ath South Africa investigates local shops as death toll passes 20 By www.foodsafetynews.com Published On :: Wed, 13 Nov 2024 05:05:00 +0000 More than 20 people are believed to have died in one South African province after consuming food from local shops. Gauteng Premier Panyaza Lesufi said the majority of deaths have been children aged between six and nine. “The first uniform approach across the province was to adopt a mechanism of... Continue Reading Full Article Foodborne Illness Investigations World 2024 outbreaks children food poisoning informal market snacks South Africa
ath Man arrested in NYC strangulation death of woman found outside Times Square hotel By www.foxnews.com Published On :: Tue, 12 Nov 2024 21:55:46 -0500 Authorities arrested a man accused of strangling a woman outside a Times Square hotel who later died from her injuries, police said Tuesday. Full Article d7d30f82-1959-5dbe-99be-c4c6d3d7b418 fnc Fox News fox-news/us/crime fox-news/us/new-york-city fox-news/us fox-news/us article
ath Katherine Bennell-Pegg: Australia’s First Astronaut Makes History By spectrum.ieee.org Published On :: Mon, 04 Nov 2024 15:24:40 +0000 This is a sponsored article brought to you by BESydney. In July 2024, Sydney woman Katherine Bennell-Pegg made history as the first astronaut to graduate under the Australian flag and the first female astronaut in Australia. Her journey, marked by determination and discipline, showcases Australia’s growing prominence in space exploration and research. From her academic achievements at the University of Sydney (USYD) to her rigorous training at the European Space Agency (ESA), Bennell-Pegg’s success has paved a path forward for aspiring space and aerospace professionals in Australia and globally. A journey to the stars begins in Sydney Katherine Bennell-Pegg was born in Sydney, New South Wales, and grew up in the Northern Beaches area. Her fascination with space began at an early age. “I always dreamed of being an astronaut,” Bennell-Pegg shared in her “Insights from an Australian Astronaut” Space Forum Speech in July 2024. “When I was young, it was for the adventure, but after more than a decade working in space, it’s now because I know the role it plays in tackling real-world problems and developing new knowledge that can benefit our society, environment and science.” Sydney: A Hub for Space InnovationSydney, the vibrant heart of the state of New South Wales (NSW), stands at the forefront of aerospace innovation in Australia. With its world-class research facilities, leading academic institutions and strategic geographic positioning, Sydney is not only Australia’s gateway to the Indo-Pacific but also a burgeoning hub for international aerospace endeavours.NSW is home to more than 40 per cent of Australia’s aerospace industry. Substantial investments from both the state and federal governments support this concentration of capabilities, underpinning Sydney’s role as a leader in aerospace. From advanced manufacturing and cybersecurity to quantum technologies and space exploration, this progressive city is truly thriving.Sydney’s appeal as a desirable location for hosting aerospace conferences and business events is bolstered by its comprehensive infrastructure, vibrant startup community and strategic position as a transport hub.Sydney’s track record of successfully hosting events highlights the city’s ability to organise impactful international gatherings, including:Australian Space SummitNew Horizons SummitCubeSatPlus2024 - NEW SPACE: Unbounded SkiesSydney will also host the 76th International Astronautical Congress from 29 September to 3 October 2025 and the 34th Congress of the International Council for the Aeronautical Sciences (ICAS) to be held 13 to 17 September 2026. Both will take place at ICC Sydney, further solidifying Sydney’s status as a central hub for aerospace events.Would you like to know more about Sydney’s credentials in Aerospace? Download our Aerospace eBook or visit besydney.com.au Sydney proved to be the ideal location for Bennell-Pegg’s journey to begin. She studied at the University of Sydney, where she earned a Bachelor of Engineering (Honors) in Aeronautical Engineering (Space) and a Bachelor of Science (Advanced) in Physics. Sydney’s universities are at the forefront of aerospace education and research. Institutions such as the University of Sydney (USYD), the University of New South Wales (UNSW Sydney) and the University of Technology Sydney (UTS) attract students from around the world. UNSW Sydney, with its School of Aerospace, Mechanical, and Mechatronic Engineering, is renowned for its innovative research in space technology and satellite systems, while UTS provides cutting-edge programs in aerospace engineering and physics, emphasizing practical applications and industry partnerships. USYD excels in aeronautical engineering and space science, supported by advanced facilities and strong ties to major aerospace organisations. Together, these universities offer comprehensive programs that integrate theoretical knowledge with hands-on experience, preparing students for dynamic careers in the rapidly evolving aerospace and space sectors. Having excelled in her studies at USYD, Bennell-Pegg was awarded the Charles Kuller Graduation Prize for her top-placed undergraduate thesis. Subsequently, her quest for knowledge took her to Europe, where she earned two Master of Science degrees: one in Astronautics and Space Engineering from Cranfield University and another in Space Technology from Luleå University of Technology. Reflecting on her educational path, Bennell-Pegg stated, “With the encouragement of my parents, I researched what it would take to become an astronaut and worked hard at school, participating in everything from aerobatic flying lessons to amateur astronomy.” Inside the rigorous training regimen of an astronaut Bennell-Pegg’s professional career began with roles at Airbus UK, where she contributed to numerous space missions and concept studies, such as Martian in-situ resource utilisation and space debris removal. Her expertise led her to the Australian Space Agency, where she became the Director of Space Technology. In 2021, Bennell-Pegg was invited by the European Space Agency (ESA) to undertake Basic Astronaut Training at the European Astronaut Centre in Germany. When the ESA application opened in 2021, it was the first opening in 15 years. Bennell-Pegg jumped at the opportunity to apply alongside over 22,000 others from 22 countries. She endured six knock-out rounds, including medical, psychometrics, psychology and technical tests and made it to the group of 25 who passed. This historic invitation marked the first time an international astronaut candidate was offered training by the ESA. “The training was demanding, but it was also an incredible opportunity to learn from some of the best minds in the field and to be part of a team that is pushing the boundaries of human exploration.”