Cindy J.M. Loomans
Jan 1, 2004; 53:195-199
Complications

Patrice D. Cani
Jun 1, 2008; 57:1470-1481
Metabolism

Patrice D. Cani
Jul 1, 2007; 56:1761-1772
Obesity Studies

Central to the development of diabetic macro- and microvascular disease is endothelial dysfunction, which appears well before any clinical sign but, importantly, is potentially reversible. We previously demonstrated that hyperglycemia activates nuclear factor of activated T cells (NFAT) in conduit and medium-sized resistance arteries and that NFAT blockade abolishes diabetes-driven aggravation of atherosclerosis. In this study, we test whether NFAT plays a role in the development of endothelial dysfunction in diabetes. NFAT-dependent transcriptional activity was elevated in skin microvessels of diabetic Akita (Ins2^+/–) mice when compared with nondiabetic littermates. Treatment of diabetic mice with the NFAT blocker A-285222 reduced NFATc3 nuclear accumulation and NFAT-luciferase transcriptional activity in skin microvessels, resulting in improved microvascular function, as assessed by laser Doppler imaging and iontophoresis of acetylcholine and localized heating. This improvement was abolished by pretreatment with the nitric oxide (NO) synthase inhibitor l-N^G-nitro-l-arginine methyl ester, while iontophoresis of the NO donor sodium nitroprusside eliminated the observed differences. A-285222 treatment enhanced dermis endothelial NO synthase expression and plasma NO levels of diabetic mice. It also prevented induction of inflammatory cytokines interleukin-6 and osteopontin, lowered plasma endothelin-1 and blood pressure, and improved mouse survival without affecting blood glucose. In vivo inhibition of NFAT may represent a novel therapeutic modality to preserve endothelial function in diabetes.

16 December 2019

Angelo Avogaro
May 1, 2011; 34:S285-S290
Hypertension

OBJECTIVE

In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34⁺ cells predicted cardiovascular mortality at 18 months after revascularization. This study aimed to provide long-term validation and mechanistic understanding of the biomarker.

Gottingen : Dieterich, 1843.

London : printed by W. Wilson, for E. Brewster, and George Sawbridge, at the Bible on Ludgate-Hill, neere Fleet-bridge, 1653.

Masaki Yamamoto
May 22, 2019; 39:4179-4192
Neurobiology of Disease

Adolescent obesity is characterized by endothelial dysfunction at the macrovascular and microvascular level; high endothelial microparticle (EMP) and low endothelial progenitor cell (EPC) counts contribute to these processes. Although reversal of macrovascular endothelial dysfunction is feasible, clinical evidence regarding microvascular endothelial dysfunction is scarce.

Ten months of diet and exercise training improves microvascular endothelial function (peak response) in obese adolescents. EPC and EMP displayed a biphasic response, with an increase in EPC at 5 months and a decrease in EMP at the end of the treatment. (Read the full article)

Although it's pricey, the intuitive Salesforce Pardot offers standout features, making it a leader among today's marketing automation platforms.

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Right now the popular Echo Dot is $20 off and Echo Buds are $40 off. Plus, you can save up to $35 on the Kindle and Kindle Paperwhite, and up to $40 on the Echo Show 5 or 8.

By Bishop Arthur Serratelli

Beneath the soil of every continent lie buried the ruins of fallen civilizations. The Sumerians, Akkadians, Mayans, Assyrians, Babylonians, Minoans, Romans: all of them, faded memories of past grandeur and glory. History records the collapse of at least thirty-two major civilizations that once thrived and prospered before our time. 

No great civilization is built in a day. No great civilization disappears in a single instant. Historians try to explain how these civilizations once so great have slowly vanished into the dustbin of history. Weather, economics, population decline, wars, politics are some of the reasons that they offer. But, ultimately, a civilization disappears when it loses its identity, forfeits its unity and jettisons its commitment to the common good.

Today’s relentless front-page news reports of scandal and sin (many times, stale news served up as current), the incessant discord of our politicians, the unending string of acrimonious tweets, and the rage of angry voices make one wonder whether or not we are facing the decline of our own civilization. Has our unity as a nation become so fragmented that it cannot be repaired?

