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X-ray photoelectron spectroscopy of piperdinium ionic liquids: A comparison to the charge delocalised pyridinium analogues

Phys. Chem. Chem. Phys., 2020, Accepted Manuscript
DOI: 10.1039/D0CP01454K, Paper
Shuang Men, Peter Licence, Chi-Linh Do-Thanh, Huimin Luo, Sheng Dai
In this study, nine piperidinium-based ionic liquids are analysed by X-ray photoelectron spectroscopy. The effect of alkyl substituent length and the nature of the anion on the electronic environment of...
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Kinetics of 1H-13C multiple-contact cross-polarization as a powerful tool to determine the structure and dynamics of complex materials : application to graphene oxide

Phys. Chem. Chem. Phys., 2020, Accepted Manuscript
DOI: 10.1039/D0CP00454E, Paper
Jesus Raya, Alberto Bianco, Jerome Hirschinger
Hartmann-Hahn cross-polarization (HHCP) is the most widely used solid-state NMR technique to enhance the magnetization of dilute spins from abundant spins. Furthermore, as the kinetics of CP depends on dipolar...
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Dynamical Signatures from Competing, Nonadiabatic Fragmentation Pathways of S-Nitrosothiophenol

Phys. Chem. Chem. Phys., 2020, Accepted Manuscript
DOI: 10.1039/D0CP00941E, Paper
K. Jacob Blackshaw, Marcus Marracci, Robert T. Korb, Naa-Kwarley Quartey, Annalise K. Ajmani, David J. Hood, Christopher J Abelt, Belinda Ortega, Kate Luong, Andrew S. Petit, Nathanael M Kidwell
S-Nitrosothiols (RSNOs) are derived from the combination of sulfur and nitric oxide (NO) radicals in the Earth’s atmosphere and fragment to products following photolysis. Extensive theoretical studies have focused on...
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The importance of the composite mechanisms with two transition states in the F- + NH2I SN2 reaction

Phys. Chem. Chem. Phys., 2020, Accepted Manuscript
DOI: 10.1039/D0CP01942A, Communication
Yan Li, Yongfang Li, Dunyou Wang
The dynamics of the bimolecular nucleophilic substitution (SN2) reactions at nitrogen are less understood than their corresponding reactions at carbon. In this paper, we report an ab initio molecular dynamics...
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[ASAP] Isolation of Elusive Electrophilic Phosphinidene Complexes with p-Donor N-Heterocyclic Vinyl Substituents

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00176




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[ASAP] Asymmetric Synthesis of a Bacteriochlorophyll Model Compound Containing <italic toggle="yes">trans</italic>-Dialkyl Substituents in Ring D

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00608




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[ASAP] Chiral Vanadyl(V) Complexes Enable Efficient Asymmetric Reduction of ß-Ketoamides: Application toward (<italic toggle="yes">S</italic>)-Duloxetine

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00221




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[ASAP] Quantitative Kinetic Modeling in Photoresponsive Supramolecular Chemistry: The Case of Water-Soluble Azobenzene/Cyclodextrin Complexes

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00461




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[ASAP] One-Pot Multicomponent Reaction of Catechols, Ammonium Acetate, and Aldehydes for the Synthesis of Benzoxazole Derivatives Using the Fe(III)–Salen Complex

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00560




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[ASAP] Synthesis of Indolizine Derivatives Triggered by the Oxidative Addition of Aroyl Chloride to Pd(0) Complex

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00161




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Highly sensitive endotoxin detection using a gold nanoparticle loaded layered molybdenum disulfide-polyacrylic acid nanocomposite

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00567C, Paper
Biyas Posha, N. Sandhyarani
A highly sensitive and selective endotoxin sensor is developed with a Au nanoparticle anchored MoS2-PAA nanocomposite.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Electrochemical biosensing platforms on the basis of reduced graphene oxide and its composites with Au nanodots

Analyst, 2020, Advance Article
DOI: 10.1039/C9AN02592H, Paper
Liang Mei, Qingyong Zhang, Min Du, Zhiyuan Zeng
rGO and AuNDs-rGO, synthesized by a simple photochemical reduction method, are used for electrochemical biosensors and show good glucose detection.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Combined Raman and AFM detection of changes in HeLa cervical cancer cells induced by CeO2 nanoparticles – molecular and morphological perspectives

Analyst, 2020, Advance Article
DOI: 10.1039/C9AN02518A, Paper
Mirjana Miletić, Sonja Aškrabić, Jan Rüger, Borislav Vasić, Lela Korićanac, Abdullah Saif Mondol, Jan Dellith, Jürgen Popp, Iwan W. Schie, Zorana Dohčević-Mitrović
Raman and AFM analyses represent a tool for the evaluation of cytotoxic and anti-proliferative effects in cells induced by CeO2 nanoparticles.
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Rapid and sensitive detection of NGAL for the prediction of acute kidney injury via a polydopamine nanosphere/aptamer nanocomplex coupled with DNase I-assisted recycling amplification