—Katherine Bennell-Pegg Bennell-Pegg’s training regimen was intense, encompassing physical conditioning, complex simulations, and theoretical classes designed to prepare candidates for long-duration missions to the International Space Station (ISS) and beyond. This included: Studies in biology, astronomy, earth sciences, meteorology, materials, medical and fluids, both in theory and in labs. Radiation research – an area of expertise for Australia. This will increase as humans travel back to the Moon. Medical operations: Astronauts need to be able to perform medical procedures on themselves and others. Training for expeditions: This included honing team dynamics through behavioral training, ocean and winter survival training, rescue and firefighting. Sharing her thoughts on this transformative experience, Bennell-Pegg said, “The training was demanding, but it was also an incredible opportunity to learn from some of the best minds in the field and to be part of a team that is pushing the boundaries of human exploration.” In April 2024, Bennell-Pegg completed her training, graduating with her ESA classmates from “The Hoppers” group. Upon graduation, she became fully qualified for assignments on long-duration missions to the ISS, making her the first Australian female astronaut and the first person to train as an astronaut under the Australian flag. “I want to use this experience to open doors for Australian scientists and engineers to utilize space for their discoveries,” Bennell-Pegg said. “I hope to inspire the pursuit of STEM careers and show all Australians that they too can reach for the stars.” Elevating Australia’s role in space exploration Katherine Bennell-Pegg’s achievements represent a significant milestone. Her journey from the University of Sydney to the rigorous training programs at the European Astronaut Centre showcases the potential of Australian talent in the global space community. “Being the first astronaut trained under the Australian flag is an incredible honor,” Bennell-Pegg said. “I’m grateful for the support that has fueled me through intense training and opened doors for more Australians in space exploration. Whether I fly or not, there is much to accomplish here on Earth. I’m excited to leverage this experience to inspire future generations in STEM and elevate Australia’s presence in the global space community. Becoming an astronaut is just the beginning.” Bennell-Pegg’s dream to become an Australian astronaut is more than just a personal triumph; it is a win for anyone who aspires to a career in space or aerospace. Sydney, with its world-class educational institutions, advanced manufacturing facilities scheduled for the Western Sydney Aerotropolis and expanding opportunities in aerospace and defence, is an ideal starting point for anyone looking to make their mark in these sectors. Would you like to know more about Sydney’s credentials in Aerospace? Download our Aerospace eBook or visit besydney.com.au Full Article Astronauts Australia Space Space flight Type:sponsored
ath Comment on Are You Breathing More Than Just Festive Cheer This Diwali? Beware Of The Air Pollution by Emlakçılık Belgesi By www.thehealthsite.com Published On :: Fri, 01 Nov 2024 07:24:16 +0000 https://maps.google.co.uk/url?q=https://yukselenakademi.com/kurs/detay/emlakcilik-belgesi-seviye-5 Full Article
ath Comment on Are You Breathing More Than Just Festive Cheer This Diwali? Beware Of The Air Pollution by Samsun Perdeci By www.thehealthsite.com Published On :: Fri, 01 Nov 2024 07:35:46 +0000 Bütün ihtiyaçlara en iyi şekilde karşılık veren Samsun perde modelleri bütçe dostu fiyatlarla sunulmaktadır. Fon perde, tül perde, stor perde, güneşlik ve plise SAMSUN Ucuz Perde Modelleri ve Fiyatları. Siz hemen şimdi maviperde.com'dan güvenle alışveriş yapın, biz SAMSUN'un her yerine ucuz perde modellerini imalattan Samsun Perde Mağazaları ve PERDES Brillant Şubeleri: İlkadım, Atakum, Bafra, Çarşamba, Canik, Vezirköprü, Terme, Tekkeköy, Havza, 19 Mayıs, Alaçam perdeci, Samsun bölgesi zebra perdeci, zebra perdeci, perdeciler Samsun, perdeci adres Samsun, perde servisi. Samsun zebra perde montajı montajcısı. https://asrtekstil.com/ Full Article
ath Comment on Keep Your Heart Safe This Chhath Puja: Expert Fasting Tips For A Healthy Celebration by Blue Techker By www.thehealthsite.com Published On :: Thu, 07 Nov 2024 23:49:34 +0000 <a href="https://bluetechker.com/" rel="nofollow ugc">Blue Techker</a> naturally like your web site however you need to take a look at the spelling on several of your posts. A number of them are rife with spelling problems and I find it very bothersome to tell the truth on the other hand I will surely come again again. Full Article
ath Pixel phones are getting an actual weather app in 2024, with a bit of AI By arstechnica.com Published On :: Thu, 31 Oct 2024 17:27:42 +0000 Pixel 6 and newer can try out an app that has AI summaries, but no frog. Full Article Google Tech android google pixel Weather weather app
ath Thoughts on the M4 iMac, and making peace with the death of the 27-inch model By arstechnica.com Published On :: Thu, 07 Nov 2024 14:00:46 +0000 The 16GB RAM upgrade is one of many welcome, if incremental, improvements. Full Article Apple Tech apple Apple M3 apple m4 Apple silicon iMac M3 m4
ath Dinosaurs Evolved Feathers for Far More Than Flight By www.smithsonianmag.com Published On :: Fri, 20 Sep 2024 13:18:27 +0000 Fluff and fuzz helped the creatures keep warm, blend in and communicate Full Article
