[Written by Stephen Wright] A swarm of Dara Alizadeh supporters, decked out in bright pink Bermuda t-shirts and “Go Dara!” caps, descended on the Vaires-sur-Marne Nautical Stadium to cheer on the Bermuda rower. More than 30 of Alizadah’s family and friends have travelled to Paris to support the 30-year-old, who took to the water today […]

The ‘Move Your Feet’ for Autism 5K Family Walk, hosted by Tomorrow’s Voices, was held today [Nov 3] at TN Tatem Field in Warwick.  The event included music, bouncy castles, a warm-up stretch, and various family-friendly activities, creating a fun day for all in support of autism awareness. Related Stories 9-Year-Old Rico Has His Own […]

BE Solar partnered with Aeolus Capital Management to install a solar system for the Family Centre headquarters in Pembroke, and they noted that the solar system “will help the charity save over $4,800 each year by relying less on fossil fuel electricity.” A BE Solar spokesperson said, “Local solar company, BE Solar, has partnered with […]

A 6K Family Fun Walk, Run, and Roll event will be held on Saturday, September 28, starting at 8.30am from Bailey’s Bay Cricket Club to St. George’s Cricket Club to support Zhamir Denbrook-Pitt’s medical expenses. The event sign up page said, “Spinal cord injuries [SCI] can have life-altering impacts, affecting mobility, independence, and overall quality […]

Minister of Tourism, Culture, and Sport Owen Darrell paid tribute to the late Tony Bari. Minister Darrell said, “On behalf of the Ministry of Tourism, Culture, and Sport, we offer our heartfelt condolences to the family and loved ones of Mr. Tony Bari. “Mr. Bari’s captivating jazz, big band, and rhythm and blues performances of […]

Premier David Burt and his family released their annual Cup Match photo, featuring clothing by Bermudian designer, business owner and creative Jordan Carey, founder and Creative Director of the Loquat brand. A spokesperson said, “Premier David Burt, JP, MP and his family have today shared their annual Cup Match photo. “This year’s official photoshoot is particularly […]

While there is a growing body of research about carers’ experiences generally, the needs and experience of those who support individuals in forensic (secure) mental health services (forensic carers) have been neglected Support in Mind Scotland (SiMS) and the Forensic Network commissioned this study from the University of Central Lancashire to examine what they identified as ‘significant gaps and inconsistencies’, focusing in particular on the views and experiences of forensic carers.

In 2006 Mencap produced a comprehensive review of short break provision. Now, 10 years on, they are revisiting the support available for family carers to see whether recent policy initiatives and investment have delivered the much-needed change. A total of 264 family carers responded to their survey on short breaks provision and experiences of caring. They also sent Freedom of Information requests to all 152 local authorities in England that provide social care services. This report looks at short breaks provision in a climate of cuts to central and local government budgets. It examines the extent to which these cuts have impacted on the lives of people with a learning disability and their family carers. It also looks at the state of affairs for family carers of children and young people across the full spectrum of learning disability; from people with mild and moderate learning disabilities, to people with severe and profound disabilities.

In today's edition of FAFO (F*ck Around and Find Out) we have a man who is probably going to learn the hard way that being one of the "good ones" means nothing to the Trump administration.

See, MAGA loyalty only goes one way. They want your vote, but won't do anything to make your life better. This Latino male Trump voter told CNN that mass deportation won't extend to law-abiding workers.

He actually said, with a straight face: “That wouldn’t be fair. They need to make sure that they don’t throw away, they don’t kick out, they don’t deport people that are family oriented.”

Sweetie, they don't care if you are family oriented or not. If you are working a good job or not. If you are a criminal or not. To them, being non-American is enough to get you kicked out (and probably put in a camp before). Enjoy that Trump hair visor hat, honey. The leopards are coming for your face.

