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The quasi-irreversible inactivation of cytochrome P450 enzymes by paroxetine: a computational approach

Org. Biomol. Chem., 2020, 18,3334-3345
DOI: 10.1039/D0OB00529K, Paper
Emadeldin M. Kamel, Al Mokhtar Lamsabhi
The potency of paroxetine as a P450 inhibitor is mainly attributed to the availability of two active sites on its structure, its compatibility with P450's active site and the ease of its tight coordination to heme iron.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dienaminodioate based multicomponent reactions with post-benzylic oxidative transformations mediated by DDQ

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00721H, Paper
Jaice Ravindran, Velickakathu Yadhukrishnan, Reghuvaran Asha , Ravi Shankar Lankalapalli
Multicomponent reactions (MCRs) using dienaminodioate with post-benzylic oxidative transformation by DDQ that afforded a diverse array of products is described. An unprecedented rearrangement of 1,2-dihydropyridines (1,2-DHPs), 3CR products, to 2-pyridones...
The content of this RSS Feed (c) The Royal Society of Chemistry




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TN woman seeks Rs 1 cr compensation from AIDS society

A housewife has moved the Madras High Court seeking Rs 1 crore as compensation and a public apology from the Tamil Nadu AIDS Control Society.




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Five-year-old Indian becomes millionaire

A five-year-old Indian boy has become a millionaire overnight after winning a lottery at a national bond draw here.




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Coming to UP? You can use your own vehicle

More than 1.48 lakh people registered on the government's Jan Sunwai portal on Thursday, requesting to be brought back to UP from other states that they have been stuck in since the lockdown was imposed.




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62-yr-old becomes 2nd corona fatality in Noida

A 62-year-old man died due to coronavirus in Noida, becoming the second Covid-19 fatality in Uttar Pradesh's Gautam Buddh Nagar district, officials said on Saturday.




com

Apple announces new iPhone SE 2020, to come with minimum 64 GB storage

It has the same iPhone 8 design, but the camera and processor are new.




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USGS releases first comprehensive geological map of moon using Apollo data

The new map explains the 4.5-billion-year-old history of our neighbour in space.




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NASA's Hubble captures breakup of comet ATLAS into more than two dozen pieces

Hubble identified about 30 fragments on April 20, and 25 pieces on April 23.








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Novel fabric adapts to keeps you comfortable in all weathers

When conditions are warm and moist, such as those near a sweating body, the fabric allows heat to pass through. When conditions become cooler and drier, the fabric reduces the heat that escapes, researchers said.




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Reinforced concrete design / Abi O. Aghayere, P. Eng., Drexel University, George F. Limbrunner, PE, Hudson Valley Community College (emeritus)

Barker Library - TA444.L44 2014




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Composites with inorganic matrix for repair of concrete and masonry structures: held at the ACI Spring 2017 Convention, Detroit, Michigan, USA, 26-30 March 2017 / editors, Gianmarco de Felice, Lesley H. Sneed, Antonio Nanni

Barker Library - TA439.A57 2017




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Gravitational Biology II: Interaction of Gravity with Cellular Components and Cell Metabolism / Wolfgang Hanke [and more]

Online Resource




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Healthy Aging: A Complete Guide to Clinical Management / editor, Patrick P. Coll

Online Resource




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Biodefense in the age of synthetic biology / Committee on Strategies for Identifying and Addressing Potential Biodenfense Vulnerabilities Posed by Synthetic Biology, Board on Chemical Sciences and Technology, Board on Life Sciences, Division on Earth and

Online Resource




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Biomimetic lipid membranes: fundamentals, applications, and commercialization / Fatma N. Kök, Ahu Arslan Yildiz, Fatih Inci, editors

Online Resource




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Computational biology: a statistical mechanics perspective / Ralf Blossey

Hayden Library - QH506.B57 2020




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Advanced computing in electron microscopy Earl J. Kirkland

Online Resource




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‘Migration will become a human right’ – interview with Mohsin Hamid

The author of The Reluctant Fundamentalist talks to Graeme Green about extremism, the refugee crisis and feeling at home in the past.




