What do Herod, Herodias, Salome, and John the Baptist have to do with end-time Bible prophecy?

What do Herod, Herodias, Salome, and John the Baptist have to do with end-time Bible prophecy?

A Boulder mother on Wednesday admitted she killed her 2-month old son last year, court records show.

Playwright Micheal Shayan as his mother Roya welcomes you to Tehran-geles, CA in the one-mother show “Avaaz” at the Denver Center.

Carmen Bolden Day wants the mystery solved.

The police say they were unintended victims.

The 25-year-old was killed on Feb. 23, 2020.

1. New program will see pregnant mothers and babies protected from life-threatening virus  SBS
2. World-leading approach to protect babies from RSV  Department of Health
3. Government-funded RSV vaccines to protect infants from severe disease  Australian Pharmacist
4. 'Very scary': Wagga mum's plea for parents to protect babies through RSV jab  The Daily Advertiser
5. Guild backs free RSV vaccinations  Australian Journal of Pharmacy

1. Cindy Crossthwaite's estranged husband faces Supreme Court murder trial over mother of three's death  ABC News
2. 'Deep-seated hatred' for estranged wife led to killing, jury told  9News
3. 'Deep-seated hatred' for estranged wife led to killing, court hears  9News

The post Russian Grandmothers Who Break the Social Norms appeared first on English Russia.

Pioneering Indian Muslim feminist Rokeya Sakhawat Hossain (1880-1932) wrote speculative science fiction, manifestoes, radical reportage, and incisive essays that transformed her experience of enforced segregation into unique interventions against gender oppression everywhere. Her radical imagination links the realities of living in a British colony to the technological and scientific breakthroughs of her time, the effects of hauntingly pervasive systems of sexual domination, and collective dreams of the future, forging a visionary, experimental body of work. If her contemporary B. R. Ambedkar urged the “annihilation of caste,” Rokeya demands nothing less than the annihilation of sexism, with education as the primary instrument of this revolution. Her brilliant wit and creativity reflect profoundly on the complexities of undoing deep-seated gender supremacy and summon her readers to imagine hitherto undreamed freedoms.

Ukraine has said that the toll from a Russian strike on the hometown of President Volodymyr Zelensky had risen to four people, identifying the dead as a mother and her three children, including a newborn.

Kadian Morgan was overwhelmed with grief as she leaned against a wall outside her gate on Jackson Lane, East Kingston, yesterday, tears streaming down her face. Her 19-year-old son, Kayshan 'Bem Bem' Smith, was lying in the morgue after being...

Lucille Bridges, the mother of civil rights activist Ruby Bridges, who walked with her then-6-year-old daughter past crowds screaming racist slurs as she became the first Black student at her all-white New Orleans elementary school, has died at the age of 86.

We recently demonstrated that transient attenuation of Toll-like receptor 4 (TLR4) in dorsal root ganglion (DRG) neurons, can both prevent and reverse pain associated with chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of cancer chemotherapy, for which treatment options are limited. Given the reduced efficacy of opioid analgesics to treat neuropathic, compared with inflammatory pain, the cross talk between nociceptor TLR4 and mu-opioid receptors (MORs), and that MOR and TLR4 agonists induce hyperalgesic priming (priming), which also occurs in CIPN, we determined, using male rats, whether (1) antisense knockdown of nociceptor MOR attenuates CIPN, (2) and attenuates the priming associated with CIPN, and (3) CIPN also produces opioid-induced hyperalgesia (OIH). We found that intrathecal MOR antisense prevents and reverses hyperalgesia induced by oxaliplatin and paclitaxel, two common clinical chemotherapy agents. Oxaliplatin-induced priming was also markedly attenuated by MOR antisense. Additionally, intradermal morphine, at a dose that does not affect nociceptive threshold in controls, exacerbates mechanical hyperalgesia (OIH) in rats with CIPN, suggesting the presence of OIH. This OIH associated with CIPN is inhibited by interventions that reverse Type II priming [the combination of an inhibitor of Src and mitogen-activated protein kinase (MAPK)], an MOR antagonist, as well as a TLR4 antagonist. Our findings support a role of nociceptor MOR in oxaliplatin-induced pain and priming. We propose that priming and OIH are central to the symptom burden in CIPN, contributing to its chronicity and the limited efficacy of opioid analgesics to treat neuropathic pain.

For the second year in a row, Grazer bested the massive male named Chunk to take the crown in the single elimination online popularity contest at Katmai National Park and Preserve

By raising her son to be curious about the natural world, this mother helped shape the trajectory of the National Museum of Natural History

Families of Norton Elementary School won’t be seeing their kids return anytime soon. Repairs are going to take longer than expected and students are expected to be back in the school by the start of the next school year.

On 12 May, 130 people in Atlanta, Georgia, participate in a hike at to benefit trafficked and exploited women across our world.

A local Chinese mother teaches Cantonese to three Pakistani mothers before they all watch the film 'Magdalena: Released from Shame' together.

