channel DUAL-CHANNEL DIMM By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A dual inline memory module can include a module card having first and second opposed surfaces and a plurality of microelectronic elements each having a surface facing a surface of the module card. The module card can have a plurality of parallel edge contacts, the edge contacts including first and second contacts, the first and second contacts configured to carry command and address information and data signals corresponding to first and second memory channels, respectively, the first memory channel being independent from the second memory channel. Each microelectronic element can have memory storage array function being of type LPDDRx and being configured to sample the command and address information at least twice per clock cycle. The plurality of microelectronic elements can be configured to implement the first and second memory channels. The first and second microelectronic elements can be configured for communication via the first and second contacts, respectively. Full Article
channel USING RESOURCE ELEMENT LOCATION PATTERN TO CONVEY MCS OF CONTROL CHANNEL By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A mechanism that allows the successful decoding of MCS information of cell edge UEs while retaining the performance for the other UEs of the cell is provided. In one aspect, a UE may determine an uplink control coding rate based on an uplink signal quality. The UE may encode uplink control data based on the uplink control coding rate. The UE may apply a pattern of unused resource element locations in uplink control resource elements based on the uplink control coding rate. The UE may transmit the uplink control resource elements with the pattern of unused resource element locations. In another aspect, an eNB may receive uplink control resource elements. The eNB may determine an uplink control coding rate based on a pattern of resource element locations in the uplink control resource elements. The eNB may decode uplink control data based on the uplink control coding rate. Full Article
channel Orthogonal frequency-division multiple (OFDM) access distributed channel access with uplink OFDM multiple input multiple output (MIMO) By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT This disclosure describes methods, devices, and systems related to an OFDMA Distributed Channel Access. Devices are disclosed comprising: at least one processor; and at least one memory that stores computer-executable instructions, wherein the at least one processor is configured to access the at least one memory and execute the computer-executable instructions to identify a trigger frame received on the communication channel from the computing device. The at least one processor may determine an uplink frame to be sent to a computing device on a communication channel. The at least one processor may identify one or more random access resource allocations, wherein the one or more random access resource allocations are associated with the trigger frame. The at least one processor may assign a respective numerical value to each of the one or more random access resource allocations. The at least one processor may also select a numerical value based at least in part on a probability distribution. The at least one processor may also determine a particular resource allocation of the one or more random access resource allocations that corresponds to the numerical value. The at least one processor may also cause the uplink frame to be sent to the computing device using the particular resource allocation. Full Article
channel EMULATING VIRTUAL PORT CONTROL OF AIRTIME FAIRNESS USING PER STATION ENHANCED DISTRIBUTED CHANNEL ACCESS (EDCA) PARAMETERS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A technique for emulating virtual port control of airtime fairness for wireless stations using per station Enhanced Distributed Channel Access (EDCA) parameters. Specific parameters are received for each of a plurality of stations connected to the access point. An EDCA field of a beacon that stores a general EDCA parameter is set to an empty state. The beacon is broadcast to a plurality stations on the wireless communication network and within range of an access point. The beacon comprises a BSSID (Basic Service Set Identifier) for use by the plurality of stations to connect with the access point for access to the wireless communication network. The beacon also comprises an empty EDCA field. In response to broadcasting the empty EDCA parameter, receiving a direct inquiry from each of the plurality of stations for the general EDCA parameter. Each of the plurality of stations is responded to with a direct communication of a specific parameter corresponding to each station. A transmission is received from at least one of the stations complying with the specific parameter. Full Article
