Children's Geographies; 08/01/2023
(AN 167303411); ISSN: 14733285
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Children's Geographies; 02/01/2024
(AN 175911763); ISSN: 14733285
Academic Search Premier

Children's Geographies; 10/01/2024
(AN 180134757); ISSN: 14733285
Academic Search Premier

The post The role and value of counsellors in the treatment journeys of people with tuberculosis and their families: Qualitative insights from the South Fly District of Papua New Guinea was curated by information for practice.

Building on the theme, ‘Make the impossible, possible’, Manhattan Associates has opened its annual EMEA Exchange event to an audience of more than 300 customers and press, with keynotes that introduced the European market to Manhattan Active Supply Chain Planning and Generative AI solutions; Manhattan Active Maven and Manhattan Assist.

A research team has identified 2,586 orphan genes (OGs) in Rosa chinensis, offering new insights into the role of these unique genes in flower development, stress response, and environmental adaptation.

A research team has identified 2,586 orphan genes (OGs) in Rosa chinensis, offering new insights into the role of these unique genes in flower development, stress response, and environmental adaptation.

Explore Virgo men's traits, compatibility, and relationship dynamics. Learn what makes a Virgo man unique in love and if he's the right zodiac match for you.

The crystal structure of a neo­pentyl­oxypillar[5]arene with two pyridine mol­ecules encapsulated in the macrocyclic cavity is reported.

The crystal structure of 1,4-bis­(neopent­yloxy)pillar[5]arene, C95H140N2O10 (TbuP), featuring two encapsulated pyridine mol­ecules, reveals significant host–guest inter­actions. Inter­estingly, the pyridine guests are positioned near the neopent­yloxy substituents instead of the electron-rich aromatic core of the pillar[5]arene. This spatial arrangement suggests a preference for the pyridine mol­ecules to engage with the aliphatic regions of the host. Detailed analysis of the structural characteristics of this host–guest system (TbuP·2Py), as well as its packing pattern within the crystal network, is presented and discussed.

Three 2,4-di­aryl­pyrroles were synthesized starting from 4-nitro­butano­nes and the crystal structures of two derivatives were analysed. These are 4-(4-meth­oxy­phen­yl)-2-(thio­phen-2-yl)-1H-pyrrole, C15H13NOS, and 3-(4-bromo­phen­yl)-2-nitroso-5-phenyl-1H-pyrrole, C16H11BrN2O. Although pyrroles without sub­stituents at the α-position with respect to the N atom are very air sensitive and tend to polymerize, we succeeded in growing an adequate crystal for X-ray diffraction analysis. Further derivatization using sodium nitrite afforded a nitrosyl pyrrole derivative, which crystallized in the triclinic space group Poverline{1} with Z = 6. Thus, herein we report the first crystal structure of a nitrosyl pyrrole. Inter­estingly, the co-operative hydrogen bonds in this NO-substituted pyrrole lead to a trimeric structure with bifurcated halogen bonds at the ends, forming a two-dimensional (2D) layer with inter­stitial voids having a radius of 5 Å, similar to some reported macrocyclic porphyrins.

Type VII secretion (T7S) systems, also referred to as ESAT-6 secretion (ESX) systems, are molecular machines that have gained great attention due to their implications in cell homeostasis and in host–pathogen interactions in mycobacteria. The latter include important human pathogens such as Mycobacterium tuberculosis (Mtb), the etiological cause of human tuberculosis, which constitutes a pandemic accounting for more than one million deaths every year. The ESX-5 system is exclusively found in slow-growing pathogenic mycobacteria, where it mediates the secretion of a large family of virulence factors: the PE and PPE proteins. The secretion driving force is provided by EccC5, a multidomain ATPase that operates using four globular cytosolic domains: an N-terminal domain of unknown function (EccC5DUF) and three FtsK/SpoIIIE ATPase domains. Recent structural and functional studies of ESX-3 and ESX-5 systems have revealed EccCDUF to be an ATPase-like fold domain with potential ATPase activity, the functionality of which is essential for secretion. Here, the crystal structure of the MtbEccC5DUF domain is reported at 2.05 Å resolution, which reveals a nucleotide-free structure with degenerated cis-acting and trans-acting elements involved in ATP binding and hydrolysis. This crystallographic study, together with a biophysical assessment of the interaction of MtbEccC5DUF with ATP/Mg2+, supports the absence of ATPase activity proposed for this domain. It is shown that this degeneration is also present in DUF domains from other ESX and ESX-like systems, which are likely to exhibit poor or null ATPase activity. Moreover, based on an in silico model of the N-terminal region of MtbEccC5DUF, it is hypothesized that MtbEccC5DUF is a degenerated ATPase domain that may have retained the ability to hexamerize. These observations draw attention to DUF domains as structural elements with potential implications in the opening and closure of the membrane pore during the secretion process via their involvement in inter-protomer interactions.

