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Cleveland Clinic Foundation Internal Medicine Residency Program

Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with the American College of Physicians, Inc. (ACP), and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of Clinical Diabetes. The following article describes an initiative of the Cleveland Clinic’s internal medicine residents to improve diabetes care and outcomes within an underserved patient population at an East Cleveland, OH, health center.




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Li-Fraumeni Exploration Consortium Data Coordinating Center: Building an Interactive Web-Based Resource for Collaborative International Cancer Epidemiology Research for a Rare Condition

Background:

The success of multisite collaborative research relies on effective data collection, harmonization, and aggregation strategies. Data Coordination Centers (DCC) serve to facilitate the implementation of these strategies. The utility of a DCC can be particularly relevant for research on rare diseases where collaboration from multiple sites to amass large aggregate datasets is essential. However, approaches to building a DCC have been scarcely documented.

Methods:

The Li-Fraumeni Exploration (LiFE) Consortium's DCC was created using multiple open source packages, including LAM/G Application (Linux, Apache, MySQL, Grails), Extraction-Transformation-Loading (ETL) Pentaho Data Integration Tool, and the Saiku-Mondrian client. This document serves as a resource for building a rare disease DCC for multi-institutional collaborative research.

Results:

The primary scientific and technological objective to create an online central repository into which data from all participating sites could be deposited, harmonized, aggregated, disseminated, and analyzed was completed. The cohort now include 2,193 participants from six contributing sites, including 1,354 individuals from families with a pathogenic or likely variant in TP53. Data on cancer diagnoses are also available. Challenges and lessons learned are summarized.

Conclusions:

The methods leveraged mitigate challenges associated with successfully developing a DCC's technical infrastructure, data harmonization efforts, communications, and software development and applications.

Impact:

These methods can serve as a framework in establishing other collaborative research efforts. Data from the consortium will serve as a great resource for collaborative research to improve knowledge on, and the ability to care for, individuals and families with Li-Fraumeni syndrome.




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[PERSPECTIVES] Regulating Preimplantation Genetic Testing across the World: A Comparison of International Policy and Ethical Perspectives

Preimplantation genetic testing (PGT) is a reproductive technology that, in the course of in vitro fertilization (IVF), allows prospective parents to select their future offspring based on genetic characteristics. PGT could be seen as an exercise of reproductive liberty, thus potentially raising significant socioethical and legal controversy. In this review, we examine—from a comparative perspective—variations in policy approaches to the regulation of PGT. We draw on a sample of 19 countries (Australia, Austria, Belgium, Brazil, Canada, China, France, Germany, India, Israel, Italy, Japan, Mexico, Netherlands, Singapore, South Korea, Switzerland, United Kingdom, and the United States) to provide a global landscape of the spectrum of policy and legislative approaches (e.g., restrictive to permissive, public vs. private models). We also explore central socioethical and policy issues and contentious applications, including permissibility criteria (e.g., medical necessity), nonmedical sex selection, and reproductive tourism. Finally, we further outline genetic counseling requirements across policy approaches.




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Assessment of Apparent Internal Carotid Tandem Occlusion on High-Resolution Vessel Wall Imaging: Comparison with Digital Subtraction Angiography [EXTRACRANIAL VASCULAR]

BACKGROUND AND PURPOSE:

Not all tandem occlusions diagnosed on traditional vascular imaging modalities, such as MRA, represent actual complete ICA occlusion. This study aimed to explore the utility of high-resolution vessel wall imaging in identifying true ICA tandem occlusions and screening patients for their suitability for endovascular recanalization.

MATERIALS AND METHODS:

Patients with no signal in the ICA on MRA were retrospectively reviewed. Two neuroradiologists independently reviewed their high-resolution vessel wall images to assess whether there were true tandem occlusions and categorized all cases into intracranial ICA occlusion, extracranial ICA occlusion, tandem occlusion, or near-occlusion. DSA classified patient images into the same 4 categories, which were used as the comparison with high-resolution vessel wall imaging. The suitability for recanalization of occluded vessels was evaluated on high-resolution vessel wall imaging compared with DSA.

RESULTS:

Forty-five patients with no ICA signal on MRA who had available high-resolution vessel wall imaging and DSA images were included. Among the 34 patients (34/45, 75.6%) with tandem occlusions on DSA, 18 cases also showed tandem occlusions on high-resolution vessel wall imaging. The remaining 16 patients, intracranial ICA, extracranial ICA occlusions and near-occlusions were found in 2, 6, and 8 patients, respectively, on the basis of high-resolution vessel wall imaging. A total of 20 cases (20/45, 44.4%) were considered suitable for recanalization on the basis of both DSA and high-resolution vessel wall imaging. Among the 25 patients deemed unsuitable for recanalization by DSA, 11 were deemed suitable for recanalization by high-resolution vessel wall imaging.