channel MULTICHANNEL TRANSDUCER DEVICES AND METHODS OF OPERATION THEREOF By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present disclosure is directed to multichannel transducer devices and methods of operation thereof. One example device includes at least two acquisition modules that have different sensitives and a signal processing stage that generates a blended signal representative of a lower gain signal mapped onto a higher gain signal. One example method of operation includes receiving a first signal from a first sensor having a first sensitivity, receiving a second signal from a second sensor having a second sensitivity that is different from the first sensitivity, generating a blended signal by mapping the second signal to the first signal, outputting the first signal while the first signal is below a first threshold and above a second threshold, and outputting the blended signal when the first signal is above the first threshold and when the first signal is below the second threshold. Full Article
channel DEVICE FOR EXTRACTION OF POLLUTANTS BY MULTICHANNEL TUBULAR MEMBRANE By www.freepatentsonline.com Published On :: Thu, 11 May 2017 08:00:00 EDT A device for extraction of pollutants by multichannel tubular membrane containing at least one fluid channel allowing the fluid to go through a feed inlet to an outlet end characterized in that membrane comprises at least an extraction channel filled with molten salt in order to adsorb said pollutants having to be extracted from the said fluid. Advantageously, the membrane is a ceramic membrane. An application is for the treatment of traces of pollutants in a liquid or gaseous fluid. For example, the removal of small pollutants as volatile organic compounds from an aqueous stream in industrial wastewater treatment or other water treatment applications, or the separation of aromatic compounds form an hydrocarbon feed in petrochemical applications. Another application is in the removal of water traces in products of high added value as pharmaceutical, cosmetic or biocarburant for example. Full Article
channel SEMICONDUCTOR DEVICE INCLUDING NANOWIRE TRANSISTORS WITH HYBRID CHANNELS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A semiconductor device is provided that includes an n-type field effect transistor including a plurality of vertically stacked silicon-containing nanowires located in one region of a semiconductor substrate, and a p-type field effect transistor including a plurality of vertically stacked silicon germanium alloy nanowires located in another region of a semiconductor substrate. Each vertically stacked silicon-containing nanowire of the n-type field effect transistor has a different shape than the shape of each vertically stacked silicon germanium alloy nanowire of the p-type field effect transistor. Full Article
channel Aquaponic vertical garden with integrated air channel for plant-based air filtration By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT Embodiments are described for a closed-loop, vertical garden system for growing plants and filtering air and water comprising: a support structure; a composite, grow media configured to physically support the growth of plants and distribute water to the roots of the plants through capillary action through the area of the grow media; a water source coupled to the grow media through a pump and plumbing system, wherein the plumbing system is configured to draw water from the water source through the grow media and back to the water source in substantially closed loop aquatic system; and an air flow subsystem configured to draw outside air through the plants and transmit filtered air back out of the support structure. Full Article