Alexandra Persiko, interim director of global partnerships in Penn State Global, received a Fulbright IEA award in 2024, notable not only because she was one of 14 university administrators across the U.S. to garner such an award this year, but also because of her unique connection to the program through her mother, Alice Ann, who completed a Fulbright student program in Germany in 1957.

This week, SA Money Report drills down into the 'game changing' oil find off the coast of Namibia, and how this factors into the recent court battles over seismic blasting on the SA West Coast.

This week, SA Money Report journeys in the heart of war, and comes back with a tale about Naspers' exposure in Russia, and its ties to VKontakte, whose 38-year-old CEO Vladimir Kiriyenko was sanctioned by the US.

Nick Jonas even grooved a bit with his mother-in-law, Madhu Chopra at Priyanka Chopra’s cousin’s wedding

Archana's son also joined her on the trip

Sitting at the dining table with a hearty plateful in front of her, Avantika looked blissful as Bhagyashree fed her dal chawal with her hands.

Delaware Natural Resources Police arrested two men on June 22, 2024 following an investigation into the assault at Cape Henlopen State Park.

Read the in depth Review of MSI MEG Z490 ACE Motherboard PC Components. Know detailed info about MSI MEG Z490 ACE Motherboard configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

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The Ondo State Police Command, on Tuesday, said it had arrested one prophetess, Mrs Folashade Adekola, over the death of a woman, Jumoke Adesuwa and her newborn baby inside the church. Our correspondent gathered on Tuesday that the deceased bled to death from complications after childbirth inside the suspect’s church located in the Oke-Aro area

Mariska Hargitay on mother Jayne Mansfield's deathMariska Hargitay got candid on “dealing” with the death of her mother, Hollywood diva, Jayne Mansfield at the age of 3.“I lost my mother when I was 3 years old, and I grew up in a house of people dealing with the tragedy in...

“We’re ready to testify before the QuadComm as victims of extrajudicial killings,” Rosenda Lemita said, stressing that they want Duterte and those responsible to face investigation. For these families, the government’s “nanlaban” excuse is not just for the drug war but also for silencing activists.

The eruption of the Shiveluch volcano on the Kamchatka Peninsula in Russia on 11 April sent plumes of volcanic ash many kilometres into the air and could affect flights

Title: A Mother's Hopes and Worries for Adult Sons With Autism
Category: Health News
Created: 8/23/2013 12:35:00 PM
Last Editorial Review: 8/26/2013 12:00:00 AM

Title: Health Tip: Food Safety for Pregnant and Nursing Mothers
Category: Health News
Created: 8/27/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM

Title: Alex Trebek Back Hosting 'Jeopardy!' After Completing Chemotherapy
Category: Health News
Created: 8/30/2019 12:00:00 AM
Last Editorial Review: 8/30/2019 12:00:00 AM

Title: Texas Mother Transmitted COVID-19 to Unborn Baby: Study
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM

Title: AHA News: He Got Help F.A.S.T. For His Stroke. His Mother Wasn't as Lucky.
Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy treatment, routinely manifesting as increased pain sensitivity (allodynia) in distal extremities. Despite its prevalence, effective treatment options are limited. Cannabinoids are increasingly being evaluated for their ability to treat chronic pain conditions, including CIPN. While previous studies have revealed sex differences in cannabinoid-mediated antinociception in acute and chronic pain models, there is a paucity of studies addressing potential sex differences in the response of CIPN to cannabinoid treatment. Therefore, we evaluated the long-term antiallodynic efficacy of cannabinoid receptor type 1 (CB₁)-selective, cannabinoid receptor type 2 (CB₂)-selective, and CB₁/CB₂ mixed agonists in the cisplatin CIPN model, using both male and female mice. CB₁ selective agonism was observed to have sex differences in the development of tolerance to antiallodynic effects, with females developing tolerance more rapidly than males, while the antiallodynic effects of selective CB₂ agonism lacked tolerance development. Compound-specific changes to the female estrous cycle and female plasma estradiol levels were noted, with CB₁ selective agonism decreasing plasma estradiol while CB₂ selective agonism increased plasma estradiol. Chronic administration of a mixed CB₁/CB₂ agonist resulted in increased mRNA expression of proinflammatory cytokines and endocannabinoid regulatory enzymes in female spinal cord tissue. Ovarian tissue was noted to have proinflammatory cytokine mRNA expression following administration of a CB₂ acting compound while selective CB₁ agonism resulted in decreased proinflammatory cytokines and endocannabinoid regulatory enzymes in testes. These results support the need for further investigation into the role of sex and sex hormones signaling in pain and cannabinoid-mediated antinociceptive effects.