ath Just How Much Can We Trust A.I. to Predict Extreme Weather? By www.smithsonianmag.com Published On :: Mon, 23 Sep 2024 12:00:00 +0000 Computer scientist and meteorologist Amy McGovern has studied the technology for two decades, and she weighs in with some answers Full Article
ath Here's How Weather Balloons Can Harm Marine Animals By www.smithsonianmag.com Published On :: Fri, 18 Oct 2024 12:00:00 +0000 Latex balloons designed to collect high-altitude data can become a threat after they burst Full Article
ath Hurricane Helene Battered the 'Salamander Capital of the World' With Floods and Landslides. Will the Beloved Amphibians Survive the Aftermath? By www.smithsonianmag.com Published On :: Thu, 07 Nov 2024 13:00:00 +0000 The storm decimated a region rich with dozens of species already struggling with habitat loss and disease Full Article
ath The Tears of Unfathomable Sadness: SNL Cast Member Admits That Elon Musk Made Her Cry By twitchy.com Published On :: Tue, 12 Nov 2024 15:30:00 -0500 Full Article <![CDATA[crying]]> <![CDATA[Elon Musk]]> <![CDATA[saturday night live]]> <![CDATA[SNL]]>
ath Lefties ALWAYS Eat Their Own: Dem Rep. Seth Moulton Defends Trans Athlete Remarks (and He SHOULD) By twitchy.com Published On :: Tue, 12 Nov 2024 16:00:13 -0500 Full Article <![CDATA[boys]]> <![CDATA[CBS News]]> <![CDATA[daughter]]> <![CDATA[Democratic party]]> <![CDATA[father]]> <![CDATA[girl]]> <![CDATA[transgender]]> <![CDATA[women's rights]]> <![CDATA[trans kids]]>
ath Elijah McClain's Parents Sue Colorado Police Over His Death By feedproxy.google.com Published On :: Tue, 11 Aug 2020 17:20:37 PDT The parents of the 23-year-old Black man, who died last year, sued police and medical officials. [[ This is a content summary only. Visit my website for full links, other content, and more! ]] Full Article News
ath 'AGT': Daredevil Annaliese Nock Terrifies Judges With Wheel of Death Stunt By feedproxy.google.com Published On :: Tue, 11 Aug 2020 19:13:06 PDT 'AGT' returned on Tuesday with live shows from Universal Studios Hollywood. [[ This is a content summary only. Visit my website for full links, other content, and more! ]] Full Article TV
ath For fame or a death wish? Kids’ TikTok challenge injuries stump psychiatrists By arstechnica.com Published On :: Wed, 06 Nov 2024 22:19:01 +0000 As clinicians see more TikTok challenge injuries, explaining them is often hard. Full Article Health Science mental health psychiatry suicide tiktok tiktok challenge
ath New secret math benchmark stumps AI models and PhDs alike By arstechnica.com Published On :: Tue, 12 Nov 2024 22:49:58 +0000 FrontierMath's difficult questions remain unpublished so that AI companies can't train against it. Full Article AI Biz & IT AI benchmarks Anthropic benchmarks Claude 3.5 Epoch AI FrontierMath google GPT-4o large language models machine learning o1-preview openai research papers vibemarks
ath Dry weather in New York and New Jersey leads to a rash of dangerous wildfires By www.npr.org Published On :: Tue, 12 Nov 2024 04:11:25 -0500 Wildfires have been raging in New York and New Jersey. People in some areas have been asked to prepare for possible evacuations. Full Article
ath Whoopi Goldberg Endorses Harris Voters Avoiding Holidays with Trump-Supporting Family — 'It Might Not Be the Time to Gather' By www.breitbart.com Published On :: Wed, 13 Nov 2024 00:46:35 +0000 Whoopi Goldberg told her co-hosts Tuesday on ABC's "The View" that she agrees with Vice President Kamala Harris voters who want to avoid family members who voted for President-elect Donald Trump during the holidays. The post Whoopi Goldberg Endorses Harris Voters Avoiding Holidays with Trump-Supporting Family — ‘It Might Not Be the Time to Gather’ appeared first on Breitbart. Full Article Clips Politics 2024 Presidential Election Donald Trump Kamala Harris Sunny Hostin Whoopi Goldberg
ath Team at Kolkata institute engineers bacteria to solve maths problems - The Hindu By news.google.com Published On :: Wed, 13 Nov 2024 00:00:00 GMT Team at Kolkata institute engineers bacteria to solve maths problems The Hindu Full Article
ath Eight-month-old among six abducted in Manipur; two burnt to death - The Hindu By news.google.com Published On :: Tue, 12 Nov 2024 11:21:00 GMT Eight-month-old among six abducted in Manipur; two burnt to death The HinduManipur on boil: 2 more bodies found, 6 missing The Times of IndiaCentre rushes 20 more CAPF companies to Manipur after fresh violence The Indian ExpressThree women, three children missing after Jiribam gunfight; Meiteis and Kukis hold bandhs in Manipur The New Indian ExpressLetters to The Editor — November 13, 2024 The Hindu Full Article
ath ‘I Am Kathalan’ movie review: Fast-paced cyber crime thriller ends up an average fare By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:52:27 +0530 Despite being an engaging watch, ‘I Am Kathalan’ hits a little below the mark compared to director Girish A.D’s previous outings Full Article Movies
ath Lead melam artiste Satheesan Marar gears up for Kerala’s annual temple festival season By www.thehindu.com Published On :: Fri, 08 Nov 2024 17:37:47 +0530 Peruvanam Satheesan Marar recalls his initiation into the percussion ensemble and how he gained expertise in playing different instruments Full Article Music
ath Anne Hathaway and Zendaya join Christopher Nolan’s next starring Matt Damon and Tom Holland By www.thehindu.com Published On :: Sat, 09 Nov 2024 12:54:28 +0530 Nolan has set up his much-awaited ‘Oppenheimer’ follow-up at Universal Pictures, eyeing a mid-2026 IMAX release Full Article Movies
ath Andra Day joins cast of ‘Percy Jackson and the Olympians’ Season 2 as Athena By www.thehindu.com Published On :: Mon, 11 Nov 2024 12:22:51 +0530 The new season will explore Percy’s evolving relationships and his quest to navigate the dangerous Sea of Monsters, facing the mounting threats from Kronos Full Article Movies
ath SwitchArcade Round-Up: ‘Fragrant Story & Papaya’s Path’, Plus Today’s Other Releases and Sales By toucharcade.com Published On :: Tue, 27 Aug 2024 00:07:03 +0000 Hello gentle readers, and welcome to the SwitchArcade Round-Up for August 26th, 2024. In today’s article, we get the week … Continue reading "SwitchArcade Round-Up: ‘Fragrant Story & Papaya’s Path’, Plus Today’s Other Releases and Sales" Full Article Featured Games News SwitchArcade
