Wien : W. Braumuller, 1867.

Leipzig : J.A. Barth, 1899.

Edinburgh : printed for J. Carfrae, 1823.

London : J. Churchill, 1864.

Berlin : Heuser, 1894.

Berlin : Hirschwald, 1900.

Londres : H. Bailliere, 1843-1847.

Berlin : A. Hirschwald, 1896-1900.

Gottingen : A. Rente, 1866.

Paris : A. Parent, 1878.

Paris : Béchet jeune, 1838.

Paris : Steinheil, 1888.

Amstelodami : Typis A. Wolfgang, 1674.

London : Scribe, 2019.

München [Munich] : Jos. Albert K.B. Hof-Photograph, [1860]

London : Published by J.B. Virtue & Co. Ltd. : Jean Boussod Manzi Joyant & Co., [1897]

London : Published for the proprietors, [between 1800 and 1899]

London (No. 90, Cheapside, & 8, Pall Mall) : Published ... by Hurst, Robinson & Co., March 1st. 1824.

London (No. 90, Cheapside, & 8, Pall Mall) : Published ... by Hurst, Robinson & Co., March 1st. 1824.

[London], [1824]

[Dresden?], [1754?]

[Paris] : [publisher not identified], 1782.

London : Printed and sold by Thos. and John Bowles, printsellers, [1728]

Brian Whiston, who was hired in 2015, set ambitious goals for the state and helped create its accountability plan under the Every Student Succeeds Act.

Old habits die hard, and for Hall of Fame goalie Gerry Cheevers, the Bruins-Canadiens rivalry manifested when Cheesy took a shot a Montreal's Carey Price during a Zoom town hall with B's season-ticket holders on Thursday.

Few things in sports are better than overtime in the Stanley Cup Playoffs, and May 8 has seen the Boston Bruins play in a couple memorable games that required bonus hockey.

Paris, [France] : J.B. Baillière, Libraire de l'Académie Impériale de Médicine, 1854.

Paris, [France] : J.B. Baillière, Libraire de l'Académie Impériale de Médicine, 1856.

Paris, [France] : J.B. Baillière, Libraire de l'Académie Impériale de Médicine, 1855.

Paris, [France] : J.B. Baillière, Libraire de l'Académie Impériale de Médicine, 1855.

Paris, [France] : J.B. Baillière, Libraire de l'Académie Impériale de Médicine, 1857.

Halle (Saale) : Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften ; Stuttgart : Wissenschaftliche Verlagsgesellschaft, 2019.

Rockville, Maryland : National Institute on Drug Abuse, 1978.

The Pac-12 Student-Athlete Advisory Committee voted to award the Oregon State women’s basketball team with the Pac-12 Sportsmanship Award for the 2019-20 season, honoring their character and sportsmanship before a rivalry game against Oregon in Jan. 2020 -- the day Kobe Bryant, his daughter, Gigi, and seven others passed away in a helicopter crash in Southern California. In the above video, Aleah Goodman and Madison Washington share how the teams came together as one in a circle of prayer before the game.

We study the least-squares regression problem over a Hilbert space, covering nonparametric regression over a reproducing kernel Hilbert space as a special case. We first investigate regularized algorithms adapted to a projection operator on a closed subspace of the Hilbert space. We prove convergence results with respect to variants of norms, under a capacity assumption on the hypothesis space and a regularity condition on the target function. As a result, we obtain optimal rates for regularized algorithms with randomized sketches, provided that the sketch dimension is proportional to the effective dimension up to a logarithmic factor. As a byproduct, we obtain similar results for Nystr"{o}m regularized algorithms. Our results provide optimal, distribution-dependent rates that do not have any saturation effect for sketched/Nystr"{o}m regularized algorithms, considering both the attainable and non-attainable cases, in the well-conditioned regimes. We then study stochastic gradient methods with projection over the subspace, allowing multi-pass over the data and minibatches, and we derive similar optimal statistical convergence results.