The TV sitcoms, the talk shows, the din of warring cable news channels do little to promote serious discourse. Rather, they seem at times to make us despair of receiving unbiased reporting. They hardly inspire us to respond to the gospel’s clarion call for truth, justice, compassion and charity. Have we lost our commitment to the common good? Are we in the midst of an unstoppable decline of our nation? 

Some say this is the age of tolerance. As a result, good and evil, right and wrong, vice and virtue, truth and error are accepted as equally valid. But, this is not the age of tolerance. Those who are pro-life are marginalized. Those who cherish and protect the life of the child waiting-to-be-born, the elderly and the terminally ill are branded as bigots, unwilling to show compassion to those suffering. Those who accept the sanctity of marriage and human sexuality as designed by the Creator are vilified. We live at a time when some are not only intolerant to our basic Christian values, but are actively engaged to silence Christians, target the Church and reduce her to ruins. 

In an age of relativism, has it become almost impossible to dialogue rationally on the major issues that face us, such as poverty, migration, and the sanctity of life itself ? “Relativism is the order of the day. Good and evil, right and wrong, innocence and guilt – all these binaries are deliberately confused as antipodal extremes are brought into artificial congruence. Moral clarity is muddled and logical cogency diluted. All inherent preference is suspended out of a misguided attempt to achieve balance where there is none” (Brandon Marlon, “The Decline and Fall of Modern Civilization: 8 Simple Steps to Squandering It All,” The Algemeiner, January 22, 2015).

From the Church, we receive a rich heritage of truth, morality and charity. We have solid and clear moral principles given to us by Jesus. These are the solid building blocks with which to construct a just and peaceful society. Could it be that we ourselves are slowly abandoning these principles? How is it possible that those trained in the Catholic faith assume leadership roles in government and then jettison their Catholic morals? How is it that any one of us can remain complacent to the slow moral deterioration of our country? 

Our country will not collapse if we refuse to hand over our future to those who deny the existence of God and live as if this world is all that there is. Our society will not collapse if we are courageous enough to draw on our moral and spiritual heritage to solve the issues that divide us. Our nation will not collapse if we remain true to our identity given to us by our Founding Fathers as a nation founded on Judeo-Christian principles. Our courage as moral individuals to stand for justice, truth and compassion is the antidote to the collapse of our country.
 

By Bishop Arthur Serratelli

In February 1915, only six months after the beginning of World War I, Lancet, a British medical journal, used for the first time the expression “shell shock.” This newly coined expression was used to describe the feeling of helplessness that soldiers felt after exposure to constant bombardment. The term was new, but not the reality. After every war, soldiers return from combat, suffering “shell shock.” 

Watching their comrades mowed down by enemy fire or left maimed and strewn on the battlefield, combatants become immune to feelings of connectedness and concern. Today, this phenomenon is becoming an epidemic. We are constantly being bombarded by bad news. The catastrophic and inhumane events that interrupt our everyday life are causing many people to escape from the brutality by becoming shell shocked. 

Terrorist attacks in Belgium, Syria, Africa, and in England; daily violence on the streets of Chicago, New York, Paterson; the massacre of our children in their schools and of believers in their churches, synagogues and mosques; the interminable disputes and rancor over immigration; allegations of racism and sexism; the incessant reporting of scandals, present and past!  Moment by moment these evils confront us. So fast does news travel that one story stumbles over the other with images of the dead, the wounded, the homeless imprinted on our minds. These problems do not admit of simple solutions. And, since we are more aware of them today than in the past and yet less able to find solutions, many, left numb and disillusioned, drift into apathy.  

In addition, newspapers, blogs and TV commentaries flash before us cause after cause, such as global poverty and climate change. “Every cause seems urgent, but nobody has the time, the energy, or the information necessary to make an impact. Knowing all the ways in which the world is flawed in a very real, raw, up-close kind of way without the ability to make any sort of important change is perhaps the most unwelcome symptom of the digital age” (Jamie Varon, “Generation apathy: How internet outrage is making us all numb and hopeless,” August 20, 2015).