ath Out Now: ‘Harvest Moon Home Sweet Home’, ‘Ocean Keeper Mobile’, ‘Ogu and the Secret Forest’, ‘Death Travelers’, ‘Snake.io’, ‘RWBY: Arrowfell’ and More By toucharcade.com Published On :: Thu, 29 Aug 2024 03:19:57 +0000 Each and every day new mobile games are hitting the App Store, and so each week we put together a … Continue reading "Out Now: ‘Harvest Moon Home Sweet Home’, ‘Ocean Keeper Mobile’, ‘Ogu and the Secret Forest’, ‘Death Travelers’, ‘Snake.io’, ‘RWBY: Arrowfell’ and More" Full Article Featured News
ath Why thousands gathering around rancid 'dead whale' by world's biggest lake... By www.cnn.com Published On :: 2024-11-13T06:19:38Z Why thousands gathering around rancid 'dead whale' by world's biggest lake... (Third column, 18th story, link) Full Article
ath OPENAI and others seek new path to smarter AI as current methods hit wall... By finance.yahoo.com Published On :: 2024-11-13T06:19:37Z OPENAI and others seek new path to smarter AI as current methods hit wall... (Second column, 9th story, link) Related stories:AMAZON latest to launch driverless car tests in San Fran... Full Article
ath Friends burn to death in TESLA as electronic doors wouldn't open after crash... By www.mirror.co.uk Published On :: 2024-11-13T06:19:36Z Friends burn to death in TESLA as electronic doors wouldn't open after crash... (First column, 15th story, link) Drudge Report Feed needs your support! Become a Patron Full Article
ath Republican Euphoria Punctured by Tough Math in House... By www.wsj.com Published On :: 2024-11-13T06:19:36Z Republican Euphoria Punctured by Tough Math in House... (Top headline, 1st story, link) Related stories:WILL WHITE HOUSE RESULTS STAY ABOVER 50%? DEVELOPING...From 'Little Marco' to 'Mr Secretary': Rubio In Spotlight... Drudge Report Feed needs your support! Become a Patron Full Article
ath Barney & Friends music director recalls ‘horrible’ death threats over infectious songs By www.independent.co.uk Published On :: 2024-11-13T03:22:59+00:00 Bob Singleton revealed he was threatened with ‘death and dismemberment’ as music director for ‘Barney & Friends’ Full Article News TV & Radio Culture
ath The path to achieving family dreams By www.starobserver.com.au Published On :: Mon, 25 Apr 2016 23:10:42 +0000 FOR the first time ever, LGBTI Australians seeking fertility and IVF treatment will be able to attend newly-opened centres designed especially for rainbow patients and their families. The post The path to achieving family dreams appeared first on Star Observer. Full Article Healthy Living LUXE Sponsored Content fertility IVF Rainbow Families Rainbow Fertility
ath J. D. Vance Is Walking a Historically Unusual Path By www.nationalreview.com Published On :: Tue, 12 Nov 2024 00:14:27 +0000 There are not many usable precedents for what J. D. Vance can do with a one-term vice presidency. Full Article
ath Wild weather: ’It was like a tidal wave’ By www.couriermail.com.au Published On :: Mon, 20 Jun 2016 01:34:00 GMT UPDATE: An emergency situation has been declared after wild storms left a trail of destruction on the Sunshine Coast. Brisbane residents have also described what was “like a tidal wave” hitting their homes. Full Article
ath India's Hindus bathe in holy river defiled by pollution By www.terradaily.com Published On :: Wed, 13 Nov 2024 05:57:03 GMT New Delhi (AFP) Nov 7, 2024 Sweeping aside thick toxic scum, thousands of Hindu devotees ignored court warnings Thursday against bathing in the sacred but sewage-filled Yamuna river, a grim display of environmental degradation in India's capital. Thousands celebrated the festival of Chhath Puja for the Hindu sun god Surya, entering the stinking waters to pray as the evening rays set in the sky. A parliamentary repo Full Article
ath Feeling anxious about the U.S. election results? Elmo says, 'Stop scrolling, take a deep breath' By www.cbc.ca Published On :: Tue, 05 Nov 2024 12:13:04 EST Canadians are watching the U.S. election results with trepidation, knowing they have no control over the outcome that will still affect them. Polling shows Vice-President Kamala Harris and former president Donald Trump are neck-and-neck. Full Article News/World
ath 3 charged in One Direction singer Liam Payne's death By www.cbc.ca Published On :: Thu, 07 Nov 2024 17:03:36 EST Three people have been charged in relation to One Direction singer Liam Payne's death in a fall from his Buenos Aires hotel balcony last month, Argentine authorities said on Thursday. Full Article News/Entertainment
ath Thousands gather in Ottawa for Remembrance Day tribute to Canada's veterans By www.cbc.ca Published On :: Mon, 11 Nov 2024 04:00:00 EST Thousands of veterans, military personnel and their supporters gathered at Canada's National War Memorial in Ottawa to remember those who have fought and died to protect this country and its freedoms. Full Article News/Politics
ath Wessex Water fined £500,000 over fish deaths By www.bbc.com Published On :: Mon, 11 Nov 2024 15:44:03 GMT The company is handed its second biggest fine over the deaths of thousands of fish in two rivers. Full Article
ath National online certificate course for pathologists on cervical cancer screening to begin from November 25 By www.pharmabiz.com Published On :: Saturday, November 9, 2024 08:00 IST The Indian Council of Medical Research─National Institute of Cancer Prevention and Research (ICMR─NICPR) is set to launch its first─ever DHR─funded National NICPR─ECHO online certificate course on cervical Full Article
ath In 2024’s Record-Hottest Year, U.S. Voters Will Decide Climate’s Path Forward By www.scientificamerican.com Published On :: Wed, 30 Oct 2024 16:30:00 +0000 Global temperatures through September point to 2024 besting 2023 as the hottest year on record. How many future years set records depends in part on the outcome of the 2024 U.S. presidential election Full Article
ath New Prime Number, 41 Million Digits Long, Breaks Math Records By www.scientificamerican.com Published On :: Fri, 01 Nov 2024 15:30:00 +0000 The discovery of a new prime number highlights the rising price of mathematical gold Full Article