We propose graph-dependent implicit regularisation strategies for synchronised distributed stochastic subgradient descent (Distributed SGD) for convex problems in multi-agent learning. Under the standard assumptions of convexity, Lipschitz continuity, and smoothness, we establish statistical learning rates that retain, up to logarithmic terms, single-machine serial statistical guarantees through implicit regularisation (step size tuning and early stopping) with appropriate dependence on the graph topology. Our approach avoids the need for explicit regularisation in decentralised learning problems, such as adding constraints to the empirical risk minimisation rule. Particularly for distributed methods, the use of implicit regularisation allows the algorithm to remain simple, without projections or dual methods. To prove our results, we establish graph-independent generalisation bounds for Distributed SGD that match the single-machine serial SGD setting (using algorithmic stability), and we establish graph-dependent optimisation bounds that are of independent interest. We present numerical experiments to show that the qualitative nature of the upper bounds we derive can be representative of real behaviours.

We propose expected policy gradients (EPG), which unify stochastic policy gradients (SPG) and deterministic policy gradients (DPG) for reinforcement learning. Inspired by expected sarsa, EPG integrates (or sums) across actions when estimating the gradient, instead of relying only on the action in the sampled trajectory. For continuous action spaces, we first derive a practical result for Gaussian policies and quadratic critics and then extend it to a universal analytical method, covering a broad class of actors and critics, including Gaussian, exponential families, and policies with bounded support. For Gaussian policies, we introduce an exploration method that uses covariance proportional to the matrix exponential of the scaled Hessian of the critic with respect to the actions. For discrete action spaces, we derive a variant of EPG based on softmax policies. We also establish a new general policy gradient theorem, of which the stochastic and deterministic policy gradient theorems are special cases. Furthermore, we prove that EPG reduces the variance of the gradient estimates without requiring deterministic policies and with little computational overhead. Finally, we provide an extensive experimental evaluation of EPG and show that it outperforms existing approaches on multiple challenging control domains.

Regularized least-squares (kernel-ridge / Gaussian process) regression is a fundamental algorithm of statistics and machine learning. Because generic algorithms for the exact solution have cubic complexity in the number of datapoints, large datasets require to resort to approximations. In this work, the computation of the least-squares prediction is itself treated as a probabilistic inference problem. We propose a structured Gaussian regression model on the kernel function that uses projections of the kernel matrix to obtain a low-rank approximation of the kernel and the matrix. A central result is an enhanced way to use the method of conjugate gradients for the specific setting of least-squares regression as encountered in machine learning.

We consider the standard model of distributed optimization of a sum of functions $F(mathbf z) = sum_{i=1}^n f_i(mathbf z)$, where node $i$ in a network holds the function $f_i(mathbf z)$. We allow for a harsh network model characterized by asynchronous updates, message delays, unpredictable message losses, and directed communication among nodes. In this setting, we analyze a modification of the Gradient-Push method for distributed optimization, assuming that (i) node $i$ is capable of generating gradients of its function $f_i(mathbf z)$ corrupted by zero-mean bounded-support additive noise at each step, (ii) $F(mathbf z)$ is strongly convex, and (iii) each $f_i(mathbf z)$ has Lipschitz gradients. We show that our proposed method asymptotically performs as well as the best bounds on centralized gradient descent that takes steps in the direction of the sum of the noisy gradients of all the functions $f_1(mathbf z), ldots, f_n(mathbf z)$ at each step.

Stochastic gradient Langevin dynamics (SGLD) is a fundamental algorithm in stochastic optimization. Recent work by Zhang et al. (2017) presents an analysis for the hitting time of SGLD for the first and second order stationary points. The proof in Zhang et al. (2017) is a two-stage procedure through bounding the Cheeger's constant, which is rather complicated and leads to loose bounds. In this paper, using intuitions from stochastic differential equations, we provide a direct analysis for the hitting times of SGLD to the first and second order stationary points. Our analysis is straightforward. It only relies on basic linear algebra and probability theory tools. Our direct analysis also leads to tighter bounds comparing to Zhang et al. (2017) and shows the explicit dependence of the hitting time on different factors, including dimensionality, smoothness, noise strength, and step size effects. Under suitable conditions, we show that the hitting time of SGLD to first-order stationary points can be dimension-independent. Moreover, we apply our analysis to study several important online estimation problems in machine learning, including linear regression, matrix factorization, and online PCA.