Human peptidylarginine deiminase isoform VI (PAD6), which is predominantly limited to cytoplasmic lattices in the mammalian oocytes in ovarian tissue, is essential for female fertility. It belongs to the peptidylarginine deiminase (PAD) enzyme family that catalyzes the conversion of arginine residues to citrulline in proteins. In contrast to other members of the family, recombinant PAD6 was previously found to be catalytically inactive. We sought to provide structural insight into the human homologue to shed light on this observation. We report here the first crystal structure of PAD6, determined at 1.7 Å resolution. PAD6 follows the same domain organization as other structurally known PAD isoenzymes. Further structural analysis and size-exclusion chromatography show that PAD6 behaves as a homodimer similar to PAD4. Differential scanning fluorimetry suggests that PAD6 does not coordinate Ca2+ which agrees with acidic residues found to coordinate Ca2+ in other PAD homologs not being conserved in PAD6. The crystal structure of PAD6 shows similarities with the inactive state of apo PAD2, in which the active site conformation is unsuitable for catalytic citrullination. The putative active site of PAD6 adopts a non-productive conformation that would not allow protein–substrate binding due to steric hindrance with rigid secondary structure elements. This observation is further supported by the lack of activity on the histone H3 and cytokeratin 5 substrates. These findings suggest a different mechanism for enzymatic activation compared with other PADs; alternatively, PAD6 may exert a non-enzymatic function in the cytoplasmic lattice of oocytes and early embryos.

Immunodominant membrane protein (IMP) is a prevalent membrane protein in phytoplasma and has been confirmed to be an F-actin-binding protein. However, the intricate molecular mechanisms that govern the function of IMP require further elucidation. In this study, the X-ray crystallographic structure of IMP was determined and insights into its interaction with plant actin are provided. A comparative analysis with other proteins demonstrates that IMP shares structural homology with talin rod domain-containing protein 1 (TLNRD1), which also functions as an F-actin-binding protein. Subsequent molecular-docking studies of IMP and F-actin reveal that they possess complementary surfaces, suggesting a stable interaction. The low potential energy and high confidence score of the IMP–F-actin binding model indicate stable binding. Additionally, by employing immunoprecipitation and mass spectrometry, it was discovered that IMP serves as an interaction partner for the phytoplasmal effector causing phyllody 1 (PHYL1). It was then shown that both IMP and PHYL1 are highly expressed in the S2 stage of peanut witches' broom phytoplasma-infected Catharanthus roseus. The association between IMP and PHYL1 is substantiated through in vivo immunoprecipitation, an in vitro cross-linking assay and molecular-docking analysis. Collectively, these findings expand the current understanding of IMP interactions and enhance the comprehension of the interaction of IMP with plant F-actin. They also unveil a novel interaction pathway that may influence phytoplasma pathogenicity and host plant responses related to PHYL1. This discovery could pave the way for the development of new strategies to overcome phytoplasma-related plant diseases.

A polycrystalline sample LuCrO3 has been characterized by neutron powder diffraction (NPD) and magnetization measurements. Its crystal structure has been Rietveld refined from NPD data in space group Pnma; this perovskite contains strongly tilted CrO6 octahedra with extremely bent Cr—O—Cr superexchange angles of ∼142°. The NPD data show that below Néel temperature (TN ≃ 131 K), the magnetic structure can be defined as an A-type antiferromagnetic arrangement of Cr3+ magnetic moments, aligned along the b axis, with a canting along the c axis. A noticeable magneto­strictive effect is observed in the unit-cell parameters and volume upon cooling down across TN. The AC magnetic susceptibility indicates the onset of magnetic ordering below 112.6 K; the magnetization isotherms below TN show a nonlinear behaviour that is associated with the described canting of the Cr3+ magnetic moments. From the Curie–Weiss law, the effective moment of the Cr3+ sublattice is found to be μeff = 3.55 μB (calculated 3.7 μB) while the ΘCW parameter yields a value of −155 K, indicating antiferromagnetic interactions. There is a conspicuous increase of TN upon the application of external pressure, which must be due to shortening of the Cr—O bond length under compression that increases the orbital overlap integral.

