Building intellectual capacity and fostering learning partnerships enhance long-term capabilities in organizations and communities. Localized solutions rooted in indigenous knowledge and governance reforms empower societies to achieve resilient, sustainable development.

Cities are engines of economic growth, generating over 80% of the global gross domestic product. As centers of innovation and technological development, they play a crucial role in creating jobs, driving commerce, and providing social services.

Lead exposure remains a significant public health threat in Asia and the Pacific, especially in low- and middle-income countries. The global effort to address lead poisoning must focus on stricter regulations, enhanced healthcare capacity, and coordinated international action to protect vulnerable populations.

Extreme heat is an invisible but increasingly tangible climate risk. It varies by time and place and has wide-reaching but unequal impacts, particularly to women and vulnerable people. As global temperatures rise, extreme heat events (heat waves) are becoming more frequent and severe.

Overcoming poor market depth and liquidity is crucial for Asia's capital markets to grow and remain attractive to investors. A coordinated approach addressing regulatory frameworks, market infrastructure, and risk management is essential for building resilient, diverse, and efficient markets.

Inclusive sports can empower women with disabilities, and foster accessibility, social integration, and gender equality in the Pacific. Recent Paralympic milestones and policy examples illustrate the ongoing need for supportive infrastructures and greater representation to create equitable opportunities in sports.

These charts illustrate that despite the broader adoption of disaster risk reduction strategies, escalating greenhouse gas emissions and intensified disaster impacts underscore the urgent need for more robust climate action and support across the region.

Asia and the Pacific is central to global climate change efforts, but robust capital markets are needed to mobilize private climate finance. Sustainable finance frameworks, transition finance, and carbon markets can build deeper markets that empower climate action.

South Asia study of foreign direct investments impact in India, Pakistan, Bangladesh, Sri Lanka and Nepal on economic growth, domestic investment, and export; special emphasis on the role of infrastructure.

This paper examines the causes of export success in East and South East Asia and assesses the role of industrial policy.

Growth model finds evidence of agricultural convergence among Asian countries, but changes in factors including foreign aid may make this impossible to realize.

What should the transitional economies of Southeast Asia do, if anything, to address their multiple currency situations?

Bangladesh and India should pursue bilateral economic cooperation to enhance South Asian regional cooperation.

South Asian private sector participation in infrastructure development is examined, and recommendations are made for future development.

Research on ICT and capacity building for poverty reduction, focusing on lessons learned from a distant learning course in microfinance.

This brochure outlines how nature is being rapidly degraded and shows how ADB-designed nature-based solutions (NBS) can help protect vulnerable communities and ecosystems to make countries in Asia and the Pacific more climate resilient.

Gender-lens investing (GLI) represents an opportunity to channel targeted funds to women’s businesses and other gender equality areas.

This report considers how finance and planning ministries can respond strategically to climate risk, highlighting best practices from Southeast Asia and identifying crosscutting priorities.

This report examines the progress of trade facilitation in Asia and the Pacific, highlights recent trends in paperless trade, and evaluates the impact of trade facilitation initiatives on trade costs and overall trade.

This brief shows how India sparked a digital payments boom and boosted financial inclusion through the introduction of its Unified Payments Interface (UPI) and outlines ways countries in the region can ramp up their own digital transformation.

This report emphasizes that open and fair trade is essential for Asia and the Pacific’s transition to low-carbon economies and outlines the important role of Aid for Trade in this transition.

This report outlines the cascading environmental, social, and economic impacts of aquatic biodiversity loss in Southeast Asia and recommends ways to develop scalable projects that tackle river pollution and support sustainable development.

Asia and the Pacific’s developing economies are projected to grow 5.0% this year on the back of resilient domestic demand and strong export growth, particularly in the electronics sector.

This publication provides updated statistics on a comprehensive set of economic, financial, social, and environmental measures as well as select indicators for the Sustainable Development Goals (SDGs).

Long feted by fossil hunters and geologists, if UNESCO recognises the extraordinary rock formation at Madygen in Kyrgyzstan, it will soon be a player on the world stage

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

Although the progressive histologic steps leading to endometrial cancer (EndoCA), the most common female reproductive tract malignancy, from endometrial hyperplasia are well-established, the molecular changes accompanying this malignant transformation in a single patient have never been described. We had the unique opportunity to investigate the paired histologic and molecular features associated with the 12-yr development of EndoCA in a postmenopausal female who could not undergo hysterectomy and instead underwent progesterone treatment. Using a specially designed 58-gene next-generation sequencing panel, we analyzed a total of 10 sequential biopsy samples collected over this time frame. A total of eight pathogenic/likely pathogenic mutations in seven genes, APC, ARID1A, CTNNB1, CDKN2A, KRAS, PTEN, and TP53, were identified. A PTEN nonsense mutation p.W111* was present in all samples analyzed except histologically normal endometrium. Apart from this PTEN mutation, the only other recurrent mutation was KRAS G12D, which was present in six biopsy samplings, including histologically normal tissue obtained at the patient's first visit but not detectable in the cancer. The PTEN p.W111* mutant allele fractions were lowest in benign, inactive endometrial glands (0.7%), highest in adenocarcinoma (36.9%), and, notably, were always markedly reduced following progesterone treatment. To our knowledge, this report provides the first molecular characterization of EndoCA development in a single patient. A single PTEN mutation was present throughout the 12 years of cancer development. Importantly, and with potential significance toward medical and nonsurgical management of EndoCA, progesterone treatments were consistently noted to markedly decrease PTEN mutant allele fractions to precancerous levels.