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A Companion to Ancient Near Eastern Languages


 

Covers the major languages, language families, and writing systems attested in the Ancient Near East 

Filled with enlightening chapters by noted experts in the field, this book introduces Ancient Near Eastern (ANE) languages and language families used during the time period of roughly 3200 BCE to the second century CE in the areas of Egypt, the Levant, eastern Anatolia, Mesopotamia, and Iran. In addition to providing grammatical sketches of the respective



Read More...




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Companion to Women's and Gender Studies


 

A comprehensive overview of the interdisciplinary field of Women's and Gender Studies, featuring original contributions from leading experts from around the world

The Companion to Women's and Gender Studies is a comprehensive resource for students and scholars alike, exploring the central concepts, theories, themes, debates, and events in this dynamic field. Contributions from leading scholars and researchers cover a wide range of topics while providing



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IndusInd Bank Q4 preview: Profit may dip 95% QoQ on exposure to telecom cos

According to analysts at ICICI Securities, the Rs 8,800 crore-exposure to the telecom sector may cast shadow over the bank's asset quality.




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Tech Mahindra Q4 net falls 29%; recommends final dividend of Rs 5/share

The Pune-headquartered company reported Rs 804 crore in consolidated net profit for the March quarter (Q4FY20), a decline of 29.1 per cent on year-on-year (YoY) basis




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8 Hand and Wrist Exercises for Computer Users

Good exercises for web designers and programmers, which are at higher risk of developing carpal tunnel or RSI injuries.




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Community science: Not just a hobby

Community science brings a DIY sensibility to a range of research areas, providing a collegial atmosphere of collaboration and support.




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The compassionate educator : understanding social issues and the ethics of care in Canadian schools / edited by Allyson Jule.

Toronto ; Vancouver : Canadian Scholars, 2019.




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E-learning [electronic resource] : nuovi strumenti per insegnare, apprendere, comunicare online / Silvia Selvaggi, Gennaro Sicignano, Enrico Vollono

Milano : Springer, [2007]




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Cross national policies and practices on computers in education [electronic resource] / edited by Tjeerd Plomp and Ronald E. Anderson and Georgia Kontogiannopoulou-Polydorides

Dordrecht ; Boston : Kluwer Academic Publishers, [1996]




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Economics of education [electronic resource] : a comprehensive overview / edited by Steve Bradley, Colin Green.

London ; San Diego, CA : Academic Press, [2020]




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[ASAP] Exposure to Trichloroethylene Metabolite <italic toggle="yes">S</italic>-(1,2-Dichlorovinyl)-L-cysteine Causes Compensatory Changes to Macronutrient Utilization and Energy Metabolism in Placental HTR-8/SVneo Cells

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00356




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[ASAP] Carbon Nanotubes Modulate Activity of Cytotoxic Compounds via a Trojan Horse Mechanism

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00370




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[ASAP] Applicability Domains Enhance Application of PPAR? Agonist Classifiers Trained by Drug-like Compounds to Environmental Chemicals

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00498




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[ASAP] Computational Approaches to Identify Structural Alerts and Their Applications in Environmental Toxicology and Drug Discovery

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00006




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[ASAP] Comprehensive <italic toggle="yes">In Vitro</italic> Metabolism Study of Bisphenol A Using Liquid Chromatography-High Resolution Tandem Mass Spectrometry

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00042




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[ASAP] Synergy between Experiments and Computations: A Green Channel for Revealing Metabolic Mechanism of Xenobiotics in Chemical Toxicology

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00448




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[ASAP] Binding and Metabolism of Brominated Flame Retardant ß-1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane in Human Microsomal P450 Enzymes: Insights from Computational Studies

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00076




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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00151




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[ASAP] Comparison of the Base Excision and Direct Reversal Repair Pathways for Correcting 1,<italic toggle="yes">N</italic><sup>6</sup>-Ethenoadenine in Strongly Positioned Nucleosome Core Particles

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00089




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Compendium of the study of philosophy / Roger Bacon ; edited and translated by Thomas S. Maloney.

