When can schools use federal funds to help students with disabilities prepare for life after special education? A new resource from the federal education department offers a road map.

The resignation of the former U.S. Department of Education staffer, who has led ASCD since mid-2015, follows a long run of membership declines for the organization.

About two dozen teachers from across the country spent a week wrestling with questions about how to remember the Confederacy.

Texas has become the first state to have its "alternate assessment aligned to modified academic-achievement standards" pass the U.S. Department of Education's peer-review process.

The quinoline MK-571 is the most commonly used inhibitor of multidrug resistance protein-1 (MRP-1) but was originally developed as a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist. While studying the modulatory effect of MRP-1 on anti-hepatitis C virus (HCV) direct acting-antivirals (DAA) efficiency, we observed an unexpected anti-HCV effect of compound MK-571 alone. This anti-HCV activity was characterized in Huh7.5 cells stably harboring a subgenomic genotype 1b replicon. A dose-dependent decrease of HCV RNA levels was observed upon MK-571 administration, with an EC₅₀ of 9±0.3 μM and a maximum HCV RNA level reduction of approximatively 1 Log₁₀. MK-571 also reduced the replication of the HCV full-length J6/JFH1 model in a dose-dependent manner. However, probenecid and apigenin homodimer (APN), two specific inhibitors of MRP-1, had no effect on HCV replication. In contrast, the CysLTR1 antagonists SR2640 increased HCV-SGR RNA levels in a dose-dependent manner, with a maximum increase of 10-fold. In addition, a combination of natural CysLTR1 agonist (LTD4) or antagonists (zafirlukast, cinalukast, and SR2640) with MK-571 completely reversed its antiviral effect, suggesting its anti-HCV activity is related to CysLTR1 rather to MRP-1 inhibition. In conclusion, we showed that MK-571 inhibits HCV replication in hepatoma cell cultures by acting as a CysLTR1 receptor antagonist, thus unraveling a new host-virus interaction in the HCV life cycle.

BACKGROUND AND OBJECTIVES:

Antibiotic therapy is often prescribed for suspected community-acquired pneumonia (CAP) in children despite a lack of knowledge of causative pathogen. Our objective in this study was to investigate the association between antibiotic prescription and treatment failure in children with suspected CAP who are discharged from the hospital emergency department (ED).

Matthew J. Lipshaw
Apr 1, 2020; 145:e20193138-e20193138
ARTICLES

Hazleton native Megan Bobish has joined the Penn State Hazleton Athletics Department as the newest member of its team.

When the novel coronavirus pandemic prompted the transition to remote learning at Penn State, faculty and administrators in the Department of Mechanical Engineering were prepared for the challenge.

Despite being rebuked by Congress in its bid to do so last year, the U.S. Department of Education says it will use Education Innovation and Research funds for teacher professional development vouchers.

Paul L. Aronson
Oct 1, 2014; 134:667-677
ARTICLES

G. C. Liggins
Oct 1, 1972; 50:515-525
ARTICLES

The National Council on Teacher Quality has found that the number of elementary programs teaching scientifically based reading instruction is increasing.

Nearly every state in the nation has experienced enrollment declines, with some states seeing steep declines of more than 50 percent.

The National Council on Teacher Quality has found that the number of elementary programs teaching scientifically based reading instruction is increasing.

When was the last time you opened these Windows apps?

The experiences that Chris Eggerman, a 2017 graduate, had while at Penn State gave him a glimpse of the challenges and rewards he would enjoy in a career, and, paired with his education in the College of Information Sciences and Technology, equipped him with the skills he uses in his current profession as a security adviser at Liberty Mutual.

Within days of the University's shift to remote learning, faculty, instructors and teaching assistants in the Department of Geography moved 35 resident instruction courses into remote delivery mode to teach 1,947 students.

Sprint will need to divest to Boost Mobile, Virgin Mobile and its prepaid business to Dish Network, a satellite TV provider, so Dish can become a viable fourth competitor in the market.

Penn State York student-athlete Austin Lehman has received the Chancellor's Award for Academic Character, the most prestigious athletic award given by the campus.

Relaxed travel begins at home. This also includes the correct packing of your luggage.

Want to encourage girls to become professional technologists? Here's how to make sure your girls-in-tech events help them to accurately set their Science, Technology, Engineering, and Mathematics (STEM) career expectations.

The flu season has started here in the U.S., and according to the Centers for Disease Control and Prevention (CDC) data it has caused 214 deaths in the first week of 2020. Is this number higher, or lower, than usual? When does the flu season start, and how long does [...]

The post How to prepare (your graphs) for flu season appeared first on Graphically Speaking.

Statewide Emergency Repair Program launches from Delaware State Housing Authority MILFORD – Qualified homeowners in need of assistance to keep their homes livable can apply for assistance from the new Statewide Emergency Repair Program announced today by Governor John Carney and the Delaware State Housing Authority. “No one should live in a home with broken […]

DOVER — Delaware’s new home repair assistance initiative, the Statewide Emergency Repair Program, has received national recognition from the National Council of State Housing Agencies with a 2017 Annual Award for Program Excellence. “We are honored to receive this award on behalf of our partners and the many Delawareans that this home repair work has […]

The department currently has a fleet of 810 drones, which are used to monitor federal lands. Of those, 786 are Chinese-made and 121 come from DJI, the leading provider of consumer drones. DJI denies that its technology poses a threat.

A new worker is able to use his profession to reach out in Central Asia.