ath Water under Threat, Wooden Satellites and a Mud Bath for Baseballs By www.scientificamerican.com Published On :: Mon, 11 Nov 2024 11:00:00 +0000 Droughts in 48 of 50 U.S. states, evidence of microplastics mucking up wastewater recycling and the science of a baseball mud bath in this week’s news roundup. Full Article
ath New drug cuts the risk of death in bladder cancer by 30% compared with chemotherapy, study suggests By www.pharmaceutical-journal.com Published On :: Thu, 18 Feb 2021 15:30 GMT A new type of drug that targets chemotherapy directly to cancer cells reduces the risk of death from the most common type of bladder cancer by 30%, a phase III trial in the New England Journal of Medicine has suggested. Full Article
ath Questionable Enrollment Math at the UK's NIHR By www.placebocontrol.com Published On :: Mon, 16 Sep 2013 18:04:00 +0000 There has been considerable noise coming out of the UK lately about successes in clinical trial enrollment. First, a couple months ago came the rather dramatic announcement that clinical trial participation in the UK had "tripled over the last 6 years". That announcement, by the chief executive of the Sweet creature of bombast: is Sir John writing press releases for the NIHR? National Institute of Health Research's Clinical Research Network, was quickly and uncritically picked up by the media. That immediately caught my attention. In large, global trials, most pharmaceutical companies I've worked with can do a reasonable job of predicting accrual levels in a given country. I like to think that if participation rates in any given country had jumped that heavily, I’d have heard something. (To give an example: looking at a quite-typical study I worked on a few years ago: UK sites were overall slightly below the global average. The highest-enrolling countries were about 2.5 times as fast. So, a 3-fold increase in accruals would have catapulted the UK from below average to the fastest-enrolling country in the world.) Further inquiry, however, failed to turn up any evidence that the reported tripling actually corresponded to more human beings enrolled in clinical trials. Instead, there is some reason to believe that all we witnessed was increased reporting of trial participation numbers. Now we have a new source of wonder, and a new giant multiplier coming out of the UK. As the Director of the NIHR's Mental Health Research Network, Til Wykes, put it in her blog coverage of her own paper: Our research on the largest database of UK mental health studies shows that involving just one or two patients in the study team means studies are 4 times more likely to recruit successfully. Again, amazing! And not just a tripling – a quadrupling! Understand: I spend a lot of my time trying to convince study teams to take a more patient-focused approach to clinical trial design and execution. I desperately want to believe this study, and I would love having hard evidence to bring to my clients. At first glance, the data set seems robust. From the King's College press release: Published in the British Journal of Psychiatry, the researchers analysed 374 studies registered with the Mental Health Research Network (MHRN). Studies which included collaboration with service users in designing or running the trial were 1.63 times more likely to recruit to target than studies which only consulted service users. Studies which involved more partnerships - a higher level of Patient and Public Involvement (PPI) - were 4.12 times more likely to recruit to target. But here the first crack appears. It's clear from the paper that the analysis of recruitment success was not based on 374 studies, but rather a much smaller subset of 124 studies. That's not mentioned in either of the above-linked articles. And at this point, we have to stop, set aside our enthusiasm, and read the full paper. And at this point, critical doubts begin to spring up, pretty much everywhere. First and foremost: I don’t know any nice way to say this, but the "4 times more likely" line is, quite clearly, a fiction. What is reported in the paper is a 4.12 odds ratio between "low involvement" studies and "high involvement" studies (more on those terms in just a bit). Odds ratios are often used in reporting differences between groups, but they are unequivocally not the same as "times more likely than". This is not a technical statistical quibble. The authors unfortunately don’t provide the actual success rates for different kinds of studies, but here is a quick example that, given other data they present, is probably reasonably close: A Studies: 16 successful out of 20 Probability of success: 80% Odds of success: 4 to 1 B Studies: 40 successful out of 80 Probability of success: 50% Odds of success: 1 to 1 From the above, it’s reasonable to conclude that A studies are 60% more likely to be successful than B studies (the A studies are 1.6 times as likely to succeed). However, the odds ratio is 4.0, similar to the difference in the paper. It makes no sense to say that A studies are 4 times more likely to succeed than B studies. This is elementary stuff. I’m confident that everyone involved in the conduct and analysis of the MHRN paper knows this already. So why would Dr Wykes write this? I don’t know; it's baffling. Maybe someone with more knowledge of the politics of British medicine can enlighten me. If a pharmaceutical company had promoted a drug with this math, the warning letters and fines would be flying in the door fast. And rightly so. But if a government leader says it, it just gets recycled verbatim. The other part of Dr Wykes's statement is almost equally confusing. She claims that the enrollment benefit occurs when "involving just one or two patients in the study team". However, involving one or two patients would seem to correspond to either the lowest ("patient consultation") or the middle level of reported patient involvement (“researcher initiated collaboration”). In fact, the "high involvement" categories that are supposed to be associated with enrollment success are studies that were either fully designed by patients, or were initiated by patients and researchers equally. So, if there is truly a causal relationship at work here, improving enrollment would not be merely a function of adding a patient or two to the