are increasing concerns about the future direction and pace of reforms, according to a new OECD report.

There's no rest for the wicked and a host of radio personalities were up bright and early on Wednesday morning after the BRIT Awards 2020.

By Uzmi Athar New Delhi, May 10 () Several NGOs working in the disability sector are facing severe financial crunch as most of the funds and donations they would earlier get has been diverted towards tackling the COVID-19 crisis.Prashant Verma, general secretary, National Association for the Blind, says he could just pay 65 per cent salary to his employees in the last two months due to financial crunch and if no fresh donations are made he does not have any money to pay his 120 staff members this month."We feel as if we are at the end of the line," he told .Verma said his organisation used to get grants from many companies under Corporate Social Responsibility (CSR) and even from individuals, especially during March as it was the end of the financial year."But this year we didn't get any money.

Several NGOs working in the disability sector are facing severe financial crunch as most of the funds and donations they would earlier get has been diverted towards tackling the COVID-19 crisis. Prashant Verma, general secretary, National Association for the Blind, says he could just pay 65 per cent salary to his employees in the last two months due to financial crunch and if no fresh donations are made he does not have any money to pay his 120 staff members this month. "We feel as if we are at the end of the line," he told PTI. Verma said his organisation used to get grants from many companies under Corporate Social Responsibility (CSR) and even from individuals, especially during March as it was the end of the financial year. "But this year we didn't get any money. Some of the companies, which even committed to us, are saying that this time they have to think about their own survival. Many individuals (who earlier donated) don't have money to support us. A lot of the money is ...

Desi jugad: How to pluck mangoes without letting them fall

London, May 8: The anteater-like mammals, pangolins, possess an evolutionary advantage against coronavirus, according to researchers, who say that understanding the animal's immune system may help develop new treatment options for COVID-19. According to the scientists from the Medical

Aditya Dhar's debut movie as director, Uri: The Surgical Strike (2019), was a great success among audiences and at the box office. Starring Vicky Kaushal in the lead, Uri was based on India's retaliation to the attack in Uri, a small

Aditya Dhar's debut movie as director, Uri: The Surgical Strike (2019), was a great success among audiences and at the box office. Starring Vicky Kaushal in the lead, Uri was based on India's retaliation to the attack in Uri, a small

Mykhailo Pinchuk takes a short walk around his empty zoo, greeting some animals with a stroke and a morsel of food.

Archives, Room Use Only - Q143.H6.A2 1972

Archives, Room Use Only - DK755.C65 1864

Migrant flamingos and migrated family fly into Mumbai every winter.

NGO charts unique way to induce people into donating

Throughout 2015 the Smithsonian Environmental Research Center (SERC) in Edgewater, Md., has marked its 50th year of operation. Now there’s another reason for SERC to […]

The post Smithsonian lab receives GreenGov Presidential Award appeared first on Smithsonian Insider.

One of Earth’s most evolutionarily unique species is also the world’s most trafficked mammal: pangolins, or “scaly anteaters.” A new study from the Smithsonian Conservation […]

The post Using genetics to help save world’s most trafficked mammal: the pangolin appeared first on Smithsonian Insider.

Pullulanase (EC 3.2.1.41) is a well known starch-debranching enzyme that catalyzes the cleavage of α-1,6-glycosidic linkages in α-glucans such as starch and pullulan. Crystal structures of a type I pullulanase from Paenibacillus barengoltzii (PbPulA) and of PbPulA in complex with maltopentaose (G5), maltohexaose (G6)/α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) were determined in order to better understand substrate binding to this enzyme. PbPulA belongs to glycoside hydrolase (GH) family 13 subfamily 14 and is composed of three domains (CBM48, A and C). Three carbohydrate-binding sites identified in PbPulA were located in CBM48, near the active site and in domain C, respectively. The binding site in CBM48 was specific for β-CD, while that in domain C has not been reported for other pullulanases. The domain C binding site had higher affinity for α-CD than for G6; a small motif (FGGEH) seemed to be one of the major determinants for carbohydrate binding in this domain. Structure-based mutations of several surface-exposed aromatic residues in CBM48 and domain C had a debilitating effect on the activity of the enzyme. These results suggest that both CBM48 and domain C play a role in binding substrates. The crystal forms described contribute to the understanding of pullulanase domain–carbohydrate interactions.

The post Learn about the National Zoo’s flamingo flock with keeper Sara Hallager appeared first on Smithsonian Insider.