channel NOVEL MICROCHANNEL STRUCTURE AND HEAT SINK HAVING THE SAME By www.freepatentsonline.com Published On :: Thu, 15 Jun 2017 08:00:00 EDT The present invention mainly provides a novel microchannel structure comprising a plurality of first fluid-guiding channels, a plurality of micro fluid-guiding channels and a plurality of second fluid-guiding channels. Particularly, the first fluid-guiding channel has an arc-shaped fluid-guiding end corner communicating with a first channel opening of the micro fluid-guiding channel, and the second fluid-guiding channel has an arc-shaped fluid-guiding start corner communicating with a second channel opening of the micro fluid-guiding channel. Therefore, when a refrigerant fluid flows in the heat sink, the flow speed of the refrigerant fluid would be changed because the cross sectional area of an U-shaped fluid-guiding channel constructed by the arc-shaped fluid-guiding end corner, the micro fluid-guiding channel and the arc-shaped fluid-guiding start corner varies along the flow direction of the refrigerant fluid, such that the heat dissipating ability of the heat sink is enhanced without increasing the power of circulation pump. Full Article
channel Supervision of Input Signal Channels By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present disclosure pertains to systems and methods for monitoring a plurality of analog-to-digital converters. In one embodiment, a plurality of input channels may each be in communication with a different phase of a three-phase electric power delivery system. The input channels may be configured to receive analog signals from the different phases. A composite signal subsystem may be configured to generate a composite signal based on the plurality of input channels. An analog-to-digital converter subsystem may be configured to produce a digitized representation of each of the plurality of input channels and a digitized representation of the composite signal. An analog-to-digital converter monitor subsystem may identify an error in the analog-to-digital conversion based on the digitized representation of the composite signal and the digitized representations of the plurality of input channels. Full Article
channel OPERATION OF DIAGNOSTIC DEVICES INVOLVING MICROCHANNELS AND ELECTRODES By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT An assembly is provided for interfacing with a microfluidic chip having at least one microscopic channel configured to receive a liquid sample for analysis. The assembly includes a chip carrier, an electronics module, an optical module, and a mechanical module. The chip carrier includes a base and a cover defining a cavity to receive the microfluidic chip. The electronics module includes a signal generator which applies at least one electrokinetic signal electrode(s) of the chip. The optical module includes an excitation radiation source which causes excitation radiation to impinge on the sample, and an emission radiation detector which detects radiation emitted from the sample. The mechanical module includes a chip-carrier receiving structure, relatable with respect to the optical module for focus and at least one degree of translational freedom. Full Article
channel MULTI-CHANNEL PARALLEL OPTICAL TRANSCEIVER MODULE By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present disclosure provides a multi-channel parallel optical transceiver module. The disclosed optical transceiver module/device may include a shell body and a circuit board located in the shell body, and an optical emitter base soldered to a first end of the circuit board. A notch located on the base, for engaging the first end of the circuit board, and the optical emitter base engaged with the first end of the circuit board may be soldered to two sides of the circuit board. The optical emitters may be disposed in parallel on the base, and separated from each other by a block. A lens and a laser may be disposed at a first side of each of the optical emitters that is adjacent to the circuit board, and an optical monitor may be disposed on a second end of the circuit board adjacent to the laser. Full Article
channel TANGENTIAL FILTER WITH A SUPPORTING ELEMENT INCLUDING A SET OF CHANNELS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A tangential filter for filtration of a fluid includes a support element, wherein, along a transverse plane perpendicular to the central axis of the support element a) the support element includes in its central portion only inner channels that do not share a common wall with its outer surface, the inner channels having a substantially equivalent hydraulic diameter, b) the support element includes peripheral channels, including at least first and second adjacent peripheral channels, each of the two channels sharing a common wall with the outer surface, c) the ratio of the hydraulic diameter of the first channel to the hydraulic diameter of the second channel is greater than or equal to 1.1, d) the number of peripheral first channels is greater than or equal to the number of peripheral second channels, e) the second channel has a hydraulic diameter substantially identical to the hydraulic diameter of the inner channels. Full Article