conversation. There are a number of other frustrating aspects of this study as well. It doesn't actually measure patient involvement in any specific research program, but uses just 3 broad categories (that the researchers specified at the beginning of each study). It uses an arbitrary and undocumented 17-point scale to measure "study complexity", which collapses and quite likely underweights many critical factors into a single number. The enrollment analysis excluded 11 studies because they weren't adequate for a factor that was later deemed non-significant. And probably the most frustrating facet of the paper is that the authors share absolutely no descriptive data about the studies involved in the enrollment analysis. It would be completely impossible to attempt to replicate its methods or verify its analysis. Do the authors believe that "Public Involvement" is only good when it’s not focused on their own work? However, my feelings about the study and paper are an insignificant fraction of the frustration I feel about the public portrayal of the data by people who should clearly know better. After all, limited evidence is still evidence, and every study can add something to our knowledge. But the public misrepresentation of the evidence by leaders in the area can only do us harm: it has the potential to actively distort research priorities and funding. Why This Matters We all seem to agree that research is too slow. Low clinical trial enrollment wastes time, money, and the health of patients who need better treatment options. However, what's also clear is that we lack reliable evidence on what activities enable us to accelerate the pace of enrollment without sacrificing quality. If we are serious about improving clinical trial accrual, we owe it to our patients to demand robust evidence for what works and what doesn’t. Relying on weak evidence that we've already solved the problem ("we've tripled enrollment!") or have a method to magically solve it ("PPI quadrupled enrollment!") will cause us to divert significant time, energy, and human health into areas that are politically favored but less than certain to produce benefit. And the overhyping those results by research leadership compounds that problem substantially. NIHR leadership should reconsider its approach to public discussion of its research, and practice what it preaches: critical assessment of the data. [Update Sept. 20: The authors of the study have posted a lengthy comment below. My follow-up is here.] [Image via flikr user Elliot Brown.] Ennis L, & Wykes T (2013). Impact of patient involvement in mental health research: longitudinal study. The British journal of psychiatry : the journal of mental science PMID: 24029538 Full Article NIHR patient recruitment trial delays UK trials
ath Questionable Enrollment Math(s) - the Authors Respond By www.placebocontrol.com Published On :: Fri, 20 Sep 2013 04:09:00 +0000 The authors of the study I blogged about on Monday were kind enough to post a lengthy comment, responding in part to some of the issues I raised. I thought their response was interesting, and so reprint it in its entirety below, interjecting my own reactions as well. There were a number of points you made in your blog and the title of questionable maths was what caught our eye and so we reply on facts and provide context. Firstly, this is a UK study where the vast majority of UK clinical trials take place in the NHS. It is about patient involvement in mental health studies - an area where recruitment is difficult because of stigma and discrimination. I agree, in hindsight, that I should have titled the piece “questionable maths” rather than my Americanized “questionable math”. Otherwise, I think this is fine, although I’m not sure that anything here differs from my post. 1. Tripling of studies - You dispute NIHR figures recorded on a national database and support your claim with a lone anecdote - hardly data that provides confidence. The reason we can improve recruitment is that NIHR has a Clinical Research Network which provides extra staff, within the NHS, to support high quality clinical studies and has improved recruitment success. To be clear, I did not “dispute” the figures so much as I expressed sincere doubt that those figures correspond with an actual increase in actual patients consenting to participate in actual UK studies. The anecdote explains why I am skeptical – it's a bit like I've been told there was a magnitude 8 earthquake in Chicago, but neither I nor any of my neighbors felt anything. There are many reasons why reported numbers can increase in the absence of an actual increase. It’s worth noting that my lack of confidence in the NIHR's claims appears to be shared by the 2 UK-based experts quoted by Applied Clinical Trials in the article I linked to. 2. Large database: We have the largest database of detailed study information and patient involvement data - I have trawled the world for a bigger one and NIMH say there certainly isn't one in the USA. This means few places where patient impact can actually be measured 3. Number of studies: The database has 374 studies which showed among other results that service user involvement increased over time probably following changes by funders e.g. NIHR requests information in the grant proposal on how service users have been and will be involved - one of the few national funders to take this issue seriously. As far as I can tell, neither of these points is in dispute. 