National development banks (NDBs) and development finance institutions are poised to play a role in bridging the investment gap for climate-compatible infrastructure in developing countries. This paper highlights the role of NDBs drawing from case studies of the Brazilian Banco Nacional de Desenvolvimento Econômico e Social and the Development Bank of Southern Africa.

Let’s be honest, waste reduction doesn’t have much of a ring to it. To many, it’s a complex policy issue without much hope if consumers keep throwing their cans away in the street.

The Green Growth and Sustainable development Forum is an annual event, and the third Forum will take place on 13-14 November 2014. This blog highlights the importance of the Forum, and how, far from being "abstract", this year's Forum offers an invaluable opportunity to address the social implications of implementing green growth strategies.

This will be “the mother of all years for summits on international development". International delegates will gather in Addis Ababa in July to discuss how poorer countries can fund their development. In September, attention will shift to New York, where the UN will sign off on the successors to the Millennium Development Goals (MDGs). In December, Paris will take centre stage to host the global climate change conference, COP21.

Ever plodded through flood waters to get to a conference? In late January, the Green Growth Knowledge Platform (GGKP) held their 3rd annual conference in Venice, Italy. The flooded city reminded attendees about the real world changes that are occurring and the need for continued action towards going green.

A new OECD publication highlights notable economic and environmental benefits of phasing out fossil-fuel subsidies in Indonesia. Interestingly, the study is based on the context that pertained until mid-2014, when international oil prices where high and before the recent phase-out of subsidies by the government.

To mark the opening of the International Transport Forum’s Annual Summit, today’s post addresses three broad issues of the complex and multidimensional triangular relationship between transport, trade and tourism.

With the world welcoming the new comprehensive global climate agreement at COP21 aiming to limit the global average temperature rise to well below 2 degrees Celsius, it is worth noting the significant contribution that the OECD family has made. These contributions were aptly summarized in a useful joint statement by the secretariats of OECD, IEA, International Transport Forum and Nuclear Energy Agency right after COP21 kicked off.

The OECD defines policy coherence for sustainable development (PCSD) as an approach and policy tool to integrate the economic, social, environmental, and governance dimensions of sustainable development at all stages of domestic and international policy making. This blog details the OECD's PCSD framework and its goals.

The Sustainable Development Goals which world leaders agreed on in 2015 are focussed on people, peace and planet. Achieving goals requires a transformational, integrated, and universal agenda that is based on effective policies, sufficient pecunia and true partnerships. Latest OECD Insights blog post by Erik Solheim, Chair of the OECD Development Assistance Committee.

Despite great strides in reducing the number of people in abject poverty, Asia and the Pacific remains home to more than half of the world’s extreme poor. With the global and regional economic outlook uncertain, the key challenge facing Asia is to sustain the growth needed to create jobs and reduce poverty. Read the latest blog by Mr. Stephen P. Groff, Vice President of the Asian Development Bank.

Read the latest OECD Insights blog written by Mrs. Gabriela Ramos, Special Counsellor to the OECD Secretary-General, Chief of Staff and G20 Sherpa.

Read the latest blog by Patrick Paul Walsh, Professor of International Development Studies, University College Dublin, Ireland and Senior Advisor, UN SDSN, Earth Institute, on the Implications of the UN 2030 Sustainable Development Agenda for the OECD.

At one time, I might have said that sustainable development is in the OECD’s blood, but biological metaphors have made enormous progress over the past few years and now I’d say it’s in the Organisation’s DNA... Blog by Ron Gass, founding Director of the OECD Directorate of Social Affairs, Manpower and Education and the OECD Centre for Educational Research and Education (CERI).

Read the newest OECD's Insights blog based on the latest report from the New Approaches to Economic Challenges (NAEC) "Debate the Issues: New Approaches to Economic Challenges".

The OECD Behavioural Insights Conference brings together behavioural practitioners and policy makers from around the world to discuss how using behavioural insights can affect policy change.

This report offers a broader view of teachers and school principals across all levels of compulsory education, and all the similarities and differences in the issues they are facing.

