The neighborhood has a history of white supremacy..

He played with the exhibition team for 22 seasons.

Shaq's son and Mamba were extremely close.

He is survived by his wife and three children.

His team confirmed the tragic news.

The news was announced during the 2020 NFL Draft.

The neighborhood has a history of white supremacy..

Hint: She got it from her mama's mama.

Coincidental to TRB's 1982 promotion to a stand-alone unit within the NRC and its acceptance of the responsibility to oversee consensus studies, Congress was working on an update to surface transportation legislation. The timing meant that TRB was not going to be able to ease into its new responsibilities. To learn the whole story, check out the latest release in the TRB History Highlights series. As part of the Centennial Celebration, TRB has initiated the History Highlights series that will regularly r...

TRB's Airport Cooperative Research Program (ACRP) WebResource 5: Tools and Case Studies for NextGen for Airports is a companion to the five-volume ACRP Report 150: NextGen for Airports. It provides downloadable engagement materials from the NextGen Outreach Toolkit, discussed in Volume 2: Engaging Airport Stakeholders, and the Public Information Toolkit, discussed in Volume 3: Resources for Airports. A table that identifies the volume and page number of all case studies discussed in the five volumes is a...

UC San Diego Health launches pilot project using drones to move medical samples, supplies and documents between Jacobs Medical Center, Moores Cancer Center and the Center for Advanced Laboratory Medicine, speeding delivery of services and patient care currently managed through ground transport.

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytokine gene expression. Energy expenditure and brown adipose tissue metabolism in Asxl2ΔLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with relatively increased catecholamines likely due to their suppressed degradation by macrophages. White adipose tissue of HFD-fed Asxl2ΔLysM mice also exhibited none of the pathological remodeling extant in their control counterparts. Suppression of macrophage Asxl2 expression, via nanoparticle-based siRNA delivery, prevented HFD-induced obesity. Thus, ASXL2 controlled the response of macrophages to dietary factors to regulate metabolic homeostasis, suggesting modulation of the cells’ inflammatory phenotype may impact obesity and its complications.

Tumor-associated peptide–human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface–expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an anti-CD3 effector function are being developed to redirect T cells against these targets using 2 different approaches. The first achieves pHLA recognition via affinity-enhanced versions of natural TCRs (e.g., immune-mobilizing monoclonal T cell receptors against cancer [ImmTAC] molecules), whereas the second harnesses an antibody-based format (TCR-mimic antibodies). For both classes of reagent, target specificity is vital, considering the vast universe of potential pHLA molecules that can be presented on healthy cells. Here, we made use of structural, biochemical, and computational approaches to investigate the molecular rules underpinning the reactivity patterns of pHLA-targeting bispecifics. We demonstrate that affinity-enhanced TCRs engage pHLA using a comparatively broad and balanced energetic footprint, with interactions distributed over several HLA and peptide side chains. As ImmTAC molecules, these TCRs also retained a greater degree of pHLA selectivity, with less off-target activity in cellular assays. Conversely, TCR-mimic antibodies tended to exhibit binding modes focused more toward hot spots on the HLA surface and exhibited a greater degree of crossreactivity. Our findings extend our understanding of the basic principles that underpin pHLA selectivity and exemplify a number of molecular approaches that can be used to probe the specificity of pHLA-targeting molecules, aiding the development of future reagents.

IBM and the University of California San Diego have announced a multi-year project to enhance quality of life and independence for aging populations through the new Artificial Intelligence for Healthy Living Center (AIHL), located on the campus of UC San Diego. The groundbreaking center will bring together the technology, artificial intelligence and life sciences knowledge of IBM and UC San Diego to promote critical research and applications in two thematic areas: Healthy Aging and the Human Microbiome.

was inspired to make a giant geometrical shape, that of the 20-side die, or isocahedron.

dollypopinspiration:

Diego Delgado-Elias

http://diegodelgadoelias.com/

Mary Pratt, believed to be the last surviving member of the Rockford Peaches, has died at age 101.

This may sound funny, but in the nearly 1.5 years that Dan and I have been dating, we have yet to fully integrate our dog packs. Well, mostly we have avoided fully introducing Maizy and Greta, our two bossy ladies.

musicisart magazine 2017 Best Music: Slenderbodies

Los Angeles-based duo Slenderbodies create music that feels like your watching the ocean. Slenderbodies recently released their brand new project fabulist out now via Majestic Casual Records. The five-track collection is full of whispers of sensuality found within falsetto vocals accompanied with vibrations of soft guitars melted into funky and soulful bass-lines that collide together […]

The post 2017 Best Music: Slenderbodies appeared first on musicisart magazine.

Why Do The Good Die Young?

I thought back to the summer when I was eleven years old, after my father had discovered making money and had moved us “on up” from the dregs of Weehawken, New Jersey, situated on the ass end of the Lincoln Tunnel to the posh suburb, Englewood Cliffs just north of the George Washington Bridge.

I Mean…What?!?

Man die fietspad bezaait met prikkeldraad, spijkers en glas praat zichzelf aan de galg tegen visser die stiekem filmt  Het Laatste Nieuws

1. Little Richard, rock pioneer behind hits Long Tall Sally, Tutti Frutti, dies aged 87  ABC News
2. Rock legend Little Richard dead at 87  NEWS.com.au
3. Little Richard, Flamboyant Rock and Roll Pioneer, Dies at 87  9Honey
4. Little Richard, flamboyant rock 'n' roll pioneer, dies at 87  The Times of Israel
5. Musician Little Richard dies aged 87  Sky News Australia
6. View Full coverage on Google News