channel COOLING OF ELECTRONICS USING FOLDED FOIL MICROCHANNELS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Embodiments are generally directed to cooling of electronics using folded foil microchannels. An embodiment of an apparatus includes a semiconductor die; a substrate, the semiconductor die being coupled with the substrate; and a cooling apparatus for the semiconductor die, wherein the cooling apparatus includes a folded foil preform, the folded foil forming a plurality of microchannels, and a fluid coolant system to direct a fluid coolant through the microchannels of the folded foil. Full Article
channel Music Interview: Stamford Symphony Orchestra Launches A Video Channel By www.wshu.org Published On :: Tue, 14 Apr 2020 19:28:00 +0000 The Stamford Symphony Orchestra has launched its very own video channel as a way for the musians to connecct with audience members from around the world. Kate Remington talks with Music Director Designate Michael Stern about the diverse videos on the channel, and the most recent project featuring musicians in the orchestra and soloists of next season coming together to perform Amazing Grace , dedicated to all healthcare workers in Fairfield County on the frontlines during the COVID-19 crisis. Full Article
channel AudioFB releases Daga’s StripTeaser channel strip effect plugin By rekkerd.org Published On :: Fri, 01 May 2020 13:39:56 +0000 AudioFB has launched a channel strip effect plugin developed for all styles of mixing. Daga’s StripTeaser was developed in collaboration with producer brothers Adriano and Giu Daga. Stripteaser’s multi-effect rack features: 4-band equalizer, where the extreme bands can be switched to bell or shelf types, ‘high pass’ filter with option of 12db / octave or […] The post AudioFB releases Daga’s StripTeaser channel strip effect plugin appeared first on rekkerd.org. Full Article Effect plugins News AAX AU channel strip VST
channel Softube launches Weiss EQ1 & Gambit Series channel strip for Console 1 By rekkerd.org Published On :: Thu, 07 May 2020 11:38:45 +0000 Softube has announced the availability of the Weiss EQ1, a line-by-line code port boasting 1:1 accuracy of the pioneering original hardware, known as the standard of digital mastering EQs. The Weiss EQ1 plugin offers increased functionality of the original algorithms, plus 32-bit/192 kHz operation and updated ergonomics. It comes with easy manual recall of presets […] The post Softube launches Weiss EQ1 & Gambit Series channel strip for Console 1 appeared first on rekkerd.org. Full Article Effect plugins News Sales and promotions channel strip equalizer sale Softube
channel Market dynamics are different for all channels; e-commerce ecosystem will stabilise: Tupperware MD Deepak Chhabra By retail.economictimes.indiatimes.com Published On :: 2020-02-07T15:46:40+05:30 Tupperware India's managing director Deepak Chhabra talks about how integrating the direct sales force with the retail franchisee model is working for the home and kitchen-ware maker. Full Article
channel Bata to use multi-channel retail strategy to reach more customers By retail.economictimes.indiatimes.com Published On :: 2019-11-27T08:12:48+05:30 The company, which has a retail network in 450 towns, is further expanding by adding new stores in smaller towns through franchise route. Full Article
channel Covid-19 Impact: Titan reworks omnichannel directive for its jewellery wing to gain recovery in third quarter By retail.economictimes.indiatimes.com Published On :: 2020-04-19T11:17:49+05:30 We foresee a deferred demand. Most of the weddings in Q1 got pushed to Q3 or Q4 due to the lockdown. People may spend less money on destination weddings, clothes and other events around it. But we expect investment in jewellery for weddings, said Ajoy Chawla, CEO of Titan’s jewellery division. Full Article
channel Routing Maschine Channels to the SSL Mixer in Reason 11 By maschinetutorials.com Published On :: Thu, 21 Nov 2019 18:51:00 +0000 Still checking out the Reason 11 demo and wanted to make a quick video showing how to route channels from Maschine out to the SSL mixer in Reason. This gives you more control over individual pads or groups when creating a mixing. The post Routing Maschine Channels to the SSL Mixer in Reason 11 appeared first on Maschine Tutorials. Full Article DAW & Host Integration Free Maschine Tutorials