CONCLUSIONS:

High-resolution vessel wall imaging could allow identification of true ICA tandem occlusion in patients with an absence of signal on MRA. Findings on high-resolution vessel wall imaging can be used to screen more suitable candidates for recanalization therapy.




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UK plans to regulate the internet won't make much difference at all

The UK government has announced plans to police content on platforms like YouTube and Facebook, but it won't be able to do more than the social networks are already doing




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The coronavirus crisis could fundamentally alter the internet

The covid-19 pandemic has many of us stuck at home. The result could completely reshape how we use the internet, writes Annalee Newitz




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I help people who are addicted to the internet wean themselves off

Can you really be addicted to your smartphone? Daria Kuss has shown that it is only a problem for a small number of people - and she knows how to help




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Somebody Is Furiously Uploading '90s Windows Desktop Themes to the Internet Archive

Please, I implore you: jump on this bandwagon.




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The Internet Reacts To The Original Star Wars

Imagine an alternate universe where the Star Wars movies were released in chronological order - where Episodes I to III were the original, beloved trilogy. How would the internet have reacted to the film that followed? More »
    




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Watch Astrobee's First Autonomous Flight on the International Space Station

For the first time, NASA's Astrobee robot has demonstrated autonomous free flight in space




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Oh, Internet: Artificial Intelligence Attempts To Create Additional Lyrics To Rick Astley's 'Never Gonna Give You Up'

This is a video of the result of Youtuber Lil'Alien [Agentalex9 Alt.] feeding Rick Astley's rickrolling classic 'Never Gonna Give You Up' into the Jukebox neural network developed by OpenAI to create more song lyrics for the song. The music video consists of AI upscaled gifs from the original video. If you're really interested in the technology utilized and just what the hell is going on, there are a bunch of links on the video's Youtube page HERE. I just managed to watch the whole video and I can attest that, uh, that was really something. "Something good?" Haha, now let's not get ahead of ourselves. Keep going for whatever this is.




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Oh, Internet: Seals Perform Seal's 'Kiss From A Rose'

Because the internet never stops churning out the hits, this is a video of seals barking edited to perform a snippet of Seal's 1995 Batman Forever closing credits classic 'Kiss From A Rose'. I insisted my girlfriend watch it and she hated it. Although as a rule anything that I laugh out loud watching on my phone next to her in bed, she hates. I don't even wait for her to ask what I'm laughing at anymore because I know she doesn't want to see it. It's heartbreaking really. Great now she's glaring at me. Keep going for the video.





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International Space Station crew lands safely in Kazakhstan after more than 200 days in orbit

The crew of three returned to a planet troubled by the coronavirus pandemic Coronavirus: the symptoms Read our LIVE updates on the coronavirus here




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Is Virgin Media still down? How to check your internet connection

Millions of people had difficulty accessing the internet yesterday as Virgin Media had a series of outages across the country.




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White House's Dr Deborah Birx dazzles internet with range of scarves as Instagram account set up in honour

She's perhaps best known to the internet as the woman who wore a face of mild disbelief when US President Donald Trump discussed disinfectant as a possible treatment for coronavirus.




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No TV, no sat nav, no internet: how to fix space's junk problem – video

As Elon Musk's Starlink and Jeff Bezos's Project Kuiper race to create high-speed internet using satellites orbiting Earth, there's a small problem that could get in the way: debris. From dead spacecraft that have been around since the dawn of the space age to flecks of paint smashing windows on the International Space Station, rubbish is clogging up our orbits. And with objects moving as fast as 15,500mph (25,000 kmph), the satellite services we've come to depend on are at constant risk of collision. So how to fix the problem with junk in space? Ian Anderson investigates

Continue reading...





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Astronauts return to Earth after watching coronavirus outbreak from International Space Station

'We can tell you that the Earth still looks just as stunning as always from up here, so it's difficult to believe all the changes that have taken place since both of us have been up here,' one astronaut had said before coming back home




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Raw meat dog foods pose 'international public health risk' due to high levels of drug-resistant bacteria, scientists warn

Uncooked pet food could be source of pathogens dangerous to humans, research suggests





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What Traveling Internationally Is Like in the Age of Coronavirus

I've traveled a lot over the years, saving up all the dollars and vacation days I can manage to embark on solo adventures around the globe. Whether I've ended up road-tripping...




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Anti-Semitism campaigners accuse Jeremy Corbyn allies of 'smearing' whistleblowers as internal probe finds 'no evidence'

Jeremy Corbyn's allies have been accused of using a report to "smear whistleblowers" and "discredit allegations" of anti-Semitism in the Labour Party during his tenure.