Some Christians have drunk the hemlock of apathy. They are becoming more and more indifferent to evil in the world and, sadly, more and more detached from religion. Unconnected. Not invested. Religion may be good; but, when it comes to God, they have hung up a “Do Not Disturb Sign.” For them, weddings, funerals, First Communions, Confirmations, if even celebrated, are mostly social occasions. 

Apathy within the Church is far more devastating than outside the Church. The Church is the sign and sacrament of salvation for the world. It is an instrument in God’s hands. But if the instrument is dull and listless, it hinders God’s activity. When people become apathetic, something more is needed than telling them to be kind and compassionate. Such preaching falls on deaf ears and hardened hearts. What is needed today is the bold proclamation of the kerygma, that is, the love of God given us in the death and resurrection of Jesus.  

God is not apathetic. He is intensely passionate about his relationship with us and his world. He is the lover who pursues his beloved. He never gives up on us, despite our sins. He woos us back to himself (cf. Hosea 2:11). He did not turn his back on the evil of our world, but sent his Son to be our Redeemer.

 “God so loved the world that he gave his only-begotten Son” (Jn 3:16). In the death and resurrection of Jesus, God’s love is a fact. In Jesus, God has begun the work of forgiving sins and recreating the world. And, he gifts us with the Holy Spirit so that, together with him, we make all things new. We are not helpless. We are not alone. Apathy makes people murmur a half-silent “No” to the world in which we live. But, faith in Jesus Crucified and Risen makes us shout a resounding “Yes” to God’s work of the New Creation. Faith is the antidote to apathy.


 

Citizen coders and civic technologists from across Delaware are set to take on the state’s second annual Open Data Challenge, harnessing the power of public datasets to come up with new solutions to big statewide problems.

DelDOT and the Department of Agriculture are urging Delaware drivers to be alert for the presence of agricultural equipment on roads and to practice safe road-sharing techniques when encountering them. The state is the midst of harvest season and farmers are moving large tractors, trailers, trucks and other large equipment on state roads as they move between fields or to equipment staging areas.

Dover --

In support of the State of Emergency issued by Governor Carney advising the public against gathering in large crowds, the Delaware Department of Transportation (DelDOT) is strongly encouraging customers who are in need of Division of Motor Vehicle (DMV) services to utilize mydmv.delaware.gov which offers more than 20 services online, including renewal of Delaware Driver License/ID, renewing vehicle registration, and changing your home address.

Also, to keep DMV Lobby crowds to a minimum DMV will immediately begin waiving late fees for vehicle registration and driver license renewals until further notice. The Department is also encouraging exclusive use of the drive through services at all DMV locations statewide. [More]

Dover --

Due to the presence of Coronavirus (COVID-19) in Delaware and the direction of medical professionals, the Delaware Department of Transportation (DelDOT) has implemented several additional measures to clean facilities and vehicles used by the public to help limit the spread of the illness.

At Delaware's four motor vehicle service centers, three toll plazas, and two rest areas, additional cleaning is taking place throughout the day including disinfecting all public seating, as well as door handles, kiosks, and counters.

"DelDOT provides services to thousands of Delawareans each day, and we want to do all we can to ensure their safety and that of our employees as we work together to limit the spread of Coronavirus," said Secretary of Transportation Jennifer Cohan. [More]

Dover --

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind. To that end, all public facing buildings that deliver various services will be going cashless across the State, including toll plazas and all Division of Motor Vehicle locations, effective Tuesday, March 17, 2020.

At DelDOT's four DMV locations, only credit or debit cards will be accepted, and the Department continues to urge all customers to utilize mydmv.delaware.gov which offers more than 20 services online, including renewal of Delaware Driver License/ID, renewing vehicle registration, and changing your home address. [More]

Dover --

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind.

Effective Tuesday, March 17, 2020 at 6:00pm, the Biden Welcome Center on I-95 in Newark will temporarily close to the public as efforts continue to limit crowds from gathering in response to the Coronavirus. Fuel will still be available at the gas station located on the north side of the property and bathroom facilities in the convenience store will also be available to motorists. [More]

Dover --

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind.