A Maryland woman who caused a fatal crash while driving under the influence of drugs has been sentenced to prison. Deputy Attorneys General Barzilai Axelrod and William Leonard secured the sentence for Michelle Park, 35, of Earlville. In March 2018, with her 2-year-old child in the car, Park failed to negotiate a curve while driving […]

  FOR IMMEDIATE RELEASE September 9, 2019                                                     MEDIA ADVISORY WHAT:  Delaware Insurance Commissioner Trinidad Navarro will be hosting a ribbon cutting and ceremony to commemorate the opening of the […]

FOR IMMEDIATE RELEASE September 10, 2019 Delaware Department of Insurance Opens New Building in Dover, Delaware   Delaware Insurance Commissioner Trinidad Navarro cut the ribbon during a ceremony held this morning at 11 AM to commemorate the opening of the Delaware Department of Insurance’s new Dover office location at 1351 West North Street, Suite 101 […]

Investigations result in discovery and correction of issues impacting consumers The Delaware Department of Insurance’s Market Conduct Examinations resulted in the receipt of nearly $700,000 in fines during 2019 from more than a dozen companies found to violate the Insurance Code or other related regulations. The fines are contributed to the General Fund, providing funding […]

The Delaware Department of Insurance made great strides in fraud detection and response during 2019. Throughout the year, 6 criminal arrests that included 21 charges were recommended from the Department’s Fraud Prevention Bureau to the Department of Justice, and 16 civil cases were brought forward resulting in more than $21,000 in fines. The Bureau received 551 referral cases in 2019.

Activities to include demonstrations by the First Delaware Regiment and "Caesar Rodney in his Own Words," a historical play exploring the views of the famed Delaware patriot.

Kobe and Gianna Bryant were among nine people who died in the January 26 helicopter crash in the mountains west of Los Angeles.

Jio Rs. 2,399 prepaid recharge plan brings 2GB daily high-speed data benefits along with unlimited voice calling benefits for 365 days. Jio has also introduced new add-on packs at Rs. 151, Rs. 201,...

Umar Akmal was banned from all forms of cricket for three years by the PCB after pleading guilty to failing to report corrupt approaches.

Bhaat literally means rice and bhaja means fry; bhaat bhaja is the home-style fried rice among Bengalis. This recipe needs almost nothing for preparation; tastes best with leftover rice.

"Agneepath was made years before.. how did this happen," wrote Big B

Democratic Party's presumptive presidential nominee and former US vice president Joe Biden alleged on Friday that President Donald Trump utterly failed to prepare for the COVID-19 pandemic and said...

The Delaware Division of Libraries and Delaware Department of Labor (DOL) rolled out the partnership in February 2019 to be able to reach out to more residents who may be in need of services but can’t travel to Department of Labor locations. With the many computers available at libraries, a staff member can offer residents […]

DOVER (January 3, 2020): As part of a systems-wide upgrade to State of Delaware banking processes, the Office of State Treasurer Colleen C. Davis and the Department of Labor have announced improvements to unemployment benefit payment distribution. By the end of this month, the state will move unemployment debit cards to the U.S. Bank ReliaCard®, […]

Director Ann Shepard Visalli will conclude her tenure leading Delaware’s Office of Management and Budget (OMB) next month following more than seven years leading the Markell Administration’s efforts to balance challenging budgets while making key investments that have strengthened the economy, improved the education system, and enhanced quality of life throughout the state.

Dover – Today, the State of Delaware announced that it appears as No. 56 on the U.S. Environmental Protection Agency’s (EPA’s) National Top 100 list of the largest green power users from the Green Power Partnership. Delaware is using nearly 122 million kilowatt-hours (kWh) of green power annually, which represents 40 percent of its total […]

With hurricane season about to begin, Delaware agricultural authorities are urging farmers and pet owners to plan ahead and prepare for weather emergencies. Hurricane Preparedness Week runs from May 26 to June 1, with hurricane season beginning June 1. The Department of Agriculture’s Delaware Animal Response Program works with state emergency officials and animal welfare organizations to assist animal owners with preparation, sheltering in place and evacuation. “Preparing and acting early can save animals’ lives,” said Secretary of Agriculture Ed Kee. “The time to take action is now, before storms create disaster conditions.”

The Delaware Department of Agriculture's marketing team has been honored by the Delaware Food Industry Council for its work connecting farmers and grocers.

A wildfire crew led by the Delaware Forest Service is near completion of a two-week assignment on the Fork Complex Fire, a 28,736-acre blaze near Hayfork, California in the Shasta-Trinity National Forest. Almost 2,400 personnel are battling the fire that is currently 26 percent contained. The Fork Complex is one of several large wildfires in Northern California that together cover more than 223,000 acres, one of the major factors that prompted the National Interagency Fire Center (NIFC) to increase its National Preparedness Level today to the maximum of 5 on a 5-point scale.

Livestock owners should prepare now for possible weather effects from Hurricane Joaquin, Delaware agricultural authorities said Thursday. "Being prepared is never wasted effort," said Delaware Secretary of Agriculture Ed Kee.

To protect our State, we are asking Delawareans to join us in the battle against invasive plant pest and diseases. If you suspect an invasive pest or disease, contact our Plant Industries section at (302) 698-4500. Get acquainted with the hungry pests that would like to dine in Delaware by visiting www.hungrypests.com. This April—Invasive Plant Pest and Disease Awareness Month—we urge you to help stop the spread of these harmful pests.

In the scam, the homeowner is told that they must leave their house for a period of twelve hours while the individual sprays crops in the nearby vicinity. There are some indicators that these visits are a scam in an attempt to get the homeowner to leave their house unattended. There are currently no agricultural pesticide spraying practices in Delaware that would require one to leave their home.