Durba Bhattacharya, Sourabh Bhattacharya.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 71--89.

Abstract:
Present day bio-medical research is pointing towards the fact that cognizance of gene–environment interactions along with genetic interactions may help prevent or detain the onset of many complex diseases like cardiovascular disease, cancer, type2 diabetes, autism or asthma by adjustments to lifestyle. In this regard, we propose a Bayesian semiparametric model to detect not only the roles of genes and their interactions, but also the possible influence of environmental variables on the genes in case-control studies. Our model also accounts for the unknown number of genetic sub-populations via finite mixtures composed of Dirichlet processes. An effective parallel computing methodology, developed by us harnesses the power of parallel processing technology to increase the efficiencies of our conditionally independent Gibbs sampling and Transformation based MCMC (TMCMC) methods. Applications of our model and methods to simulation studies with biologically realistic genotype datasets and a real, case-control based genotype dataset on early onset of myocardial infarction (MI) have yielded quite interesting results beside providing some insights into the differential effect of gender on MI.

Oleksandr Sverdlov, Weng Kee Wong, Yevgen Ryeznik.

Source: Statistics Surveys, Volume 8, 2--44.

Abstract:
Adaptive clinical trials are becoming increasingly popular research designs for clinical investigation. Adaptive designs are particularly useful in phase I cancer studies where clinical data are scant and the goals are to assess the drug dose-toxicity profile and to determine the maximum tolerated dose while minimizing the number of study patients treated at suboptimal dose levels. In the current work we give an overview of adaptive design methods for phase I cancer trials. We find that modern statistical literature is replete with novel adaptive designs that have clearly defined objectives and established statistical properties, and are shown to outperform conventional dose finding methods such as the 3+3 design, both in terms of statistical efficiency and in terms of minimizing the number of patients treated at highly toxic or nonefficacious doses. We discuss statistical, logistical, and regulatory aspects of these designs and present some links to non-commercial statistical software for implementing these methods in practice.

Model Stealing (MS) attacks allow an adversary with black-box access to a Machine Learning model to replicate its functionality, compromising the confidentiality of the model. Such attacks train a clone model by using the predictions of the target model for different inputs. The effectiveness of such attacks relies heavily on the availability of data necessary to query the target model. Existing attacks either assume partial access to the dataset of the target model or availability of an alternate dataset with semantic similarities.

This paper proposes MAZE -- a data-free model stealing attack using zeroth-order gradient estimation. In contrast to prior works, MAZE does not require any data and instead creates synthetic data using a generative model. Inspired by recent works in data-free Knowledge Distillation (KD), we train the generative model using a disagreement objective to produce inputs that maximize disagreement between the clone and the target model. However, unlike the white-box setting of KD, where the gradient information is available, training a generator for model stealing requires performing black-box optimization, as it involves accessing the target model under attack. MAZE relies on zeroth-order gradient estimation to perform this optimization and enables a highly accurate MS attack.

Our evaluation with four datasets shows that MAZE provides a normalized clone accuracy in the range of 0.91x to 0.99x, and outperforms even the recent attacks that rely on partial data (JBDA, clone accuracy 0.13x to 0.69x) and surrogate data (KnockoffNets, clone accuracy 0.52x to 0.97x). We also study an extension of MAZE in the partial-data setting and develop MAZE-PD, which generates synthetic data closer to the target distribution. MAZE-PD further improves the clone accuracy (0.97x to 1.0x) and reduces the query required for the attack by 2x-24x.

The next seminar in the 2017–18 History of Pre-Modern Medicine seminar series takes place on Tuesday 16 January. Speaker: Dr Catherine Rider (University of Exeter) Medieval Ideas about Infertility and Old Age Abstract: When they discussed fertility and reproductive disorders it was common… Continue reading