Former England stars John Terry and Jack Wilshere are among those sharing 'matchday selfies' to raise money for Muscular Dystrophy UK.

1. Inside Salman Khan's Panvel farmhouse: Actor bonds with Jacqueline, Iulia Vantur, and Waluscha - entertainment  Mid-Day
2. Salman Khan on life during the lockdown: This is the longest I have been sitting idle  India Today
3. Tere Bina teaser: Salman Khan romances Jacqueline Fernandez in his ‘cheapest production’. Watch  Hindustan Times
4. Salman Khan and Jacqueline Fernandez share the inspiration behind their upcoming track 'Tere Bina' in the  Times of India
5. Salman Khan reveals lockdown journey and COVID-19 relief initiatives  NEWS9 live
6. View Full coverage on Google News

Deeply worried about Beijing's insatiable desire for land and the way its military has occupied areas by stealth, Washington has sent three warships to the region.

Use different-coloured tomatoes for this easy dinner that's perfect for warm summer evenings

Deeply worried about Beijing's insatiable desire for land and the way its military has occupied areas by stealth, Washington has sent three warships to the region.

Gregg Sulkin was spotted enjoying a grueling workout in his local park on Friday. The 27-year-old wore activewear and ensured he still masked up while outdoors during the session.

Two Air India Express flights bring them home, another flight from Doha to bring 183

Ripon sinkhole: British Geological Survey says area susceptible to holes  BBC News

Human muscarinic receptor M4 belongs to the class A subfamily of the G-protein-coupled receptors (GPCRs). M4 has emerged as an attractive drug target for the treatment of Alzheimer's disease and schizophrenia. Recent results showed that M4-mediated cholinergic transmission is related to motor symptoms in Parkinson's disease. Selective ligand design for the five muscarinic acetylcholine receptor (mAchR) subtypes currently remains challenging owing to the high sequence and structural similarity of their orthosteric binding pockets. In order to obtain M4-selective antagonists, a new approach was tried to lock M4 into an inactive form by rationally designing an N4497.49R mutation, which mimics the allosteric sodium binding in the conserved sodium site usually found in class A GPCRs. In addition, the crystal structure of the mutation-induced inactive M4 was determined. By comparative analysis with other mAchR structures, followed by functional assays, the N4497.49R mutation was shown to stabilize M4 into an inactive state. Virtual screening of a focused ligand library using the crystal structure showed that the inactive M4 prefers antagonists much more than agonists. This study provides a powerful mutation strategy to stabilize GPCRs in inactive states and facilitate their structure determination.

Fond of a range of marine and freshwater vegetation such as turtle grass and eelgrass, the Florida manatee spends most of its waking hours grazing […]

The post Algae bloom toxins may make Florida’s manatees and sea turtles susceptible to deadly accidents appeared first on Smithsonian Insider.

Yinlong Song, Yikan Zhang, Ying Pan, Jianfeng He, Yan Wang, Wei Chen, Jing Guo, Haiteng Deng, Yi Xue, Xianyang Fang, and Xin Liang

Microtubules dynamics is regulated by the plus end-tracking proteins (+TIPs) in cells. End binding protein 1 (EB1) acts as a master regulator in +TIPs networks by targeting microtubule growing ends and recruiting other factors. However, the molecular mechanism of how EB1 binds to microtubule ends with a high affinity remains to be an open question. Using single-molecule imaging, we show that the end-binding kinetics of EB1 changes along with the polymerizing and hydrolysis rate of tubulin dimers, confirming the binding of EB1 to GTP/GDP-Pi tubulin at microtubule growing ends. The affinity of wild-type EB1 to these sites is higher than monomeric EB1 mutants, suggesting that two CH domains in the dimer contribute to the end-binding. Introducing phosphomimicking mutations into the linker domain of EB1 weakens the end-binding affinity and confers a more curved conformation to EB1 dimer without compromising dimerization, suggesting that the overall architecture of EB1 is important for the end-binding affinity. Taken together, our results provide insights into understanding how the high-affinity end-binding of EB1 can be achieved and how this activity may be regulated in cells.

Researchers from the University of Oxford's Bodleian Libraries and from universities in the Netherlands have used high-tech imaging to uncover the details of a rare Mexican codex dating from before the colonization of the Americas. The newly revealed codex, or book, has been hidden from view for almost 500 years, concealed beneath a layer of plaster and chalk on the back of a later manuscript known as the Codex Selden, which is housed at the Bodleian Libraries. Scientists have used hyperspectral imaging to reveal pictographic scenes from this remarkable document and have published their findings in the Journal of Archaeological Science: Reports.

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Archaeologists translating a very rare inscription on an ancient Etruscan temple stone have discovered the name Uni -- an important female goddess.

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Coral and mollusc species with an outer layer of protective tissue are more able to withstand acidic seawater than some other species, according to a recent study. However, higher temperatures projected under climate change are likely to worsen the impact of ocean acidification on coral and molluscs, even affecting those that are otherwise resistant to higher levels of acidity.

LEESBURG – The two-lane Cochran Mill Road (Route 653) bridge over Tuscarora Creek has been reduced to one lane of alternating traffic until further...

No matter how much nostalgia they generate, they're out of step with $4 a gallon gas and concern about foreign oil dependence.