An NCI clinical trial finds the drug selumetinib improves outcomes for children with neurofibromatosis type 1 (NF1), shrinking inoperable tumors called plexiform neurofibromas, reducing pain, and improving function and overall quality of life.

In a new study, higher daily step counts were associated with lower mortality risk from all causes. Researchers found that the number of steps taken each day, but not the intensity of the stepping, had a strong association with mortality.

The diagnosis of Katie Miller, who is married to White House immigration adviser Stephen Miller, was revealed by Mr. Trump in a meeting with Republican lawmakers.

The board of directors of the company will meet at a 15th century heritage villa in the capital city of the Italian region of Tuscany.

The company is known for innovative features such as keyless alarm system and blind spot mirror system. Its commuter models include 150cc Razor, and 125cc and 150cc Falcon, among others.

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Termite-inspired builder robots; why some mammalian cells have so many copies of their chromosomes.

Samuel Wasser discusses using genetics to track down sources of elephant ivory, Suzanne Boyce talks with Susanne Bard about why it's so hard to say the letter R, and David Grimm brings online news stories about declining devils, keeping dinos out of North America, and the tiniest flea circus. Hosted by Sarah Crespi. [Img: guido da rozze/Flickr CC BY 2.0]

Online News Editor David Grimm shares stories on how our abilities shape our minds, killing cancer cells with gold nanoparticles, and catching art forgery with cat hair.   Laura Blanton joins host Sarah Crespi to discuss how nourishing our gut microbes may prevent malnutrition. Read the related research in Science.   [Image: D. S. Wagner et al., Biomaterials, 31 (2010)]   Authors: Sarah Crespi; David Grimm

News intern Nala Rogers shares stories on mineral-mining microbes, mapping hurricane damage using social media, and the big takeaway from the latest human-versus-computer match up.   Hal Weaver joins host Sarah Crespi to discuss five papers from New Horizons Pluto flyby, including a special focus on Pluto’s smaller moons.   [Image: Saran_Poroong/iStockphoto]

Online news editor Catherine Matacic shares stories on the evolution of sign language, short conversations than can change minds on social issues, and finding the one-in-a-million people who seem to be resistant to certain genetic diseases—even if they carry genes for them.   Nuno Faria joins host Sarah Crespi to explain how genomic analysis can track Zika’s entry date into Brazil and follow its spread.     [Image: r.a. olea/Flickr]

Listen to stories on how once we lose cartilage it’s gone forever, genetically engineering a supersniffing mouse, and building an artificial animal from silicon and heart cells, with Online News Editor David Grimm.  As we learn more and more about exoplanets, we find we know less and less about what were thought of as the basics: why planets are where they are in relation to their stars and how they formed. Kevin Wagner joins host Sarah Crespi to talk about the latest unexpected exoplanet—a young jovian planet in a three-star system.  [Image: Hellerhoff/Wikipedia/CC BY-SA 3.0;Music: Jeffrey Cook]

Sarah Crespi takes a pop quiz on literal life hacking, spotting poverty from outer space, and the size of the average American vocabulary with Catherine Matacic.   From the magazine You can already buy a quantum dot television, but it’s really just the beginning of the infiltration of quantum dots into our everyday lives. Cherie Kagan is here to talk about her in depth review of the technology published in this week’s issue.   [Image: Public domain; Music: Jeffrey Cook]

 This week, we chat about cement’s shrinking carbon footprint, commuting hazards for ancient Egyptian artisans, and a new bipartisan group opposed to government-funded animal research in the United States with Online News Editor David Grimm. Plus, Science’s Alexa Billow talks to news writer Sam Kean about the kinds of data that can only be gathered at night as part of the special issue on circadian biology.  Listen to previous podcasts.  [Image: roomauction/iStockphoto; Music: Jeffrey Cook]

This week, we chat about cleaning blueberries with purple plasma, how Tibetan dogs adapted to high-altitude living, and who’s checking ocelot message boards with Online News Editor David Grimm. Plus, Science’s Alexa Billow talks to Joe Paton about how we know time flies when mice are having fun.   Listen to previous podcasts.   [Image: Joseph Sites/USDA ARS; Music: Jeffrey Cook]

This week, we chat about what it means if a monkey can learn to recognize itself in a mirror, injecting people with live malaria parasites as a vaccine strategy, and insect-inspired wind turbines with Online News Editor David Grimm. And Joleah Lamb joins Alexa Billow to discuss how seagrass can greatly reduce harmful microbes in the ocean—protecting people and corals from disease. Read the research.   Listen to previous podcasts.   [Image: peters99/iStock; Music: Jeffrey Cook]

This week, new estimates for the depths of the world’s lakes, a video game that could help kids be safer bike riders, and teaching autonomous cars to read road signs with Online News Editor David Grimm. And Ariana Orvell joins Sarah Crespi to discuss her study of how the word “you” is used when people recount meaningful experiences. Listen to previous podcasts. Download the show transcript. Transcripts courtesy of Scribie.com. [Image: VisualCommunications/iStockphoto; Music: Jeffrey Cook]

This week we have stories on blocking dangerous or annoying distractions in augmented reality, gene therapy applied with ultrasound to heal bone breaks, and giving robots geckolike gripping power with Online News Editor David Grimm. Deputy News Editor Elizabeth Culotta joins Sarah Crespi to discuss a special package on human migrations—from the ancient origins of Europeans to the restless and wandering scientists of today. Listen to previous podcasts. Download the show transcript. Transcripts courtesy of Scribie.com. [Image: Public domain; Music: Jeffrey Cook]