"Fucketh around and ye shall findeth out" - A Twitter User in 2024

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divine creation evolution discussing politics during a family reunion is never a good idea

I’m meditating now because it slows down time and I only have 14 more weeks until both my kids are at college. When Z is reading on the couch, and Nino is reading next to him, I pull up a chair and meditate with my eyes open because I don’t want to miss this moment. […]

The post How to keep a family together appeared first on Penelope Trunk Careers.

Having lived in London for four years, American Kassondra Cloos thought a trip see her adopted city as imagined by the Wizarding World of Harry Potter in Orlando would be fairly pointless – but instead she finds a home from home that’s suited to even grown-up kids

Choosing the right location for a family reunion is crucial, and Gatlinburg, Tennessee, offers the perfect blend of natural beauty and activities to suit every age. Nestled in the scenic Smoky Mountains, this charming town provides the perfect backdrop for families looking to strengthen bonds, share adventures, and create memories that last a lifetime. Gatlinburg’s appeal lies in its ability to offer a retreat into nature while ensuring the comforts and conveniences that make a family gathering unforgettable. Let’s take a look at all the reasons why this town should be your pick for the next family reunion! 1.Cabins for Every Family Size and Budget Accommodations play a crucial role in the success of any family reunion, and Gatlinburg shines in this aspect with its wide array of cabin options. From quaint, cozy cabins perfect for smaller families to sprawling lodges that can accommodate large groups, there’s a cabin to fit every need and budget. These cabins offer the perfect blend of rustic charm and modern comfort, with amenities like fully equipped kitchens, hot tubs, and game rooms to keep everyone entertained. What sets cabin stays in Gatlinburg apart is the opportunity to truly personalize your family reunion. Imagine gathering your loved ones in a spacious cabin, where you can share meals, stories, and laughter in a private, comfortable setting. For an even more hassle-free experience, you can arrange for a reputable Gatlinburg catering service to take care of your meals. 2. Stunning Natural Scenery Gatlinburg is a gem tucked away in the Smoky Mountains, renowned for its beautiful natural landscapes. The beauty of this location is a call to adventure for families, offering a multitude of outdoor activities that cater to all ages and interests. Hiking enthusiasts will find solace in the myriad of trails in the Great Smoky Mountains National Park, ranging from easy walks to challenging treks, each leading to breathtaking vistas, cascading waterfalls, and serene forest settings. For those who prefer a more relaxed encounter with nature, the opportunity to fish in crystal-clear streams or simply enjoy a picnic amidst the beauty of the mountains offers a peaceful retreat from the hustle and bustle of daily life. 3. A Wide Range of Activities for All Ages Gatlinburg’s allure is magnified by its diverse array of attractions and activities, ensuring that every family member, from the youngest to the oldest, will find something enjoyable. The town itself offers everything from thrilling amusement parks and unique museums to artisan shops and live entertainment. Adventure seekers can look forward to zip-lining through the treetops, skiing down the slopes in winter, or challenging each other in friendly competitions at local go-kart tracks. Meanwhile, those with a penchant for culture and art will appreciate Gatlinburg’s galleries, craft shops, and live shows, showcasing the rich heritage of the Smoky Mountains. This wide range of activities not only provides endless fun but also caters to the diverse interests within a family, making every day of the reunion an opportunity to try something new together. 4. Easy Accessibility Gatlinburg’s appeal as a prime destination for family reunions is significantly enhanced by its easy accessibility. Tucked away in the Smoky Mountains, it might seem like a secluded retreat, yet it is surprisingly easy to reach from many major cities in the Southeast. Whether driving from Atlanta, Charlotte, Nashville, or beyond, families find that the journey to Gatlinburg is part of the adventure—winding roads with scenic vistas that build anticipation for the reunion. The town itself is designed to be navigated with ease, thanks to its layout and public transportation options, including trolleys that make stops at major attractions and accommodations. This accessibility ensures that family members of all ages, from energetic toddlers to grandparents, can move around comfortably and safely. The ease of getting to and around Gatlinburg means less time spent on logistics and more time enjoying the company of loved ones. 5. Year-round Events and Festivals Gatlinburg’s calendar is packed with events and festivals that add an extra layer of excitement to family reunions. No matter what time of year you plan to gather, there’s likely to be something special happening in town. These festivals and events not only provide entertainment but also enrich the reunion experience, giving families the chance to create new traditions and share in the cultural and natural beauty of Gatlinburg. They serve as a backdrop to the family memories being made, offering unique experiences that can be cherished for years to come. Conclusion Gatlinburg stands out as the perfect destination for family reunions not just for its stunning natural scenery, cozy cabins, and an array of attractions but for the deeper connection it fosters among family members. The town’s easy accessibility and the year-round calendar of events ensure that every family reunion can be filled with joy, adventure, and memorable experiences. But more than that, Gatlinburg offers a setting where families can come together, away from the distractions of everyday life, to celebrate their bond and create new memories that will last a lifetime.