channel Channel 4 are looking for people who have cancelled their wedding because of lockdown By www.glasgowtimes.co.uk Published On :: Sat, 18 Apr 2020 05:00:00 +0100 Channel 4 have launched a search for a couple who have cancelled their wedding due to the Covid-19 pandemic. Full Article
channel I need to watch 9 different channels. By ask.metafilter.com Published On :: Fri, 01 May 2020 09:22:42 -0800 I need 9 TV tuners so I can display 9 different over the air TV channels on 9 separate screens. 9 TVs is not an option. Output resolution is not at all critical. What is the cheapest solution you can come up with? Full Article television televisiontuner panopticon zeitgeist iamnotelvis resolved
channel The Black News Channel (Ep. 5, 2020) By kutpodcasts.org Published On :: Sun, 05 Jan 2020 06:14:10 +0000 This week, In Black America producer and host John L. Hanson, Jr. discusses the introduction of the new Black News Channel with Gary Wordlaw, Vice President of News and Programming. Also featured is former Congressman J.C. Watts, co-founder and Chairman of the Black News Channel. Full Article In Black America BET cable news programming Gary Wordlaw J.C. Watts mainstream media The Black News Channel
channel FESTIVAL: The Bebop Channel Issues Stock Grants To Official Selections Amid Worldwide Festival Cancellations By news.allaboutjazz.com Published On :: 2020-04-19T17:54:36+00:00 Many up-and-coming filmmakers' dreams for success have been crushed indefinitely due to the COVID- 19 pandemic. As pointed out in Shirley Li's piece in The Atlantic entitled The Pandemic Is Hitting One Part of Hollywood Especially Hard, film festivals around the world—arguably the most important life-line for new filmmakers—have been cancelled.... Full Article
channel A channel on Noonbah Station By www.abc.net.au Published On :: Sun, 21 Jul 2019 09:49:00 +1000 Full Article ABC Western Queensland westqld Disasters and Accidents:Drought:All Disasters and Accidents:Floods:All Environment:Climate Change:All Rural:Livestock:Beef Cattle Rural:Sustainable and Alternative Farming:All Australia:QLD:Birdsville 4482 Australia:QLD:Longreach 4730
channel Channels near Windorah By www.abc.net.au Published On :: Sun, 21 Jul 2019 09:49:00 +1000 Full Article ABC Western Queensland westqld Disasters and Accidents:Drought:All Disasters and Accidents:Floods:All Environment:Climate Change:All Rural:Livestock:Beef Cattle Rural:Sustainable and Alternative Farming:All Australia:QLD:Birdsville 4482 Australia:QLD:Longreach 4730
channel Life in Queensland's Channel Country means you can have a huge flood without any rain By www.abc.net.au Published On :: Sun, 21 Jul 2019 10:06:00 +1000 Floodwaters more than 50 kilometres wide came through Queensland's Channel Country earlier this year, but the extended weather forecast is not promising a return to average rainfalls. Full Article ABC Western Queensland westqld Disasters and Accidents:Drought:All Disasters and Accidents:Floods:All Environment:Climate Change:All Rural:Livestock:Beef Cattle Rural:Sustainable and Alternative Farming:All Australia:QLD:Birdsville 4482 Australia:QLD:Longreach 4730
channel Mixed blessings for Channel Country graziers as floodwater brings strong season for some but leaves others desperate By www.abc.net.au Published On :: Fri, 09 Aug 2019 16:44:00 +1000 Floodwaters that crippled North Queensland's cattle industry have turned the Channel Country further downstream into a landscape of dramatic contrasts. Full Article ABC Western Queensland westqld Disasters and Accidents:All:All Disasters and Accidents:Drought:All Disasters and Accidents:Floods:All Rural:All:All Rural:Livestock:All Rural:Livestock:Beef Cattle Science and Technology:Animals:Birds Australia:All:All Australia:QLD:All Australia:QLD:Diamantina Lakes 4735
channel Albert Priest Channel By www.abc.net.au Published On :: Mon, 07 Oct 2019 06:17:00 +1100 Full Article ABC Western Plains westernplains Disasters and Accidents:Drought:All Environment:All:All Environment:Water:All Australia:NSW:Nyngan 2825
channel Water in channel in Murrumbidgee Irrigation Area By www.abc.net.au Published On :: Wed, 23 Oct 2019 13:04:00 +1100 Full Article ABC Riverina riverina Australia:NSW:Griffith 2680
channel Former Tennis Australia director was 'pushing' for Channel 7 to win Australian Open rights, court hears By www.abc.net.au Published On :: Mon, 04 Nov 2019 17:30:00 +1100 A court hears Harold Mitchell was "pushing" for Tennis Australia to sign a contract for the broadcast rights of the Australian Open with Channel 7 when he was the sports body's director in 2013. Full Article ABC Radio Melbourne melbourne Business Economics and Finance:All:All Information and Communication:Broadcasting:All Information and Communication:Broadcasting:Television Law Crime and Justice:All:All Law Crime and Justice:Courts and Trials:All Sport:Tennis:All Australia:All:All Australia:VIC:Melbourne 3000
