Co-fractionation MS (CF-MS) is a technique with potential to characterize endogenous and unmanipulated protein complexes on an unprecedented scale. However this potential has been offset by a lack of guidelines for best-practice CF-MS data collection and analysis. To obtain such guidelines, this study thoroughly evaluates novel and published Saccharomyces cerevisiae CF-MS data sets using very high proteome coverage libraries of yeast gold standard complexes. A new method for identifying gold standard complexes in CF-MS data, Reference Complex Profiling, and the Extending 'Guilt-by-Association' by Degree (EGAD) R package are used for these evaluations, which are verified with concurrent analyses of published human data. By evaluating data collection designs, which involve fractionation of cell lysates, it is found that near-maximum recall of complexes can be achieved with fewer samples than published studies. Distributing sample collection across orthogonal fractionation methods, rather than a single high resolution data set, leads to particularly efficient recall. By evaluating 17 different similarity scoring metrics, which are central to CF-MS data analysis, it is found that two metrics rarely used in past CF-MS studies – Spearman and Kendall correlations – and the recently introduced Co-apex metric frequently maximize recall, whereas a popular metric—Euclidean distance—delivers poor recall. The common practice of integrating external genomic data into CF-MS data analysis is also evaluated, revealing that this practice may improve the precision and recall of known complexes but is generally unsuitable for predicting novel complexes in model organisms. If studying nonmodel organisms using orthologous genomic data, it is found that particular subsets of fractionation profiles (e.g. the lowest abundance quartile) should be excluded to minimize false discovery. These assessments are summarized in a series of universally applicable guidelines for precise, sensitive and efficient CF-MS studies of known complexes, and effective predictions of novel complexes for orthogonal experimental validation.

LONDON, Nov. 1, 2024 — Quantum Motion, a UK-based quantum computing scale-up founded by Professor John Morton, University College London (UCL), and Professor Simon Benjamin, University of Oxford, has worked […]

The post Quantum Motion and Goldman Sachs Identify Quantum Applications in Financial Services Project appeared first on HPCwire.

Actor/TV personality Whoopi Goldberg turns 69 and singer Julia Michaels turns 30, among the famous birthdays for Nov. 13.

EAU CLAIRE— This weekend saw the first basketball games for Blugold men’s and women’s basketball during the Market & Johnson Blugold Tip-Off Tournament. The games were the first to be played at the Sonnentag Event Center, a part of the new $122 million multi-purpose facility which opened earlier this year. The event center has a capacity of 3,500 people for sporting events as compared to the ...

This sacred shrine in India feeds over 100,000 people a day regardless of race, religion and class.

In 1896, Thomas Edison set off to a remote Canadian district near the Alaska border, with cameras in tow. He succeeded in capturing fascinating images of the prospectors brought in by the Gold Rush.

The quest drew thousands of curious participants hoping to solve a series of elaborate riddles—and win a bejeweled statue worth an estimated $165,000

The critter found in New York represents a new, extinct species of arthropod that could shed light on the evolution of today's insects, crustaceans and spiders

The votive plaque was found amid the ruins of an ancient Roman fortress. Researchers think a temple dedicated to the mysterious deity may have stood nearby

In the international competition, people with physical disabilities put state-of-the-art devices to the test as they race to complete the tasks of everyday life

Water quality guidelines for mercury are 0.02 micrograms per litre of water. Several results show that levels at four sites are far above that threshold. During the second week of October, one value close to the mine was more than seven times the acceptable level.

With flinty perseverance and a golden touch, Belinda Mulrooney earned an unlikely fortune in the frozen north and reshaped the Canadian frontier

That Figure Skating Show recaps the ice dance event at Rostelecom Cup that saw Canadians Laurence Fournier Beaudry and Nikolaj Sorensen take their second bronze this season.

Nathan Chen has accomplished just about everything that one can accomplish in the sport of figure skating. The only thing he's yet to accomplish? Winning Olympic gold.

New Solution Helps Designers Calculate and Reduce the Environmental Impact of Their Materials, Production Methods

Life is not a movie, says one worker who shares her life and Christ with the many broken women in Hong Kong’s brothels.

Gold remains at record highs, but there are various ways to get exposure to the metal that are less cumbersome and more investor-friendly than holding physical gold.

Indian buyers of gold brushed off record high prices and made purchases for the Dhanteras and Diwali festivals starting on Tuesday, hoping bullion would continue to rally and deliver promising returns amid a cooling stock market, industry officials told Reuters.

