The 'accelerator suppression function' is a new safety feature which ignores accelerator pedal input if the car thinks the driver pressed it by mistake.

If you want a hybrid vehicle that can get you through winter weather, the Toyota Prius XLE AWD-e offers solid value for the price.

"I find my job very exciting; every day is new, as we are creating a brand in the Indian market which is a challenge in itself," says Rahul Vira, CEO, Skechers, South Asia.

Rohit Sharma shared a picture of daughter Samaira surrounded by her toys.

NEW CASTLE (May 15, 2019) – During Supervised Visitation Awareness Month, the Department of Health and Social Services’ Office of Community Services is conducting a toy drive to provide new toys, books and games for use at Delaware’s six Family Visitation Centers (FVCs). Through June 10, drop-off bins will be located at all State Service […]

Toyota plans to make 1,50,000 of the Toyota Yaris Cross in France a year alongside the hatchback for the European market. But will only go on sale next year.

The Toyota Etios Cross wasn't a huge commercial success but the Yaris Cross looks upmarket as well as has modern equipment in the form of a hybrid powertrain.

The flagship Mahindra, Alturas G4, in its BS6 avatar is Rs 1 lakh expensive and still comes in two variants.

'New type of analysis' deployed to determine plastics' toxicity

The first Japanese automaker to win the title twice with a self-charging hybrid electric vehicle—the TS050.

Compact sedans like the Elantra and Corolla mostly form the role of commuter cars in American households, and they’re spacious enough to be family vehicles for those with smaller kids or pets to put in the back seat. If your budget is tight, the 2020 Toyota Corolla and 2020 Hyundai Elantra are two of the best values on the market. They both...

Tesla Motors Inc.’s Elon Musk said the electric-car maker may form another partnership with Toyota Motor Corp., as the companies conclude an initial vehicle project that met with mixed results.

In recent months, a veritable open patent war has erupted between Tesla Motors and Toyota. Both companies have been widely cited in the industry and financial press for their respective announcements opening up their electric vehicle (Tesla) and fuel cell (Toyota) patents. Tesla CEO Elon Musk opened the first salvo with a blog post last June in which he announced that Tesla would “not initiate patent lawsuits against anyone who, in good faith, wants to use our technology.”

BEST DEALS ON SEX TOYS:

• Ella Paradis — Get up to 80% off

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If Instagram is to be believed, then self care for women basically amounts to face masks and daily affirmation apps.

Hot take: Sex toys are the ultimate self-care purchase.

Orgasms release oxytocin, the anti-stress hormone that gets you warm and fuzzy when cuddling, while dopamine, a neurotransmitter that regulates sleep, also makes an appearance. It stands to reason, then, that "I need to get laid" is a thing that actually makes sense to say when you're having a rough week. Read more...

The world is experiencing what some may think is a “typical” black swan event: rare, extremely impactful, and only retrospectively predictable. 

Title: Animals More Interesting to Kids Than Toys, Study Shows
Category: Health News
Created: 4/27/2012 2:05:00 PM
Last Editorial Review: 4/30/2012 12:00:00 AM

In mammalian cells, alphavirus replication complexes are anchored to the plasma membrane. This interaction with lipid bilayers is mediated through the viral methyl/guanylyltransferase nsP1 and reinforced by palmitoylation of cysteine residue(s) in the C-terminal region of this protein. Lipid content of membranes supporting nsP1 anchoring remains poorly studied. Here, we explore the membrane binding capacity of nsP1 with regard to cholesterol. Using the medically important chikungunya virus (CHIKV) as a model, we report that nsP1 cosegregates with cholesterol-rich detergent-resistant membrane microdomains (DRMs), also called lipid rafts. In search for the critical factor for cholesterol partitioning, we identify nsP1 palmitoylated cysteines as major players in this process. In cells infected with CHIKV or transfected with CHIKV trans-replicase plasmids, nsP1, together with the other nonstructural proteins, are detected in DRMs. While the functional importance of CHIKV nsP1 preference for cholesterol-rich membrane domains remains to be determined, we observed that U18666A- and imipramine-induced sequestration of cholesterol in late endosomes redirected nsP1 to these compartments and simultaneously dramatically decreased CHIKV genome replication. A parallel study of Sindbis virus (SINV) revealed that nsP1 from this divergent alphavirus displays a low affinity for cholesterol and only moderately segregates with DRMs. Behaviors of CHIKV and SINV with regard to cholesterol, therefore, match with the previously reported differences in the requirement for nsP1 palmitoylation, which is dispensable for SINV but strictly required for CHIKV replication. Altogether, this study highlights the functional importance of nsP1 segregation with DRMs and provides new insight into the functional role of nsP1 palmitoylated cysteines during alphavirus replication.