4. Analysis of patient involvement involves the 124 studies that have completed. You cannot analyse recruitment success unless then. I agree you cannot analyze recruitment success in studies that have not yet completed. My objection is that in both the KCL press release and the NIHR-authored Guardian article, the only number mentioned in 374, and references to the recruitment success findings came immediately after references to that number. For example: Published in the British Journal of Psychiatry, the researchers analysed 374 studies registered with the Mental Health Research Network (MHRN). Studies which included collaboration with service users in designing or running the trial were 1.63 times more likely to recruit to target than studies which only consulted service users. Studies which involved more partnerships - a higher level of Patient and Public Involvement (PPI) - were 4.12 times more likely to recruit to target. The above quote clearly implies that the recruitment conclusions were based on an analysis of 374 studies – a sample 3 times larger than the sample actually used. I find this disheartening. The complexity measure was developed following a Delphi exercise with clinicians, clinical academics and study delivery staff to include variables likely to be barriers to recruitment. It predicts delivery difficulty (meeting recruitment & delivery staff time). But of course you know all that as it was in the paper. Yes, I did know this, and yes, I know it because it was in the paper. In fact, that’s all I know about this measure, which is what led me to characterize it as “arbitrary and undocumented”. To believe that all aspects of protocol complexity that might negatively affect enrollment have been adequately captured and weighted in a single 17-point scale requires a leap of faith that I am not, at the moment, able to make. The extraordinary claim that all complexity issues have been accounted for in this model requires extraordinary evidence, and “we conducted a Delphi exercise” does not suffice. 6. All studies funded by NIHR partners were included – we only excluded studies funded without peer review, not won competitively. For the involvement analysis we excluded industry studies because of not being able to contact end users and where inclusion compromised our analysis reliability due to small group sizes. It’s only that last bit I was concerned about. Specifically, the 11 studies that were excluded due to being in “clinical groups” that were too small, despite the fact that “clinical groups” appear to have been excluded as non-significant from the final model of recruitment success. (Also: am I being whooshed here? In a discussion of "questionable math" the authors' enumeration goes from 4 to 6. I’m going to take the miscounting here as a sly attempt to see if I’m paying attention...) I am sure you are aware of the high standing of the journal and its robust peer review. We understand that our results must withstand the scrutiny of other scientists but many of your comments were unwarranted. This is the first in the world to investigate patient involvement impact. No other databases apart from the one held by the NIHR Mental Health Research Network is available to test – we only wish they were. I hope we can agree that peer review – no matter how "high standing" the journal – is not a shield against concern and criticism. Despite the length of your response, I’m still at a loss as to which of my comments specifically were unwarranted. In fact, I feel that I noted very clearly that my concerns about the study’s limitations were minuscule compared to my concerns about the extremely inaccurate way that the study has been publicized by the authors, KCL, and the NIHR. Even if I conceded every possible criticism of the study itself, there remains the fact that in public statements, you Misstated an odds ratio of 4 as “4 times more likely to” Overstated the recruitment success findings as being based on a sample 3 times larger than it actually was Re-interpreted, without reservation, a statistical association as a causal relationship Misstated the difference between the patient involvement categories as being a matter of merely “involving just one or two patients in the study team” And you did these consistently and repeatedly – in Dr Wykes's blog post, in the KCL press release, and in the NIHR-written Guardian article. To use the analogy from my previous post: if a pharmaceutical company had committed these acts in public statements about a new drug, public criticism would have been loud and swift. Your comment on the media coverage of odds ratios is an issue that scientists need to overcome (there is even a section in Wikipedia). It's highly unfair to blame "media coverage" for the use of an odds ratio as if it were a relative risk ratio. In fact, the first instance of "4 times more likely" appears in Dr Wykes's own blog post. It's repeated in the KCL press release, so you yourselves appear to have been the source of the error. You point out the base rate issue but of course in a logistic regression you also take into account all the other variables that may impinge on the outcome prior to assessing the effects of our key variable patient involvement - as we did – and showed that the odds ratio is 4.12 - So no dispute about that. We have followed up our analysis to produce a statement that the public will understand. Using the following equations: Model predicted recruitment lowest level of involvement exp(2.489-.193*8.8-1.477)/(1+exp(2.489-.193*8.8-1.477))=0.33 Model predicted recruitment highest level of involvement exp(2.489-.193*8.8-1.477+1.415)/(1+exp(2.489-.193*8.8-1.477+1.415)=0.67 For a study of typical complexity without a follow up increasing involvement from the lowest to the highest levels increased recruitment from 33% to 66% i.e. a doubling. So then, you agree that your prior use of “4 times more likely” was not true? Would you be willing to concede that in more or less direct English? This is important and is the first time that impact has been shown for patient involvement on the study success. Luckily in the UK we have a network that now supports clinicians to be involved and a system for ensuring study feasibility. The addition of patient involvement is the additional bonus that allows recruitment to increase over time and so cutting down the time for treatments to get to patients. No, and no again. This study shows an association in a model. The gap between that and a causal relationship is far too vast to gloss over in this manner. In summary, I thank the authors for taking the time to response, but I feel they've overreacted to my concerns about the study, and seriously underreacted to my more important concerns about their public overhyping of the study. I believe this study provides useful, though limited, data about the potential relationship between patient engagement and enrollment success. On the other hand, I believe the public positioning of the study by its authors and their institutions has been exaggerated and distorted in clearly unacceptable ways. I would ask the authors to seriously consider issuing public corrections on the 4 points listed above. Full Article NIHR patient recruitment trial delays UK trials