In Finland, the numeracy and literacy skills of adults are among the highest in the countries measured through the OECD’s 2012 Survey of Adult Skills. The Survey assessed the skills of adults in literacy, numeracy and problem solving in technology-rich environments in 24 countries and sub-national regions in the first round of the Survey.

Despite the progress observed by PISA over the last decade, Latin American education systems still have a long way to go to reach world class standards. Ibero-American countries will also need to rethink their instructional system to better anticipate the knowledge and skills it will need to reignite its economy.

Archived webinar - School Leadership for Learning: Insights from TALIS 2013 (September 20, 2016)

Education’s purpose is to prepare children for a fast-moving, ever-changing world. Teaching faces the additional challenge of classrooms becoming increasingly more culturally diverse. Now, more than ever, this requires an adaptation of current teaching strategies.

In a rapidly changing world, having a strong knowledge base in their subject area, good classroom management skills and a commitment to helping students learn may no longer be enough to meet the expanding role of teachers.

with Andreas Schleicher, Director for the Directorate of Education and Skills

Almost all mathematics teachers across participating countries use clear and structured teaching practices, according to both teachers and students. A vast majority of teachers also use student-oriented practices and enhanced learning activities in their classroom.

The Innovative Teaching for Effective Learning (ITEL) Teacher Knowledge Survey is the first international study to explore the nature, function and development of teachers’ pedagogical knowledge, i.e. what teachers know about teaching and learning.

The new Sustainable Development Goals (SDGs) include a significant number of interconnected objectives related to agriculture and food.

Imagine you have an important decision to make. Do you carefully consider the long-term implications of each possible option or do you act impulsively? Would you approach the decision-making process differently if the consequences stretched out to 30 or even 50 years?

Are you a city-dweller, concerned about the challenges of urbanisation, resilience and inclusiveness? Cities and urban areas represent unrivalled concentrations of people, economic growth, commercial networks, and innovation – and have the potential to make a significant contribution to the transition towards a low-carbon world.

A neutron crystallographic study of perdeuterated transthyretin reveals important aspects of the structure relating to its stability and its propensity to form fibrils, as well as evidence of a single water molecule that affects the symmetry of the two binding pockets.

The structural dimension of metal–organic frameworks (MOFs) is of great importance in defining their properties and thus applications. In particular, 2D layered MOFs are of considerable interest because of their useful applications, which are facilitated by unique structural features of 2D materials, such as a large number of open active sites and high surface areas. Herein, this work demonstrates a methodology for the selective synthesis of a 2D layered MOF in the presence of the competitive formation of a 3D MOF. The ratio of the reactants, metal ions and organic building blocks used during the reaction is found to be critical for the selective formation of a 2D MOF, and is associated with its chemical composition. In addition, the well defined and uniform micro-sized 2D MOF particles are successfully synthesized in the presence of an ultrasonic dispersion. Moreover, the laminated 2D MOF layers are directly synthesized via a modified bottom-up lamination method, a combination of chemical and physical stimuli, in the presence of surfactant and ultrasonication.

The stressosome transduces environmental stress signals to SigB to upregulate SigB-dependent transcription, which is required for bacterial viability. The stressosome core is composed of RsbS and at least one of the RsbR paralogs. A previous cryo-electron microscopy (cryo-EM) structure of the RsbRA–RsbS complex determined under a D2 symmetry restraint showed that the stressosome core forms a pseudo-icosahedron consisting of 60 STAS domains of RsbRA and RsbS. However, it is still unclear how RsbS and one of the RsbR paralogs assemble into the stressosome. Here, an assembly model of the stressosome is presented based on the crystal structure of the RsbS icosahedron and cryo-EM structures of the RsbRA–RsbS complex determined under diverse symmetry restraints (nonsymmetric C1, dihedral D2 and icosahedral I envelopes). 60 monomers of the crystal structure of RsbS fitted well into the I-restrained cryo-EM structure determined at 4.1 Å resolution, even though the STAS domains in the I envelope were averaged. This indicates that RsbS and RsbRA share a highly conserved STAS fold. 22 protrusions observed in the C1 envelope, corresponding to dimers of the RsbRA N-domain, allowed the STAS domains of RsbRA and RsbS to be distinguished in the stressosome core. Based on these, the model of the stressosome core was reconstructed. The mutation of RsbRA residues at the binding interface in the model (R189A/Q191A) significantly reduced the interaction between RsbRA and RsbS. These results suggest that nonconserved residues in the conserved STAS folds between RsbS and RsbR paralogs determine stressosome assembly.