To catch lizards on the offshore islands close to St. Croix in the Caribbean, Smithsonian herpetologist Nicole Angeli uses a lasso of thread looped at […]

The post Mongooses wiped them out. Now Nicole Angeli wants the St. Croix ground lizard home again appeared first on Smithsonian Insider.

Announcement cards and envelopes by designer Marc Friedland which are used by presenters at the Oscars to announce winners are on display at the food and decor preview Feb. 4, 2015 of this years Governors Ball, the post-Oscar celebration which follows the 87th Oscars ceremony on Feb. 22 in Hollywood.; Credit: Robyn Beck/AFP/Getty Images

Ready for your 2015 Oscars party? We've got printable Oscars ballots and the bingo cards you need to prove your superiority over your movie-loving friends during your Academy Awards viewing party. Here are the party printables you'll need to play along with Sunday's show, with TV coverage kicking off at 4 p.m. Pacific. (Get caught up on KPCC's 2015 Oscars coverage right here to have more fun and help make your picks!)

Printable official Oscars ballot

• Download, print, and play at home. Listen to "The Frame's" preview of the Academy Awards, see what "FilmWeek's" critics have to say about who will win, then make your own decisions on Sunday. Our crystal ball Oscars predictor/awards tracker can also help the prognostication efforts with a rundown of nominee buzz, awards already won, official trailers, photos and more.
• You can also play along with friends online on the official Academy Awards site or with the New York Times. (If you want to see KPCC's Mike Roe's picks and play against him in either online game, go here for the official site and here for the New York Times.)

2015 Oscars ballot

Printable Oscars bingo cards

• Download, print and play at home. Use our custom generator to create as many cards as you need for your party.
• How to play: Mark off each block when you hear these words or see these things happen during the Oscars telecast on Sunday. When you get five blocks in a row (horizontally, vertically, or diagonally) stand up and shout "OSCAR!!" Alternate rules: Play as a drinking game and for every block, take a sip. Finished a row? Finish your scotch.

Interactive Oscars bingo cards 

• WNYC pays tribute to the annual exercise in entertainment award show parody with a portable, computerized bingo. Play on your phone, iPad, computer or print a card. Refresh for new combinations.

This content is from Southern California Public Radio. View the original story at SCPR.org.

A new report from the National Academies of Sciences, Engineering and Medicine finds that the U.S. Environmental Protection Agencys (EPA) approach to its ongoing Integrated Risk Information System (IRIS) assessment plan is appropriate for synthesizing the scientific evidence and quantifying estimates of inorganic arsenic toxicity.

Peter Epstein of Epstein Research discusses the macro picture for precious metals prices and one junior that he believes will benefit from higher prices.

Visit the aureport.com for more information and for a free newsletter

Opera singer Plácido Domingo, shown here speaking in Spain last July, said earlier this month that he tested positive for the coronavirus.; Credit: Ricardo Rubio/Europa Press via Getty Images

Plácido Domingo has been hospitalized because of COVID-19-related complications, according to multiple reports.

He is in stable condition in an Acapulco, Mexico, hospital and will receive medical attention for "as long as the doctors find it necessary until a hoped-for full recovery," a spokesperson for Domingo told Opera News over the weekend.

Domingo's reported hospitalization comes just days after he posted a March 22 message on Facebook revealing that he had tested positive for the disease caused by the coronavirus.

"I feel it is my moral duty to announce that I tested positive for COVID19, also known as the Corona Virus. My family and I are and will remain individually isolated for as long as it is medically necessary. Today we all enjoyed good health, but I presented symptoms of coughing and fever, so I decided to take the test and the result was positive," Domingo said.

Domingo has been one of opera's most reliable and bankable stars and is known for his ability to sing tenor and baritone and in multiple languages, including Italian, English, Russian and Spanish.

Recently, the 79-year-old has been embroiled in controversy as several women accused the Spanish-born singer of sexual misconduct.

On March 10, NPR reported that LA Opera, which Domingo helped establish, announced that its investigation substantiated 10 "inappropriate conduct" claims levied against him dating back to as early as 1986. Domingo resigned as the LA Opera's general director in October.

Prior to that, he withdrew from a production of the Metropolitan Opera's performance of "Macbeth" amid allegations of sexual misconduct.

He has denied the allegations.

Domingo is among a growing list of celebrities who have announced they have tested positive for the coronavirus, including actor Tom Hanks and his wife Rita Wilson, actor Idris Elba, NBA star Kevin Durant, talk show host Andy Cohen and British Prime Minister Boris Johnson.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Another in our occasional series demystifying Latin American banking trojans

The post Grandoreiro: How engorged can an EXE get? appeared first on WeLiveSecurity