The post 5 Reasons Gatlinburg Is The Perfect Destination For A Family Reunion appeared first on Geeky Traveller.

They are accused of hate speech as rights groups say the law is being used to restrict freedoms.

It’s refreshing to see manufacturers still making sedans that the average South African family can afford. The Volkswagen Polo Sedan is one of those cars, but now it’s bigger than the previous generation and a lot more modern.

A family in Brackenfell, Cape Town, is looking for their missing teenage son, whom they last saw on Saturday morning heading to visit a friend in the area.

David A. Mitchell
Jun 1, 2006; 47:1118-1127
Thematic Reviews

Michael Dean
Jul 1, 2001; 42:1007-1017
Thematic Reviews

Dawn L. Brasaemle
Dec 1, 2007; 48:2547-2559
Thematic Reviews

T. A. Suslina
St. Petersburg Math. J. 35 (), 537-570.
Abstract, references and article information

α-Linked galactose is a common carbohydrate motif in nature that is processed by a variety of glycoside hydrolases from different families. Terminal Galα1–3Gal motifs are found as a defining feature of different blood group and tissue antigens, as well as the building block of the marine algal galactan λ-carrageenan. The blood group B antigen and linear α-Gal epitope can be processed by glycoside hydrolases in family GH110, whereas the presence of genes encoding GH110 enzymes in polysaccharide utilization loci from marine bacteria suggests a role in processing λ-carrageenan. However, the structure–function relationships underpinning the α-1,3-galactosidase activity within family GH110 remain unknown. Here we focus on a GH110 enzyme (PdGH110B) from the carrageenolytic marine bacterium Pseudoalteromonas distincta U2A. We showed that the enzyme was active on Galα1–3Gal but not the blood group B antigen. X-ray crystal structures in complex with galactose and unhydrolyzed Galα1–3Gal revealed the parallel β-helix fold of the enzyme and the structural basis of its inverting catalytic mechanism. Moreover, an examination of the active site reveals likely adaptations that allow accommodation of fucose in blood group B active GH110 enzymes or, in the case of PdGH110, accommodation of the sulfate groups found on λ-carrageenan. Overall, this work provides insight into the first member of a predominantly marine clade of GH110 enzymes while also illuminating the structural basis of α-1,3-galactoside processing by the family as a whole.

The Discoidin, CUB, and LCCL domain-containing protein (DCBLD) family consists of two type-I transmembrane scaffolding receptors, DCBLD1 and DCBLD2, which play important roles in development and cancer. The nonreceptor tyrosine kinases FYN and ABL are known to drive phosphorylation of tyrosine residues in YXXP motifs within the intracellular domains of DCBLD family members, which leads to the recruitment of the Src homology 2 (SH2) domain of the adaptors CT10 regulator of kinase (CRK) and CRK-like (CRKL). We previously characterized the FYN- and ABL-driven phosphorylation of DCBLD family YXXP motifs. However, we have identified additional FYN- and ABL-dependent phosphorylation sites on DCBLD1 and DCBLD2. This suggests that beyond CRK and CRKL, additional DCBLD interactors may be regulated by FYN and ABL activity. Here, we report a quantitative proteomics approach in which we map the FYN- and ABL-regulated interactomes of DCBLD family members. We found FYN and ABL regulated the binding of several signaling molecules to DCBLD1 and DCBLD2, including members of the 14-3-3 family of adaptors. Biochemical investigation of the DCBLD2/14-3-3 interaction revealed ABL-induced binding of 14-3-3 family members directly to DCBLD2.