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00474J, Paper
Yiting Hu, Xie-an Yu, Ying Zhang, Ran Zhang, Xuefei Bai, Mi Lu, Jiwei Li, Lifei Gu, Ji-Hua Liu, Bo-Yang Yu, Jiangwei Tian
A rapid and sensitive method for NGAL detection has been developed to predict acute kidney injury and evaluate the protective effect of drug on renal disease.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Changes in latent fingermark glyceride composition as a function of sample age using UPLC-IMS-QToF-MSE

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00379D, Paper
Amanda Frick, Natalie Kummer, Ana Moraleda, Celine Weyermann
The composition of fingermark residue has been an important topic in forensic science, mainly in efforts to better understand and eventually improve the efficacy of latent fingermark detection methods. While...
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A traceless clean-up method coupled with gas chromatography and mass spectrometry for analyzing polycyclic aromatic hydrocarbons in complex plant leaf matrices

Analyst, 2020, 145,3266-3273
DOI: 10.1039/D0AN00128G, Paper
Xiangzi Jin, Han Yeong Kaw, Huijie Li, Zhao Wang, Jinhua Zhao, Xiangfan Piao, Donghao Li, Dongri Jin, Miao He
This study developed a traceless clean-up method by combining solid phase extraction (SPE) with gas purge–microsyringe extraction (GP–MSE) to purify sample extracts for the determination of polycyclic aromatic hydrocarbons (PAHs) in plant leaves.
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Highly sensitive and selective optosensing of quercetin based on novel complexation with yttrium ions

Analyst, 2020, 145,3376-3384
DOI: 10.1039/D0AN00117A, Paper
Nguyen Ngoc Nghia, Bui The Huy, Yong-Ill Lee
A simple and fast method was developed for the determination of quercetin using a Arduino-based portable device.
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Novel ratiometric electrochemical sensor for no-wash detection of fluorene-9-bisphenol based on combining CoN nanoarrays with molecularly imprinted polymers

Analyst, 2020, 145,3320-3328
DOI: 10.1039/D0AN00345J, Paper
Zhaoyi Liu, Yong Zhang, Bing Li, Xiang Ren, Hongmin Ma, Qin Wei
A ratiometric molecularly imprinted polymers electrochemical sensor was fabricated based on the direct electrochemical oxidation of BHPF on CoN nanoarray electrode.
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Synthesis of a manganese dioxide nanorod-anchored graphene oxide composite for highly sensitive electrochemical sensing of dopamine

Analyst, 2020, 145,3283-3288
DOI: 10.1039/D0AN00348D, Paper
Juan Li, Huifang Shen, Suhua Yu, Geshan Zhang, Chuanli Ren, Xiaoya Hu, Zhanjun Yang
A novel manganese dioxide nanorod-anchored graphene oxide (MnO2 NRs/GO) composite was synthesized by a simple hydrothermal method for the development of a highly sensitive electrochemical sensor for dopamine.
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An electrochemical biosensor based on methylene blue-loaded nanocomposites as signal-amplifying tags to detect pathogenic bacteria

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00470G, Paper
Shengjun Bu, Kuiyu Wang, Zhongyi Li, Chengyu Wang, Zhuo Hao, Wensen Liu, Jiayu Wan
Synthesis of new methylene blue–magainin I organic–inorganic nanocomposites as electrochemical signal labels for the detection of bacteria.
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Naked-Eye Sensing of Phytic Acid at Sub-Nanomolar Level in 100% Water Medium by Charge Transfer Complex Derived from off-the-shelf Ingredients

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00671H, Paper
Nilanjan Dey
Naked-eye sensing of phytic acid, one of the most abundant antinutrients, was achieved in 100% water medium using charge transfer complex, comprised of pyranine and methyl viologen. Since both the...
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Biocompatible Alkyne arms containing Schiff base Fluorescence Indicator for Duel detection of CdII and PbII at Physiological pH and its Application to Live Cell Imaging

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00862A, Paper
Jebastin Andrews S.G, Benita Jeba Silviya S, Jeyanthi Dharmaraj, Winfred Jebaraj J, Sathya Devi E, C. Balakrishnan
An alkyne arms containing salen-type Schiff base ligand, 6,6'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(3-(prop-2-yn-1-yloxy)phenol) (H2L), is reported here as a dual chemosensor for CdII and PbII ions. The ligand, H2L was characterized by various spectral...
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Rapid on-site and naked-eye detection of common nitro pesticides with ionic liquids