For Heusler-type Ni–Mn–Ga ferromagnetic shape-memory alloys, the configuration of the martensite variants is a decisive factor in achieving a large magnetic shape-memory effect through field-induced variant reorientation. Based upon the spatially resolved electron backscatter diffraction technique, the microstructural evolution associated with the martensitic transformation from austenite to seven-layered modulated (7M) martensite was investigated on a polycrystalline Ni53Mn22Ga25 alloy. It was clearly shown that grain interior nucleation led to the formation of diamond-shaped 7M martensite within the parent austenite matrix. This diamond microstructure underwent further growth through an isotropic expansion with the coordinated outward movement of four side habit planes, followed by an anisotropic elongation with the forward extension of a type-I twin pair. A two-step growth model is proposed to describe the specific morphology and crystallography of 7M martensite. In addition, the habit planes were revealed to possess a stepped structure, with the {1 0 1}A plane as the terrace and the {0 1 0}A plane as the step. The characteristic combination of martensite variants and the underlying mechanism of self-accommodation in the martensitic transformation have been analysed in terms of the minimum total transformation strain, where the deformation gradient matrix was constructed according to the experimentally determined orientation relationship between the two phases. The present results may deepen the understanding of special martensite microstructures during the martensitic transformation in ferromagnetic shape-memory alloys.

MICAL is an oxidoreductase that participates in cytoskeleton reorganization via actin disassembly in the presence of NADPH. Although three MICALs (MICAL1, MICAL2 and MICAL3) have been identified in mammals, only the structure of mouse MICAL1 has been reported. Here, the first crystal structure of human MICAL3, which contains the flavin-containing monooxygenase (FMO) and calponin-homology (CH) domains, is reported. MICAL3 has an FAD/NADP-binding Rossmann-fold domain for mono­oxygenase activity like MICAL1. The FMO and CH domains of both MICAL3 and MICAL1 are highly similar in structure, but superimposition of the two structures shows a different relative position of the CH domain in the asymmetric unit. Based on kinetic analyses, the catalytic efficiency of MICAL3 dramatically increased on adding F-actin only when the CH domain was available. However, this did not occur when two residues, Glu213 and Arg530, were mutated in the FMO and CH domains, respectively. Overall, MICAL3 is structurally highly similar to MICAL1, which suggests that they may adopt the same catalytic mechanism, but the difference in the relative position of the CH domain produces a difference in F-actin substrate specificity.

Transforming growth factor β-1 (TGFβ-1) is a secreted signalling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. The primary endogenous activity regulatory mechanism for TGFβ-1 is sequestration by its pro-peptide, latency-associated peptide (LAP), which sterically prohibits receptor binding by caging TGFβ-1. As such, recombinant LAP is promising as a protein-based therapeutic for modulating TGFβ-1 activity; however, the mechanism of binding is incompletely understood. Comparison of the crystal structure of unbound LAP (solved here to 3.5 Å resolution) with that of the bound complex shows that LAP is in a more open and extended conformation when unbound to TGFβ-1. Analysis suggests a mechanism of binding TGFβ-1 through a large-scale conformational change that includes contraction of the inter-monomer interface and caging by the `straight-jacket' domain that may occur in partnership through a loop-to-helix transition in the core jelly-roll fold. This conformational change does not appear to include a repositioning of the integrin-binding motif as previously proposed. X-ray scattering-based modelling supports this mechanism and reveals possible orientations and ensembles in solution. Although native LAP is heavily glycosylated, solution scattering experiments show that the overall folding and flexibility of unbound LAP are not influenced by glycan modification. The combination of crystallography, solution scattering and biochemical experiments reported here provide insight into the mechanism of LAP sequestration of TGFβ-1 that is of fundamental importance for therapeutic development.