Concerns about local school systems can pose recruitment and retention hurdles for the armed services as they seek to meet the needs of military families.

Marie Pino, who taught generations of children in her Navajo community, died at 67. She had lost one of her sons, a school basketball coach, to coronavirus-related illness just weeks before; her husband, an emergency medical coordinator and pastor, died of the illness shortly after she did.

Family farming is inextricably linked to national and global food security. Both in developing and developed countries, family farming is the leading form of agriculture in food production. Family farmers [...]

Santiago, Chile- The declaration of the XXI Specialized Meeting on Family Farming of MERCOSUR (REAF, in Spanish) held last week in Argentina, acknowledged the advances promoted by FAO’s Director General, [...]

Policy makers should support a broad array of approaches to overhauling global food systems, [...]

In December 2017, the United Nations General Assembly proclaimed the UN Decade of Family Farming 2019-2028 (UNDFF) to serve as a framework for developing public policies and investments to [...]

In December 2017, the United Nations General Assembly proclaimed the UN Decade of Family Farming 2019-2028 (UNDFF) to serve as a framework for developing public policies and investments to [...]

The Food and Agriculture Organization of the United Nations, through the Globally Important Agricultural Heritage Systems (GIAHS) Programme, will organise the International Symposium on Globally Important Agricultural Heritage Systems and Family Farming from [...]

In December 2017, the United Nations General Assembly proclaimed the UN Decade of Family Farming 2019-2028 (UNDFF) to serve as a framework for developing public policies and investments to support family [...]

In December 2017, the United Nations General Assembly proclaimed the UN Decade of Family Farming 2019-2028 (UNDFF) to serve as a framework for developing public policies and investments to [...]

How did a god fearing church-goer like Lizzie Borden become a suspect in the gruesome crime of the century? Her inconsistent account, and an eerie nonchalance, immediately damaged her credibility with investigators.

The World Wildlife Fund films a family of western lowland gorillas in the Dzanga-Sangha reserve

The grandson of Gen. George S. Patton shares his family's home movies

The Gestapo seized the Impressionist painting from storage after its owners fled from their home in Vienna. Now, the piece has been returned to their granddaughters

Featuring more than 100 original artifacts, a new immersive exhibition in New York City will explore the young Jewish diarist's life and legacy

The 3,800-year-old site near the city of Luxor holds the remains of 11 individuals, who may have been members of the same family. Researchers think the tomb was used for several generations

The 50th Christmas Craft Fair gathered over a hundred vendors and thousands of customers in Torbay over the weekend. One family business was inspired by the early years of the fair and a passion to keep traditional crafts in style.

Lindley's Farm and Market in Hamilton will be "winding down" operations after 180 years of operations, including selling locally grown produce and offering activities to the community.

It took Kitchener resident Laura McBride and her family 80 years to discover what happened to her great uncle Thomas Ferguson Wilson after he died in April 1944 during a training mission.

The family of forklift operator Bill Sherstobitoff says that the company he worked for, the Great Little Box Company (GLBC), has not made enough of an effort to make things right in the two years since his death in December 2022.

"It's just like a big blur. It doesn't seem real," says the mother of 16-year-old Kaylie Smith.

A woman and her husband accept the Lord after hearing the gospel from an OM team visiting the island of Sante Marie.

Ministry opportunities in Hungary open up the mission experience for families with younger children.