This study characterizes the microstructure and mineralogy of 132 (ODP sample), 1000 and 1880 million-year-old chert samples. By using ultra-small-angle X-ray scattering (USAXS), wide-angle X-ray scattering and other techniques, the preservation of organic matter (OM) in these samples is studied. The scarce microstructural data reported on chert contrast with many studies addressing porosity evolution in other sedimentary rocks. The aim of this work is to solve the distribution of OM and silica in chert by characterizing samples before and after combustion to pinpoint the OM distribution inside the porous silica matrix. The samples are predominantly composed of alpha quartz and show increasing crystallite sizes up to 33 ± 5 nm (1σ standard deviation or SD). In older samples, low water abundances (∼0.03%) suggest progressive dehydration. (U)SAXS data reveal a porous matrix that evolves over geological time, including, from younger to older samples, (1) a decreasing pore volume down to 1%, (2) greater pore sizes hosting OM, (3) decreasing specific surface area values from younger (9.3 ± 0.1 m2 g−1) to older samples (0.63 ± 0.07 m2 g−1, 1σ SD) and (4) a lower background intensity correlated to decreasing hydrogen abundances. The pore-volume distributions (PVDs) show that pores ranging from 4 to 100 nm accumulate the greater volume fraction of OM. Raman data show aromatic organic clusters up to 20 nm in older samples. Raman and PVD data suggest that OM is located mostly in mesopores. Observed structural changes, silica–OM interactions and the hydro­phobicity of the OM could explain the OM preservation in chert.

As COVID-19 vaccinations continue and accelerate across the U.S., a new rapid expert consultation from the National Academies of Sciences, Engineering, and Medicine offers advice for decision-makers communicating to the public about vaccine efficacy, effectiveness, and equity — drawing on findings from social and behavioral science.

Leading women data scientists and AI leaders talk about fostering more female candidates in the industry and navigating the challenges associated with it.

What does mandated bioengineered labeling mean for product manufacturers like snack producers and bakers? SF&WB reached out to AIB International to find out.

Outstanding Foods turns to Crisp for a more efficient and effective way to look at its data.

Clean-label snack and bakery insight and analysis for new product development, including ingredient options.

Givaudan has published initial insights and the first commercial innovation inspired by the fifth savory edition of its global Chef’s Council event – The Protein Challenge.

Near the end of December 2019, the Wuhan Municipal Health Commission, Wuhan City, China, reported several pneumonia cases that officials eventually tied to a new coronavirus called SARS-CoV-2, now generally known as COVID-19.

Eating occasions and flavor directions factor into industry activity and planning.

Machining and handling of dough prior to the cutting action requires several steps/actions, as they are critical to the textural characteristics of the finished product.

On average, 83% of consumers are limiting or avoiding sugars in their diets, but the products of particular concern vary widely.

From flavors to popular culture, what’s hot and cool are what drives new products from the Battle Creek, Mich.-based company.

Here are a few insights I'd like to share on how to lead our businesses with confidence, regardless of what's happening in the broader world.

The effectiveness of workplace communication is reliant on a number of factors, such as environment, skillset and structure.

Technomic released its Beverage Global Menu Category Report, which explores foodservice category sizing by country, outlook and expectations, consumer patronage and preferences, menu trends, global and local chains, and brands to watch.

Natural and organic retailers anticipate certain consumer trends for the year.

The Coca-Cola Co. showcased its full portfolio of brands in one booth at this year’s NACS Show, including flavor innovations coming in 2025: Coca-Cola Orange Cream, Sprite + Tea and POWERADE Xtra Sour.

Survey finds employees who perceive their workplace policies as not inclusive are twice as likely to be actively looking for new employment opportunities elsewhere

Discover the future of revenue optimization technology with Kalibri Labs' latest innovation, Summary View, designed to empower hoteliers with instant, comprehensive insights into their performance data.

Sunil Jagani, a prominent figure in Philadelphia's technology landscape and founder of AllianceTek, is making waves in the AI industry with his pioneering work on Retrieval-Augmented Generation (RAG)

Crypto Job Market Insights

CEO Jaime Raskulinecz Explains How to Include Equipment Leases as an Alternative Asset in a Self-Directed Retirement Plan

A good estate attorney will work to accurately reflect your wishes and provide for the smooth transfer of your assets to your chosen beneficiaries.

Embarking on a Soulful Exploration, Nancy Smith, the esteemed angel card reader, unveils profound healing and akashic insights, paving the way for an enlightening spiritual quest.

The season one finale of 'Soul-Bridge with Toby Evans' has finally arrived, showcasing a feature-length episode over a year in the making, also marking the debut of two original songs with a unique twist.

Innovative Startup Seeks Funding to Empower Teachers with Inquiry-Based Learning Tools, Aiming to Transform Student Engagement Nationwide

Owners of self-directed IRAs can invest in distressed and other commercial real estate to diversify their retirement plans by including this alternative asset

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CEO of Next Generation and Forbes Finance Council thought leader explains the alternative asset and how it can be used to build retirement wealth

DW Excavation emphasizes its commitment to excellence and environmental stewardship, which is particularly important in regions with diverse ecosystems and stringent regulations.

MelaMed Wellness is proud to introduce "The Calm-Collective Wellness Blog"

Hear From Industry Leaders on The Role of Blockchains in Combating Corruption

Emerging storyteller Richard Runyon announces his forthcoming autobiography, adding to his impressive body of work, which includes an acclaimed interview series and the upcoming "Richard Runyon's Storybook" web program.

Fast Guard Service provides tips for Guards looking for employment