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00452A, Paper
Kovida, Vikas Sharma, Apurba Lal Koner
Rapid ‘in-field’ detection of environmentally hazardous organophosphorus and nitro-containing pesticides is highly essential due to the lethal effects caused by the inhibition of the activity of acetylcholinesterase (AChE).
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[ASAP] A Coculture Based Tyrosine-Tyrosinase Electrochemical Gene Circuit for Connecting Cellular Communication with Electronic Networks

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00469




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[ASAP] Blue-Light-Switchable Bacterial Cell–Cell Adhesions Enable the Control of Multicellular Bacterial Communities

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00054




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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00216




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[ASAP] Determinants for Efficient Editing with Cas9-Mediated Recombineering in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00440




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[ASAP] Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00028




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[ASAP] Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00038




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[ASAP] Molecule Property Analyses of Active Compounds for <italic toggle="yes">Mycobacterium tuberculosis</italic>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02075




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[ASAP] Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02164




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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00641




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[ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02161




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[ASAP] Molecular Interactions of Pyrazine-Based Compounds to Proteins

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02021




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[ASAP] Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources<subtitle>Miniperspective</subtitle>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02126




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[ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00339




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[ASAP] Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to <italic toggle="yes">In Vivo</italic> Studies

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00431




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[ASAP] Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00664




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[ASAP] Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00041




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[ASAP] Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00076




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[ASAP] Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00594




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[ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00129




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[ASAP] Complete Regression of Carcinoma via Combined C-RAF and EGFR Targeted Therapy

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00159




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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00206




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[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00192




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Nesting Components

Using CSS components is somewhat straightforward. We add the markup and give it the component’s class name and all is good. Where it gets trickier is when we try to nest components. And when they need to be tweaked based on the context. Where should the styles be defined? It’s a question I’ve been asking myself a few times and what this article is trying to explore.

Just to clarify before we start, with “CSS components”, I mean the small building blocks that get used to assemble a website or app. Like buttons, inputs, navs, headers etc. Some also call them modules or patterns. Also I’m using the SUIT naming convention in the examples below, but any other convention would be fine as well. And just a heads, there isn’t some awesome solution at the end that solves all the problems. It’s just me whining most of the time.

Ok, best is to go straight into it and look at an example. Let’s say we have a Header component where we would like to add a Button component inside.

<header class=“Header”>
  <button class=“Button”>Button</button>
</header>

Now because the Button is inside the Header, we want to make the Button a bit smaller than it would be on its own.

Here a few approaches how to do that:

Option 1 - Descendant selector

Maybe the most common way is to use a descendant selector to change the font-size whenever a Button is inside a Header.

.Header .Button {
  font-size: .75em;
}

This works great but the question is, where should this rule be added? We probably split our components into separate files, so is it in header.scss or in button.scss? In other words, should the Header know about what other components might get nested or should the Button know in what environment it will get placed?

But wait, the point of creating components is to separate them, make them modular. Each component should be kept isolated and shouldn’t know about other components. So we can make changes, rename or remove them without having to check if they might get used somewhere else.

Option 2 - Variations

Another way is to create variations. We add a .Button--small class that we can use whenever we would like the button to be smaller without having to worry about ancestors.

.Button--small {
  font-size: .75em;
}
<header class=“Header”>
  <button class=“Button Button--small>Button</button>
</header>

This works great too, but could get out of hand quickly. What do you do if at some point you want the font-size to be .9em? Create yet another variation? Button--justALittleSmaller. As the project keeps growing, the number of variations will too. We will start to loose sight where they actually get used and we’re not sure anymore if we can change a variation or if it will have side effects in some other place. We could create “contextual” variations like Button--header or Button--footer, but then we’re back at the beginning and could just as well use “descendant selectors”.

Same goes for using states. .Button.is-small should only be used if there is a change in state and not to fit a certain context.

Option 3 - Adopted Child

I can’t remember where I read about this approach but somehow it stuck with me. I also forgot how it was called. So for now I’ll just call it “Adopted Child”.

Let’s switch it around and look at it from the Header’s perspective. What would we do if we wouldn’t know what the components are called that might get nested? But we know that we want to make them a bit smaller. Well, we probably would create a generic .Header-item class and use it like this:

.Header-item {
  font-size: .75em;
}
<header class=“Header”>
  <div class=“Header-item”></div>
</header>

Ok, that gets us a bit closer. Now, it’s probably strange saying it like that when talking about CSS, but what would we do if we don’t want to create an own child, but still have one. Right, we could adopt one. In our example we adopt a Button component as our own child. We didn’t create it, but now we can tweak.. erm.. I mean “raise” it like it’s our own:

// born in button.scss
.Button {
  font-size: 1em;
}

// raised in header.css
.Header .Header-item {
  font-size: .75em;
}
<header class=“Header”>
  <button class=“Header-item Button>Button</button>
</header>

It is a bit uncommon that the same HTML element shares classes from two different components. And it’s not without any risks. More about them later. But I really like this approach because it keeps the components independent without having to know about each other.