Sonali Bendre and Goldie Behl tied the knot in a lavish ceremony on November 12, 2002

Defendant faces decades in prison Department of Justice prosecutors indicted a man Monday for robbing and brutally assaulting the owner of a Wilmington jewelry store in September 2022.  Calvin Ushery, Jr., 39, is charged with multiple felonies — including Assault 1st Degree — for the attack, which was caught on video. In the video, Ushery pistol-whips the victim […]

Gov. Jack Markell attends grand opening of company’s new headquarters in Newark NEWARK, Del. –   Independent, family-owned Natural Dairy Products Corporation found the perfect match in Newark for its relocated headquarters and gold-standard quality dairy operation, where it will make and distribute its organic, grass-fed dairy products. That feeling of synergy was mutual on Friday, […]

I want to use jaspergold to formally verify functionality of my custom multiplier. I am computing the expected result using A*B to check against output of my multiplier. Here, A and B are two logic signed operands. However, jaspergold is performing the operation A*B incorrectly.

I have reproduced this issue using the attached example. JasperGold compiles and elaborates the module and subsequently runs a formal proof. The tool raises a counterexample to assertion whose screenshot is attached below:

I simulated the same example using xrun and it was giving the correct product output in simvision waveform. Please help me resolve this issue. I am using 2023.03 version of Jasper Apps.

Thanks and regards

Anubhav Agarwal

Australia’s proud mining history, the quality of its workers and high working standards were instrumental in bringing Canadian mining and exploration company Kirkland Lake Gold to the Victorian gold fields.

HOST China snapped up more gold medals at the Hangzhou Asian Games yesterday. A shooting world record fell to Chinese teenager Sheng Lihao in the men’s 10-meter air rifle with his 253.3 points surpassing

Dakar, Senagal — The CEO and two executives of Australian gold mine Resolute in Mali have been arrested while in Bamako to discuss ongoing disputes with authorities, the company confirmed Sunday. CEO Terence Holohan and his two colleagues "were in Bamako to discuss with mining and tax authorities the company's business practices in Mali generally and to make progress on ongoing claims against Resolute, which continues to claim they are unfounded," Resolute said in a statement posted on its website. "Unexpectedly, the three employees were arrested after the end of these meetings on Friday," she reported. The three executives were taken the same day to the unit specializing in the fight against corruption and economic and financial delinquency — and were placed in police custody in a case of alleged forgery and damage to public property, AFP learned Saturday from a judicial and industrial source. Four employees of the Canadian company Barrick Gold, also in dispute with the Malian authorities, were detained for several days at the end of September, then released. Foreign mining companies are subject to increased pressure from the junta that came to power by force in 2020 and pays particular attention to the juicy revenues of the mining industry. "Resolute is working to reach an agreement with the Malian government that secures the long-term future of the Syama gold mine; at the same time its top priority remains the safety and well-being of its employees," the company said. The executives benefit from the support of the embassies and consulates of the United Kingdom and other countries present in Mali, she said. Resolute holds 80% of the shares in the subsidiary that owns the Syama mine, with the remaining 20% in the hands of the Malian state, according to the company's website. The Malian authorities have made the fight against corruption and the restoration of national sovereignty over natural resources their mantras. Mali, one of the poorest countries in the world, faces jihadis and a multidimensional crisis, and is also one of the leading gold producers in Africa. Gold contributes to a quarter of the national budget and three quarters of export revenues. The increased pressure on foreign companies coincided with the junta's strategic pivot toward Russia.