Alveolar capillary dysplasia (ACD) is a fatal disorder that typically presents in the neonatal period with refractory hypoxemia and pulmonary hypertension. Lung biopsy is traditionally required to establish the diagnosis. We report a 22-mo-old male who presented with anemia, severe pulmonary hypertension, and right heart failure. He had a complicated hospital course resulting in cardiac arrest and requirement for extracorporeal membrane oxygenation. Computed tomography of the chest showed a heterogenous pattern of interlobular septal thickening and pulmonary edema. The etiology of his condition was unknown, lung biopsy was contraindicated because of his medical fragility, and discussions were held to move to palliative care. Rapid whole-genome sequencing (rWGS) was performed. In 2 d it resulted, revealing a novel FOXF1 gene pathogenic variant that led to the presumptive diagnosis of atypical ACD. Cases of atypical ACD have been reported with survival in patients using medical therapy or lung transplantation. Based on the rWGS diagnosis and more favorable potential of atypical ACD, aggressive medical treatment was pursued. The patient was discharged home after 67 d in the hospital; he is currently doing well more than 30 mo after his initial presentation with only one subsequent hospitalization and no requirement for lung transplantation. Our case reveals the potential for use of rWGS in a critically ill child in which the diagnosis is unknown. rWGS and other advanced genetic tests can guide clinical management and expand our understanding of atypical ACD and other conditions.

A new species of Jurassic dinosaur related to Tyrannosaurus rex has been discovered by paleontologists in Kyrgyzstan in Central Asia.

Administrative innovations in south-west Asia during the 4th millennium BCE, including the cylinder seals that were rolled on the earliest clay tablets, laid the foundations for proto-cuneiform script.

The post Study: Cylinder Seals and Sealing Practices Stimulated Invention of Writing in Ancient South-West Asia appeared first on Sci.News: Breaking Science News.

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IV Eurasian Higher Education Leaders Forum, Astana, Kazakhstan

Special guests helped celebrate the opening of Ondori Asian Kitchen, a distinctive new dining concept at The Orleans Hotel and Casino, on March 2, 2016.

EAMF 2016 Highlights

Tax revenues fell in 2019 in two-thirds of economies across Asia and the Pacific as a result of an economic slowdown prior to the COVID-19 pandemic, according to a new OECD report.

On March 10, the OECD released a new VAT Digital Toolkit for Asia-Pacific (APAC) nations. The toolkit is intended to support local tax authorities to better collect value-added tax on e-commerce activities.

On March 10, the OECD released a new VAT Digital Toolkit for Asia-Pacific (APAC) nations. The toolkit is intended to support local tax authorities to better collect value-added tax on e-commerce activities.

Allogeneic hematopoietic cell transplantation (HCT) serves as a widely recognized curative treatment option for patients suffering from inborn errors of immunity (IEI).

medlinkEuthanasia/medlink, often referred to as "mercy killing" or "assisted dying," is a highly debated ethical and legal issue concerning the deliberate

Study shows potential for smallholder water management innovations to boost crop yields and household revenue by tens of billions of US dollars

The post Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia first appeared on International Water Management Institute (IWMI).

New report underlines vulnerability of agriculture to climate hazards.

The post Press Release: Almost 75 Crore people in South Asia affected by climate hazards in last decade first appeared on International Water Management Institute (IWMI).

IWMI and the Swiss Agency for Development and Cooperation have awarded five organisations with funds to develop innovations for solar irrigation.

The post Grantees from South Asia awarded funds to develop innovations enhancing solar irrigation first appeared on International Water Management Institute (IWMI).

Creating the food systems that people want & need across Central Asia will depend in part on how water is managed under climate uncertainty.

The post Innovations and smart water technologies key to food systems transformation in Central Asia first appeared on International Water Management Institute (IWMI).

Next-generation system will enable proactive drought measures in South Asia.

The post IWMI launches South Asia Drought Monitoring System first appeared on International Water Management Institute (IWMI).

A new study of global cholesterol levels has revealed that cholesterol levels are declining sharply in Western nations, but rising in low- and middle-income nations - particularly in Asia.