Another nice thing is that if we want to add other components to the Header that also need the same adjustments, we can reuse the same Header-item class, like for example on a text Input.

<header class=“Header”>
	<input class=“Header-item Input>
  <button class=“Header-item Button>Button</button>
</header>

Ok, about those risks. Well, depending on what properties we wanna change, it might not always be ideal. For example, because the Button already had font-size defined, we had to increase specificity by using .Header .Header-item. But that would also override variations like .Button--small. That might be how we want it, but there are also situations where we’d like the variation to always be “stronger”. An example would be when changing colors. When the color of Buttons should be different inside a Header, but not when its a variation, like .Button—primary. Yeah, we could take a look inside button.scss or our style-guide, but remember our goal.. we actually don’t want to make decisions by looking how other components are made.

So, as a general rule, don’t use “adopted children” for any properties that are theme related and only where you can be sure that you want to override them all the time. Like for layout/size related properties or adjusting the position.

More options?

There are some more ways to do contextual styling that came to mind. I’ll just mention them briefly for completeness, but think the 3 above are better suited.

Option 4 - We could use a preprocessor to extend an existing component. In our example it would be a clone of the Button with some tweaks added and used as a new child component .Header-button. Now we only rely that the Button exists in the source, but don’t have to worry about other contexts. Downside is inflating our CSS output. As well as having to remember lots of new child component classes.

Option 5 - We could create a utility class like .u-small. It’s similar to variations, but not scoped to a single component and could be used for other components as well. And for that reason it becomes very risky to ever change later.

Option 6 - And of course, we could use inline styles. But I would leave that to JavaScript only.


So after all that, which is best? I’m afraid there isn’t a clear winner. It would be nice to keep it consistent with a single approach throughout the entire project, but I guess we just have to decide on a per case basis:

  1. Descendant selectors if we can expect that components don’t change much. Like when using a UI Kit or library.
  2. Variations if it makes sense that a component has different versions that get reused anyways, and not just for a specific context.
  3. Adopted Child for layout, sizing, positioning or where we are sure to always want to override a property. Also for changing multiple child components at once.
  4. Extending when we truly want the components to be separated and don’t mind inflating the CSS output.
  5. Utilities for very specific things, that once the class is defined, it will never change, like clearing floats.
  6. Inline styles if it needs to be dynamically added with JavaScript.

As said at the beginning, I haven’t found a “fits all” solution and maybe the conclusion is: Try to keep contextual styling to a minimum.

Updates

The “Adopted Child” approach is called “Mixes” in BEM. Here some more infos.


SUIT also recommends using “Adopted Child/Mixes”. But also another option:

Option 7 - Adding a wrapper element. It’s the <div class="Excerpt-wrapButton"> in that example. I think it works great in most cases. But for example when using Flexbox, because it has this parent/child relationship, adding an extra wrapper in between would break it. And then you might still need to set the width of the wrapped component to 100% or so. Anyways, this is a great addition. Thanks Pablo in the comments.


Option 8 - Single Purpose Classes. It’s where every class has only a single property. It’s somewhere between utilities (Option 5) and inline styles (Option 6). Atomic CSS and Tachyons use this approach. I haven’t used them on a real project, but just from looking at it, the concerns are similar to the ones from utilities. If you want to change the value in a SP class, it seems unpredictable. Because in another place (where that same class is used), you might want to keep the current value. So you would have to first check if the change has any unwanted effects somewhere else.




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Art for people's sake: artists and community in Black Chicago, 1965-1975 / Rebecca Zorach

Rotch Library - NX512.3.A35 Z67 2019




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The stronger we become: the South African pavilion / Dineo Seshee Bopape, Tracey Rose, Mawande Ka Zenzile ; curated by Nkule Mabaso, Nomusa Makhubu

Rotch Library - N6488.I8 V433 2019 S6




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Art beyond borders: artistic exchange in communist Europe (1945-1989) / edited by Jérôme Bazin, Pascal Dubourg Glatigny, and Piotr Piotrowski

Online Resource




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Comradely objects: design and material culture in Soviet Russia, 1960s-1980s / Yulia Karpova

Rotch Library - N6988.K37 2020