NEW YORK — The rush for gold just keeps coming. Gold hit another all-time high this week. Recent gains for the precious metal are largely credited to ongoing economic uncertainty, geopolitical tensions and strong demand from central banks around the world. If trends continue, analysts have bullish outlooks on the price of gold for the months ahead. But the future is never promised. Here's what you need to know. Where does the price of gold stand today? The New York spot price of gold closed Tuesday at just over $2,657 per Troy ounce — the standard for measuring precious metals, which is equivalent to 31 grams — the highest recorded to date, per FactSet. That would make a gold bar or brick weighing 400 Troy ounces worth more than $1.06 million today. This week's record high means that the price of gold has climbed hundreds of dollars per Troy ounce over the last year. Tuesday's price is up nearly $145 from a month ago and more than $740 from this time in 2023. The price of gold is up nearly 30% year to date, analysts note — outpacing the benchmark S&P 500's roughly 20% gain since the start of 2024. Why is the price of gold going up? There are a few factors behind the recent gains. Interest in buying gold often comes at times of uncertainty — with potential concerns around inflation and the strength of the U.S. dollar, for example, causing some to look for alternative places to park their money. Gold also surged in the early days of the COVID-19 pandemic. Among sources of uncertainty today are geopolitical tensions — which escalated over recent days with Israel's deadly strikes in Lebanon. And the ongoing wars in Gaza and Ukraine have continued to fuel fears about the future worldwide. In markets like the U.S., there's also particular concern about the health of the job market. Last week's larger-than-usual half-point cut by the Federal Reserve signals a new focus on slowing employment numbers, and more rate cuts are expected before the end of the year. And such action arrives in the midst of a tumultuous election year — which could prove crucial to economic policy in the road ahead, too. In the near future, people are considering "any case of turbulence in the economy," FxPro senior market analyst Michel Saliby explained. "This is why they're keeping a decent portion of gold in their portfolio as a 'safe haven.'" Analysts also point to strong demand from central banks around the world. Joe Cavatoni, senior market strategist at the World Gold Council, noted last month that central bank demand was well-above the five year average — reflecting "heightened concern with inflation and economic stability." Recent stimulus measures in China aimed at boosting consumer spending are also expected to up retail investments, Saliby added, further boosting gold's performance. Is gold worth the investment? Advocates of investing in gold call it a "safe haven," arguing the commodity can serve to diversify and balance your investment portfolio, as well as mitigate possible risks down the road. Some also take comfort in buying something tangible that has the potential to increase in value over time. Experts caution against putting all your eggs in one basket. Both retail and institutional investors shouldn't be influenced by the "FOMO effect," or fear of missing out, Saliby notes — explaining that people should not risk all their money just because they are seeing others rake in gains. He advises investors to watch the market and always have a clear risk management strategy for their position. If geopolitical tensions cool, Saliby expects the price of gold to correct slightly, perhaps falling around $50 to $80. But he remains bullish overall for the near future — expecting gold's spot price to soon surpass the $2,700 mark previously predicted for 2025, and perhaps reach as high as $2,800 or $2,900 if trends continue. Still, future gains are never promised and not everyone agrees gold is a good investment. Critics say gold isn't always the inflation hedge many say it is — and that there are more efficient ways to protect against potential loss of capital, such as through derivative-based investments. The Commodity Futures Trade Commission has also previously warned people to be wary of investing in gold. Precious metals can be highly volatile, the commission said, and prices rise as demand goes up — meaning "when economic anxiety or instability is high, the people who typically profit from precious metals are the sellers." If you do choose to invest in gold, the commission adds, it's important to educate yourself on safe trading practices and be cautious of potential scams and counterfeits on the market.

Police on Wednesday are investigating the theft of a large number of gold items after a search at a Nicosia gold shop. The owner of the property, aged 78, has been arrested and taken into custody for questioning. According to the police, the search happened as part of an ongoing investigation into a spate of […]

Almost all the stars that will ever exist have already been born, and they have been around long enough for life to evolve on planets that orbit them

Almost all the stars that will ever exist have already been born, and they have been around long enough for life to evolve on planets that orbit them

Geologists think there may be vast natural stores of hidden hydrogen gas within Earth, but no one is sure how much there is or how much could be recovered for energy

Quartz crystals produce electricity when they are deformed by mechanical stress, which may explain how enormous chunks of gold can form in inert rock

Title: Senior Years May Truly Be Golden for Happiness
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/25/2016 12:00:00 AM

Title: goldenseal
Category: Medications
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM

Extract

We read with great interest the review article by Randerath et al. [1] recently published in the European Respiratory Review. We would like to congratulate the authors on this clearly structured review, which emphasises the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

The Bank of Mum and Dad has been a major sponsor of Olympic athletes for more than a century, but may be about to be superseded.

Kelley's cat decided Christmas was over. Chris is scared to return to Vana'diel and hates Norrath, but is strangely interested in hanging out with river hobbits in Middle Earth. Meanwhile, Phil tries to recruit everyone into his multilevel Monster Hunter scheme.

The post RPG Cast – Episode 705: “Trip the Gold Digger” appeared first on RPGamer.

The Rise Of The Golden Idol will crack its new case wide open on November 12th, but the detective sequel is just the beginning. Color Gray Games are planning another tranche of DLC akin to that received by the first game, The Case Of The Golden Idol: four standalone mysteries that introduce more mysteries to solve.

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