Oxford : Published for the British Academy by Oxford University Press, 2018.




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Poetry & Literature: News & Events: UPCOMING VIRTUAL EVENTS

Thursday, April 30, 7:00 PM
SPILLOVER: ANIMAL INFECTIONS AND THE NEXT HUMAN PANDEMIC

Prize-winning science writer David Quammen will discuss “Spillover,” in which he tracks the animal origins of human diseases through the centuries, with David Rubenstein. Presented in partnership with National Book Festival Presents.

Location: Online only—this event will be streamed from both the Library's Facebook page and its YouTube site (with captions), and will be archived as a webcast on the Library’s website. Contact: specialevents@loc.gov

 

Thursday, May 7, 7:00 PM
HOW ONE 21ST CENTURY PANDEMIC, SARS, PREDICTED ANOTHER, COVID-19

Author and journalist Karl Taro Greenfeld will discuss his prescient book on the SARS epidemic, which foreshadowed the more devastating COVID-19 pandemic, with the Library of Congress’s Roswell Encina, chief of communications. Presented in partnership with National Book Festival Presents.

Location: Online only—this event will be streamed from both the Library's Facebook page and its YouTube site (with captions), and will be archived as a webcast on the Library’s website. Contact: specialevents@loc.gov

 

Friday, May 8, 5:00 PM
BEYOND SUNRISE, THERE IS A SONG WE FOLLOW: U.S. POET LAUREATE JOY HARJO IN CONVERSATION

U.S. Poet Laureate Joy Harjo will discuss her poetry and her work in the laureate position with Rob Casper, head of the Poetry and Literature Center. Co-sponsored by The Association of Writers & Writing Programs (AWP).

Location: Online only—this event will be streamed from AWP’s website, where it will also be archived.
Contact: juanita@awpwriter.org

 

Thursday, May 14, 7:00 PM
ONCE UPON A TIME I LIVED ON MARS: SPACE, EXPLORATION AND LIFE ON EARTH

NASA astronaut and scientist Kate Greene lived in a simulated Martian environment located on the slopes of Mauna Loa in Hawai’i, where she spent several months in isolation, doing research. She will discuss the stress, loneliness and other challenges of sequestration with Library of Congress Literary Director Marie Arana. Presented in partnership with National Book Festival Presents.

Location: Online only—this event will be streamed from both the Library's Facebook page and its YouTube site (with captions), and will be archived as a webcast on the Library’s website. Contact: specialevents@loc.gov

 

Thursday, May 21, 7:00 PM
WHY IT’S HARD TO KNOW THINGS, LATELY. AND HOW COVID-19 WILL GO DOWN IN HISTORY

Bestselling historian and Harvard professor Jill Lepore will discuss how the current pandemic, its effects and our reaction to them say something very real about America in this moment and in the historical record that will emerge from it with John Haskell, director of the John M. Kluge Center at the Library of Congress. Presented in partnership with National Book Festival Presents.

Location: Online only—this event will be streamed from both the Library's Facebook page and its YouTube site (with captions), and will be archived as a webcast on the Library’s website. Contact: specialevents@loc.gov

 

For more information about upcoming events, please visit the Poetry and Literature Center's website.




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This Computerized Power Tool Turns You Into a Master Woodworker

You may not think of yourself as an excellent craftsman, but the new computer-guided Shaper Origin woodworking tool can change that.




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How to Become a Master Archer Like Katniss Everdeen

Want to survive the Hunger Games? No problem. Here are a few pro tips that will keep you in the game. It's all about getting the right equipment and having the correct form.




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E3 2012: XCOM - Enemy Unknown

2K Games revives its classic strategy role playing game with the release of XCOM: Enemy Unknown.




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Comic-Con 2012 - Do I Really Need To Check-In My Proton Pack?

And we're off! Comic-Con is just starting and if we're to judge by this video, already super awesome! Check out a glimpse of whats to come...




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Comic-Con 2012: Small Press Area

Indie makers show their goods at Comic-Con 2012.




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Comic-Con 2012 Kevin Smith

Kevin Smith talks Comic-Con, pop culture, and mainstreaming online.