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Theresa May hits out at world leaders for 'incoherent international response' to coronavirus pandemic

Theresa May has hit out at world leaders for failing "to forge a coherent international response" to the coronavirus pandemic.




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How VPN is Changing the Way we Use Internet




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WeChat's surveillance of international users boosts censorship in China, researchers say

WeChat is one of the world’s most popular apps, but researchers at the University of Toronto caution it is surveilling international users and using their information to broaden censorship on the app in China.



  • News/Technology & Science


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The winner announcement for the 2020 International Booker Prize has been postponed

The winner will be announced 'late summer', organisers say




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Music Canada Celebrates International Women’s Day 2020

Every year on March 8th, people around the world celebrate International Women’s Day, and at Music Canada we’re showing our commitment to gender equality by celebrating this year’s theme of #EachForEqual. The theme draws from a notion of ‘Collective Individualism,’ and the way that our individual actions can collectively make change and help create a […]

The post Music Canada Celebrates International Women’s Day 2020 appeared first on Music Canada.




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Tom Cruise to shoot movie aboard International Space Station

Tom Cruise is making the first-ever feature film to be shot in outer space.




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Norman Hunter, Leeds United legend and ex-England international, in hospital after testing positive for coronavirus

Leeds United legend and one of England's 1966 World Cup winners Norman Hunter has been admitted to hospital after testing positive for coronavirus.




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Coronavirus sport news LIVE: International Champions Cup cancelled, Kenny Dalglish tests positive for Covid-19

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.




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International football may not return until 2021, warns Fifa vice-president

International football may not be able to return until 2021 as priority is given to club fixtures, a Fifa vice-president has warned.




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Newcastle takeover by Saudi Arabian-backed consortium is 'sportswashing', says Amnesty International

Newcastle United are in danger of being used as a "PR tool" by Saudi Arabia if the club's proposed takeover goes through, according to Amnesty International UK.




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Coronavirus sport news LIVE: Premier League return plan scrutinised, international rugby faces revamp

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.




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Newcastle takeover: Amnesty International warns Premier League over Saudi Arabia-backed bid

Amnesty International has written to the Premier League saying it "risks becoming a patsy" unless it takes a serious look at Saudi Arabia's human rights record with regard to the takeover of Newcastle United.




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What Traveling Internationally Is Like in the Age of Coronavirus

I've traveled a lot over the years, saving up all the dollars and vacation days I can manage to embark on solo adventures around the globe. Whether I've ended up road-tripping...






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Google fires four for accessing internal documents. Workers say it's retaliation

Google terminated four employees for what the tech firm said were "repeated violations of our data security policies." At least one of them, Rebecca Rivers, had spoken out publicly against company initiatives including Google's past work with government agencies.




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California is rewriting the rules of the internet. Businesses are scrambling to keep up

A new law that will let you opt out of the online data economy goes into effect on Jan. 1 — assuming businesses can figure out how to make that happen in time.




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Lazarus: It's time to regulate internet service like any other utility

Telecom companies will do everything possible to protect shareholder value. That means offsetting losses in TV subscribers by increasing revenue from internet-only customers.




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Pop-up sports internship program helps ease pain for USC students

A virtual sports internship program at USC will help students this summer who had their original summer internship displaced by COVID-19.




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International research improves quality of CT scan imagery

Computerized tomography (CT) is one of the most effective medical tests for analysing the effects of many illnesses, including COVID-19. An international team has developed a new method that improves the quality of the images obtained from CT scans. The algorithm, tested on simulated data, enables them to distinguish different body's tissue types better and opens the door to lowering the doses of radiation to which patients are exposed during this type of test.




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International flights still grounded but regional and local travel allowed

International travel remains on hold for "the foreseeable future" as the Government announces plans to open up local, regional and interstate travel.




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Prime Minister rules out reopening international travel in the near future

Stage three of National Cabinet's plan for lifting restrictions includes allowing interstate travel, but Scott Morrison says that's still some time away.




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Telco customer sees internet bill more than triple during pandemic — and she's not alone

Customers who rely on cellular connections to access the internet say they're being hit with unfair overage fees when many are required to work and study from home. They want better price breaks and say promises to beef up high-speed access outside major cities haven’t resulted in action.




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What Traveling Internationally Is Like in the Age of Coronavirus

I've traveled a lot over the years, saving up all the dollars and vacation days I can manage to embark on solo adventures around the globe. Whether I've ended up road-tripping...





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Presenting the Internet of “Security” Things

A closer look at the strategic technical developments aimed at improving mobile data security and endpoint experience.

Keep on reading: Presenting the Internet of “Security” Things