This week we have stories on what body cams reveal about interactions between black drivers and U.S. police officers, the world’s oldest Homo sapiens fossils, and how modern astronomers measured the mass of a star—thanks to an old tip from Einstein—with Online News Intern Ryan Cross. Sarah Crespi talks to Eyal Ben-David about a pair of selfish genes—one toxin and one antidote—that have been masquerading as essential developmental genes in a nematode worm. She asks how many more so-called “essential genes” are really just self-perpetuating freeloaders? Science Careers Editor Rachel Bernstein is also here to talk about stress and work-life balance for researchers and science students. Listen to previous podcasts. [Image: Chris Burns/Science; Music: Jeffrey Cook]

This week we hear stories on smooth sailing with giant, silolike sails, a midsized black hole that may be hiding out in the Milky Way, and new water-cooling solar panels that could cut air conditioning costs with Online News Editor David Grimm. Sarah Crespi talks to Sabrina McCormick about climate science in the U.S. courts and the growing role of the judiciary in climate science policy. Listen to previous podcasts. [Image: NASA Goddard Space Flight Center; Music: Jeffrey Cook]

This week we hear stories on the gut microbiome’s involvement in multiple sclerosis, how wildfires start—hint: It’s almost always people—and a new record in quantum computing with Online News Editor David Grimm. Andrew Wagner talks to Lulu Qian about DNA-based robots that can carry and sort cargo. Sarah Crespi goes behind the scenes with Science’s Photography Managing Editor Bill Douthitt to learn about snapping this week’s cover photo of the world’s smallest neutrino detector. Listen to previous podcasts. [Image: Curtis Perry/Flickr; Music: Jeffrey Cook]

David Grimm—online news editor for Science—talks with Sarah Crespi about a long-term project monitoring raccoon latrines in California. What influence do these wild bathrooms have on the ecosystem? Sarah also interviews Christian Jobin of the University of Florida in Gainesville about his Perspective on three papers linking the success of cancer immunotherapy with microbes in the gut—it turns out which bacteria live in a cancer patient’s intestines can predict their response to this cutting-edge cancer treatment. Read the related papers: Routy et al., Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors, Science 2018 Gopalakrishnan et al., Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients, Science 2018 Matson et al., The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients, Science 2018 aan4236 Listen to previous podcasts. [Image: cuatrok77/Flickr; Music: Jeffrey Cook]

Freelance science writer Michael Price talks with Sarah Crespi about recently revealed deliberations for a coveted mathematics prize: the Fields Medal. Unearthed letters suggest early award committees favored promise and youth over star power. Sarah also interviews Julia Dressel about her Science Advances paper on predicting recidivism—the likelihood that a criminal defendant will commit another crime. It turns out computers aren’t better than people at these types of predictions, in fact—both are correct only about 65% of the time.   Jen Golbeck interviews Paul Shapiro about his book, Clean Meat: How Growing Meat Without Animals Will Revolutionize Dinner and the World, in our monthly books segment.   Listen to previous podcasts. [Image: Greg Chiasson/Flickr; Music: Jeffrey Cook]

DNA fingerprinting has been used to link people to crimes for decades, by matching DNA from a crime scene to DNA extracted from a suspect. Now, investigators are using other parts of the genome—such as markers for hair and eye color—to help rule people in and out as suspects. Staff Writer Gretchen Vogel talks with Sarah Crespi about whether science supports this approach and how different countries are dealing with this new type of evidence. Sarah also talks with Jill Fernandes of the University of Queensland in Brisbane, Australia, about her Science Advances paper on a light-based technique for detecting Zika in mosquitoes. Instead of grinding up the bug and extracting Zika DNA, her group shines near-infrared light through the body. Mosquitoes carrying Zika transmit this light differently from uninfected ones. If it’s successful in larger trials, this technique could make large-scale surveillance of infected mosquitoes quicker and less expensive. In our monthly books segment, Jen Golbeck talks with author Sarah-Jayne Blakemore about her new work: Inventing Ourselves: The Secret Life of the Teenage Brain. You can check out more book reviews and share your thoughts on the Books et al. blog. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: National Institute of Allergy and Infectious Diseases, National Institutes of Health; Music: Jeffrey Cook]

We now live in the Meghalayan age—the last age of the Holocene epoch. Did you get the memo? A July decision by the International Commission on Stratigraphy, which is responsible for naming geological time periods, divided the Holocene into three ages: the Greenlandian, the Northgrippian, and the Meghalayan. The one we live in—the Meghalayan age (pronounced “megalion”)—is pegged to a global drought thought to have happened some 4200 years ago. But many critics question the timing of this latest age and the global expanse of the drought. Staff writer Paul Voosen talks with host Sarah Crespi about the evidence for and against the global drought—and what it means if it’s wrong. Sarah also talks to staff writer Kelly Servick about her feature story on what happens when biocontrol goes out of control. Here’s the setup: U.S. Department of Agriculture researchers wanted to know whether brown marmorated stink bugs that have invaded the United States could be controlled—aka killed—by importing their natural predators, samurai wasps, from Asia. But before they could find out, the wasps showed up anyway. Kelly discusses how using one species to combat another can go wrong—or right—and what happens when the situation outruns regulators. This week’s episode was edited by Podigy. Download a transcript of this episode (PDF) Listen to previous podcasts. [Image: Melissa McMasters/Flickr; Music: Jeffrey Cook]