channel Man who claimed to be filming Channel 7 program, scammed $5k 'a repeat offender' By www.abc.net.au Published On :: Mon, 17 Jun 2019 20:19:00 +1000 A self-described online news service operator who admitted to duping a woman out of $5,000 in Tasmania is wanted on similar allegations in South Australia, a court hears. Full Article ABC Local hobart northtas Law Crime and Justice:Crime:All Australia:TAS:All Australia:TAS:Hobart 7000 Australia:TAS:Launceston 7250
channel Channel Seven loses long-running defamation case over Today Tonight story By www.abc.net.au Published On :: Mon, 30 Sep 2019 21:46:00 +1000 An Adelaide woman who sued Channel Seven over a Today Tonight story which portrayed her as a "welfare fraudster" wins her defamation case on appeal, almost eight years after the report aired. Full Article ABC Radio Adelaide adelaide Arts and Entertainment:All:All Arts and Entertainment:Television:All Information and Communication:Broadcasting:All Information and Communication:Broadcasting:Television Law Crime and Justice:All:All Law Crime and Justice:Courts and Trials:All Australia:All:All Australia:SA:Adelaide 5000 Australia:SA:All
channel Ord Irrigation Scheme M1 channel By www.abc.net.au Published On :: Fri, 21 Jun 2019 06:10:00 +1000 Full Article ABC Kimberley kimberley perth Environment:Water Management:All Environment:Water Supply:All Rural:Irrigation:All Australia:WA:Kununurra 6743 Australia:WA:Perth 6000
channel Post Covid-19 will the omnichannel model still be relevant? By www.logisticsit.com Published On :: What can retailers learn from the lockdown and could it be the death-knell of the store, asks Tania Oakey, a retail expert at software vendor Cegid? Full Article
channel Daily dose of inclusive Social Business. Discovery Channel Canada interviews IBM HA&AC Advocacy and Outreach Program Manager Peter Fay. By www.ibm.com Published On :: Tue, 04 Dec 2012 09:00:00 EST The Daily Planet team from the Discovery Channel Canada is hip. They highlight cool new technologies and explore interesting people, places and things. So, when their FutureTech team wanted to get a first-hand look at the New Mobile Workplace, they came to IBM. Full Article
channel International Duo Channels Past And Present To Win Best Rock Act At Worlds Largest Indie Music Awards By feedproxy.google.com Published On :: Follow No One, Colorado-based Vocalist Rich Hall And Portuguese Guitarist Pedro Murino Almeida, Won Best Rock Act At The 2019 JMAs In Dollywood. Full Article
channel International Duo Channels Past And Present To Win Best Rock Act At Worlds Largest Indie Music Awards By feedproxy.google.com Published On :: Follow No One, Colorado-based Vocalist Rich Hall And Portuguese Guitarist Pedro Murino Almeida, Won Best Rock Act At The 2019 JMAs In Dollywood. Full Article
channel Watch “Portals to Hell” tear open Denver’s urban ghost history on the Travel Channel By www.denverpost.com Published On :: Thu, 07 May 2020 15:00:37 +0000 Remember when it was fun to be afraid of things other than a global pandemic? Full Article Colorado News Entertainment Latest News Lifestyle News Television Things To Do Entertainment for isolation Ghostbusters
channel Normani Channels Icon, Mariah Carey By www.bet.com Published On :: Sun, 24 Jun 2018 23:24:56 EDT We hope Miss Mariah knows her! Full Article Mariah Carey Normani Kodei Fashion BET Awards Style BET Her
channel First Responders Channel Wu-Tang Clan In Coronavirus Fight By feeds.bet.com Published On :: Fri, 1 May 2020 13:00:00 EDT “Wuhan virus ain’t nothing to be stuck with.” Full Article Music News Wu-Tang Clan
channel Prince Radio Channel Will Air Unreleased Music By feeds.bet.com Published On :: Fri, 1 May 2020 23:35:00 EDT The channel will also feature Sheila E. Full Article Prince Music News
channel Allen Iverson Channels Kobe Bryant And Nipsey Hussle In Message Of Hope By feeds.bet.com Published On :: Wed, 8 Apr 2020 14:00:00 EDT He has some uplifting words for anyone struggling right now. Full Article Allen Iverson Kobe Bryant Nipsey Hussle Sports News
channel Rick Ross and Lira Mercer Channel Modern Royalty By feeds.bet.com Published On :: Mon, 7 Dec 2015 17:15:00 EST The couple shows off swanky Atlanta estate. Full Article Rick Ross Celebrity Style News