Effective Monday, March 23, 2020, all four Delaware Division of Motor Vehicles (DMV) locations will go to kiosk, drive-through and emergency appointment only. Dealer paperwork can be dropped off for processing and picked up when notified. [More]

In support of the State of Emergency issued by Governor Carney advising the public against gathering in large crowds, the Delaware Department of Transportation (DelDOT) is strongly encouraging customers who are in need of Division of Motor Vehicle (DMV) services to utilize mydmv.delaware.gov which offers more than 20 services online, including renewal of Delaware Driver […]

Due to the presence of Coronavirus (COVID-19) in Delaware and the direction of medical professionals, the Delaware Department of Transportation (DelDOT) has implemented several additional measures to clean facilities and vehicles used by the public to help limit the spread of the illness. At Delaware’s four motor vehicle service centers, three toll plazas, and two […]

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind. To that end, all public facing buildings that deliver various services will be going cashless across the State, including toll plazas and all Division of Motor Vehicle locations, effective Tuesday, March […]

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind. Effective Tuesday, March 17, 2020 at 6:00pm, the Biden Welcome Center on I-95 in Newark will temporarily close to the public as efforts continue to limit crowds from gathering in response […]

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind. Effective Monday, March 23, 2020, all four DMV locations will go to kiosk, drive-through and emergency appointment only. Dealer paperwork can be dropped off for processing and picked up when notified. […]

The DoT sent a notice to GAIL soon after the February 14 hearing in the Supreme Court on dues owned by telecom companies such as Bharti Airtel and Vodafone Idea.

As the rest of the world is suffering from the COVID-19 pandemic, things seem to be looking up in China! The smartphone companies have moved to digital mode to launch their products.  Xiaomi is the latest to launch a new product from its Redmi brand, the Redmi Airdots S true wireless earphones. The Redmi AirDots […]

The post Redmi Airdots S Wireless Earphones Launched For Rs 1100! Is This A Gamechanger? first appeared on Trak.in . Trak.in Mobile Apps: Android | iOS.

Picture 1 show a Shape created in Allegro PCB Editor 16.6, file LTshape.ssm      The Shape Origin is dead center of the outline 565X400 mils.    This Shape is utilized in the PadStack Editor to create a special Pin for a custom Footprint.
Picture 2 show the PadStack Editor first page with drill size and offset. File  LTshape16.pad         Picture 3 show the PadStack Editor page 2 with that LTshape utilized as the BEGIN LAYER for copper area. Picture 4 show the actual Package (footprint) finished with Outline, padstacks for pin 1,2,4,5 and that special Pin 3 LTshape. Its origin is also dead center, same as LTshape.ssm

Notice the round dot at the bottom of Pin 3. It only appear in the Package drawing, not in the original Picture 1, the actual LTshape.ssm or LTshape.dra

Picture 5 shows that same Footprint in the final board in PCB Editor. That same dot, now pink, is still there and cannot be selected separately. When using the Find Option and selecting each object separately, the only way to select Pin 3 is when Option > Pin is selected. Then I can hover on the dot near Pin 3 and the whole LTshape lights up as pin 3, but not the pink dot. There is absolutely no way I can select that dot as an object. There is no way to know the existence of that dot except by looking at it. Cannot be deleted, cannot be selected, can only be invisible if I use the Color Visibility manager and disable all 4 layers, TOP GND VCC BOTTOM. If I turn On TOP then the dot becomes pink. With GND On the dot is green, VCC On will get a Red dot, BOTTOM On will not show the dot but Pin 3 turn On since LTshape is the actual Net connected. This Net is not GND nor VCC, it is N357726.

Where is this dot coming from and why is it not a selectable object ? Why can I not delete it ?

DotNetNuke CMS version 9.4.4 suffers from zip split issue where a directory traversal attack can be performed to overwrite files or execute malicious code.

DotNetNuke CMS version 9.5.0 suffers from file extension check bypass vulnerability that allows for arbitrary file upload.

Ryan Reynolds said: "I’m guessing we might’ve finished the movie if we didn’t spend most of the time in laughing around.”

STAMFORD, CT -- HARMAN International Industries, Inc. (NYSE:HAR), the premium global audio and infotainment group, announced today that 19 of its audio products have been selected as winners in the prestigious Red Dot Award: Product Design 2014 competition.