Mitochondrial calcium uptake proteins 1 and 2 (MICU1 and MICU2) mediate mitochondrial Ca2+ influx via the mitochondrial calcium uniporter (MCU). Its molecular action for Ca2+ uptake is tightly controlled by the MICU1–MICU2 heterodimer, which comprises Ca2+ sensing proteins which act as gatekeepers at low [Ca2+] or facilitators at high [Ca2+]. However, the mechanism underlying the regulation of the Ca2+ gatekeeping threshold for mitochondrial Ca2+ uptake through the MCU by the MICU1–MICU2 heterodimer remains unclear. In this study, we determined the crystal structure of the apo form of the human MICU1–MICU2 heterodimer that functions as the MCU gatekeeper. MICU1 and MICU2 assemble in the face-to-face heterodimer with salt bridges and me­thio­nine knobs stabilizing the heterodimer in an apo state. Structural analysis suggests how the heterodimer sets a higher Ca2+ threshold than the MICU1 homodimer. The structure of the heterodimer in the apo state provides a framework for understanding the gatekeeping role of the MICU1–MICU2 heterodimer.

The Open Banking Report 2019 clarifies the role of key key-players in a post-September 14th world and assesses how the landscape has shifted within Europe and beyond.

Yaya Wang
Apr 7, 2020; 133:jcs228072-jcs228072
REVIEW

Comprehensive flood risk management should include household measures, such as improving a home’s stability and relocating heating systems to safe places within the house. According to new research, better communication with householders by authorities on the effectiveness of such measures, and how to implement them, could increase their uptake.

Phytoplankton are essential to marine food webs and fisheries. However, a new study indicates that their levels have declined in the North Atlantic since the beginning of the 19th century. This coincides with weakening ocean-circulation patterns, partly caused by melting ice caps. If the melting continues, the study warns of a dramatic fall in North Atlantic plankton levels that could have cascading effects across marine food webs, reducing the ocean’s ability to absorb carbon and threatening the supply of seafood for humans.

Constructed wetlands serve as a cost-effective and multi-purpose option for storm-water treatment in urban landscapes, offering flood protection as well as wildlife habitat. However, a new study shows that when nearby land use includes industry, wetlands can accumulate high levels of pollution and potentially become toxic to wildlife. This new piece of research offers important insights for the planning and management of wetlands.

Rare earth elements (REE) are used to make many low-carbon technologies, including electric vehicles and wind turbines. Mining and processing of REE, which mostly takes place in China, has a reputation for causing environmental damage. A new study presents a method for evaluating the environmental impacts of REE production based on life-cycle assessment (LCA: a way of determining a product's overall impact during some or all of its journey from extraction to end-of-life). The researchers applied the method to a prospective REE mine in Malawi, south-east Africa, to reveal the most environmentally impactful stages of production, and the greenest source of energy.

A mixture of fine particles in air leads to harmful effects on human health. Currently, particulate matter (PM) is defined in policy by particle size, but according to a new study, focusing on air pollutants and their toxic effects on cells may provide an effective way to legislate for PM.

Makower, one of the most respected voices in green business, talks about greener corporations, what the government could be doing to foster more environmentally

Scott, who founded Aston Scott Group, has invested in the start-up which was launched by former Aviva broker distribution director Fraser Edmond.

New research on streaming data systems will identify trends in analytics and data management

New research on engaging candidates effectively will guide HR teams and business leaders in this critical arena

Source One Director Jennifer Ulrich will discuss end-to-end supplier engagement in a webinar sponsored by ISM-New Jersey.

Healthcare industry to reach $372 billion by 2022

South Africa currently runs a two-tiered healthcare system, comprising of the public and the smaller, rapidly -growing private sector.