Neuropathic pain is a form of chronic pain that develops because of damage to the nervous system. Treatment of neuropathic pain is often incompletely effective, and most available therapeutics have only moderate efficacy and present side effects that limit their use. Opioids are commonly prescribed for the management of neuropathic pain despite equivocal results in clinical studies and significant abuse potential. Thus, neuropathic pain represents an area of critical unmet medical need, and novel classes of therapeutics with improved efficacy and safety profiles are urgently needed. The cannabidiol structural analog and novel antagonist of GPR55, KLS-13019, was screened in rat models of neuropathic pain. Tactile sensitivity associated with chemotherapy exposure was induced in rats with once-daily 1-mg/kg paclitaxel injections for 4 days or 5 mg/kg oxaliplatin every third day for 1 week. Rats were then administered KLS-13019 or comparator drugs on day 7 in an acute dosing paradigm or days 7–10 in a chronic dosing paradigm, and mechanical or cold allodynia was assessed. Allodynia was reversed in a dose-dependent manner in the rats treated with KLS-13019, with the highest dose reverting the response to prepaclitaxel injection baseline levels with both intraperitoneal and oral administration after acute dosing. In the chronic dosing paradigm, four consecutive doses of KLS-13019 completely reversed allodynia for the duration of the phenotype in control animals. Additionally, coadministration of KLS-13019 with paclitaxel prevented the allodynic phenotype from developing. Together, these data suggest that KLS-13019 represents a potential new drug for the treatment of neuropathic pain.

Identifying cancer therapy resistance is a key time-saving tool for physicians. Part of chemotherapy resistance includes senescence, a persistent state without cell division or cell death. Chemically inducing senescence with the combination of trametinib and palbociclib (TP) yields several tumorigenic and prometastatic factors in pancreatic cancer models with many potential antibody-based targets. In particular, urokinase plasminogen activator receptor (uPAR) has been shown to be a membrane-bound marker of senescence in addition to an oncology target. Methods: Here, 2 antibodies against murine uPAR and human uPAR were developed as immuno-PET agents to noninvasively track uPAR antigen abundance. Results: TP treatment increased cell uptake both in murine KPC cells and in human MiaPaCa2 cells. In vivo, subcutaneously implanted murine KPC tumors had high tumor uptake with the antimurine uPAR antibody independently of TP in young mice, yet uPAR uptake was maintained in aged mice on TP. Mice xenografted with human MiaPaCa2 tumors showed a significant increase in tumor uptake on TP therapy when imaged with the antihuman uPAR antibody. Imaging with either uPAR antibody was found to be more tumor-selective than imaging with [¹⁸F]FDG or [¹⁸F]F-DPA-714. Conclusion: The use of radiolabeled uPAR-targeting antibodies provides a new antibody-based PET imaging candidate for pancreatic cancer imaging as well as chemotherapy-induced senescence.

This single-center, single-arm, phase II trial (ChiCTR2100050057) investigated the ability of ¹⁸F-labeled fibroblast activation protein inhibitor ([¹⁸F]AlF-NOTA-FAPI-04, denoted as ¹⁸F-FAPI) PET/CT to predict the response to neoadjuvant camrelizumab plus chemotherapy (nCC) in locally advanced esophageal squamous cell carcinoma (LA-ESCC). Methods: This study included 32 newly diagnosed LA-ESCC participants who underwent ¹⁸F-FAPI PET/CT at baseline, of whom 23 also underwent scanning after 2 cycles of nCC. The participants underwent surgery after 2 cycles of nCC. Recorded PET parameters included maximum, peak, and mean SUVs and tumor-to-background ratios (TBRs), metabolic tumor volume, and total lesion FAP expression. PET parameters were compared between patient groups with good and poor pathologic responses, and the predictive performance for treatment response was analyzed. Results: The good and poor response groups each included 16 participants (16/32, 50.0%). On ¹⁸F-FAPI PET/CT, the posttreatment SUVs were significantly lower in good responders than in poor responders, whereas the changes in SUVs with treatment were significantly higher (all P < 0.05). SUV_max (area under the curve [AUC], 0.87; P = 0.0026), SUV_peak (AUC, 0.89; P = 0.0017), SUV_mean (AUC, 0.88; P = 0.0021), TBR_max (AUC, 0.86; P = 0.0031), and TBR_mean (AUC, 0.88; P = 0.0021) after nCC were significant predictors of pathologic response to nCC, with sensitivities of 63.64%–81.82% and specificities of 83.33%–100%. Changes in SUV_max (AUC, 0.81; P = 0.0116), SUV_peak (AUC, 0.82; P = 0.0097), SUV_mean (AUC, 0.81; P = 0.0116), and TBR_mean (AUC, 0.74; P = 0.0489) also were significant predictors of the pathologic response to nCC, with sensitivities and specificities in similar ranges. Conclusion: ¹⁸F-FAPI PET/CT parameters after treatment and their changes from baseline can predict the pathologic response to nCC in LA-ESCC participants.

Growing research indicates a pregnant woman’s stress level and overall mental well-being can affect fetal and child development, yet access to prenatal mental health care remains inadequate