Isolation, quarantine, social distancing… all of these terms have two things in common: 1.) they are necessary and powerful tools that are saving lives in the global battle against Covid-19. 2.) they are cutting people off from one another and...

Title: There May Be Antidote for Ocean's Most Venomous Creature
Category: Health News
Created: 5/1/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM

ABSTRACT

Viral diseases cause significant losses in aquaculture. Prophylactic measures, such as immune priming, are promising control strategies. Treatment of the Pacific oyster (Crassostrea gigas) with the double-stranded RNA analog poly(I·C) confers long-term protection against infection with ostreid herpesvirus 1, the causative agent of Pacific oyster mortality syndrome. In a recent article in mBio, Lafont and coauthors (M. Lafont, A. Vergnes, J. Vidal-Dupiol, J. de Lorgeril, et al., mBio 11:e02777-19, 2020, https://doi.org/10.1128/mBio.02777-19) characterized the transcriptome of oysters treated with poly(I·C). This immune stimulator induced genes related to the interferon and apoptosis pathways. This response overlaps the response to viral infection, and high expression levels of potential effector genes are maintained for up to 4 months. This work opens the door to characterization of the phenomena of immune priming in a poorly studied invertebrate model. It also highlights the importance of interferon-like responses for invertebrate antiviral immunity.

Recent earthquakes involving complex multi-fault rupture have increased our appreciation of the variety of rupture geometries and fault interactions that occur within the short duration of coseismic slip. Geometrical complexities are intrinsically linked with spatially heterogeneous slip and stress drop distributions, and hence need incorporating into seismic hazard analysis. Studies of exhumed ancient fault zones facilitate investigation of rupture processes in the context of lithology and structure at seismogenic depths. In the Gairloch Shear Zone, NW Scotland, foliated amphibolites host pseudotachylytes that record rupture geometries of ancient low-magnitude (≤M_W 3) seismicity. Pseudotachylyte faults are commonly foliation parallel, indicating exploitation of foliation planes as weak interfaces for seismic rupture. Discordance and complexity are introduced by fault segmentation, stepovers, branching and brecciated dilational volumes. Pseudotachylyte geometries indicate that slip nucleation initiated simultaneously across several parallel foliation planes with millimetre and centimetre separations, leading to progressive interaction and ultimately linkage of adjacent segments and branches within a single earthquake. Interacting with this structural control, a lithological influence of abundant low disequilibrium melting-point amphibole facilitated coseismic melting, with relatively high coseismic melt pressure encouraging transient dilational sites. These faults elucidate controls and processes that may upscale to large active fault zones hosting major earthquake activity.

Supplementary material: Supplementary Figures 1 and 2, unannotated versions of field photographs displayed in Figures 4a and 5 respectively, are available at https://doi.org/10.6084/m9.figshare.c.4573256

Thematic collection: This article is part of the SJG Collection on Early-Career Research available at: https://www.lyellcollection.org/cc/SJG-early-career-research

Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced Plasmodium falciparum and P. vivax infection. Participants were enrolled in induced blood-stage malaria clinical trials. Plasma osteoprotegerin, angiopoietin-2, and von Willebrand Factor (vWF) levels were measured as biomarkers of endothelial activation. Microvascular function was assessed using peripheral arterial tonometry and near-infrared spectroscopy, and the endothelial glycocalyx was assessed by sublingual videomicroscopy and measurement of biomarkers of degradation. Forty-five healthy, malaria-naive participants were recruited from 5 studies. Osteoprotegerin and vWF levels increased in participants following inoculation with P. vivax (n = 16) or P. falciparum (n = 15), with the angiopoietin-2 level also increasing in participants following inoculation with P. falciparum. For both species, the most pronounced increase was seen in osteoprotegerin. This was particularly marked in participants inoculated with P. vivax, where the osteoprotegerin level correlated with the levels of parasitemia and the malaria clinical score. There were no changes in measures of endothelial glycocalyx or microvascular function. Plasma biomarkers of endothelial activation increased in early P. falciparum and P. vivax infection and preceded changes in the endothelial glycocalyx or microvascular function. The more pronounced increase in osteoprotegerin suggests that this biomarker may play a role in disease pathogenesis.