ath Bath Engineers Bet on Dirt for Micropower By spectrum.ieee.org Published On :: Tue, 25 Jun 2024 21:52:30 +0000 A thimbleful of soil can contain a universe of microorganisms, up to 10 billion by some estimates. Now a group of researchers in Bath, United Kingdom, are building prototype technologies that harvest electrons exhaled by some micro-species. The idea is to power up low-yield sensors and switches, and perhaps help farmers digitally optimize crop yields to meet increasing demand and more and more stressful growing conditions. There could be other tasks, too, that might make use of a plant-and-forget, low-yield power source—such as monitoring canals for illegal waste dumping.The research started small, based out of the University of Bath, with field-testing in a Brazilian primary school classroom and a green pond near it—just before the onset of the pandemic.“We had no idea what the surroundings would be. We just packed the equipment we needed and went,” says Jakub Dziegielowski, a University of Bath, U.K. chemical engineering Ph.D. student. “And the pond was right by the school—it was definitely polluted, very green, with living creatures in it, and definitely not something I’d feel comfortable drinking from. So it got the job done.”The experiments they did along with kids from the school and Brazilian researchers that summer of 2019 were aimed at running water purifiers. It did so. However, it also wasn’t very efficient, compared to, say, a solar panel. So work has moved on in the Bath labs: in the next weeks, Dziegielowski will both turn 29 and graduate with his doctorate. And he, along with two other University of Bath advisors and colleagues recently launched a spinoff company—it’s called Bactery—to perfect a prototype for a network of soil microbial fuel cells for use in agriculture. A microbial fuel cell is a kind of power plant that converts chemical energy stored in organic molecules into electrical energy, using microbes as a catalyst. It’s more often used to refer to liquid-based systems, Dziegielowski says. Organics from wastewater serve as the energy source, and the liquid stream mixes past the electrodes.A soil microbial fuel cell, however, has one of its electrodes—the anode, which absorbs electrons—in the dirt. The other electrode, the cathode, is exposed to air. Batteries work because ions move through an electrolyte between electrodes to complete a circuit. In this case, the soil itself acts as the electrolyte—as well as source of the catalytic microbes, and as the source of the fuel. The Bath, U.K.-based startup Bactery has developed a set up fuel cells powered by microbes in the soil—with, in the prototype pictured here, graphite mats as electrodes. University of BathFields full of WattsIn a primary school in the fishing village of Icapuí on Brazil’s semi-arid northeastern coast, the group made use of basic components: graphite felt mats acting as electrodes, and nylon pegs to maintain spacing and alignment between them. (Bactery is now developing new kinds of casing.)By setting up the cells in a parallel matrix, the Icapuí setup could generate 38 milliwatts per square meter. In work since, the Bath group’s been able to reach 200 milliwatts per square meter.Electroactive bacteria—also called exoelectrogens or electricigens—take in soluble iron or acids or sugar and exhale electrons. There are dozens of species of microbes that can do this, including bacteria belonging to genera such as Geobacter and Shewanella. There are many others.But 200 milliwatts per square meter is not a lot of juice: enough to charge a mobile phone, maybe, or keep an LED nightlight going—or, perhaps, serve as a power source for sensors or irrigation switches. “As in so many things, it comes down to the economics,” says Bruce Logan, an environmental engineer at Penn State who wrote a 2007 book, Microbial Fuel Cells. A decade ago Palo Alto engineers launched the MudWatt, a self-contained kit that could light a small LED. It’s mostly marketed as a school science project. But even now, some 760 million people do not have reliable access to electricity. “In remote areas, soil microbial fuel cells with higher conversion and power management efficiencies would fare better than batteries,” says Sheela Berchmans, a retired chief scientist of the Central Electrochemical Research Institute in Tamil Nadu, India.Korneel Rabaey, professor in the department of biotechnology at the University of Ghent, in Belgium, says electrochemical micro-power sources—a category that now includes the Bactery battery—is gaining buzz in resource recovery, for uses such as extracting pollutants from wastewater, with electricity as a byproduct. “You can think of many applications that don’t require a lot of power,” he says, “But where sensors are important.” Full Article Microbial fuel cells Soil microbial fuel Bioelectronics Renewables Renewable energy Micropower
ath Thai drama under fire for drugging cat for real in death scene, allegedly causing it seizures By www.asiaone.com Published On :: Tue, 12 Nov 2024 17:56:00 +0800 The quest for realism in Thai drama The Empress of Ayodhaya went too far when a cat was reportedly drugged in a poisoning scene. In episode five of the show, the character Indravedi (Fern Nopjira Lerkkajornnamkul) suspects her drink has been drugged, so she asks nanny Thongdee (Ja Molywon Phantara) to test it out on the black feline. The cat can be seen convulsing and retching, and the camera moves to show Indravedi looking concerned, while Thongdee declares that it is dead. The scene caused public outrage with fears that the cat had actually been killed, and calls to ban the period drama were trending on X. On Nov 7, a now-deleted X account reportedly belonging to Ja posted: "The cat didn't actually die. We put it under anaesthesia, but while filming, the cat retched and seized." She and Fern initially thought the cat had actually died while filming and their faces "turned pale", she added. Full Article