channel Jeremy Wade Explores World's Most Astounding Underwater Mysteries in All-New Discovery Channel Series, "Mysteries of the Deep" Premiering May 27 on Discovery Channel By www.thefutoncritic.com Published On :: Fri, 08 May 2020 11:06:00 GMT The series was previously scheduled to roll out Thursday, April 2 on sibling Science Channel. Full Article
channel Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine By www.jci.org Published On :: Levodopa-induced dyskinesia (LID) poses a significant health care challenge for Parkinson’s disease (PD) patients. Amantadine is currently the only drug proven to alleviate LID. Although its efficacy in treating LID is widely assumed to be mediated by blockade of N-methyl-D-aspartate (NMDA) glutamate receptors, our experiments demonstrate that at therapeutically relevant concentrations, amantadine preferentially blocks inward-rectifying K+ channel type 2 (Kir2) channels in striatal spiny projection neurons (SPNs) — not NMDA receptors. In so doing, amantadine enhances dendritic integration of excitatory synaptic potentials in SPNs and enhances — not antagonizes — the induction of long-term potentiation (LTP) at excitatory, axospinous synapses. Taken together, our studies suggest that the alleviation of LID in PD patients is mediated by diminishing the disparity in the excitability of direct- and indirect-pathway SPNs in the on state, rather than by disrupting LTP induction. This insight points to a pharmacological approach that could be used to effectively ameliorate LID and improve the quality of life for PD patients. Full Article
channel TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation By www.jci.org Published On :: Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and necrosis, ultimately leading to pancreatitis. Although stimulation of the mechanically activated, calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-induced pancreatitis, activation of Piezo1 produces only transient elevation in intracellular calcium that is insufficient to cause pancreatitis. Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreatitis is unknown. We demonstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in intracellular calcium levels, mitochondrial depolarization, intracellular trypsin activation, and cell death. Notably, these effects were dependent on the degree and duration of force applied to the cell. Low or transient force was insufficient to activate these pathological changes, whereas higher and prolonged application of force triggered sustained elevation in intracellular calcium, leading to enzyme activation and cell death. All of these pathological events were rescued in acinar cells treated with a Piezo1 antagonist and in acinar cells from mice with genetic deletion of Piezo1. We discovered that Piezo1 stimulation triggered transient receptor potential vanilloid subfamily 4 (TRPV4) channel opening, which was responsible for the sustained elevation in intracellular calcium that caused intracellular organelle dysfunction. Moreover, TRPV4 gene–KO mice were protected from Piezo1 agonist– and pressure-induced pancreatitis. These studies unveil a calcium signaling pathway in which a Piezo1-induced TRPV4 channel opening causes pancreatitis. Full Article
channel The Weather Channel Launches Bot For Facebook Messenger, Powered By IBM Watson By www.ibm.com Published On :: Tue, 25 Oct 2016 07:01:49 GMT The Weather Company, an IBM Business announced today that The Weather Channel has launched a cognitive weather bot for Facebook Messenger – powered by IBM Watson. Around the world, Messenger is used to stay in touch with friends and family. Now with The Weather Channel bot, it offers a way to view and share personalized weather-related news content, current conditions, forecasts, severe weather notifications, and other relevant weather information. Full Article IBM Social Business
channel Chase the Total Solar Eclipse and Join Celestial Celebrations Across the Country with The Weather Channel and Twitter By www.ibm.com Published On :: Wed, 16 Aug 2017 12:01:09 GMT Millions of consumers depend on The Weather Channel and weather.com for their daily forecasts, breaking weather news, and the latest in health and travel. And, on August 21, they will be able to experience a solar eclipse like never before. The Weather Channel digital properties and Twitter have teamed up for a live stream of this once-in-a lifetime celestial event, which will allow consumers to chase the total solar eclipse in real time as it moves from coast-to-coast. Full Article IBM Social Business