IMPORTANCE Functional alphavirus replication complexes are anchored to the host cell membranes through the interaction of nsP1 with the lipid bilayers. In this work, we investigate the importance of cholesterol for such an association. We show that nsP1 has affinity for cholesterol-rich membrane microdomains formed at the plasma membrane and identify conserved palmitoylated cysteine(s) in nsP1 as the key determinant for cholesterol affinity. We demonstrate that drug-induced cholesterol sequestration in late endosomes not only redirects nsP1 to this compartment but also dramatically decreases genome replication, suggesting the functional importance of nsP1 targeting to cholesterol-rich plasma membrane microdomains. Finally, we show evidence that nsP1 from chikungunya and Sindbis viruses displays different sensitivity to cholesterol sequestering agents that parallel with their difference in the requirement for nsP1 palmitoylation for replication. This research, therefore, gives new insight into the functional role of palmitoylated cysteines in nsP1 for the assembly of functional alphavirus replication complexes in their mammalian host.

Toyota-Suzuki अपनी पार्टनरशिप के तहत आने वाले दिनों में भारतीय बाजार में नई गाड़ी लॉन्च करने जा रही हैं। कंपनी की यह कार Vitara Brezza पर आधारित होगी। जिसे Toyota Urban Cruiser नाम से लॉन्च किया जाएगा।

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Three people have been arrested after a staggering 190kg of cocaine worth about £19 million was found hidden in lorries carrying toys and paper at the Port of Dover.

Despite everything, the Tory party is sticking to the ideology of the free market, rather than saving lives and jobs

“How on earth did it come to this?” Keir Starmer’s question could skewer Boris Johnson at every PMQs from now on. It encompasses all the damage the government did in the last decade, as well as all it has failed to do to protect the country from Covid-19. The list of derelictions in the early stage of the crisis is long, the testing and the protective equipment still shamefully inadequate. Have lessons been learned? The auguries are not good.

Related: Picnics and sunbathing on cards as PM expected to allow more time outside

100% of the proceeds will go towards the NHS

Quarantine just got a whole lot more fun

Plus, her husband shows off his skills on the grill.

New version of the classic doll, which can chat with children, makes her debut at New York Toy Fair.

Japan-based Toyo Ink SC Holdings Co. Ltd. and various affiliated entities (collectively, Toyo Ink) have agreed to pay $45 million, plus interest, to settle allegations that they violated the False Claims Act by knowingly failing to pay antidumping and countervailing duties, the Justice Department announced today.

Five individuals and five corporations have been charged in an indictment unsealed today in Brooklyn, N.Y., for allegedly importing hazardous and counterfeit toys from China for sale in the United States.

A Detroit federal grand jury returned an indictment against a Panasonic Automotive Systems Corporation executive for his role in an international conspiracy to fix prices of switches and steering angle sensors sold to Toyota and installed in U.S. cars.

A Cleveland federal grand jury returned an indictment against two executives of a Japanese automotive supplier for their roles in an international conspiracy to fix prices of automotive anti-vibration rubber parts sold to Toyota and installed in U.S. cars.

Osaka, Japan-based Toyo Tire & Rubber Co. Ltd. has agreed to plead guilty and to pay a $120 million criminal fine for its role in two separate conspiracies to fix the prices of automotive components involving anti-vibration rubber and driveshaft parts installed in cars sold in the United States and elsewhere.

U.S. Attorney General Eric Holder, U.S. Secretary of Transportation Anthony Foxx, U.S. Attorney for the Southern District of New York Preet Bharara, Inspector General of the U.S. Department of Transportation Calvin L. Scovel, III, National Highway Traffic Safety Administration Acting Administrator David Friedman, and FBI Deputy Assistant Director Joe Campbell announced a criminal wire fraud charge against Toyota Motor Corporation, an automotive company headquartered in Toyota City, Japan, that designs, manufactures, assembles, and sells Toyota and Lexus brand vehicles.

Today’s announcement underscores the fact that the Departments of Justice and Transportation remain firmly committed to protecting consumers, ensuring the safety of the American people, and combating fraud in all its forms.

Be sure to dispose of these toys if they are in the attic, and know how to stay on top of product recalls

From reuse to recycling, there are a variety of ways for the eco-minded parent to clean the house of old and broken children's toys without ever touching the garbage bin.

These sets of precision-cut oak blocks and planks, combined with clever connectors, are intended to help spark creativity and imagination in kids, and to "make playtime more meaningful."

Because every preschooler needs insecurity-boosting, sexualizing, toxic cosmetics to slather on their beautiful little faces!

These beautiful toys are creative, unusual, and eco-friendly.

Toy innovation has stagnated in recent years and kids are bored. Who's at fault?

Often marketed as educational, electronic toys have the opposite effect, resulting in parents and children speaking less to each other.

A new study shows that there is such thing as too many toys.

"Reuse" is usually a good motto; this study reminds parents to take care in the case of toys originally sold in yesteryears. We offer some tips for selecting safer used toys.

The fleeting distraction they provide isn't worth the surprising costs.

It's not urgent in the big picture, but it's something we should be doing more.

Their hugely successful petition has even gotten a response – and a promise – from the fast food giant.

Mark your calendars: Toyota is promising (well, hinting very strongly), their 2015 model year collection will include a full-production hydrogen fuel cell vehicle.

Last week at CES in Las Vegas, Toyota revealed the FCV concept car for the fuel cell vehicle they will be making available next year. I had a chance to see the concept this week at the Detroit Auto Show.

After years of promises, hydrogen-powered vehicles are finally arriving on the scene.